alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Pain in 37 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bradykinin, an inflammatory mediator, sensitizes nociceptor peripheral terminals reducing pain threshold." | 7.73 | Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. ( Allchorne, A; Amaya, F; Brenner, GJ; Ito, N; Ji, RR; Kohno, T; Wang, H; Woolf, CJ, 2005) |
| "Considerable evidence has demonstrated that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor blockade has an antinociceptive effect on inflammatory pain." | 7.73 | New role for spinal Stargazin in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated pain sensitization after inflammation. ( Johns, RA; Skinner, J; Su, Q; Tao, F, 2006) |
| " After having established the mouse model of analgesia by intraperitoneal or subcutaneous injections of appropriate doses of emulsified enflurane, isoflurane or sevoflurane, we injected different doses of AMPA intrathecally and observed effects on the pain threshold using the hot-plate and acetic acid-induced writhing tests." | 3.74 | Spinal alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors may mediate the analgesic effects of emulsified halogenated anaesthetics. ( Dai, TJ; Hang, LH; Shao, DH; Yang, YH; Zeng, YM, 2007) |
| "Bradykinin, an inflammatory mediator, sensitizes nociceptor peripheral terminals reducing pain threshold." | 3.73 | Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. ( Allchorne, A; Amaya, F; Brenner, GJ; Ito, N; Ji, RR; Kohno, T; Wang, H; Woolf, CJ, 2005) |
| "Considerable evidence has demonstrated that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor blockade has an antinociceptive effect on inflammatory pain." | 3.73 | New role for spinal Stargazin in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated pain sensitization after inflammation. ( Johns, RA; Skinner, J; Su, Q; Tao, F, 2006) |
| "Joint pain is one of the most debilitating symptoms of rheumatoid arthritis (RA) and patients frequently rate improvements in pain management as their priority." | 1.91 | Insights into FcγR involvement in pain-like behavior induced by an RA-derived anti-modified protein autoantibody. ( Agalave, NM; Barbier, J; Bersellini Farinotti, A; Eijkelkamp, N; Grönwall, C; Hunt, MA; Jimenéz-Andrade, JM; Jurczak, A; Klareskog, L; Krock, E; Marchand, F; Martinez-Martinez, A; Raoof, R; Rudjito, R; Sandor, K; Simon, N; Svensson, CI; Vazquez-Mora, JA; Wang, Z, 2023) |
| "Homo-AMPA decreased mechanical allodynia in diabetic neuropathic mice." | 1.72 | Homo-AMPA in the periaqueductal grey modulates pain and rostral ventromedial medulla activity in diabetic neuropathic mice. ( Bagetta, G; Belardo, C; Boccella, S; De Dominicis, E; Iannotta, M; Infantino, R; Maione, S; Marabese, I; Pagano, M; Palazzo, E; Perrone, M; Scuteri, D, 2022) |
| "Secondary mechanical allodynia resulting from a thermal stimulus (52." | 1.33 | Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model. ( Jones, TL; Sorkin, LS, 2005) |
| " Morphine dose-response curves were carried out for morphine and fixed doses of ACEA 1021 (12 microg) or AP-5 (10 microg)." | 1.30 | Effects of intrathecal NMDA and non-NMDA antagonists on acute thermal nociception and their interaction with morphine. ( Nishiyama, T; Weber, E; Yaksh, TL, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (32.43) | 18.2507 |
| 2000's | 21 (56.76) | 29.6817 |
| 2010's | 1 (2.70) | 24.3611 |
| 2020's | 3 (8.11) | 2.80 |
| Authors | Studies |
|---|---|
| Zanetti, L | 1 |
| Regoni, M | 1 |
| Ratti, E | 1 |
| Valtorta, F | 1 |
| Sassone, J | 1 |
| Palazzo, E | 1 |
| Boccella, S | 1 |
| Marabese, I | 1 |
| Perrone, M | 1 |
| Belardo, C | 1 |
| Iannotta, M | 1 |
| Scuteri, D | 1 |
| De Dominicis, E | 1 |
| Pagano, M | 1 |
| Infantino, R | 1 |
| Bagetta, G | 1 |
| Maione, S | 1 |
| Jurczak, A | 1 |
| Sandor, K | 1 |
| Bersellini Farinotti, A | 1 |
| Krock, E | 1 |
| Hunt, MA | 1 |
| Agalave, NM | 1 |
| Barbier, J | 1 |
| Simon, N | 1 |
| Wang, Z | 1 |
| Rudjito, R | 1 |
| Vazquez-Mora, JA | 1 |
| Martinez-Martinez, A | 1 |
| Raoof, R | 1 |
| Eijkelkamp, N | 1 |
| Grönwall, C | 1 |
| Klareskog, L | 1 |
| Jimenéz-Andrade, JM | 1 |
| Marchand, F | 1 |
| Svensson, CI | 1 |
| Dong, XD | 1 |
| Svensson, P | 1 |
| Cairns, BE | 1 |
| Li, J | 1 |
| Baccei, ML | 1 |
| Li, X | 1 |
| Clark, JD | 1 |
| Jones, TL | 2 |
| Sorkin, LS | 2 |
| Minami, T | 2 |
| Matsumura, S | 2 |
| Nishizawa, M | 1 |
| Sasaguri, Y | 1 |
| Hamanaka, N | 1 |
| Ito, S | 2 |
| Aumeerally, N | 1 |
| Allen, G | 1 |
| Sawynok, J | 1 |
| Dominguez, E | 1 |
| Iyengar, S | 1 |
| Shannon, HE | 1 |
| Bleakman, D | 1 |
| Alt, A | 1 |
| Arnold, BM | 1 |
| Bell, MG | 1 |
| Bleisch, TJ | 1 |
| Buckmaster, JL | 1 |
| Castano, AM | 1 |
| Del Prado, M | 1 |
| Escribano, A | 1 |
| Filla, SA | 1 |
| Ho, KH | 1 |
| Hudziak, KJ | 1 |
| Jones, CK | 1 |
| Martinez-Perez, JA | 1 |
| Mateo, A | 1 |
| Mathes, BM | 1 |
| Mattiuz, EL | 1 |
| Ogden, AM | 1 |
| Simmons, RM | 1 |
| Stack, DR | 1 |
| Stratford, RE | 1 |
| Winter, MA | 1 |
| Wu, Z | 1 |
| Ornstein, PL | 1 |
| Wang, H | 1 |
| Kohno, T | 1 |
| Amaya, F | 1 |
| Brenner, GJ | 1 |
| Ito, N | 1 |
| Allchorne, A | 1 |
| Ji, RR | 1 |
| Woolf, CJ | 1 |
| Yoon, MH | 1 |
| Bae, HB | 1 |
| Choi, JI | 1 |
| Jeong, SW | 1 |
| Chung, SS | 1 |
| Yoo, KY | 1 |
| Jeong, CY | 1 |
| Kim, SJ | 2 |
| Chung, ST | 1 |
| Kim, CM | 1 |
| An, TH | 1 |
| Sharif Naeini, R | 1 |
| Cahill, CM | 1 |
| Ribeiro-da-Silva, A | 1 |
| Ménard, HA | 1 |
| Henry, JL | 1 |
| Christoph, T | 1 |
| Schiene, K | 1 |
| Englberger, W | 2 |
| Parsons, CG | 1 |
| Chizh, BA | 2 |
| Gadotti, VM | 1 |
| Tibola, D | 1 |
| Paszcuk, AF | 1 |
| Rodrigues, AL | 1 |
| Calixto, JB | 1 |
| Santos, AR | 1 |
| Tao, F | 1 |
| Skinner, J | 1 |
| Su, Q | 1 |
| Johns, RA | 1 |
| Gu, XL | 1 |
| Yu, LC | 1 |
| Hang, LH | 1 |
| Shao, DH | 1 |
| Yang, YH | 1 |
| Dai, TJ | 1 |
| Zeng, YM | 1 |
| Jedema, HP | 1 |
| Moghaddam, B | 1 |
| Morris, R | 1 |
| Southam, E | 1 |
| Gittins, SR | 1 |
| de Vente, J | 1 |
| Garthwaite, J | 1 |
| Neugebauer, V | 3 |
| Lücke, T | 2 |
| Schaible, HG | 3 |
| Cumberbatch, MJ | 1 |
| Herrero, JF | 1 |
| Headley, PM | 1 |
| Meller, ST | 1 |
| Dykstra, CL | 1 |
| Gebhart, GF | 1 |
| Rumenapp, P | 1 |
| Zhou, S | 1 |
| Bonasera, L | 1 |
| Carlton, SM | 1 |
| Menéndez, L | 2 |
| Hidalgo, A | 2 |
| Baamonde, A | 2 |
| Nishiyama, T | 1 |
| Yaksh, TL | 1 |
| Weber, E | 1 |
| Li, P | 1 |
| Wilding, TJ | 1 |
| Calejesan, AA | 1 |
| Huettner, JE | 1 |
| Zhuo, M | 1 |
| Pollard, M | 1 |
| Chung, KM | 1 |
| Lee, KC | 1 |
| Song, DK | 1 |
| Huh, SO | 1 |
| Choi, MR | 1 |
| Kim, YH | 1 |
| Suh, HW | 1 |
| Schlütz, H | 1 |
| Scheede, M | 1 |
| Okuda-Ashitaka, E | 1 |
| Shimamoto, K | 1 |
| Sakimura, K | 1 |
| Mishina, M | 1 |
| Mori, H | 1 |
| Alvarez-Vega, M | 1 |
| Ahmadi, S | 1 |
| Lippross, S | 1 |
| Neuhuber, WL | 1 |
| Zeilhofer, HU | 1 |
| Coderre, TJ | 1 |
| Melzack, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
1 review available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Pain
| Article | Year |
|---|---|
Presynaptic AMPA Receptors in Health and Disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Humans; Neurons; Pain; Receptors, | 2021 |
36 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Pain
| Article | Year |
|---|---|
Homo-AMPA in the periaqueductal grey modulates pain and rostral ventromedial medulla activity in diabetic neuropathic mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Diabetes Mellitus; Diabetic Neuro | 2022 |
Insights into FcγR involvement in pain-like behavior induced by an RA-derived anti-modified protein autoantibody.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arthritis, Rheumatoid; Autoantibo | 2023 |
The analgesic action of topical diclofenac may be mediated through peripheral NMDA receptor antagonism.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, | 2009 |
Neonatal tissue damage facilitates nociceptive synaptic input to the developing superficial dorsal horn via NGF-dependent mechanisms.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Ca | 2011 |
Spinal cord heme oxygenase participates in glutamate-induced pain-related behaviors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cyclic GMP; Dos | 2002 |
Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate receptors mediate development, but not maintenance, of secondary allodynia evoked by first-degree burn in the rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anim | 2004 |
Acute and late effects on induction of allodynia by acromelic acid, a mushroom poison related structurally to kainic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basidiomycota; Benzodiazepines; D | 2004 |
Glutamate-evoked release of adenosine and regulation of peripheral nociception.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; alpha-Amino-3-hydroxy- | 2004 |
Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Analgesics; Animals; Biologic | 2005 |
Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bradykinin; Drug Synergism; Gluta | 2005 |
Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Area | 2005 |
Evaluation of interaction between intrathecal adenosine and MK801 or NBQX in a rat formalin pain model.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Disease Models, Animal | 2005 |
Remodelling of spinal nociceptive mechanisms in an animal model of monoarthritis.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ankle; Arthrit | 2005 |
The antiallodynic effect of NMDA antagonists in neuropathic pain outlasts the duration of the in vivo NMDA antagonism.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Opioid; Animals; Cold Temperat | 2006 |
Contribution of spinal glutamatergic receptors to the antinociception caused by agmatine in mice.
Topics: Agmatine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Cycloleucin | 2006 |
New role for spinal Stargazin in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated pain sensitization after inflammation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anal | 2006 |
The colocalization of CGRP receptor and AMPA receptor in the spinal dorsal horn neuron of rat: a morphological and electrophysiological study.
Topics: Afferent Pathways; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcitonin Gen | 2007 |
Spinal alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors may mediate the analgesic effects of emulsified halogenated anaesthetics.
Topics: Acetic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Anesthetics, Inha | 2007 |
Glutamatergic control of dopamine release during stress in the rat prefrontal cortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4- | 1994 |
The NO-cGMP pathway in neonatal rat dorsal horn.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Anima | 1994 |
Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons.
Topics: Acute Disease; Afferent Pathways; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; | 1994 |
Exposure of rat spinal neurones to NMDA, AMPA and kainate produces only short-term enhancements of responses to noxious and non-noxious stimuli.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Hot Temperatur | 1994 |
Differential effects of N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists on the responses of rat spinal neurons with joint input.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4- | 1993 |
Acute mechanical hyperalgesia is produced by coactivation of AMPA and metabotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Hot Temperature; Ib | 1993 |
The role of spinal neurokinin-2 receptors in the processing of nociceptive information from the joint and in the generation and maintenance of inflammation-evoked hyperexcitability of dorsal horn neurons in the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arthritis; Benzamides; Carrageena | 1996 |
Peripheral administration of NMDA, AMPA or KA results in pain behaviors in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Excitatory Amin | 1996 |
Spinal calmodulin inhibitors reduce N-methyl-D-aspartate- and septide-induced nociceptive behavior.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium-Calmodulin-Dependent Prot | 1997 |
Effects of intrathecal NMDA and non-NMDA antagonists on acute thermal nociception and their interaction with morphine.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesia; Analgesics, Opioid; Animals; Do | 1998 |
Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anim | 1999 |
Ionotropic glutamate receptor-mediated responses in the rat primary somatosensory cortex evoked by noxious and innocuous cutaneous stimulation in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Antagonists | 2000 |
Differential modulatory roles of cholera toxin and pertussis toxin in the regulation of pain responses induced by excitatory amino acids administered intrathecally in mice.
Topics: Adjuvants, Immunologic; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cholera T | 2000 |
The N-methyl-D-aspartate antagonistic and opioid components of d-methadone antinociception in the rat spinal cord.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesia; Analgesics, | 2000 |
Characterization of the glutamatergic system for induction and maintenance of allodynia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; | 2001 |
Effects of the calcium release inhibitor dantrolene and the Ca2+-ATPase inhibitor thapsigargin on spinal nociception in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Behavior, Animal; Cal | 2001 |
PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cholera Toxin; Cyclic AMP-Depende | 2002 |
Central neural mediators of secondary hyperalgesia following heat injury in rats: neuropeptides and excitatory amino acids.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4- | 1991 |