zetekitoxin AB: a sodium channel blocker; isolated from the frog Atelopus zeteki; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 21589240 |
| CHEMBL ID | 3617050 |
| MeSH ID | M0469215 |
| Synonym |
|---|
| zetekitoxin ab |
| 62996-38-7 |
| c7a2uz79fj , |
| CHEMBL3617050 , |
| bdbm50118519 |
| DTXSID401336333 |
| PD189253 |
| [(3r,5s,6s,11r,12s,16s)-14,17-diamino-19,19-dihydroxy-6-(hydroxymethyl)-10-oxo-3-sulfooxy-8-oxa-1,9,13,15,18-pentazapentacyclo[9.5.2.13,16.05,9.012,16]nonadeca-14,17-dien-13-yl]methyl n-hydroxycarbamate |
| ((3as,4r,6r,7as,8s,13r,13as)-2,15-diamino-5,6,7,7a,8,9,13,13a-octahydro-16,16-dihydroxy-8-(hydroxymethyl)-12-oxo-6-(sulfooxy)-3a,6-methano-13,4-(nitrilometheno)imidazo(4,5-g)isoxazolo(2,3-a)(1,6)diazecin-1(12h)-yl)methyl n-hydroxycarbamate |
| carbamic acid, hydroxy-, ((3as,4r,6r,7as,8s,13r,13as)-2,15-diamino-5,6,7,7a,8,9,13,13a-octahydro-16,16-dihydroxy-8-(hydroxymethyl)-12-oxo-6-(sulfooxy)-3a,6-methano-13,4-(nitrilometheno)imidazo(4,5-g)isoxazolo(2,3-a)(1,6)diazecin-1(12h)-yl)methyl ester |
Zetekitoxin AB is an extremely potent blocker of voltage-dependent sodium channels expressed in Xenopus oocytes.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Zetekitoxin AB proved to be an extremely potent blocker of voltage-dependent sodium channels expressed in Xenopus oocytes." | ( The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: a potent sodium-channel blocker. Choudhary, G; Daly, JW; Dudley, SC; Kim, YH; Oshima, Y; Pfahnl, A; Yotsu-Yamashita, M, 2004) | 1.38 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | IC50 (µMol) | 0.0001 | 0.0001 | 3.5075 | 10.0000 | AID1246043 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 (µMol) | 0.0003 | 0.0003 | 3.6484 | 9.2000 | AID1246044 |
| Sodium channel protein type 2 subunit alpha | Homo sapiens (human) | IC50 (µMol) | 0.0000 | 0.0000 | 3.7401 | 10.0000 | AID1246042 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1246042 | Inhibition of NaV1.2 channel (unknown origin) expressed in Xenopus laevis oocytes by two-electrode oocyte voltage-clamp method | 2015 | Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18 | Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications. |
| AID1246043 | Inhibition of NaV1.4 channel (unknown origin) expressed in Xenopus laevis oocytes by two-electrode oocyte voltage-clamp method | 2015 | Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18 | Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications. |
| AID1246044 | Inhibition of NaV1.5 channel (unknown origin) expressed in Xenopus laevis oocytes by two-electrode oocyte voltage-clamp method | 2015 | Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18 | Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 3 (60.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 2 (40.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||