Compounds > atractylodin
Page last updated: 2024-12-11

atractylodin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

atractylodin: RN given for (E,E)-isomer; isolated from Atractylodes plants [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
AtractylodesgenusA plant genus of the family ASTERACEAE. Members contain hinesol and atractylon. Atractylodes rhizome is Byaku-jutsu. A. lancea rhizome is So-jutsu.[MeSH]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]

Cross-References

ID SourceID
PubMed CID5321047
CHEBI ID80795
MeSH IDM0278384

Synonyms (27)

Synonym
atractylodin
C16918
55290-63-6
2-[(1e,7e)-nona-1,7-dien-3,5-diynyl]furan
AKOS006281381
furan, 2-(1,7-nonadiene-3,5-diynyl)-, (e,e)-
unii-v73e8b6uac
v73e8b6uac ,
(e,e)-2-(1,7-nonadiene-3,5-diynyl)furan
3,5-bis(trifluoromethyl)-4-chloro-nitrobenzene
CHEBI:80795
CS-3672
AC-34063
Q-100629
GRBKWAXRYIITKG-QFMFQGICSA-N
HY-N0238
mfcd01075143
Q27149839
atractydin
BCP28324
DTXSID901019940
A14776
2-((1e,7e)-nona-1,7-dien-3,5-diyn-1-yl)furan-1-yl)furan
97235-99-9
2-(nona-1,7-dien-3,5-diyn-1-yl)furan
AS-82932
furan, 2-[(1e,7e)-1,7-nonadiene-3,5-diyn-1-yl]-

Research Excerpts

Overview

Atractylodin (ATL) is a kind of herbal medicine that has been proven to protect intestinal inflammation and attenuate acute lung injury. Atractylodes lancea is an oriental herbal medicine used for the treatment of gastrointestinal diseases.

ExcerptReferenceRelevance
"Atractylodin (ATL) is a kind of herbal medicine that has been proven to protect intestinal inflammation and attenuate acute lung injury."( Atractylodin Suppresses TGF-β-Mediated Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells and Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice.
Akhrymuk, I; Chang, KW; Li, CH; Lin, CC; Lin, SC; Lin, SH; Lin, YC; Zhang, X, 2021)		2.79
"Atractylodin is a major compound in the rhizome of Atractylodes lancea, an oriental herbal medicine used for the treatment of gastrointestinal diseases, including dyspepsia, nausea, and diarrhea. "( Atractylodin Ameliorates Colitis via PPARα Agonism.
Heo, G; Im, E; Jung, JH; Kim, EL; Kim, Y; Park, S; Rhee, SH, 2023)		3.8
"Atractylodin (ATR) is a bioactive component found in dried rhizomes of "( Atractylodin Produces Antinociceptive Effect through a Long-Lasting TRPA1 Channel Activation.
Aoki, S; Dai, Y; Duan, S; Ishikawa, M; Iwaoka, E; Kanda, H; Kogure, Y; Mizuta, K; Noguchi, K; Sonoda, H; Takeda, S; Wang, S; Yamamoto, S; Yang, Y, 2021)		3.51
"Atractylodin (Atr) is a polyethylene alkynes and has been reported to possess anti-inflammation effect."( Atractylodin attenuates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3 inflammasome and TLR4 pathways.
Bian, C; Fan, K; Tang, F; Wang, K, 2018)		2.64

Effects

Atractylodin (ATR) has anticancer effects on some tumor cells by inducing apoptosis, but its mechanism in lung cancer remains unclear. ATL has been reported to exert anti-inflammatory effects.

ExcerptReferenceRelevance
"Atractylodin (ATR) has anticancer effects on some tumor cells by inducing apoptosis, but its mechanism in lung cancer remains unclear. "( Atractylodin Induces Apoptosis and Inhibits the Migration of A549 Lung Cancer Cells by Regulating ROS-Mediated Signaling Pathways.
Cao, JL; Jin, CH; Li, SM; Li, YN; Wang, C; Xue, H; Zhang, T, 2022)		3.61
"Atractylodin (ATL) has been reported to exert anti-inflammatory effects. "( Atractylodin targets GLA to regulate D-mannose metabolism to inhibit osteogenic differentiation of human valve interstitial cells and ameliorate aortic valve calcification.
Li, L; Liu, Y; Qu, L; Wan, Q; Wang, C; Xu, H; Xu, K, 2023)		3.8

Dosage Studied

ExcerptRelevanceReference
" Blood samples were collected from forty-eight healthy subjects following oral administration of a single or multiple dosing of capsule formulation of the standardized AL extract or placebo."( A randomized placebo-controlled phase I clinical trial to evaluate the immunomodulatory activities of Atractylodes lancea (Thunb) DC. in healthy Thai subjects.
Chaijaroenkul, W; Kulma, I; Na-Bangchang, K; Panrit, L; Plengsuriyakarn, T; Warathumpitak, S, 2021)		0.62
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
furansCompounds containing at least one furan ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (39)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (2.56)18.2507
2000's2 (5.13)29.6817
2010's17 (43.59)24.3611
2020's19 (48.72)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.07

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index29.07 (24.57)
Research Supply Index3.71 (2.92)
Research Growth Index5.60 (4.65)
Search Engine Demand Index34.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (29.07)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (2.56%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other38 (97.44%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chlorine
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.		2.3110halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
1-anilino-8-naphthalenesulfonate
1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.		2.110aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
lidocaine
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.. lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.		2.3110benzenes;
monocarboxylic acid amide;
tertiary amino compound		anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic
qx-314
QX-314: triethyl analog of lidocaine; RN & NM refer to ion		2.3110monocarboxylic acid amidelocal anaesthetic
allyl isothiocyanate
allyl isothiocyanate: used in the manufacture of flavors, war gases; medical use as a counterirritant; structure. allyl isothiocyanate : An isothiocyanate with the formula CH2=CHCH2N=C=S. A colorless oil with boiling point 152degreeC, it is responsible for the pungent taste of mustard, horseradish, and wasabi.		2.3110alkenyl isothiocyanate;
isothiocyanate		antimicrobial agent;
antineoplastic agent;
apoptosis inducer;
lachrymator;
metabolite
trinitrobenzenesulfonic acid
Trinitrobenzenesulfonic Acid: A reagent that is used to neutralize peptide terminal amino groups.. 2,4,6-trinitrobenzenesulfonic acid : The arenesulfonic acid that is benzenesulfonic acid with three nitro substituents in the 2-, 4- and 6-positions.		2.1510arenesulfonic acid;
C-nitro compound		epitope;
explosive;
reagent
mannose
mannopyranose : The pyranose form of mannose.		7.610D-aldohexose;
D-mannose;
mannopyranose		metabolite
galactosamine
2-amino-2-deoxy-D-galactopyranose : The pyranose form of D-galactosamine.. D-galactosamine : The D-stereoisomer of galactosamine.		7.2110D-galactosamine;
primary amino compound		toxin
tetradecanoylphorbol acetate
Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.		2.1310acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
beta-eudesmol
beta-eudesmol: found in Atractylodes and other plants; RN given refers to (2R-(2alpha,4aalpha,8abeta))-isomer. beta-eudesmol : A carbobicyclic compound that is trans-decalin substituted at positions 2, 4a, and 8 by 2-hydroxypropan-2-yl, methyl and methylidene groups, respectively (the 2R,4aR,8aS-diastereoisomer).		10.29111carbobicyclic compound;
eudesmane sesquiterpenoid;
tertiary alcohol		volatile oil component
atractylenolide iii
atractylenolide III: from Atractylodes macrocephala Koidz; structure in first source		2.1310naphthofuranmetabolite
sesquiterpenes
[no description available]		3.360
D-fructopyranose
[no description available]		2.3110cyclic hemiketal;
D-fructose;
fructopyranose		sweetening agent
atractylon
atractylon: from Atractylodes rhizomes; has antihepatotoxic activity; structure given in first source		1.9910sesquiterpenoid
ovalbumin
Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.		7.2510
atractylenolide i
atractylenolide I: from Atractylodes macrocephala Koidz; structure in first source		2.1310
mocetinostat
mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).		2.1710aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent
hinesol
hinesol: from Atractylodes Lance rhizome; RN given refers to (2R-(2alpha,5alpha(S*)))-isomer		2.9440
calcimycin
Calcimycin: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.		2.1310benzoxazole
atractylenolide ii
atractylenolide II: from Atractylodes ovata; structure in first source		2.5220sesquiterpene lactone
transforming growth factor beta
Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.		2.3110
ConditionIndicatedRelationship StrengthStudiesTrials
Cryptogenic Fibrosing Alveolitis
[description not available]		02.3110
Idiopathic Pulmonary Fibrosis
A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.		02.3110
Breast Cancer
[description not available]		07.4110
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.4110
Cancer of Lung
[description not available]		02.4110
Lung Neoplasms
Tumors or cancer of the LUNG.		02.4110
Benign Neoplasms
[description not available]		02.4110
Anorexia
The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.		07.4110
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.4110
Colitis
Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.		07.6620
Cholangiocellular Carcinoma
[description not available]		05.0471
Bile Duct Cancer
[description not available]		03.5160
Bile Duct Neoplasms
Tumors or cancer of the BILE DUCTS.		03.5160
Cholangiocarcinoma
A malignant tumor arising from the epithelium of the BILE DUCTS.		05.0471
Asthma, Bronchial
[description not available]		02.2510
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		03.0840
Innate Inflammatory Response
[description not available]		02.6920
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).		07.2510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		07.6920
Bronchial Hyperreactivity
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.		02.2510
Ache
[description not available]		02.3110
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.		02.3110
Blue-Eared Pig Disease
[description not available]		02.1510
Lung Injury, Acute
[description not available]		02.1710
Acute Lung Injury
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).		07.1710
Acute Hepatic Failure
[description not available]		02.2110
Liver Failure, Acute
A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.		02.2110
Rheumatoid Arthritis
[description not available]		02.2110
Arthritis, Rheumatoid
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.		02.2110
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.110