Page last updated: 2024-08-07 13:12:42

Gastrin-releasing peptide receptor

A gastrin-releasing peptide receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30550]

Synonyms

GRP-R;
GRP-preferring bombesin receptor

Research

Bioassay Publications (3)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Compounds (3)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
pd 176252Homo sapiens (human)Ki0.001011
pd 168368Homo sapiens (human)Ki0.017011
bombesinHomo sapiens (human)IC500.002011
bombesinHomo sapiens (human)Ki0.000111

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
bombesinHomo sapiens (human)EC500.000311

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
pd 176252Homo sapiens (human)KB app0.024522

Enables

This protein enables 3 target(s):

TargetCategoryDefinition
neuropeptide receptor activitymolecular functionCombining with a neuropeptide to initiate a change in cell activity. [GOC:ai]
G protein-coupled peptide receptor activitymolecular functionCombining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:dph, GOC:tb]
neuropeptide bindingmolecular functionInteracting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). [http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html]

Located In

This protein is located in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 11 target(s):

TargetCategoryDefinition
phospholipase C-activating G protein-coupled receptor signaling pathwaybiological processA G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
neuropeptide signaling pathwaybiological processA G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194]
learning or memorybiological processThe acquisition and processing of information and/or the storage and retrieval of this information over time. [GOC:jid, PMID:8938125]
social behaviorbiological processBehavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group. [GOC:jh2, PMID:12848939, Wikipedia:Social_behavior]
psychomotor behaviorbiological processThe specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument. [GOC:nhn, GOC:pr, PMID:17159989, Wikipedia:Psychomotor_learning]
regulation of cell population proliferationbiological processAny process that modulates the frequency, rate or extent of cell proliferation. [GOC:jl]
response to external biotic stimulusbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things. [GOC:go_curators]
motor behaviorbiological processThe specific neuromuscular movement of a single organism in response to external or internal stimuli. [GOC:bf, GOC:PARL, PMID:25318560]
positive regulation of respiratory gaseous exchangebiological processAny process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. [GO_REF:0000058, GOC:TermGenie, PMID:22819705]
positive regulation of behavioral fear responsebiological processAny process that activates or increases the frequency, rate or extent of behavioral fear response. [GOC:obol]
G protein-coupled receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]