Page last updated: 2024-10-17

hydrogen sulfide and Pain

hydrogen sulfide has been researched along with Pain in 30 studies

Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)
hydrogen sulfide : A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.
thiol : An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Hydrogen sulfide (H(2) S), generated by enzymes such as cystathionine-γ-lyase (CSE) from L-cysteine, facilitates pain signals by activating the Ca(v) 3."7.78Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice. ( Hayashi, Y; Kawabata, A; Kubo, L; Matsunami, M; Miki, T; Nishikawa, H; Nishiura, K; Okawa, Y; Ozaki, T; Sekiguchi, F; Tsujiuchi, T, 2012)
"Hydrogen sulfide (H(2)S) is an endogenous gaseous mediator with the ability to modulate tissue inflammation and pain."7.74Leukocyte trafficking and pain behavioral responses to a hydrogen sulfide donor in acute monoarthritis. ( Andruski, B; Ignacy, T; McCafferty, DM; McDougall, JJ; Millen, B, 2008)
"Hydrogen sulfide (H(2)S) plays an important role in cardiovascular, central nervous, and gastrointestinal systems."6.46Hydrogen sulfide and substance P in inflammation. ( Bhatia, M, 2010)
"Hydrogen sulfide (H2S) is a gasotransmitter endogenously generated from the metabolism of L-cysteine by action of two main enzymes called cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE)."5.39Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats. ( Araiza-Saldaña, CI; Barragán-Iglesias, P; Flores-Murrieta, FJ; Godínez-Chaparro, B; Navarrete, A; Roa-Coria, JE; Rocha-González, HI; Torres-López, JE; Velasco-Xolalpa, ME, 2013)
"Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy."4.40Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023)
"Hydrogen sulfide (H2S), an endogenous gaseotransmitter/modulator, is becoming appreciated that it may be involved in a wide variety of processes including inflammation and nociception."3.80Upregulation of cystathionine-β-synthetase expression contributes to inflammatory pain in rat temporomandibular joint. ( Hu, S; Ju, Z; Meng, X; Miao, X; Wu, G; Xu, GY; Zhang, HH, 2014)
"2 are involved in the H(2)S-induced mucosal cytoprotection against 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats."3.78Hydrogen sulfide-induced colonic mucosal cytoprotection involves T-type calcium channel-dependent neuronal excitation in rats. ( Kawabata, A; Kirishi, S; Matsunami, M; Okui, T, 2012)
"Hydrogen sulfide (H(2) S), generated by enzymes such as cystathionine-γ-lyase (CSE) from L-cysteine, facilitates pain signals by activating the Ca(v) 3."3.78Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice. ( Hayashi, Y; Kawabata, A; Kubo, L; Matsunami, M; Miki, T; Nishikawa, H; Nishiura, K; Okawa, Y; Ozaki, T; Sekiguchi, F; Tsujiuchi, T, 2012)
"Given recent evidence that hydrogen sulfide (H(2)S), a gasotransmitter, promotes somatic pain through redox modulation of T-type Ca(2+) channels, the roles of colonic luminal H(2)S in visceral nociceptive processing in mice were examined."3.75Luminal hydrogen sulfide plays a pronociceptive role in mouse colon. ( Fukushima, O; Kawabata, A; Matsunami, M; Mitani, K; Nagasawa, K; Okubo, K; Takemura, M; Tarui, T; Yoshida, S, 2009)
"Hydrogen sulfide (H(2)S) is an endogenous gaseous mediator with the ability to modulate tissue inflammation and pain."3.74Leukocyte trafficking and pain behavioral responses to a hydrogen sulfide donor in acute monoarthritis. ( Andruski, B; Ignacy, T; McCafferty, DM; McDougall, JJ; Millen, B, 2008)
"The present study investigated the hypothesis that hydrogen sulfide (H2S) is pro-nociceptive in the formalin model of persistent inflammatory pain in the adult rat."3.74A nociceptive-intensity-dependent role for hydrogen sulphide in the formalin model of persistent inflammatory pain. ( Cheng, Y; Khanna, S; Lee, AT; Li, L; Moore, PK; Shah, JJ, 2008)
"Physiopathological mechanisms and treatment of pain remain a significant challenge."2.47Hydrogen sulphide and pain. ( Distrutti, E, 2011)
"Hydrogen sulfide (H(2)S) plays an important role in cardiovascular, central nervous, and gastrointestinal systems."2.46Hydrogen sulfide and substance P in inflammation. ( Bhatia, M, 2010)
"1."2.46Interaction of hydrogen sulfide with ion channels. ( Tang, G; Wang, R; Wu, L, 2010)
"Hydrogen sulfide also plays an important role in promoting resolution of inflammation, and restoration of normal tissue function."1.42Anti-inflammatory and cytoprotective properties of hydrogen sulfide. ( Gemici, B; Wallace, JL, 2015)
"Hydrogen sulfide (H2S) is a gasotransmitter endogenously generated from the metabolism of L-cysteine by action of two main enzymes called cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE)."1.39Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats. ( Araiza-Saldaña, CI; Barragán-Iglesias, P; Flores-Murrieta, FJ; Godínez-Chaparro, B; Navarrete, A; Roa-Coria, JE; Rocha-González, HI; Torres-López, JE; Velasco-Xolalpa, ME, 2013)
"Hydrogen sulfide (H(2)S) is an endogenous gas involved in several biological functions, including modulation of nociception."1.35Dual role of hydrogen sulfide in mechanical inflammatory hypernociception. ( Cunha, FQ; Cunha, TM; Dal-Secco, D; Ferreira, SH; Guerrero, AT; Lotufo, CM; Neto, AF; Souza, GR; Verri, WA; Vieira, SM, 2008)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.33)18.7374
1990's0 (0.00)18.2507
2000's6 (20.00)29.6817
2010's20 (66.67)24.3611
2020's3 (10.00)2.80

Authors

AuthorsStudies
Glanville, JRW1
Jalali, P1
Flint, JD1
Patel, AA1
Maini, AA1
Wallace, JL2
Hosin, AA1
Gilroy, DW1
Dichiara, M1
Artacho-Cordón, A1
Turnaturi, R1
Santos-Caballero, M1
González-Cano, R1
Pasquinucci, L1
Barbaraci, C1
Rodríguez-Gómez, I1
Gómez-Guzmán, M1
Marrazzo, A1
Cobos, EJ1
Amata, E1
Garattini, EG1
Santos, BM1
Ferrari, DP1
Capel, CP1
Francescato, HDC1
Coimbra, TM1
Leite-Panissi, CRA1
Branco, LGS1
Nascimento, GC1
Velasco-Xolalpa, ME1
Barragán-Iglesias, P1
Roa-Coria, JE1
Godínez-Chaparro, B1
Flores-Murrieta, FJ1
Torres-López, JE1
Araiza-Saldaña, CI1
Navarrete, A1
Rocha-González, HI1
Takahashi, K1
Ohta, T1
Miao, X1
Meng, X1
Wu, G1
Ju, Z1
Zhang, HH1
Hu, S1
Xu, GY1
Tsubota, M1
Kawabata, A7
Gemici, B1
Dief, AE1
Mostafa, DK1
Sharara, GM1
Zeitoun, TH1
Terada, Y1
Fukami, K2
Sekiguchi, F3
Cunha, TM2
Dal-Secco, D1
Verri, WA2
Guerrero, AT1
Souza, GR1
Vieira, SM1
Lotufo, CM1
Neto, AF1
Ferreira, SH1
Cunha, FQ1
Andruski, B1
McCafferty, DM1
Ignacy, T1
Millen, B1
McDougall, JJ1
Matsunami, M3
Tarui, T1
Mitani, K1
Nagasawa, K1
Fukushima, O1
Okubo, K1
Yoshida, S1
Takemura, M1
Bhatia, M1
Blachier, F1
Davila, AM1
Mimoun, S1
Benetti, PH1
Atanasiu, C1
Andriamihaja, M1
Benamouzig, R1
Bouillaud, F1
Tomé, D1
Distrutti, E3
Cipriani, S1
Renga, B1
Mencarelli, A1
Migliorati, M1
Cianetti, S1
Fiorucci, S4
Tang, G1
Wu, L1
Wang, R1
Santucci, L1
Kirishi, S1
Okui, T1
Lötsch, J1
Walter, C1
Felden, L1
Nöth, U1
Deichmann, R1
Oertel, BG1
Miki, T1
Nishiura, K1
Hayashi, Y1
Okawa, Y1
Nishikawa, H1
Kubo, L1
Ozaki, T1
Tsujiuchi, T1
Kobal, G1
Lee, AT1
Shah, JJ1
Li, L1
Cheng, Y1
Moore, PK1
Khanna, S1
Chmielewski, H1
Szafranko, J1
Krysińska, L1

Reviews

9 reviews available for hydrogen sulfide and Pain

ArticleYear
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
[Role of hydrogen sulfide, a gasotransmitter, in colonic pain and inflammation].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2014, Volume: 134, Issue:12

    Topics: Animals; Colitis; Gasotransmitters; Humans; Hydrogen Sulfide; Inflammation; Pain; Signal Transductio

2014
H2S and Pain: A Novel Aspect for Processing of Somatic, Visceral and Neuropathic Pain Signals.
    Handbook of experimental pharmacology, 2015, Volume: 230

    Topics: Animals; Calcium Channels; Calcium Channels, T-Type; Humans; Hydrogen Sulfide; Mice; Nerve Tissue Pr

2015
Hydrogen Sulfide and T-Type Ca2+ Channels in Pain Processing, Neuronal Differentiation and Neuroendocrine Secretion.
    Pharmacology, 2017, Volume: 99, Issue:3-4

    Topics: Animals; Calcium Channels, T-Type; Cell Differentiation; Humans; Hydrogen Sulfide; Neuroendocrine Ce

2017
Hydrogen sulfide and substance P in inflammation.
    Antioxidants & redox signaling, 2010, May-15, Volume: 12, Issue:10

    Topics: Air Pollutants; Amino Acid Sequence; Animals; Humans; Hydrogen Sulfide; Inflammation; Inflammation M

2010
Luminal sulfide and large intestine mucosa: friend or foe?
    Amino acids, 2010, Volume: 39, Issue:2

    Topics: Animals; Bacteria; Colitis, Ulcerative; Colon; Cystathionine gamma-Lyase; Energy Metabolism; Feces;

2010
Interaction of hydrogen sulfide with ion channels.
    Clinical and experimental pharmacology & physiology, 2010, Volume: 37, Issue:7

    Topics: Animals; ATP-Binding Cassette Transporters; Cytoprotection; Humans; Hydrogen Sulfide; Ion Channels;

2010
Hydrogen sulfide-based therapies: focus on H2S releasing NSAIDs.
    Inflammation & allergy drug targets, 2011, Volume: 10, Issue:2

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Drug Design

2011
Hydrogen sulphide and pain.
    Inflammation & allergy drug targets, 2011, Volume: 10, Issue:2

    Topics: Analgesics; Animals; Calcium Channels, T-Type; Disease Models, Animal; Humans; Hydrogen Sulfide; KAT

2011

Trials

2 trials available for hydrogen sulfide and Pain

ArticleYear
Potent anti-inflammatory effects of an H
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:10

    Topics: Adolescent; Adult; Dinoprostone; Escherichia coli; Humans; Hydrogen Sulfide; Inflammation; Male; Mid

2021
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023

Other Studies

20 other studies available for hydrogen sulfide and Pain

ArticleYear
Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.
    European journal of medicinal chemistry, 2022, Feb-15, Volume: 230

    Topics: Animals; Guinea Pigs; Hydrogen; Hydrogen Sulfide; Ligands; Male; Morpholines; Pain; Piperazines; Rat

2022
Propargylglycine decreases neuro-immune interaction inducing pain response in temporomandibular joint inflammation model.
    Nitric oxide : biology and chemistry, 2019, 12-01, Volume: 93

    Topics: Alkynes; Animals; Cystathionine gamma-Lyase; Enzyme Inhibitors; Glycine; Hydrogen Sulfide; Hyperalge

2019
Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats.
    Neuroscience, 2013, Oct-10, Volume: 250

    Topics: Algorithms; Alkynes; Animals; Blood Glucose; Cystathionine gamma-Lyase; Cysteine; Data Interpretatio

2013
Inflammatory acidic pH enhances hydrogen sulfide-induced transient receptor potential ankyrin 1 activation in RIN-14B cells.
    Journal of neuroscience research, 2013, Volume: 91, Issue:10

    Topics: Animals; Cell Line; Hydrogen Sulfide; Hydrogen-Ion Concentration; Inflammation; Pain; Rats; Reactive

2013
Upregulation of cystathionine-β-synthetase expression contributes to inflammatory pain in rat temporomandibular joint.
    Molecular pain, 2014, Feb-03, Volume: 10

    Topics: Action Potentials; Animals; Cystathionine beta-Synthase; Electric Stimulation; Enzyme Inhibitors; Fr

2014
Anti-inflammatory and cytoprotective properties of hydrogen sulfide.
    Methods in enzymology, 2015, Volume: 555

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Cystathionine beta-Syntha

2015
Hydrogen sulfide releasing naproxen offers better anti-inflammatory and chondroprotective effect relative to naproxen in a rat model of zymosan induced arthritis.
    European review for medical and pharmacological sciences, 2015, Volume: 19, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Hydrogen Sulfide; Injecti

2015
Dual role of hydrogen sulfide in mechanical inflammatory hypernociception.
    European journal of pharmacology, 2008, Aug-20, Volume: 590, Issue:1-3

    Topics: Analgesics; Animals; Cell Movement; Hydrogen Sulfide; Inflammation; KATP Channels; Male; Mice; Mice,

2008
Leukocyte trafficking and pain behavioral responses to a hydrogen sulfide donor in acute monoarthritis.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 295, Issue:3

    Topics: Acute Disease; Animals; Arthritis; Behavior, Animal; Carrageenan; Cell Movement; Hydrogen Sulfide; K

2008
Luminal hydrogen sulfide plays a pronociceptive role in mouse colon.
    Gut, 2009, Volume: 58, Issue:6

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Capsaicin; Colon; Extracellular Signal-

2009
Hydrogen sulphide induces micro opioid receptor-dependent analgesia in a rodent model of visceral pain.
    Molecular pain, 2010, Jun-11, Volume: 6

    Topics: Analgesia; Analgesics; Animals; Cell Line; Disease Models, Animal; Humans; Hydrogen Sulfide; KATP Ch

2010
Hydrogen sulfide: from physiology to pharmacology.
    Inflammation & allergy drug targets, 2011, Volume: 10, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Cysteine; Disease Models, Animal; Drug Design; Humans; Hydrogen S

2011
COXIBs, CINODs and H₂S-releasing NSAIDs: current perspectives in the development of safer non steroidal anti-inflammatory drugs.
    Current medicinal chemistry, 2011, Volume: 18, Issue:23

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Gastrointestinal Hemorrhage; G

2011
Hydrogen sulfide-induced colonic mucosal cytoprotection involves T-type calcium channel-dependent neuronal excitation in rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2012, Volume: 63, Issue:1

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Capsaicin; Colitis; Colon; Cystathionin

2012
The human operculo-insular cortex is pain-preferentially but not pain-exclusively activated by trigeminal and olfactory stimuli.
    PloS one, 2012, Volume: 7, Issue:4

    Topics: Adult; Benzaldehydes; Brain Mapping; Carbon Dioxide; Female; Humans; Hydrogen Sulfide; Magnetic Reso

2012
Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice.
    British journal of pharmacology, 2012, Volume: 167, Issue:4

    Topics: Acetanilides; Animals; Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; Cyclophos

2012
A new extension to the University of Erlangen Smell Test (UEST).
    Chemical senses, 2005, Volume: 30 Suppl 1

    Topics: Benzaldehydes; Carbon Dioxide; Evoked Potentials; Humans; Hydrogen Sulfide; Models, Biological; Mode

2005
Hydrogen sulfide, is it a promise analgesic drug or another inflammatory pain mediator?
    Pain, 2007, Volume: 130, Issue:3

    Topics: Analgesics; Animals; Humans; Hydrogen Sulfide; Inflammation Mediators; Pain

2007
A nociceptive-intensity-dependent role for hydrogen sulphide in the formalin model of persistent inflammatory pain.
    Neuroscience, 2008, Mar-03, Volume: 152, Issue:1

    Topics: Alkynes; Animals; Enzyme Inhibitors; Formaldehyde; Glycine; Hydrogen Sulfide; Inflammation; Irritant

2008
[Effect of sulfide-hydrosulphide baths on sulfhydryl compounds in the serum of patients with cervical pains caused by discopathy treated at Busko-spa].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1980, Feb-04, Volume: 35, Issue:5

    Topics: Female; Humans; Hydrogen Sulfide; Intervertebral Disc Displacement; Male; Mineral Waters; Neck; Pain

1980