Page last updated: 2024-10-26

doxepin and Pain

doxepin has been researched along with Pain in 35 studies

Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash for the treatment of oral mucositis-related pain."9.30Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. ( Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD, 2019)
"Overall pain was significantly reduced by doxepin, capsaicin and doxepin/capsaicin to a similar extent."9.09Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: a randomized, double-blind, placebo-controlled study. ( McCleane, G, 2000)
"Thirty patients with chronic low back or cervical pain combined with clinical depression were studied in a six-week, randomized, double-blind comparison of doxepin and placebo."9.05Doxepin effects on chronic pain, depression and plasma opioids. ( Cork, RC; Crago, BR; Davis, TP; Hameroff, SR; Neuman, C; Scherer, K; Womble, JR, 1982)
"Sixty patients with chronic pain of the low back or cervical spine concomitant with clinical depression were studied in a 6-week, randomized, double-blind comparison of doxepin and placebo."9.05Doxepin's effects on chronic pain and depression: a controlled study. ( Cork, RC; Crago, BR; Davis, TP; Hameroff, SR; Lerman, JC; Neuman, CP; Watts, KS; Weiss, JL; Womble, JR, 1984)
"The main purpose of this study was to develop a semisolid mucoadhesive formulation for the non-invasive vaginal administration of doxepin (DOX) for relief of pain derived from the scarring process after surgery."7.88Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief associated with gynecological surgery. ( Calpena, AC; Clares, B; Mallandrich, M; Montes, MJ; Sanz, R; Suñer-Carbó, J, 2018)
"This study describes the development of semisolid formulations containing doxepin (DOX) for pain relief in oral mucositis, frequently related to chemotherapy and/or radiotherapy treatments in patients with head and neck cancer."7.85Development of a buccal doxepin platform for pain in oral mucositis derived from head and neck cancer treatment. ( Calpena, AC; Clares, B; Gimeno, Á; Halbaut, L; Mallandrich, M; Sanz, R, 2017)
"This research expands on our prior study, in which we assessed pain reduction after topical doxepin rinse in patients with oral mucositis resulting from cancer and cancer therapy."7.73Oral doxepin rinse: the analgesic effect and duration of pain reduction in patients with oral mucositis due to cancer therapy. ( Epstein, JB; Epstein, JD; Epstein, MS; Oien, H; Truelove, EL, 2006)
" The purpose of this study was to assess the impact of doxepin oral rinse in the management of oral mucosal pain in cancer patients."7.71Oral topical doxepin rinse: analgesic effect in patients with oral mucosal pain due to cancer or cancer therapy. ( Allison, C; Epstein, JB; Epstein, MS; Le, ND; Oien, H; Truelove, EL, 2001)
"To provide an effective continuum of the relief of severe carcinomatous pain with minimal side reactions, we initiated treatment with piroxicam (60 to 120 mg per day) and doxepin hydrochloride (25 to 225 mg per day)."7.67Piroxicam and doxepin--an alternative to narcotic analgesics in managing advanced cancer pain. ( Bier, R; Cohn, M; Cohn, ML; Machado, AF, 1988)
"A group of patients with both depression and chronic pain were treated with doxepin for 4 weeks."7.66Urinary 3-methoxy-4-hydroxyphenethylene glycol in the prediction of pain and depression relief with doxepin: preliminary findings. ( Bloom, VL; Fawcett, J; Friedel, RO; Ward, NG, 1983)
"Doxepin and a placebo were administered after baseline measurement for 4 weeks under double blind conditions."6.64Effects of doxepin on perception of laboratory-induced pain in man. ( Butler, SH; Chapman, RC, 1978)
"To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash for the treatment of oral mucositis-related pain."5.30Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. ( Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD, 2019)
"Angiolipomas are rare benign tumours of the subcutaneous fat; they are sometimes solitary but their occurrence is more frequently multiple."5.28[Multiple angiolipomas--analgesics therapy with doxepin]. ( Behrendt, H; Faes, J; Ruzicka, T, 1992)
"Oral doxepin rinse has been reported to provide pain relief in patients with oral mucosal lesions due to cancer or cancer therapy."5.10Oral topical doxepin rinse: anesthetic effect in normal subjects. ( Epstein, JB; Epstein, MS; Le, ND; Oien, H; Truelove, EL, 2003)
"Overall pain was significantly reduced by doxepin, capsaicin and doxepin/capsaicin to a similar extent."5.09Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: a randomized, double-blind, placebo-controlled study. ( McCleane, G, 2000)
"Thirty patients with chronic low back or cervical pain combined with clinical depression were studied in a six-week, randomized, double-blind comparison of doxepin and placebo."5.05Doxepin effects on chronic pain, depression and plasma opioids. ( Cork, RC; Crago, BR; Davis, TP; Hameroff, SR; Neuman, C; Scherer, K; Womble, JR, 1982)
"Sixty patients with chronic pain of the low back or cervical spine concomitant with clinical depression were studied in a 6-week, randomized, double-blind comparison of doxepin and placebo."5.05Doxepin's effects on chronic pain and depression: a controlled study. ( Cork, RC; Crago, BR; Davis, TP; Hameroff, SR; Lerman, JC; Neuman, CP; Watts, KS; Weiss, JL; Womble, JR, 1984)
"The purpose of this review is to present relatively detailed information on the characteristics of tricyclic antidepressants, mainly amitriptyline hydrochloride and doxepin hydrochloride, for use as an integral part of the safe and effective management of fibromyalgia and, to a lesser extent, other chronic pain syndromes."4.79A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes. ( Godfrey, RG, 1996)
"The main purpose of this study was to develop a semisolid mucoadhesive formulation for the non-invasive vaginal administration of doxepin (DOX) for relief of pain derived from the scarring process after surgery."3.88Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief associated with gynecological surgery. ( Calpena, AC; Clares, B; Mallandrich, M; Montes, MJ; Sanz, R; Suñer-Carbó, J, 2018)
"This study describes the development of semisolid formulations containing doxepin (DOX) for pain relief in oral mucositis, frequently related to chemotherapy and/or radiotherapy treatments in patients with head and neck cancer."3.85Development of a buccal doxepin platform for pain in oral mucositis derived from head and neck cancer treatment. ( Calpena, AC; Clares, B; Gimeno, Á; Halbaut, L; Mallandrich, M; Sanz, R, 2017)
"This research expands on our prior study, in which we assessed pain reduction after topical doxepin rinse in patients with oral mucositis resulting from cancer and cancer therapy."3.73Oral doxepin rinse: the analgesic effect and duration of pain reduction in patients with oral mucositis due to cancer therapy. ( Epstein, JB; Epstein, JD; Epstein, MS; Oien, H; Truelove, EL, 2006)
" The purpose of this study was to assess the impact of doxepin oral rinse in the management of oral mucosal pain in cancer patients."3.71Oral topical doxepin rinse: analgesic effect in patients with oral mucosal pain due to cancer or cancer therapy. ( Allison, C; Epstein, JB; Epstein, MS; Le, ND; Oien, H; Truelove, EL, 2001)
"To provide an effective continuum of the relief of severe carcinomatous pain with minimal side reactions, we initiated treatment with piroxicam (60 to 120 mg per day) and doxepin hydrochloride (25 to 225 mg per day)."3.67Piroxicam and doxepin--an alternative to narcotic analgesics in managing advanced cancer pain. ( Bier, R; Cohn, M; Cohn, ML; Machado, AF, 1988)
"A group of patients with both depression and chronic pain were treated with doxepin for 4 weeks."3.66Urinary 3-methoxy-4-hydroxyphenethylene glycol in the prediction of pain and depression relief with doxepin: preliminary findings. ( Bloom, VL; Fawcett, J; Friedel, RO; Ward, NG, 1983)
"A group of moderately to severely depressed individuals with moderate anxiety were studied to determine the frequency and nature of pain complaints and their response to doxepin."3.66The effectiveness of tricyclic antidepressants in the treatment of coexisting pain and depression. ( Bloom, VL; Friedel, RO; Ward, NG, 1979)
"Doxepin and a placebo were administered after baseline measurement for 4 weeks under double blind conditions."2.64Effects of doxepin on perception of laboratory-induced pain in man. ( Butler, SH; Chapman, RC, 1978)
"This is a case report of a CPP treated by a pain physician."1.35Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report. ( Cole, B; Fishbain, DA; Gao, J; Lewis, JE; Rosomoff, RS, 2009)
" Specifically, doxepin was more neurotoxic than amitriptyline, and both imipramine and trimipramine were more toxic than desipramine or amitriptyline."1.34Differential neurotoxicity of tricyclic antidepressants and novel derivatives in vitro in a dorsal root ganglion cell culture model. ( Gerner, P; Haller, I; Keller, C; Klimaschewski, L; Lirk, P; Wang, GK, 2007)
"Angiolipomas are rare benign tumours of the subcutaneous fat; they are sometimes solitary but their occurrence is more frequently multiple."1.28[Multiple angiolipomas--analgesics therapy with doxepin]. ( Behrendt, H; Faes, J; Ruzicka, T, 1992)
" Regardless of the reason for use, nonpsychiatric physicians were found to use relatively low dosages, rarely plan or effect dosage increases, and rarely discontinue medication."1.27Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians. ( Callies, AL; Popkin, MK, 1987)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199017 (48.57)18.7374
1990's4 (11.43)18.2507
2000's10 (28.57)29.6817
2010's4 (11.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sanz, R2
Calpena, AC2
Mallandrich, M2
Gimeno, Á1
Halbaut, L1
Clares, B2
Suñer-Carbó, J1
Montes, MJ1
Elad, S1
Yarom, N1
Sio, TT1
Le-Rademacher, JG1
Leenstra, JL1
Loprinzi, CL1
Rine, G1
Curtis, A1
Singh, AK1
Martenson, JA1
Novotny, PJ1
Tan, AD1
Qin, R1
Ko, SJ1
Reiter, PL1
Miller, RC1
Fishbain, DA1
Lewis, JE1
Gao, J1
Cole, B1
Rosomoff, RS1
Sudoh, Y1
Cahoon, EE1
Gerner, P2
Wang, GK2
Epstein, JB4
Truelove, EL4
Oien, H4
Le, ND2
Epstein, MS4
Wordliczek, J1
Banach, M1
Labuz, D1
Przewlocka, B1
Epstein, JD2
Meagher, LJ1
McKay, D1
Herkes, GK1
Needham, M1
Haller, I1
Lirk, P1
Keller, C1
Klimaschewski, L1
Ward, NG3
Bloom, VL3
Dworkin, S1
Fawcett, J2
Narasimhachari, N1
Friedel, RO3
Hameroff, SR3
Cork, RC2
Scherer, K1
Crago, BR2
Neuman, C1
Womble, JR2
Davis, TP3
Richelson, E1
Weiss, JL1
Lerman, JC1
Watts, KS1
Neuman, CP1
Veggeberg, SK1
Watts, KL1
Aronoff, GM1
Evans, WO1
Lindsay, PG1
Wyckoff, M1
Godfrey, RG1
Berberian, BJ1
Breneman, DL1
Drake, LA1
Gratton, D1
Raimir, SS1
Phillips, S1
Sulica, VI1
Bernstein, JE1
Kiefer, G1
Fischer, W1
Feuerstein, TJ1
McCleane, G1
Allison, C1
Chapman, RC1
Butler, SH1
Behrendt, H1
Faes, J1
Ruzicka, T1
Paladini, VA1
Battigelli, D1
Antonaglia, V1
Benvegnù, M1
Longo, A1
Mocavero, G1
Sandrock, NJ1
Warfield, CA1
Cohn, ML1
Machado, AF1
Bier, R1
Cohn, M1
Tollison, CD1
Kriegel, ML1
Pelton, J1
Cunha, UV1
Callies, AL1
Popkin, MK1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 1/Phase 2 Study for the Prevention of Oral Mucositis (SPOM)[NCT05338398]Phase 1/Phase 2100 participants (Anticipated)Interventional2022-04-15Enrolling by invitation
Opioid Therapy vs Multimodal Analgesia in Head and Neck Cancer: A Randomized Clinical Trial[NCT04221165]Phase 262 participants (Anticipated)Interventional2020-08-04Recruiting
A Randomized Study of a New Medical Device for Oral Mucositis (MDOM Trial)[NCT05104268]Phase 1/Phase 2100 participants (Anticipated)Interventional2021-11-30Not yet recruiting
A Phase III Placebo-Controlled, Randomized Three-Arm Study of Doxepin and a Topical Rinse in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Radiotherapy With or Without Chemotherapy[NCT02229539]Phase 3275 participants (Actual)Interventional2014-11-30Completed
Comparison of Controlled-release Oxycodone to Control Chemoradiotherapy-induced Moderate or Severe Oral Mucositis Pain in Nasopharyngeal Carcinoma Patients[NCT03045484]70 participants (Anticipated)Interventional2016-05-31Recruiting
Internet-Enhanced Management of Fibromyalgia[NCT00423631]118 participants (Actual)Interventional2006-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Mean Area Under the Curve (AUC) of Total Pain Reduction

Total pain reduction (mouth and throat) was measured by the numerical analogue scale of mouth pain on a scale of 0 to 10, with 0=no pain and 10=worst pain in the questionnaires taken at baseline, and 5, 15, 30, 60, 120, 240 minutes after assigned treatment for doxepin or DLA vs. placebo. The total pain reduction was calculated by the (average of mouth and throat) area under the curve (AUC) adjusting for baseline, with time scale (baseline, 5, 15, 30, 60, 120 and 240 minutes post treatment) replaced by a numerical scale of 0, 1, 2, 3, 4, 5 and 6 respectively. The AUC was prorated when there are terminal missing data. If the missing data were intermittent, simple imputation by trapezoidal rules were applied to calculate the AUC. If a patient cancelled, was missing baseline data, or only provided baseline data, he/she was excluded from the statistical analysis. (NCT02229539)
Timeframe: Baseline, 5, 15, 30, 60, 120, 240 minutes post treatment

Interventionunits on a scale*time scale (Mean)
Doxepin11.9
DLA (Diphenhydramine, Lidocaine and Antacid)11.7
Placebo8.7

Reviews

3 reviews available for doxepin and Pain

ArticleYear
The use of tricyclic antidepressants in chronic gastrointestinal pain.
    The Journal of clinical psychiatry, 1982, Volume: 43, Issue:8 Pt 2

    Topics: Abdomen; Antidepressive Agents, Tricyclic; Chronic Disease; Cimetidine; Doxepin; Humans; Pain; Pepti

1982
Doxepin as an adjunct in the treatment of chronic pain.
    The Journal of clinical psychiatry, 1982, Volume: 43, Issue:8 Pt 2

    Topics: Chronic Disease; Clinical Trials as Topic; Depression; Depressive Disorder; Doxepin; Humans; Hydroxy

1982
A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes.
    Archives of internal medicine, 1996, May-27, Volume: 156, Issue:10

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Doxepin; Fibromyalgia; Humans; Lif

1996

Trials

10 trials available for doxepin and Pain

ArticleYear
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
    JAMA, 2019, 04-16, Volume: 321, Issue:15

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met

2019
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
    JAMA, 2019, 04-16, Volume: 321, Issue:15

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met

2019
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
    JAMA, 2019, 04-16, Volume: 321, Issue:15

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met

2019
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
    JAMA, 2019, 04-16, Volume: 321, Issue:15

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met

2019
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
    JAMA, 2019, 04-16, Volume: 321, Issue:15

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met

2019
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
    JAMA, 2019, 04-16, Volume: 321, Issue:15

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met

2019
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
    JAMA, 2019, 04-16, Volume: 321, Issue:15

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met

2019
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
    JAMA, 2019, 04-16, Volume: 321, Issue:15

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met

2019
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
    JAMA, 2019, 04-16, Volume: 321, Issue:15

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met

2019
Oral topical doxepin rinse: anesthetic effect in normal subjects.
    Pain research & management, 2003,Winter, Volume: 8, Issue:4

    Topics: Adolescent; Adult; Anesthetics; Doxepin; Female; Humans; Male; Middle Aged; Mouth Mucosa; Pain; Pain

2003
Management of pain in cancer patients with oral mucositis: follow-up of multiple doses of doxepin oral rinse.
    Journal of pain and symptom management, 2007, Volume: 33, Issue:2

    Topics: Adult; Antidepressive Agents, Tricyclic; Carcinoma, Squamous Cell; Doxepin; Female; Follow-Up Studie

2007
Doxepin effects on chronic pain, depression and plasma opioids.
    The Journal of clinical psychiatry, 1982, Volume: 43, Issue:8 Pt 2

    Topics: Adult; Aged; beta-Endorphin; Chronic Disease; Depression; Double-Blind Method; Doxepin; Endorphins;

1982
Doxepin's effects on chronic pain and depression: a controlled study.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:3 Pt 2

    Topics: beta-Endorphin; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method;

1984
Doxepin as an adjunct in the treatment of chronic pain.
    The Journal of clinical psychiatry, 1982, Volume: 43, Issue:8 Pt 2

    Topics: Chronic Disease; Clinical Trials as Topic; Depression; Depressive Disorder; Doxepin; Humans; Hydroxy

1982
The addition of topical doxepin to corticosteroid therapy: an improved treatment regimen for atopic dermatitis.
    International journal of dermatology, 1999, Volume: 38, Issue:2

    Topics: Administration, Cutaneous; Adrenal Cortex Hormones; Adult; Antipruritics; Dermatitis, Atopic; Double

1999
Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: a randomized, double-blind, placebo-controlled study.
    British journal of clinical pharmacology, 2000, Volume: 49, Issue:6

    Topics: Administration, Topical; Adult; Antidepressive Agents, Tricyclic; Capsaicin; Chronic Disease; Double

2000
Effects of doxepin on perception of laboratory-induced pain in man.
    Pain, 1978, Volume: 5, Issue:3

    Topics: Adult; Clinical Trials as Topic; Dental Pulp; Double-Blind Method; Doxepin; Electric Stimulation; Hu

1978
[Doxepin in pain caused by peripheral neuropathy].
    Minerva anestesiologica, 1987, Volume: 53, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Analgesics; Double-Blind Method; Doxepin; Drug Evaluation; Female; H

1987

Other Studies

23 other studies available for doxepin and Pain

ArticleYear
Development of a buccal doxepin platform for pain in oral mucositis derived from head and neck cancer treatment.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2017, Volume: 117

    Topics: Animals; Doxepin; Female; Head and Neck Neoplasms; Histamine Antagonists; Male; Mouth Mucosa; Mouthw

2017
Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief associated with gynecological surgery.
    International journal of pharmaceutics, 2018, Jan-15, Volume: 535, Issue:1-2

    Topics: Adhesiveness; Administration, Intravaginal; Analgesics; Animals; Doxepin; Drug Delivery Systems; Dru

2018
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
    JAMA, 2019, 04-16, Volume: 321, Issue:15

    Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis

2019
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
    JAMA, 2019, 04-16, Volume: 321, Issue:15

    Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis

2019
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
    JAMA, 2019, 04-16, Volume: 321, Issue:15

    Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis

2019
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
    JAMA, 2019, 04-16, Volume: 321, Issue:15

    Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis

2019
Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report.
    Pain medicine (Malden, Mass.), 2009, Volume: 10, Issue:3

    Topics: Adult; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Diazepam; Doxepin;

2009
Tricyclic antidepressants as long-acting local anesthetics.
    Pain, 2003, Volume: 103, Issue:1-2

    Topics: Amines; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Cell Line; Dose-Response Rela

2003
Intrathecal administration of doxepin attenuated development of formalin-induced pain in rats.
    Journal of neural transmission (Vienna, Austria : 1996), 2005, Volume: 112, Issue:10

    Topics: Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; Doxepin; Hindlimb; Injections, Spinal

2005
Oral doxepin rinse: the analgesic effect and duration of pain reduction in patients with oral mucositis due to cancer therapy.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Doxepin; Female; Humans; Male; Mid

2006
Parkinsonism-hyperpyrexia syndrome: the role of electroconvulsive therapy.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2006, Volume: 13, Issue:8

    Topics: Acetaminophen; Acyclovir; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Anxiety Agents; Anti-Ba

2006
Differential neurotoxicity of tricyclic antidepressants and novel derivatives in vitro in a dorsal root ganglion cell culture model.
    European journal of anaesthesiology, 2007, Volume: 24, Issue:8

    Topics: Amitriptyline; Anesthesia, Conduction; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic

2007
Psychobiological markers in coexisting pain and depression: toward a unified theory.
    The Journal of clinical psychiatry, 1982, Volume: 43, Issue:8 Pt 2

    Topics: Anxiety Disorders; Brain; Depressive Disorder; Doxepin; Humans; Hydroxyindoleacetic Acid; Methoxyhyd

1982
Urinary 3-methoxy-4-hydroxyphenethylene glycol in the prediction of pain and depression relief with doxepin: preliminary findings.
    The Journal of nervous and mental disease, 1983, Volume: 171, Issue:1

    Topics: Adult; Anxiety Disorders; Depressive Disorder; Doxepin; Female; Glycols; Humans; Male; Methoxyhydrox

1983
Sensitive and quantitative determination of plasma doxepin and desmethyldoxepin in chronic pain patients by gas chromatography and mass spectrometry.
    Journal of chromatography, 1983, Apr-08, Volume: 273, Issue:2

    Topics: Chronic Disease; Double-Blind Method; Doxepin; Drug Evaluation; Gas Chromatography-Mass Spectrometry

1983
The depression-pain syndrome and its response to antidepressants.
    Psychosomatics, 1981, Volume: 22, Issue:7

    Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Depression; Desipramine; Doxepin; Fem

1981
Effects of amitriptyline, amitriptylinoxide, doxepine and clozapine on N-methyl-D-aspartate-evoked release of [3H]-acetylcholine in rat caudatoputamen.
    Arzneimittel-Forschung, 1999, Volume: 49, Issue:10

    Topics: Acetylcholine; Algorithms; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antipsychotic A

1999
Oral topical doxepin rinse: analgesic effect in patients with oral mucosal pain due to cancer or cancer therapy.
    Oral oncology, 2001, Volume: 37, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Analgesics; Doxepin; Female; Head and Neck Neoplasms; Humans; Leukem

2001
The effectiveness of tricyclic antidepressants in the treatment of coexisting pain and depression.
    Pain, 1979, Volume: 7, Issue:3

    Topics: Chronic Disease; Depression; Doxepin; Headache; Humans; Pain; Placebos

1979
[Multiple angiolipomas--analgesics therapy with doxepin].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1992, Volume: 43, Issue:3

    Topics: Biopsy; Doxepin; Hemangioma; Humans; Lipoma; Male; Middle Aged; Neoplasms, Multiple Primary; Pain; P

1992
Managing the pain of herpes zoster.
    Hospital practice (Office ed.), 1986, Nov-30, Volume: 21, Issue:11A

    Topics: Adult; Aged; Doxepin; Female; Herpes Zoster; Humans; Lidocaine; Male; Middle Aged; Nerve Block; Neur

1986
Piroxicam and doxepin--an alternative to narcotic analgesics in managing advanced cancer pain.
    The Western journal of medicine, 1988, Volume: 148, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Doxepin; Drug Therapy, Combination; Female; Humans; Male; Middle Age

1988
Selected tricyclic antidepressants in the management of chronic benign pain.
    Southern medical journal, 1988, Volume: 81, Issue:5

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Depressive Disorder; Doxepin; Huma

1988
Piroxicam and doxepin in pain management.
    The Western journal of medicine, 1988, Volume: 149, Issue:1

    Topics: Doxepin; Drug Therapy, Combination; Humans; Pain; Piroxicam

1988
Antidepressants: their uses in nonpsychiatric disorders of aging.
    Geriatrics, 1986, Volume: 41, Issue:10

    Topics: Affective Symptoms; Aged; Antidepressive Agents; Chronic Disease; Colonic Diseases, Functional; Depr

1986
Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians.
    Archives of general psychiatry, 1987, Volume: 44, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Chronic Disease; Depressive Di

1987