Page last updated: 2024-08-01 13:13:58
4-hydroxystilbene
Description
4-hydroxystilbene: RN given refers to cpd without isomeric designation [MeSH]
trans-stilben-4-ol : no description available [CHeBI]
Cross-References
Synonyms (53)
| Synonym |
|---|
| BIDD:ER0598 |
| 4-(2-phenylethenyl)phenol |
| trans-stilben-4-ol |
| CHEBI:36664 |
| 4-[(e)-2-phenylvinyl]phenol |
| 4-[(e)-2-phenylethenyl]phenol |
| CHEBI:35101 , |
| stilben-4-ol |
| (e)-4-hydroxystilbene |
| p-styrylphenol |
| 4-(2-phenylvinyl)phenol |
| 4-stilbenol |
| 3839-46-1 |
| phenol, 4-(2-phenylethenyl)- |
| 4-hydroxyphenylstilbene |
| nsc-48625 |
| nsc43309 |
| hydroxystlbene,4- |
| nsc-43309 |
| 4-hydroxystilbene |
| nsc48625 |
| p-hydroxystilbene |
| 6554-98-9 |
| (e)-4-stilbenol |
| trans-4-hydroxystilbene |
| inchi=1/c14h12o/c15-14-10-8-13(9-11-14)7-6-12-4-2-1-3-5-12/h1-11,15h/b7-6 |
| 4-hydroxy-trans-stilbene |
| LMPK13090024 |
| (e)-4-styrylphenol |
| CHEMBL195624 , |
| A835148 |
| 4-[(e)-styryl]phenol |
| AKOS024318874 |
| 4-hydroxystilbene, trans- |
| s6e4zx5jss , |
| bdbm50410498 |
| AE-641/01920053 |
| 4-styrylphenol |
| SCHEMBL27993 |
| trans 4 hydroxystilbene |
| 4-[(e)-2-phenylethenyl]phenol # |
| phenol, 4-(2-phenylethenyl)-, (e)- |
| 4-stilbenol, (e)- |
| trans-4-stilbenol |
| trans-p-hydroxystilbene |
| DTXSID2022464 |
| mfcd00002386 |
| 4-((e)-2-phenylethenyl)phenol |
| 4-((e)-2-phenylvinyl)phenol |
| (e)-1-(4-hydroxyphenyl)-2-phenylethene |
| phenol, 4-((1e)-2-phenylethenyl)- |
| Q27116417 |
| phenol, 4-[(1e)-2-phenylethenyl]- |
Drug Classes (1)
| Class | Description |
|---|
| stilben-4-ol | A phenol having the structure of stilbene with a hydroxy function at C-4 of one of the phenyl rings; the stereochemistry across the alkene bond is not specified. |
Protein Targets (3)
Inhibition Measurements
Activation Measurements
Bioassays (13)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID1272522 | Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
ISSN: 1464-3405 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID1467689 | Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx at 30 uM preincubated for 6 mins followed by AITC addition measured for 1 min by Fluo-4 dye-based assay relative to resveratrol | 2017 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
ISSN: 1464-3405 | Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor. |
| AID1486518 | Inhibition of acid-induced wild type transthyretin (unknown origin) aggregation expressed in Escherichia coli pre-incubated for 30 mins before acid addition and further incubated for 72 hrs at 37 degC under dark conditions by UV-Vis spectrophotometry | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15
ISSN: 1464-3405 | Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors. |
| AID1486519 | Binding affinity to transthyretin in human blood plasma assessed as plasma binding selectivity by measuring stoichiometry of small molecule bound to TTR incubated for 24 hrs at 37 degC by RP-HPLC | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15
ISSN: 1464-3405 | Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors. |
| AID1272524 | Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level relative to allyl isothiocyanate | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
ISSN: 1464-3405 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID1272526 | Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
ISSN: 1464-3405 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID749799 | Antiproliferative activity against human HT-29 cells after 3 days by MTT assay | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
ISSN: 1464-3391 | Inhibition of VEGF expression in cancer cells and endothelial cell differentiation by synthetic stilbene derivatives. |
| AID749801 | Antiproliferative activity against BAEC after 3 days by MTT assay | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
ISSN: 1464-3391 | Inhibition of VEGF expression in cancer cells and endothelial cell differentiation by synthetic stilbene derivatives. |
| AID255211 | Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
ISSN: 0022-2623 | Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. |
| AID1272525 | Agonist activity at human TRPV1 expressed in HEK293 cells assessed as induction of intracellular calcium level relative to allyl isothiocyanate | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
ISSN: 1464-3405 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID749800 | Antiangiogenic activity against BAEC assessed as inhibition of tube formation after 7 hrs by matrigel assay | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
ISSN: 1464-3391 | Inhibition of VEGF expression in cancer cells and endothelial cell differentiation by synthetic stilbene derivatives. |
| AID1272523 | Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
ISSN: 1464-3405 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID1467690 | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay relative to AITC | 2017 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
ISSN: 1464-3405 | Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor. |
Research
Studies (16)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 5 (31.25) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 18 (100.00%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|
| chlordecone | | cyclic ketone;
organochlorine compound | insecticide;
persistent organic pollutant | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| hexachlorocyclohexane | | chlorocyclohexane | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| vanillin | | benzaldehydes;
monomethoxybenzene;
phenols | anti-inflammatory agent;
anticonvulsant;
antioxidant;
flavouring agent;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,4,5-trichlorophenoxyacetic acid | | chlorophenoxyacetic acid;
trichlorobenzene | defoliant;
phenoxy herbicide;
synthetic auxin | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-nonylphenol | | phenols | environmental contaminant | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| clomiphene | | tertiary amine | estrogen antagonist;
estrogen receptor modulator | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dichlorodiphenyl dichloroethylene | | chlorophenylethylene;
monochlorobenzenes | human xenobiotic metabolite;
persistent organic pollutant | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ddt | | benzenoid aromatic compound;
chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide | bridged diphenyl acaricide;
carcinogenic agent;
endocrine disruptor;
persistent organic pollutant | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| diflunisal | | monohydroxybenzoic acid;
organofluorine compound | non-narcotic analgesic;
non-steroidal anti-inflammatory drug | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| benzophenone | | benzophenones | photosensitizing agent;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| endosulfan | | cyclic sulfite ester;
cyclodiene organochlorine insecticide | acaricide;
agrochemical;
GABA-gated chloride channel antagonist;
persistent organic pollutant | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| flufenamic acid | | aromatic amino acid;
organofluorine compound | antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| heptachlor | | cyclodiene organochlorine insecticide | agrochemical;
antibacterial agent;
antifungal agent;
GABA-gated chloride channel antagonist;
persistent organic pollutant | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| meclofenamic acid | | aminobenzoic acid;
organochlorine compound;
secondary amino compound | analgesic;
anticonvulsant;
antineoplastic agent;
antipyretic;
antirheumatic drug;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-steroidal anti-inflammatory drug | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| mefenamic acid | | aminobenzoic acid;
secondary amino compound | analgesic;
antipyretic;
antirheumatic drug;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-steroidal anti-inflammatory drug;
xenobiotic | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methoxychlor | | organochlorine insecticide | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nafoxidine | | benzenes;
naphthalenes;
ring assembly | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| corticosterone | | 11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone | human metabolite;
mouse metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| prednisolone | | 11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
drug metabolite;
environmental contaminant;
immunosuppressive agent;
xenobiotic | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| estriol | | 16alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-hydroxy steroid | estrogen;
human metabolite;
human xenobiotic metabolite;
mouse metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| spironolactone | | 3-oxo-Delta(4) steroid;
oxaspiro compound;
steroid lactone;
thioester | aldosterone antagonist;
antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aldosterone | | 11beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde | human metabolite;
mouse metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| androsterone | | 17-oxo steroid;
3alpha-hydroxy steroid;
androstanoid;
C19-steroid | androgen;
anticonvulsant;
human blood serum metabolite;
human metabolite;
human urinary metabolite;
mouse metabolite;
pheromone | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 17-desoxyestradiol | | 3-hydroxy steroid;
phenolic steroid;
phenols | estrogen | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| allyl isothiocyanate | | alkenyl isothiocyanate;
isothiocyanate | antimicrobial agent;
antineoplastic agent;
apoptosis inducer;
lachrymator;
metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ethinyl estradiol | | 17-hydroxy steroid;
3-hydroxy steroid;
terminal acetylenic compound | xenoestrogen | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| chlordan | | cyclodiene organochlorine insecticide | GABA-gated chloride channel antagonist;
persistent organic pollutant | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| testosterone propionate | | steroid ester | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methyltestosterone | | 17beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
enone | anabolic agent;
androgen;
antineoplastic agent | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| androstenedione | | 17-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid | androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| norethindrone | | 17beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
terminal acetylenic compound;
tertiary alcohol | progestin;
synthetic oral contraceptive | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| norethynodrel | | oxo steroid | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| medroxyprogesterone acetate | | 20-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
corticosteroid;
steroid ester | adjuvant;
androgen;
antineoplastic agent;
antioxidant;
female contraceptive drug;
inhibitor;
progestin;
synthetic oral contraceptive | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dichlorodiphenyldichloroethane | | chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide | xenobiotic metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bisphenol a | | bisphenol | endocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| p-tert-amylphenol | | alkylbenzene | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-sec-butylphenol | | phenols | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| diphenyl | | aromatic fungicide;
benzenes;
biphenyls | antifungal agrochemical;
antimicrobial food preservative | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-phenylphenol | | hydroxybiphenyls | | 2005 | 2017 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 4-nitrobiphenyl | | biphenyls | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| propylparaben | | benzoate ester;
paraben;
phenols | antifungal agent;
antimicrobial agent | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| butylphen | | phenols | allergen | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methylparaben | | paraben | antifungal agent;
antimicrobial food preservative;
neuroprotective agent;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| monobenzone | | benzyl ether | allergen;
dermatologic drug;
melanin synthesis inhibitor | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-chlorophenol | | monochlorophenol | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,4-dihydroxybenzophenone | | benzophenones | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-fluorobiphenyl | | | | 2017 | 2017 | 7.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| cyproterone acetate | | 20-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
chlorinated steroid;
steroid ester | androgen antagonist;
geroprotector;
progestin | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| epitestosterone | | 17alpha-hydroxy steroid;
3-oxo-Delta(4) steroid;
androstanoid | androgen antagonist;
human metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| flavanone | | flavanones | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| androstenediol | | 17beta-hydroxy steroid;
3beta-hydroxy-Delta(5)-steroid | androgen;
human metabolite;
mouse metabolite;
radiation protective agent | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dihydrotestosterone | | 17beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid | androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| flavone | | flavones | metabolite;
nematicide | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-hydroxybiphenyl | | hydroxybiphenyls | | 2017 | 2017 | 7.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-cumylphenol | | diarylmethane | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| biphenyl-3-carboxylic acid | | | | 2017 | 2017 | 7.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| o,p'-ddt | | diarylmethane | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-hydroxybenzophenone | | benzophenones | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-chloro-2-cresol | | monochlorobenzenes;
phenols | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-octylphenol | | phenols | metabolite;
surfactant;
xenoestrogen | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,4,2',4'-tetrachlorobiphenyl | | dichlorobenzene;
tetrachlorobiphenyl | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ac 45594 | | aromatic ether | | 2005 | 2005 | 19.0 | high | 0 | 0 | 0 | 1 | 0 | 0 |
| kc 400 | | dichlorobenzene;
tetrachlorobiphenyl | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| promegestone | | 20-oxo steroid;
3-oxo-Delta(4) steroid | antineoplastic agent;
progesterone receptor agonist;
progestin | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3,5-dichlorobiphenyl | | dichlorobenzene;
dichlorobiphenyl | | 2017 | 2017 | 7.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,4'-dichlorobiphenyl | | dichlorobiphenyl;
monochlorobenzenes | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol | | stilbenoid | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| taleranol | | macrolide | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bisphenol b | | bisphenol | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-phenylbenzoic acid | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| alfatradiol | | 17alpha-hydroxy steroid;
3-hydroxy steroid;
estradiol | estrogen;
geroprotector | 2005 | 2005 | 19.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| 4,4'-Dihydroxybenzophenone | | benzophenones | | 2005 | 2005 | 19.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| biphenyl-2-carboxylic acid | | | | 2017 | 2017 | 7.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| 6-hydroxyflavone | | hydroxyflavonoid | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-phenoxybenzoic acid | | phenoxybenzoic acid | | 2017 | 2017 | 7.0 | high | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane | | bisphenol | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1,1-Dichloro-2,2-bis(4-hydroxyphenyl)ethylene | | diarylmethane | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| equol | | hydroxyisoflavans | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| androstan-3-ol | | 3-hydroxy steroid | androgen | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3,3',5,5'-tetrachlorobiphenyl-4,4'-diol | | dichlorobenzene;
hydroxybiphenyls | | 2005 | 2017 | 13.0 | medium | 0 | 0 | 0 | 1 | 1 | 0 |
| 3,3'-Dihydroxyhexestrol | | stilbenoid | | 2005 | 2005 | 19.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl | | biphenyls;
tetrachlorobenzene | | 2005 | 2005 | 19.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| Zearalanone | | macrolide;
resorcinols | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-androstene-3,17-diol | | 3-hydroxy steroid | androgen | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4'-hydroxyflavanone | | 4'-hydroxyflavanones;
monohydroxyflavanone | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dihydroresveratrol | | stilbenol | plant metabolite;
xenobiotic metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene | | diarylmethane | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-hydroxyestradiol | | 17beta-hydroxy steroid;
2-hydroxy steroid | carcinogenic agent;
human metabolite;
metabolite;
mouse metabolite;
prodrug | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| mibolerone | | 17beta-hydroxy steroid;
3-oxo-Delta(4) steroid | anabolic agent;
androgen | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| metribolone | | 17beta-hydroxy steroid;
3-oxo steroid;
anabolic androgenic steroid | androgen | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| resveratrol | | resveratrol | antioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger | 2013 | 2017 | 8.2 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| diethylstilbestrol | | olefinic compound;
polyphenol | antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| chalcone | | chalcone | EC 3.2.1.1 (alpha-amylase) inhibitor | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3,3',4,5'-tetrahydroxystilbene | | catechols;
polyphenol;
resorcinols;
stilbenol | antineoplastic agent;
apoptosis inducer;
geroprotector;
hypoglycemic agent;
plant metabolite;
protein kinase inhibitor;
tyrosine kinase inhibitor | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| capsaicin | | capsaicinoid | non-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| isoeugenol | | isoeugenol | | 2005 | 2005 | 19.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| tamoxifen | | stilbenoid;
tertiary amino compound | angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 6-hydroxyflavanone | | monohydroxyflavanone | fungal xenobiotic metabolite | 2005 | 2005 | 19.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| dimethylstilbestrol | | stilbenoid | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pinosylvin | | pinosylvin | | 2016 | 2017 | 7.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| genistein | | 7-hydroxyisoflavones | antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| coumestrol | | coumestans;
delta-lactone;
polyphenol | anti-inflammatory agent;
antioxidant;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Pinosylvin methyl ether | | stilbenoid | | 2016 | 2017 | 7.5 | medium | 0 | 0 | 0 | 0 | 2 | 0 |
| pterostilbene | | diether;
methoxybenzenes;
stilbenol | anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
hypoglycemic agent;
neuroprotective agent;
neurotransmitter;
plant metabolite;
radical scavenger | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 7-hydroxyflavone | | hydroxyflavonoid | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-hydroxyestradiol | | 4-hydroxy steroid | metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-hydroxychalcone | | chalcones;
phenols | antihypertensive agent;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4'-hydroxychalcone | | chalcones;
phenols | anti-inflammatory agent;
antineoplastic agent | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4,4'-dihydroxystilbene | | stilbene-4,4'-diol | | 2005 | 2016 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 3,5-dimethoxy-trans-stilbene | | stilbenoid | | 2016 | 2017 | 7.5 | medium | 0 | 0 | 0 | 0 | 2 | 0 |
| 3,4',5-trimethoxystilbene | | | | 2016 | 2017 | 7.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| 3,5-dihydroxy-4'-methoxystilbene | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3,4,4'-trihydroxy-trans-stilbene | | | | 2017 | 2017 | 7.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| ns 1652 | | | | 2017 | 2017 | 7.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| tafamidis | | 1,3-benzoxazoles;
dichlorobenzene;
monocarboxylic acid | central nervous system drug | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 27, Issue:15, 2017
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.Journal of medicinal chemistry, , Sep-08, Volume: 48, Issue:18, 2005
Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 27, Issue:15, 2017
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.Journal of medicinal chemistry, , Sep-08, Volume: 48, Issue:18, 2005
Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 27, Issue:15, 2017
Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor.Bioorganic & medicinal chemistry letters, , 07-15, Volume: 27, Issue:14, 2017
Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 27, Issue:15, 2017
Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor.Bioorganic & medicinal chemistry letters, , 07-15, Volume: 27, Issue:14, 2017
TRPA1 channels as targets for resveratrol and related stilbenoids.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016
Inhibition of VEGF expression in cancer cells and endothelial cell differentiation by synthetic stilbene derivatives.Bioorganic & medicinal chemistry, , Jun-01, Volume: 21, Issue:11, 2013
Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor.Bioorganic & medicinal chemistry letters, , 07-15, Volume: 27, Issue:14, 2017
TRPA1 channels as targets for resveratrol and related stilbenoids.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016
Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor.Bioorganic & medicinal chemistry letters, , 07-15, Volume: 27, Issue:14, 2017
TRPA1 channels as targets for resveratrol and related stilbenoids.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016
TRPA1 channels as targets for resveratrol and related stilbenoids.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.Journal of medicinal chemistry, , Sep-08, Volume: 48, Issue:18, 2005
Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor.Bioorganic & medicinal chemistry letters, , 07-15, Volume: 27, Issue:14, 2017
TRPA1 channels as targets for resveratrol and related stilbenoids.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016
Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor.Bioorganic & medicinal chemistry letters, , 07-15, Volume: 27, Issue:14, 2017
TRPA1 channels as targets for resveratrol and related stilbenoids.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016
Grape polyphenol resveratrol and the related molecule 4-hydroxystilbene induce growth inhibition, apoptosis, S-phase arrest, and upregulation of cyclins A, E, and B1 in human SK-Mel-28 melanoma cells.Journal of agricultural and food chemistry, , Jul-30, Volume: 51, Issue:16, 2003
Grape polyphenol resveratrol and the related molecule 4-hydroxystilbene induce growth inhibition, apoptosis, S-phase arrest, and upregulation of cyclins A, E, and B1 in human SK-Mel-28 melanoma cells.Journal of agricultural and food chemistry, , Jul-30, Volume: 51, Issue:16, 2003