doxepin has been researched along with Pain in 35 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash for the treatment of oral mucositis-related pain." | 9.30 | Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. ( Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD, 2019) |
| "Overall pain was significantly reduced by doxepin, capsaicin and doxepin/capsaicin to a similar extent." | 9.09 | Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: a randomized, double-blind, placebo-controlled study. ( McCleane, G, 2000) |
| "Thirty patients with chronic low back or cervical pain combined with clinical depression were studied in a six-week, randomized, double-blind comparison of doxepin and placebo." | 9.05 | Doxepin effects on chronic pain, depression and plasma opioids. ( Cork, RC; Crago, BR; Davis, TP; Hameroff, SR; Neuman, C; Scherer, K; Womble, JR, 1982) |
| "Sixty patients with chronic pain of the low back or cervical spine concomitant with clinical depression were studied in a 6-week, randomized, double-blind comparison of doxepin and placebo." | 9.05 | Doxepin's effects on chronic pain and depression: a controlled study. ( Cork, RC; Crago, BR; Davis, TP; Hameroff, SR; Lerman, JC; Neuman, CP; Watts, KS; Weiss, JL; Womble, JR, 1984) |
| "The main purpose of this study was to develop a semisolid mucoadhesive formulation for the non-invasive vaginal administration of doxepin (DOX) for relief of pain derived from the scarring process after surgery." | 7.88 | Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief associated with gynecological surgery. ( Calpena, AC; Clares, B; Mallandrich, M; Montes, MJ; Sanz, R; Suñer-Carbó, J, 2018) |
| "This study describes the development of semisolid formulations containing doxepin (DOX) for pain relief in oral mucositis, frequently related to chemotherapy and/or radiotherapy treatments in patients with head and neck cancer." | 7.85 | Development of a buccal doxepin platform for pain in oral mucositis derived from head and neck cancer treatment. ( Calpena, AC; Clares, B; Gimeno, Á; Halbaut, L; Mallandrich, M; Sanz, R, 2017) |
| "This research expands on our prior study, in which we assessed pain reduction after topical doxepin rinse in patients with oral mucositis resulting from cancer and cancer therapy." | 7.73 | Oral doxepin rinse: the analgesic effect and duration of pain reduction in patients with oral mucositis due to cancer therapy. ( Epstein, JB; Epstein, JD; Epstein, MS; Oien, H; Truelove, EL, 2006) |
| " The purpose of this study was to assess the impact of doxepin oral rinse in the management of oral mucosal pain in cancer patients." | 7.71 | Oral topical doxepin rinse: analgesic effect in patients with oral mucosal pain due to cancer or cancer therapy. ( Allison, C; Epstein, JB; Epstein, MS; Le, ND; Oien, H; Truelove, EL, 2001) |
| "To provide an effective continuum of the relief of severe carcinomatous pain with minimal side reactions, we initiated treatment with piroxicam (60 to 120 mg per day) and doxepin hydrochloride (25 to 225 mg per day)." | 7.67 | Piroxicam and doxepin--an alternative to narcotic analgesics in managing advanced cancer pain. ( Bier, R; Cohn, M; Cohn, ML; Machado, AF, 1988) |
| "A group of patients with both depression and chronic pain were treated with doxepin for 4 weeks." | 7.66 | Urinary 3-methoxy-4-hydroxyphenethylene glycol in the prediction of pain and depression relief with doxepin: preliminary findings. ( Bloom, VL; Fawcett, J; Friedel, RO; Ward, NG, 1983) |
| "Doxepin and a placebo were administered after baseline measurement for 4 weeks under double blind conditions." | 6.64 | Effects of doxepin on perception of laboratory-induced pain in man. ( Butler, SH; Chapman, RC, 1978) |
| "To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash for the treatment of oral mucositis-related pain." | 5.30 | Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. ( Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD, 2019) |
| "Angiolipomas are rare benign tumours of the subcutaneous fat; they are sometimes solitary but their occurrence is more frequently multiple." | 5.28 | [Multiple angiolipomas--analgesics therapy with doxepin]. ( Behrendt, H; Faes, J; Ruzicka, T, 1992) |
| "Oral doxepin rinse has been reported to provide pain relief in patients with oral mucosal lesions due to cancer or cancer therapy." | 5.10 | Oral topical doxepin rinse: anesthetic effect in normal subjects. ( Epstein, JB; Epstein, MS; Le, ND; Oien, H; Truelove, EL, 2003) |
| "Overall pain was significantly reduced by doxepin, capsaicin and doxepin/capsaicin to a similar extent." | 5.09 | Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: a randomized, double-blind, placebo-controlled study. ( McCleane, G, 2000) |
| "Thirty patients with chronic low back or cervical pain combined with clinical depression were studied in a six-week, randomized, double-blind comparison of doxepin and placebo." | 5.05 | Doxepin effects on chronic pain, depression and plasma opioids. ( Cork, RC; Crago, BR; Davis, TP; Hameroff, SR; Neuman, C; Scherer, K; Womble, JR, 1982) |
| "Sixty patients with chronic pain of the low back or cervical spine concomitant with clinical depression were studied in a 6-week, randomized, double-blind comparison of doxepin and placebo." | 5.05 | Doxepin's effects on chronic pain and depression: a controlled study. ( Cork, RC; Crago, BR; Davis, TP; Hameroff, SR; Lerman, JC; Neuman, CP; Watts, KS; Weiss, JL; Womble, JR, 1984) |
| "The purpose of this review is to present relatively detailed information on the characteristics of tricyclic antidepressants, mainly amitriptyline hydrochloride and doxepin hydrochloride, for use as an integral part of the safe and effective management of fibromyalgia and, to a lesser extent, other chronic pain syndromes." | 4.79 | A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes. ( Godfrey, RG, 1996) |
| "The main purpose of this study was to develop a semisolid mucoadhesive formulation for the non-invasive vaginal administration of doxepin (DOX) for relief of pain derived from the scarring process after surgery." | 3.88 | Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief associated with gynecological surgery. ( Calpena, AC; Clares, B; Mallandrich, M; Montes, MJ; Sanz, R; Suñer-Carbó, J, 2018) |
| "This study describes the development of semisolid formulations containing doxepin (DOX) for pain relief in oral mucositis, frequently related to chemotherapy and/or radiotherapy treatments in patients with head and neck cancer." | 3.85 | Development of a buccal doxepin platform for pain in oral mucositis derived from head and neck cancer treatment. ( Calpena, AC; Clares, B; Gimeno, Á; Halbaut, L; Mallandrich, M; Sanz, R, 2017) |
| "This research expands on our prior study, in which we assessed pain reduction after topical doxepin rinse in patients with oral mucositis resulting from cancer and cancer therapy." | 3.73 | Oral doxepin rinse: the analgesic effect and duration of pain reduction in patients with oral mucositis due to cancer therapy. ( Epstein, JB; Epstein, JD; Epstein, MS; Oien, H; Truelove, EL, 2006) |
| " The purpose of this study was to assess the impact of doxepin oral rinse in the management of oral mucosal pain in cancer patients." | 3.71 | Oral topical doxepin rinse: analgesic effect in patients with oral mucosal pain due to cancer or cancer therapy. ( Allison, C; Epstein, JB; Epstein, MS; Le, ND; Oien, H; Truelove, EL, 2001) |
| "To provide an effective continuum of the relief of severe carcinomatous pain with minimal side reactions, we initiated treatment with piroxicam (60 to 120 mg per day) and doxepin hydrochloride (25 to 225 mg per day)." | 3.67 | Piroxicam and doxepin--an alternative to narcotic analgesics in managing advanced cancer pain. ( Bier, R; Cohn, M; Cohn, ML; Machado, AF, 1988) |
| "A group of patients with both depression and chronic pain were treated with doxepin for 4 weeks." | 3.66 | Urinary 3-methoxy-4-hydroxyphenethylene glycol in the prediction of pain and depression relief with doxepin: preliminary findings. ( Bloom, VL; Fawcett, J; Friedel, RO; Ward, NG, 1983) |
| "A group of moderately to severely depressed individuals with moderate anxiety were studied to determine the frequency and nature of pain complaints and their response to doxepin." | 3.66 | The effectiveness of tricyclic antidepressants in the treatment of coexisting pain and depression. ( Bloom, VL; Friedel, RO; Ward, NG, 1979) |
| "Doxepin and a placebo were administered after baseline measurement for 4 weeks under double blind conditions." | 2.64 | Effects of doxepin on perception of laboratory-induced pain in man. ( Butler, SH; Chapman, RC, 1978) |
| "This is a case report of a CPP treated by a pain physician." | 1.35 | Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report. ( Cole, B; Fishbain, DA; Gao, J; Lewis, JE; Rosomoff, RS, 2009) |
| " Specifically, doxepin was more neurotoxic than amitriptyline, and both imipramine and trimipramine were more toxic than desipramine or amitriptyline." | 1.34 | Differential neurotoxicity of tricyclic antidepressants and novel derivatives in vitro in a dorsal root ganglion cell culture model. ( Gerner, P; Haller, I; Keller, C; Klimaschewski, L; Lirk, P; Wang, GK, 2007) |
| "Angiolipomas are rare benign tumours of the subcutaneous fat; they are sometimes solitary but their occurrence is more frequently multiple." | 1.28 | [Multiple angiolipomas--analgesics therapy with doxepin]. ( Behrendt, H; Faes, J; Ruzicka, T, 1992) |
| " Regardless of the reason for use, nonpsychiatric physicians were found to use relatively low dosages, rarely plan or effect dosage increases, and rarely discontinue medication." | 1.27 | Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians. ( Callies, AL; Popkin, MK, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (48.57) | 18.7374 |
| 1990's | 4 (11.43) | 18.2507 |
| 2000's | 10 (28.57) | 29.6817 |
| 2010's | 4 (11.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sanz, R | 2 |
| Calpena, AC | 2 |
| Mallandrich, M | 2 |
| Gimeno, Á | 1 |
| Halbaut, L | 1 |
| Clares, B | 2 |
| Suñer-Carbó, J | 1 |
| Montes, MJ | 1 |
| Elad, S | 1 |
| Yarom, N | 1 |
| Sio, TT | 1 |
| Le-Rademacher, JG | 1 |
| Leenstra, JL | 1 |
| Loprinzi, CL | 1 |
| Rine, G | 1 |
| Curtis, A | 1 |
| Singh, AK | 1 |
| Martenson, JA | 1 |
| Novotny, PJ | 1 |
| Tan, AD | 1 |
| Qin, R | 1 |
| Ko, SJ | 1 |
| Reiter, PL | 1 |
| Miller, RC | 1 |
| Fishbain, DA | 1 |
| Lewis, JE | 1 |
| Gao, J | 1 |
| Cole, B | 1 |
| Rosomoff, RS | 1 |
| Sudoh, Y | 1 |
| Cahoon, EE | 1 |
| Gerner, P | 2 |
| Wang, GK | 2 |
| Epstein, JB | 4 |
| Truelove, EL | 4 |
| Oien, H | 4 |
| Le, ND | 2 |
| Epstein, MS | 4 |
| Wordliczek, J | 1 |
| Banach, M | 1 |
| Labuz, D | 1 |
| Przewlocka, B | 1 |
| Epstein, JD | 2 |
| Meagher, LJ | 1 |
| McKay, D | 1 |
| Herkes, GK | 1 |
| Needham, M | 1 |
| Haller, I | 1 |
| Lirk, P | 1 |
| Keller, C | 1 |
| Klimaschewski, L | 1 |
| Ward, NG | 3 |
| Bloom, VL | 3 |
| Dworkin, S | 1 |
| Fawcett, J | 2 |
| Narasimhachari, N | 1 |
| Friedel, RO | 3 |
| Hameroff, SR | 3 |
| Cork, RC | 2 |
| Scherer, K | 1 |
| Crago, BR | 2 |
| Neuman, C | 1 |
| Womble, JR | 2 |
| Davis, TP | 3 |
| Richelson, E | 1 |
| Weiss, JL | 1 |
| Lerman, JC | 1 |
| Watts, KS | 1 |
| Neuman, CP | 1 |
| Veggeberg, SK | 1 |
| Watts, KL | 1 |
| Aronoff, GM | 1 |
| Evans, WO | 1 |
| Lindsay, PG | 1 |
| Wyckoff, M | 1 |
| Godfrey, RG | 1 |
| Berberian, BJ | 1 |
| Breneman, DL | 1 |
| Drake, LA | 1 |
| Gratton, D | 1 |
| Raimir, SS | 1 |
| Phillips, S | 1 |
| Sulica, VI | 1 |
| Bernstein, JE | 1 |
| Kiefer, G | 1 |
| Fischer, W | 1 |
| Feuerstein, TJ | 1 |
| McCleane, G | 1 |
| Allison, C | 1 |
| Chapman, RC | 1 |
| Butler, SH | 1 |
| Behrendt, H | 1 |
| Faes, J | 1 |
| Ruzicka, T | 1 |
| Paladini, VA | 1 |
| Battigelli, D | 1 |
| Antonaglia, V | 1 |
| Benvegnù, M | 1 |
| Longo, A | 1 |
| Mocavero, G | 1 |
| Sandrock, NJ | 1 |
| Warfield, CA | 1 |
| Cohn, ML | 1 |
| Machado, AF | 1 |
| Bier, R | 1 |
| Cohn, M | 1 |
| Tollison, CD | 1 |
| Kriegel, ML | 1 |
| Pelton, J | 1 |
| Cunha, UV | 1 |
| Callies, AL | 1 |
| Popkin, MK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1/Phase 2 Study for the Prevention of Oral Mucositis (SPOM)[NCT05338398] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2022-04-15 | Enrolling by invitation | ||
| Opioid Therapy vs Multimodal Analgesia in Head and Neck Cancer: A Randomized Clinical Trial[NCT04221165] | Phase 2 | 62 participants (Anticipated) | Interventional | 2020-08-04 | Recruiting | ||
| A Randomized Study of a New Medical Device for Oral Mucositis (MDOM Trial)[NCT05104268] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2021-11-30 | Not yet recruiting | ||
| A Phase III Placebo-Controlled, Randomized Three-Arm Study of Doxepin and a Topical Rinse in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Radiotherapy With or Without Chemotherapy[NCT02229539] | Phase 3 | 275 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| Comparison of Controlled-release Oxycodone to Control Chemoradiotherapy-induced Moderate or Severe Oral Mucositis Pain in Nasopharyngeal Carcinoma Patients[NCT03045484] | 70 participants (Anticipated) | Interventional | 2016-05-31 | Recruiting | |||
| Internet-Enhanced Management of Fibromyalgia[NCT00423631] | 118 participants (Actual) | Interventional | 2006-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total pain reduction (mouth and throat) was measured by the numerical analogue scale of mouth pain on a scale of 0 to 10, with 0=no pain and 10=worst pain in the questionnaires taken at baseline, and 5, 15, 30, 60, 120, 240 minutes after assigned treatment for doxepin or DLA vs. placebo. The total pain reduction was calculated by the (average of mouth and throat) area under the curve (AUC) adjusting for baseline, with time scale (baseline, 5, 15, 30, 60, 120 and 240 minutes post treatment) replaced by a numerical scale of 0, 1, 2, 3, 4, 5 and 6 respectively. The AUC was prorated when there are terminal missing data. If the missing data were intermittent, simple imputation by trapezoidal rules were applied to calculate the AUC. If a patient cancelled, was missing baseline data, or only provided baseline data, he/she was excluded from the statistical analysis. (NCT02229539)
Timeframe: Baseline, 5, 15, 30, 60, 120, 240 minutes post treatment
| Intervention | units on a scale*time scale (Mean) |
|---|---|
| Doxepin | 11.9 |
| DLA (Diphenhydramine, Lidocaine and Antacid) | 11.7 |
| Placebo | 8.7 |
3 reviews available for doxepin and Pain
| Article | Year |
|---|---|
The use of tricyclic antidepressants in chronic gastrointestinal pain.
Topics: Abdomen; Antidepressive Agents, Tricyclic; Chronic Disease; Cimetidine; Doxepin; Humans; Pain; Pepti | 1982 |
Doxepin as an adjunct in the treatment of chronic pain.
Topics: Chronic Disease; Clinical Trials as Topic; Depression; Depressive Disorder; Doxepin; Humans; Hydroxy | 1982 |
A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Doxepin; Fibromyalgia; Humans; Lif | 1996 |
10 trials available for doxepin and Pain
| Article | Year |
|---|---|
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Oral topical doxepin rinse: anesthetic effect in normal subjects.
Topics: Adolescent; Adult; Anesthetics; Doxepin; Female; Humans; Male; Middle Aged; Mouth Mucosa; Pain; Pain | 2003 |
Management of pain in cancer patients with oral mucositis: follow-up of multiple doses of doxepin oral rinse.
Topics: Adult; Antidepressive Agents, Tricyclic; Carcinoma, Squamous Cell; Doxepin; Female; Follow-Up Studie | 2007 |
Doxepin effects on chronic pain, depression and plasma opioids.
Topics: Adult; Aged; beta-Endorphin; Chronic Disease; Depression; Double-Blind Method; Doxepin; Endorphins; | 1982 |
Doxepin's effects on chronic pain and depression: a controlled study.
Topics: beta-Endorphin; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; | 1984 |
Doxepin as an adjunct in the treatment of chronic pain.
Topics: Chronic Disease; Clinical Trials as Topic; Depression; Depressive Disorder; Doxepin; Humans; Hydroxy | 1982 |
The addition of topical doxepin to corticosteroid therapy: an improved treatment regimen for atopic dermatitis.
Topics: Administration, Cutaneous; Adrenal Cortex Hormones; Adult; Antipruritics; Dermatitis, Atopic; Double | 1999 |
Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: a randomized, double-blind, placebo-controlled study.
Topics: Administration, Topical; Adult; Antidepressive Agents, Tricyclic; Capsaicin; Chronic Disease; Double | 2000 |
Effects of doxepin on perception of laboratory-induced pain in man.
Topics: Adult; Clinical Trials as Topic; Dental Pulp; Double-Blind Method; Doxepin; Electric Stimulation; Hu | 1978 |
[Doxepin in pain caused by peripheral neuropathy].
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Double-Blind Method; Doxepin; Drug Evaluation; Female; H | 1987 |
23 other studies available for doxepin and Pain
| Article | Year |
|---|---|
Development of a buccal doxepin platform for pain in oral mucositis derived from head and neck cancer treatment.
Topics: Animals; Doxepin; Female; Head and Neck Neoplasms; Histamine Antagonists; Male; Mouth Mucosa; Mouthw | 2017 |
Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief associated with gynecological surgery.
Topics: Adhesiveness; Administration, Intravaginal; Analgesics; Animals; Doxepin; Drug Delivery Systems; Dru | 2018 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report.
Topics: Adult; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Diazepam; Doxepin; | 2009 |
Tricyclic antidepressants as long-acting local anesthetics.
Topics: Amines; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Cell Line; Dose-Response Rela | 2003 |
Intrathecal administration of doxepin attenuated development of formalin-induced pain in rats.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; Doxepin; Hindlimb; Injections, Spinal | 2005 |
Oral doxepin rinse: the analgesic effect and duration of pain reduction in patients with oral mucositis due to cancer therapy.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Doxepin; Female; Humans; Male; Mid | 2006 |
Parkinsonism-hyperpyrexia syndrome: the role of electroconvulsive therapy.
Topics: Acetaminophen; Acyclovir; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Anxiety Agents; Anti-Ba | 2006 |
Differential neurotoxicity of tricyclic antidepressants and novel derivatives in vitro in a dorsal root ganglion cell culture model.
Topics: Amitriptyline; Anesthesia, Conduction; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic | 2007 |
Psychobiological markers in coexisting pain and depression: toward a unified theory.
Topics: Anxiety Disorders; Brain; Depressive Disorder; Doxepin; Humans; Hydroxyindoleacetic Acid; Methoxyhyd | 1982 |
Urinary 3-methoxy-4-hydroxyphenethylene glycol in the prediction of pain and depression relief with doxepin: preliminary findings.
Topics: Adult; Anxiety Disorders; Depressive Disorder; Doxepin; Female; Glycols; Humans; Male; Methoxyhydrox | 1983 |
Sensitive and quantitative determination of plasma doxepin and desmethyldoxepin in chronic pain patients by gas chromatography and mass spectrometry.
Topics: Chronic Disease; Double-Blind Method; Doxepin; Drug Evaluation; Gas Chromatography-Mass Spectrometry | 1983 |
The depression-pain syndrome and its response to antidepressants.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Depression; Desipramine; Doxepin; Fem | 1981 |
Effects of amitriptyline, amitriptylinoxide, doxepine and clozapine on N-methyl-D-aspartate-evoked release of [3H]-acetylcholine in rat caudatoputamen.
Topics: Acetylcholine; Algorithms; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antipsychotic A | 1999 |
Oral topical doxepin rinse: analgesic effect in patients with oral mucosal pain due to cancer or cancer therapy.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Doxepin; Female; Head and Neck Neoplasms; Humans; Leukem | 2001 |
The effectiveness of tricyclic antidepressants in the treatment of coexisting pain and depression.
Topics: Chronic Disease; Depression; Doxepin; Headache; Humans; Pain; Placebos | 1979 |
[Multiple angiolipomas--analgesics therapy with doxepin].
Topics: Biopsy; Doxepin; Hemangioma; Humans; Lipoma; Male; Middle Aged; Neoplasms, Multiple Primary; Pain; P | 1992 |
Managing the pain of herpes zoster.
Topics: Adult; Aged; Doxepin; Female; Herpes Zoster; Humans; Lidocaine; Male; Middle Aged; Nerve Block; Neur | 1986 |
Piroxicam and doxepin--an alternative to narcotic analgesics in managing advanced cancer pain.
Topics: Adult; Aged; Aged, 80 and over; Doxepin; Drug Therapy, Combination; Female; Humans; Male; Middle Age | 1988 |
Selected tricyclic antidepressants in the management of chronic benign pain.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Depressive Disorder; Doxepin; Huma | 1988 |
Piroxicam and doxepin in pain management.
Topics: Doxepin; Drug Therapy, Combination; Humans; Pain; Piroxicam | 1988 |
Antidepressants: their uses in nonpsychiatric disorders of aging.
Topics: Affective Symptoms; Aged; Antidepressive Agents; Chronic Disease; Colonic Diseases, Functional; Depr | 1986 |
Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Chronic Disease; Depressive Di | 1987 |