| Assay ID | Title | Year | Journal | Article |
|---|
| AID1133281 | Ratio of ED50 for antinociceptive activity in sc dosed mouse to ED50 for antinociceptive activity in po dosed mouse | 1978 | Journal of medicinal chemistry, Dec, Volume: 21, Issue:12
| Synthesis and antinociceptive activity of 7-methoxycodeine. |
| AID1130767 | Analgesic activity in sc dosed CF-1 mouse assessed as reduction of HCl-induced writhing pretreated for 15 mins | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
| 4-(p-Bromophenyl)-4-(dimethylamino)-1-phenethylcyclohexanol, an extremely potent respresentative of a new analgesic series. |
| AID112273 | Analgesic activity test by employing HCl writhing procedure in CF-1 female mice | 1981 | Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
| 4-aryl-4-aminocyclohexanones and their derivatives, a novel class of analgesics. 3. m-Hydroxyphenyl derivates. |
| AID112277 | Compound was tested for analgesic activity by tail-flick test after subcutaneous administration in mice | 1984 | Journal of medicinal chemistry, Sep, Volume: 27, Issue:9
| Potential synthetic codeine substitutes: (-)-3-O-aryl-N-methylmorphinans. |
| AID1133360 | Analgesic activity against po dosed yeast-induced inflamed foot Sprague-Dawley rat model assessed as increase in pain threshold in inflamed paw measured after 2 hrs | 1978 | Journal of medicinal chemistry, Sep, Volume: 21, Issue:9
| Analgesic activity of novel spiro heterocycles. 2-Amino-7-oxa-3-thia-1-azaspiro[5,5]undec-1-enes and related compounds. |
| AID1132342 | Analgesic activity in Swiss CD mouse at 10 mg/kg, ip bid for 4 days measured after naloxone challenge on day 4 by hot-plate method relative to control | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
| Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes. |
| AID114388 | Tested for analgesic activity using tail flick assay in mice | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4
| 4-Amino-4-arylcyclohexanones and their derivatives, a novel class of analgesics. 1. Modification of the aryl ring. |
| AID1123274 | Physical dependence capacity in rhesus monkey by single-dose suppression test | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids. |
| AID77991 | Inhibition of contraction of electrically stimulated guinea pig ileum | 1980 | Journal of medicinal chemistry, Oct, Volume: 23, Issue:10
| Novel analogues of enkephalin: indentification of functional groups required for biological activity. |
| AID116670 | Analgesic activity was measured by phenylquinone writhing test in male Swiss albino mice at a dose of 3.1 mg/Kg, sc. | 1982 | Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
| Synthesis of N-[[(substituted-phenyl)carbonyl]amino]-1,2,3,6-tetrahydropyridines with analgesic and hyperglycemic activity. |
| AID1151044 | Antinociceptive activity in sc dosed male white mouse by Nilsen test | 1976 | Journal of medicinal chemistry, Aug, Volume: 19, Issue:8
| (-)-3-Isothujone, a small nonnitrogenous molecule with antinociceptive activity in mice. |
| AID296744 | Antinociceptive activity in mouse at 1 mg/kg, sc by tail flick relative to morphine | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorph |
| AID1132340 | Analgesic activity in Swiss CD mouse at 10 mg/kg, ip bid for 4 days measured after 4 days by hot-plate method relative to control | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
| Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes. |
| AID19424 | Partition coefficient (logD7.4) | 2001 | Journal of medicinal chemistry, Jul-19, Volume: 44, Issue:15
| ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. |
| AID1133361 | Analgesic activity in po dosed Sprague-Dawley rat by tail flick assay | 1978 | Journal of medicinal chemistry, Sep, Volume: 21, Issue:9
| Analgesic activity of novel spiro heterocycles. 2-Amino-7-oxa-3-thia-1-azaspiro[5,5]undec-1-enes and related compounds. |
| AID149030 | Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membrane | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11
| Probes for narcotic receptor mediated phenomena. 13. Potential irreversible narcotic antagonist-based ligands derived from 6,14-endo-ethenotetrahydronororipavine with 7-(methoxyfumaroyl)amino, (bromoacetyl)amino, or isothiocyanate electrophiles: chemistry |
| AID1151047 | Toxicity in sc dosed male white mouse | 1976 | Journal of medicinal chemistry, Aug, Volume: 19, Issue:8
| (-)-3-Isothujone, a small nonnitrogenous molecule with antinociceptive activity in mice. |
| AID128008 | Compound was evaluated in vivo for the agonist activity after subcutaneous administration as aqueous solutions of HCl salt in mice using Hot plate assay | 1984 | Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
| Opioid agonists and antagonists. 6,6-Hydrazi and 6-oximino derivatives of 14-hydroxydihydromorphinones. |
| AID112274 | Analgesic activity test by employing tail-flick procedure in CF-1 female mice | 1981 | Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
| 4-aryl-4-aminocyclohexanones and their derivatives, a novel class of analgesics. 3. m-Hydroxyphenyl derivates. |
| AID1151041 | Antinociceptive activity in sc dosed male white mouse by hot plate test | 1976 | Journal of medicinal chemistry, Aug, Volume: 19, Issue:8
| (-)-3-Isothujone, a small nonnitrogenous molecule with antinociceptive activity in mice. |
| AID1123270 | Binding affinity to opiate receptor in rat brain homogenates | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids. |
| AID1149205 | Antidiarrheal activity in Charles River rat assessed as inhibition of castor oil-induced diarrhea by measuring protected animals at 1 mg/kg, po administered 1 hr prior to castor oil challenge measured after 1 hr relative to vehicle-treated control | 1976 | Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
| Drugs derived from cannabinoids. 5. delta6a,10a-Tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains. |
| AID116669 | Analgesic activity was measured by phenylquinone writhing test in male Swiss albino mice at a dose of 0.038 mg/Kg, sc. | 1982 | Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
| Synthesis of N-[[(substituted-phenyl)carbonyl]amino]-1,2,3,6-tetrahydropyridines with analgesic and hyperglycemic activity. |
| AID113103 | Analgesic activity was evaluated by tail-flick assay in mice after subcutaneous administration. | 1980 | Journal of medicinal chemistry, Aug, Volume: 23, Issue:8
| 4-Anilidopiperidine analgesics. 3. 1-Substituted 4-(propananilido)perhydroazepines as ring-expanded analogues. |
| AID1123272 | Therapeutic ratio of LD50 for sc dosed mouse to ED50 for antinociceptive activity in sc dosed mouse by Eddy-hot plate assay | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids. |
| AID1123267 | Physical dependence capacity in rhesus monkey by precipitated withdrawal test | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids. |
| AID1123214 | Binding affinity to opioid receptor in rat brain homogenates | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Deoxymorphines: role of the phenolic hydroxyl in antinociception and opiate receptor interactions. |
| AID1123268 | Antinociceptive activity in sc dosed mouse by Nilsen assay | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids. |
| AID129304 | Antinociceptive activity determined in acetic acid induced mouse writhing test | 1981 | Journal of medicinal chemistry, Dec, Volume: 24, Issue:12
| (-)-4-Hydroxymorphinanones: their synthesis and analgesic activity. |
| AID296746 | Antinociceptive activity in mouse at 30 mg/kg by tail flick relative to morphine | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorph |
| AID1132325 | Analgesic activity in Swiss CD mouse assessed as elevation of response latency at 10 mg/kg, ip measured 0.5 hr post treatment by tail flick method relative to control | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
| Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes. |
| AID128011 | Compound was evaluated in vivo for the agonist activity after subcutaneous administration as aqueous solutions of HCl salt in mice using Phenylquinone (PPQ) writhing assay | 1984 | Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
| Opioid agonists and antagonists. 6,6-Hydrazi and 6-oximino derivatives of 14-hydroxydihydromorphinones. |
| AID179387 | Concentration of drug required to inhibit the stereospecific binding of [3H]naloxone (5 nM) to homogenates of rat brain minus cerebellum in the presence of 100 mM NaCl | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| 5-Aryl-3-azabicyclo[3.2.0]heptan-6-one ketals, compounds with morphine-like analgesic activity. |
| AID127047 | Compound was evaluated for antinociceptive activity in mouse using paraphenylquinone assay | 2000 | Bioorganic & medicinal chemistry letters, Nov-06, Volume: 10, Issue:21
| N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole. |
| AID131760 | Tested for effective dose required to produce antinociceptive activity in mice by tail pinch method | 1982 | Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
| Benzeneacetamide amines: structurally novel non-m mu opioids. |
| AID1147948 | Antagonism of morphine-induced analgesia in sc dosed rat | 1976 | Journal of medicinal chemistry, May, Volume: 19, Issue:5
| Adrenergic sulfonanilides. 4. Centrally active beta-adrenergic agonists. |
| AID128654 | Analgesic potency was determined by the Eddy hotplate method on mice | 1981 | Journal of medicinal chemistry, Apr, Volume: 24, Issue:4
| Synthesis and pharmacological properties of 1,2,3,4,5,6-hexahydro-1,6-methano-2-benzazocines. |
| AID751784 | Toxicity in Sprague-Dawley rat assessed as induction of constipation measured as gastrointestinal propulsion rate at 2 umol/kg, iv administered as single bolus dose prior to aqueous activated charcoal suspension treatment measured after 1 hr (Rvb = 65.3 + | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation. |
| AID1130773 | Displacement of [3H]naloxone from opioid receptor (unknown origin) by liquid scintillation counting | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
| 4-(p-Bromophenyl)-4-(dimethylamino)-1-phenethylcyclohexanol, an extremely potent respresentative of a new analgesic series. |
| AID1146099 | Analgesic activity in Swiss-Webster mouse at 10 mg/kg, sc co-treated with 3-hydroxy-17-[2-(4-(pyrrole-2,5-dion-1-yl)phenyl)ethyl]morphinan in presence of naloxone | 1977 | Journal of medicinal chemistry, Aug, Volume: 20, Issue:8
| 3-Hydroxy-17-aralkylmorphinans as potential opiate receptor-site-directed alkylating agents. |
| AID234027 | The sodium index is the ratio of the IC50 value for the inhibition of [3H]naloxone binding to homogenates of rat brain minus cerebellum in presence of 100 mM of NaCl. | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| 5-Aryl-3-azabicyclo[3.2.0]heptan-6-one ketals, compounds with morphine-like analgesic activity. |
| AID131758 | Tested for effective dose required to produce antinociceptive activity in mice by HCl writhing method | 1982 | Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
| Benzeneacetamide amines: structurally novel non-m mu opioids. |
| AID296742 | Antinociceptive activity in sc dosed mouse by phenylquinone assay | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorph |
| AID112527 | In vivo analgesic activity determined by Hendershot and Forsaith writhing test (H and F) in mice by subcutaneous administration, 30 minutes prior to challenge | 1984 | Journal of medicinal chemistry, Oct, Volume: 27, Issue:10
| Preparation of 7-(1,3,4-oxadiazolyl)-6,14-endo-etheno-6,7,8, 14-tetrahydrothebaines and related compounds as potential analgesics. |
| AID1149208 | Antidiarrheal activity in Charles River rat assessed as inhibition of castor oil-induced diarrhea by measuring protected animals at 2 mg/kg, po administered 1 hr prior to castor oil challenge measured after 1 hr relative to vehicle-treated control | 1976 | Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
| Drugs derived from cannabinoids. 5. delta6a,10a-Tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains. |
| AID1147931 | Analgesic activity in sc dosed mouse assessed as reduction in phenylalanine-induced writhing | 1976 | Journal of medicinal chemistry, May, Volume: 19, Issue:5
| Adrenergic sulfonanilides. 4. Centrally active beta-adrenergic agonists. |
| AID354323 | Antinociceptive activity in Sprague-Dawley rat assessed as duration of antinociception at 5 mg/kg, ip by tail flick test | 2009 | Journal of medicinal chemistry, May-14, Volume: 52, Issue:9
| Synthesis, conformation, and biological characterization of a sugar derivative of morphine that is a potent, long-lasting, and nontolerant antinociceptive. |
| AID112276 | Compound was tested for analgesic activity by tail-flick test after peroral administration in mice | 1984 | Journal of medicinal chemistry, Sep, Volume: 27, Issue:9
| Potential synthetic codeine substitutes: (-)-3-O-aryl-N-methylmorphinans. |
| AID1137421 | Analgesic activity in po dosed CD-1 Charles River mouse assessed as inhibition of phenyl-p-benzoquinine-induced writhing administered 15 to 90 mins prior to phenyl-p-benzoquinine challenge measured after 5 mins | 1979 | Journal of medicinal chemistry, Jul, Volume: 22, Issue:7
| Synthesis and analgesic activity of some spiro[dibenz[b,f]oxepin-10,4'-piperidine] derivatives. |
| AID131034 | Compound was tested in mouse tail-flick antinociceptive assay. | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
| Preparation and analgesic activity of (-)-11 alpha-substituted 1,2,3,4,5,6-hexahydro-6 alpha,7-(methyleneoxy)-2,6-methano-3-benzazocines. |
| AID1133358 | Analgesic activity in po dosed CF-1 mouse assessed as reduction in phenylquinone-induced writhing responses administered 15 mins prior to phenylquinone challenge | 1978 | Journal of medicinal chemistry, Sep, Volume: 21, Issue:9
| Analgesic activity of novel spiro heterocycles. 2-Amino-7-oxa-3-thia-1-azaspiro[5,5]undec-1-enes and related compounds. |
| AID177768 | Analgesic activity of perorally administered compound was determined by the inflamed rat-paw reversal of abnormal (three-legged) gait; 5-233 | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| 5-Aryl-3-azabicyclo[3.2.0]heptan-6-one ketals, compounds with morphine-like analgesic activity. |
| AID176967 | In vivo analgesic activity was determined by rat tail pressure test (RTP) in rat by subcutaneous administration, 30 minutes prior to challenge | 1984 | Journal of medicinal chemistry, Oct, Volume: 27, Issue:10
| Preparation of 7-(1,3,4-oxadiazolyl)-6,14-endo-etheno-6,7,8, 14-tetrahydrothebaines and related compounds as potential analgesics. |
| AID1132315 | Analgesic activity in Swiss CD mouse at 10 mg/kg, ip measured 0.5 hr post treatment by hot-plate method relative to control | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
| Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes. |
| AID296741 | Antinociceptive activity in sc dosed mouse by hot plate assay | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorph |
| AID114389 | Tested for analgesic activity using tail pinch assay in mice | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4
| 4-Amino-4-arylcyclohexanones and their derivatives, a novel class of analgesics. 1. Modification of the aryl ring. |
| AID111904 | Analgesic activity was evaluated in mice by hot plate assay and percent change in foot licking latency was determined at 16 mg/kg i.p. dose | 1995 | Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
| N-substituted oxazolo[5,4-b]pyridin-2(1H)-ones: a new class of non-opiate antinociceptive agents. |
| AID128644 | Analgesic activity by mouse writhing test after subcutaneous injection. | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Novel opiates and antagonists. 5. 7-Carbethoxy-N-(cycloalkylmethyl)-3-hydroxymorphinan-6-ones and -isomorphinan-6-ones. |
| AID128500 | Analgesic activity was determined after subcutaneous administration in mice using Eddy hot plate assay or Nilsen assay. | 1982 | Journal of medicinal chemistry, Dec, Volume: 25, Issue:12
| Synthesis and pharmacological activity of 6-aryl-2-azabicyclo[4.2.1]nonanes. |
| AID229309 | Ratio of IC50 compared to [D-Ala2, D-Leu5]-enkephalin in guinea pig ileum assay | 1980 | Journal of medicinal chemistry, Oct, Volume: 23, Issue:10
| Novel analogues of enkephalin: indentification of functional groups required for biological activity. |
| AID114654 | Compound was evaluated for narcotic analgesia activity in mice by mouse writhing assay | 1981 | Journal of medicinal chemistry, Jul, Volume: 24, Issue:7
| Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists. |
| AID177769 | Analgesic activity of subcutaneously administered compound was determined by the inflamed rat-paw reversal of abnormal (three-legged) gait; 0.06-2.0 | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| 5-Aryl-3-azabicyclo[3.2.0]heptan-6-one ketals, compounds with morphine-like analgesic activity. |
| AID1132328 | Analgesic activity in Swiss CD mouse assessed as elevation of response latency at 3.2 mg/kg, ip measured 2 hrs post treatment by tail flick method relative to control | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
| Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes. |
| AID1132317 | Analgesic activity in Swiss CD mouse at 3.2 mg/kg, ip measured 0.5 hr post treatment by hot-plate method relative to control | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
| Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes. |
| AID1130769 | Analgesic activity in sc dosed CF-1 mouse pretreated for 15 mins by tail-flick method | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
| 4-(p-Bromophenyl)-4-(dimethylamino)-1-phenethylcyclohexanol, an extremely potent respresentative of a new analgesic series. |
| AID114545 | Tested for narcotic antagonistic property using tail-flick procedure in mice after giving subcutaneous dose of 6.3 mg/kg of morphine sulphate | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4
| 4-Amino-4-arylcyclohexanones and their derivatives, a novel class of analgesics. 1. Modification of the aryl ring. |
| AID129609 | Compound was evaluated for analgesic activity in a mouse hotplate test | 1985 | Journal of medicinal chemistry, Feb, Volume: 28, Issue:2
| Synthesis, stereochemistry, and analgesic activity of 4-mono- and 4,4-disubstituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines. |
| AID175509 | Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl | 1980 | Journal of medicinal chemistry, Oct, Volume: 23, Issue:10
| Novel analogues of enkephalin: indentification of functional groups required for biological activity. |
| AID112670 | In vivo antagonist/agonist nature after subcutaneous administration using hot plate assay | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11
| Probes for narcotic receptor mediated phenomena. 13. Potential irreversible narcotic antagonist-based ligands derived from 6,14-endo-ethenotetrahydronororipavine with 7-(methoxyfumaroyl)amino, (bromoacetyl)amino, or isothiocyanate electrophiles: chemistry |
| AID127049 | Compound was evaluated for antinociceptive activity in mouse using tail flick assay | 2000 | Bioorganic & medicinal chemistry letters, Nov-06, Volume: 10, Issue:21
| N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole. |
| AID112275 | Analgesic activity test by employing tail-pinch procedure in CF-1 female mice | 1981 | Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
| 4-aryl-4-aminocyclohexanones and their derivatives, a novel class of analgesics. 3. m-Hydroxyphenyl derivates. |
| AID751792 | Antiallodynic activity in iv dosed Sprague-Dawley rat chronic constriction injury model assessed as change in ipsilateral hindpaw withdrawal threshold administered as single bolus dose separated by 2 to 3 days wash-out period | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation. |
| AID296745 | Antinociceptive activity in mouse at 10 mg/kg, sc by tail flick relative to morphine | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorph |
| AID1130776 | Analgesic activity in sc dosed ICR albino mouse assessed as dose required for 50% induction of analgesia in thermal stimulus challenge after 20 mins by tail flick test | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
| 4-Anilidopiperidine analgesics. 2. A study of the conformational aspects of the analgesic activity of the 4-anilidopiperidines utilizing isomeric N-substituted 3-(propananilido)nortropane analogues. |
| AID1132318 | Analgesic activity in Swiss CD mouse at 3.2 mg/kg, ip measured 2 hrs post treatment by hot-plate method relative to control | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
| Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes. |
| AID610884 | Analgesic activity in Sprague-Dawley rat assessed as reduction in formalin-induced chronic pain at 20 to 30 mg/kg, po administered 30 mins before formalin challenge measured after 30 mins | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain. |
| AID148078 | Binding affinity against delta-opiate receptor (human) using [3H]-DPDPE radioligand | 2001 | Journal of medicinal chemistry, Oct-11, Volume: 44, Issue:21
| From hit to lead. Combining two complementary methods for focused library design. Application to mu opiate ligands. |
| AID296743 | Antinociceptive activity in sc dosed mouse by tail flick assay | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorph |
| AID179385 | Concentration of drug required to inhibit the stereospecific binding of [3H]-naloxone (5 nM) to homogenates of rat brain minus cerebellum in the absence of 100 mM NaCl | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| 5-Aryl-3-azabicyclo[3.2.0]heptan-6-one ketals, compounds with morphine-like analgesic activity. |
| AID1147932 | Analgesic activity in sc dosed rat by tail flick test | 1976 | Journal of medicinal chemistry, May, Volume: 19, Issue:5
| Adrenergic sulfonanilides. 4. Centrally active beta-adrenergic agonists. |
| AID128197 | Compound was tested for its analgesic activity in mouse hotplate assay | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
| Preparation and analgesic activity of (-)-11 alpha-substituted 1,2,3,4,5,6-hexahydro-6 alpha,7-(methyleneoxy)-2,6-methano-3-benzazocines. |
| AID1123271 | Binding affinity to opiate receptor in mouse/rat NG108-15 hybrid cells | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids. |
| AID1133277 | Antinociceptive activity in sc dosed mouse by Eddy hot-plate assay | 1978 | Journal of medicinal chemistry, Dec, Volume: 21, Issue:12
| Synthesis and antinociceptive activity of 7-methoxycodeine. |
| AID116507 | Analgesic activity in mice using phenylquinone writhing test at 0.038 mg/kg, sc dose | 1982 | Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
| Synthesis of N-(carbonylamino)-1,2,3,6-tetrahydropyridines with analgesic, antiinflammatory, and hyperglycemic activity. |
| AID751787 | Toxicity in Sprague-Dawley rat assessed as induction of respiratory depression measured as change in hypercapnia-induced stimulation of minute ventilation at 2 umol/kg, iv administered as single bolus dose after 0.5 to 1 hr (Rvb = 38.9 +/- 6.7%) | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation. |
| AID131764 | Tested for effective dose required to produce sedative activity in mice by inclined screen method | 1982 | Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
| Benzeneacetamide amines: structurally novel non-m mu opioids. |
| AID354314 | Antinociceptive activity in Sprague-Dawley rat at 5 mg/kg, ip after 30 mins by tail flick test | 2009 | Journal of medicinal chemistry, May-14, Volume: 52, Issue:9
| Synthesis, conformation, and biological characterization of a sugar derivative of morphine that is a potent, long-lasting, and nontolerant antinociceptive. |
| AID182833 | Ability to displace [3H]naloxone binding from homogenates of rat brain minus cerebellum at the concentration of 0.78 uM | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| 5-Aryl-3-azabicyclo[3.2.0]heptan-6-one ketals, compounds with morphine-like analgesic activity. |
| AID177236 | Compound was evaluated for its analgesic activity by Rat-tail-flick test after subcutaneous administration | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| Novel opiates and antagonists. 6. 7-Alkyl-6,7-didehydromorphinans. |
| AID354306 | Antinociceptive activity in Sprague-Dawley rat at 5 mg/kg, ip after 15 mins by tail flick test | 2009 | Journal of medicinal chemistry, May-14, Volume: 52, Issue:9
| Synthesis, conformation, and biological characterization of a sugar derivative of morphine that is a potent, long-lasting, and nontolerant antinociceptive. |
| AID1164358 | Antinociceptive activity in CD1 mouse assessed as reduction in thermal nociception by at 1500 nmol, iv by hot plate test | 2014 | ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9
| Novel cyclic biphalin analogue with improved antinociceptive properties. |
| AID127045 | Compound was evaluated for antinociceptive activity in mouse using hot plate assay | 2000 | Bioorganic & medicinal chemistry letters, Nov-06, Volume: 10, Issue:21
| N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole. |
| AID149035 | Inhibition of [3H]naloxone receptor binding to opioid receptor in the presence of 100 mM NaCl | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
| N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines. |
| AID131762 | Tested for effective dose required to produce narcotic stimulation in mice; Active | 1982 | Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
| Benzeneacetamide amines: structurally novel non-m mu opioids. |
| AID114653 | Compound was evaluated for narcotic analgesia activity in mice by hot plate test | 1981 | Journal of medicinal chemistry, Jul, Volume: 24, Issue:7
| Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists. |
| AID1133279 | Antinociceptive activity in po dosed mouse by Eddy hot-plate assay | 1978 | Journal of medicinal chemistry, Dec, Volume: 21, Issue:12
| Synthesis and antinociceptive activity of 7-methoxycodeine. |
| AID751782 | Toxicity in Sprague-Dawley rat castor oil-induced diarrhoea model assessed as induction of constipation at 2 umol/kg, iv administered as single bolus dose incubated for 5 mins prior to castor oil-challenge measured after 8 hrs | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation. |
| AID112278 | Compound was tested for analgesic activity by writhing test after peroral administration in mice | 1984 | Journal of medicinal chemistry, Sep, Volume: 27, Issue:9
| Potential synthetic codeine substitutes: (-)-3-O-aryl-N-methylmorphinans. |
| AID112279 | Compound was tested for analgesic activity by writhing test after subcutaneous administration in mice | 1984 | Journal of medicinal chemistry, Sep, Volume: 27, Issue:9
| Potential synthetic codeine substitutes: (-)-3-O-aryl-N-methylmorphinans. |
| AID114656 | Compound was evaluated for narcotic analgesia activity in mice by the tail flick test | 1981 | Journal of medicinal chemistry, Jul, Volume: 24, Issue:7
| Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists. |
| AID1130768 | Analgesic activity in sc dosed CF-1 mouse pretreated for 15 mins by tail-pinch method | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
| 4-(p-Bromophenyl)-4-(dimethylamino)-1-phenethylcyclohexanol, an extremely potent respresentative of a new analgesic series. |
| AID147859 | Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligand | 2001 | Journal of medicinal chemistry, Oct-11, Volume: 44, Issue:21
| From hit to lead. Combining two complementary methods for focused library design. Application to mu opiate ligands. |
| AID131759 | Tested for effective dose required to produce antinociceptive activity in mice by tail flick method | 1982 | Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
| Benzeneacetamide amines: structurally novel non-m mu opioids. |
| AID1137428 | Analgesic activity in sc dosed CD-1 Charles River mouse measured for 15 to 60 mins by tail flick test relative to control | 1979 | Journal of medicinal chemistry, Jul, Volume: 22, Issue:7
| Synthesis and analgesic activity of some spiro[dibenz[b,f]oxepin-10,4'-piperidine] derivatives. |
| AID1132335 | Analgesic activity in dog assessed as increase in response threshold at 1.5 mg/kg, sc measured 0.5 to 2 hrs post treatment by radiant heat method relative to control | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
| Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes. |
| AID1132332 | Analgesic activity in Sprague-Dawley CD rat at 17.8 mg/kg, sc measured 0.5 to 2 hrs post treatment by flinch-jump method relative to control | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
| Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes. |
| AID128012 | Compound was evaluated in vivo for the agonist activity after subcutaneous administration as aqueous solutions of HCl salt in mice using Tail flick assay | 1984 | Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
| Opioid agonists and antagonists. 6,6-Hydrazi and 6-oximino derivatives of 14-hydroxydihydromorphinones. |
| AID129613 | Compound was evaluated for analgesic activity using mouse hotplate test | 1986 | Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
| Analgesic actions of 3-substituted 6-tert-butyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines. |
| AID1164359 | Antinociceptive activity in CD1 mouse assessed as reduction in thermal nociception by at 1500 nmol, iv by tail flick test | 2014 | ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9
| Novel cyclic biphalin analogue with improved antinociceptive properties. |
| AID112973 | Compound was tested for morphine antagonist activity by measuring blockade of morphine-induced elevation of tail flick latency in CF-1 female mice | 1981 | Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
| 4-aryl-4-aminocyclohexanones and their derivatives, a novel class of analgesics. 3. m-Hydroxyphenyl derivates. |
| AID73710 | Displacement of specifically bound [3H]naloxone from guinea pig ileum, in the presence of 100 mM NaCl | 1980 | Journal of medicinal chemistry, Oct, Volume: 23, Issue:10
| Novel analogues of enkephalin: indentification of functional groups required for biological activity. |
| AID1146068 | Analgesic activity in sc dosed Swiss-Webster mouse after 30 mins | 1977 | Journal of medicinal chemistry, Aug, Volume: 20, Issue:8
| 3-Hydroxy-17-aralkylmorphinans as potential opiate receptor-site-directed alkylating agents. |
| AID1146069 | Analgesic activity in sc dosed Swiss-Webster mouse time of peak effect | 1977 | Journal of medicinal chemistry, Aug, Volume: 20, Issue:8
| 3-Hydroxy-17-aralkylmorphinans as potential opiate receptor-site-directed alkylating agents. |
| AID113111 | activity in the mouse hotplate procedure | 1982 | Journal of medicinal chemistry, Mar, Volume: 25, Issue:3
| Aminotetralins as narcotic antagonists. 2. Synthesis and opiate-related activity of 1-phenyl-3-aminotetralins. |
| AID131037 | Compound was tested in phenylquinone antinociceptive assay. | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
| Preparation and analgesic activity of (-)-11 alpha-substituted 1,2,3,4,5,6-hexahydro-6 alpha,7-(methyleneoxy)-2,6-methano-3-benzazocines. |
| AID129313 | Antinociceptive activity was evaluated after subcutaneous injection by using mouse hotplate assay | 1984 | Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
| Probes for narcotic receptor mediated phenomena. 7. Synthesis and pharmacological properties of irreversible ligands specific for mu or delta opiate receptors. |
| AID751794 | Antinociceptive activity in contralateral hindpaw of Sprague-Dawley rat chronic constriction injury model at 2 umol/kg, iv administered as single bolus dose separated by 2 to 3 days wash-out period | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation. |
| AID152239 | Binding affinity against mu-opiate receptor (human) using [3H]DAMGO radioligand | 2001 | Journal of medicinal chemistry, Oct-11, Volume: 44, Issue:21
| From hit to lead. Combining two complementary methods for focused library design. Application to mu opiate ligands. |
| AID1132327 | Analgesic activity in Swiss CD mouse assessed as elevation of response latency at 3.2 mg/kg, ip measured 0.5 hr post treatment by tail flick method relative to control | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
| Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes. |
| AID296747 | Antinociceptive activity in sc dosed rhesus monkey by single dose suppression assay | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorph |
| AID1164356 | Antinociceptive activity in CD1 mouse assessed as reduction in thermal nociception by measuring tail-flick latency at 0.1 nmol, icv measured 15 mins post dose by tail-flick assay | 2014 | ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9
| Novel cyclic biphalin analogue with improved antinociceptive properties. |
| AID232381 | Relative EC50 compared to [D-Ala2, D-Leu5]-enkephalin without NaCl in rat brain assay | 1980 | Journal of medicinal chemistry, Oct, Volume: 23, Issue:10
| Novel analogues of enkephalin: indentification of functional groups required for biological activity. |
| AID132083 | Effective dose required for antinociceptive activity in mouse | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
| Assessment of the in vivo and in vitro opioid activity of bridged hexahydroaporphine and isoquinoline molecules. |
| AID114387 | Tested for analgesic activity using HCl writhe assay in mice in mice | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4
| 4-Amino-4-arylcyclohexanones and their derivatives, a novel class of analgesics. 1. Modification of the aryl ring. |
| AID127667 | Analgesic activity in the mouse acetic acid writhing test following s.c. administration. | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| Novel opiates and antagonists. 6. 7-Alkyl-6,7-didehydromorphinans. |
| AID1123212 | Antinociceptive activity in sc dosed mouse by hot-plate assay | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Deoxymorphines: role of the phenolic hydroxyl in antinociception and opiate receptor interactions. |
| AID751790 | Antiallodynic activity in Sprague-Dawley rat chronic constriction injury model assessed as change in ipsilateral hindpaw withdrawal threshold at 2 umol/kg, iv administered as single bolus dose separated by 2 to 3 days wash-out period | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation. |
| AID177751 | Agonist activity (administered subcutaneously) determined by rat tail flick test | 1981 | Journal of medicinal chemistry, Dec, Volume: 24, Issue:12
| (-)-4-Hydroxymorphinanones: their synthesis and analgesic activity. |
| AID182830 | Ability to displace [3H]naloxone binding from homogenates of rat brain minus cerebellum at the concentration of 25 uM | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| 5-Aryl-3-azabicyclo[3.2.0]heptan-6-one ketals, compounds with morphine-like analgesic activity. |
| AID1164355 | Antinociceptive activity in CD1 mouse assessed as reduction in thermal nociception by at 0.1 nmol, icv measured 15 mins post dose by hot plate test | 2014 | ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9
| Novel cyclic biphalin analogue with improved antinociceptive properties. |
| AID128010 | Compound was evaluated in vivo for the agonist activity after subcutaneous administration as aqueous solutions of HCl salt in mice using Nilsen assay. | 1984 | Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
| Opioid agonists and antagonists. 6,6-Hydrazi and 6-oximino derivatives of 14-hydroxydihydromorphinones. |
| AID1123264 | Antinociceptive activity in sc dosed mouse by Eddy-hot plate assay | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids. |
| AID128033 | Compound was tested for analgesic activity in mouse using mouse writhing test following subcutaneous administration | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
| N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines. |
| AID145938 | Concentration required to inhibit stereospecific [3H]- naltrexone binding by 50% in rat brain homogenate | 1984 | Journal of medicinal chemistry, Sep, Volume: 27, Issue:9
| Potential synthetic codeine substitutes: (-)-3-O-aryl-N-methylmorphinans. |
| AID1149201 | Antidiarrheal activity in Charles River rat assessed as inhibition of castor oil-induced diarrhea by measuring protected animals at 0.5 mg/kg, po administered 1 hr prior to castor oil challenge measured after 1 hr relative to vehicle-treated control | 1976 | Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
| Drugs derived from cannabinoids. 5. delta6a,10a-Tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains. |
| AID1134335 | Analgesic activity in sc dosed mouse assessed as inhibition of acetic acid-induced writhing after 15 to 30 mins | 1977 | Journal of medicinal chemistry, Jul, Volume: 20, Issue:7
| Various 5-substituted and 2,5-disubstituted 1,3-dioxanes, a new class of analgesic agents. |
| AID1123213 | Antinociceptive activity in sc dosed mouse by Nilsen assay | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Deoxymorphines: role of the phenolic hydroxyl in antinociception and opiate receptor interactions. |
| AID119301 | Analgesic activity was evaluated in mice (10 mice/dose)by tail clip assay and expressed as number of protected animals upon total. Total tested was determined at 5 mg/kg p.o. dose; 5/10 | 1995 | Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
| N-substituted oxazolo[5,4-b]pyridin-2(1H)-ones: a new class of non-opiate antinociceptive agents. |
| AID150401 | Inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the absence of Na | 1981 | Journal of medicinal chemistry, Jul, Volume: 24, Issue:7
| Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists. |
| AID1132316 | Analgesic activity in Swiss CD mouse at 10 mg/kg, ip measured 2 hrs post treatment by hot-plate method relative to control | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
| Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes. |
| AID1137420 | Analgesic activity in sc dosed CD-1 Charles River mouse assessed as inhibition of phenyl-p-benzoquinine-induced writhing administered 15 to 90 mins prior to phenyl-p-benzoquinine challenge measured after 5 mins | 1979 | Journal of medicinal chemistry, Jul, Volume: 22, Issue:7
| Synthesis and analgesic activity of some spiro[dibenz[b,f]oxepin-10,4'-piperidine] derivatives. |
| AID177917 | Analgesic agonist activity by mouse acetylcholine writhing test through subcutaneous administration | 1985 | Journal of medicinal chemistry, Jun, Volume: 28, Issue:6
| Synthesis and antinociceptive activity of 4-(cyclopropylmethyl)-3,4,5,6-tetrahydro-2H-1,5-methano-1, 4-benzodiazocin-9-amine and congeners. |
| AID1132326 | Analgesic activity in Swiss CD mouse assessed as elevation of response latency at 10 mg/kg, ip measured 2 hrs post treatment by tail flick method relative to control | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
| Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes. |
| AID112975 | Sedation test by employing inclined screen test in CF-1 female mice | 1981 | Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
| 4-aryl-4-aminocyclohexanones and their derivatives, a novel class of analgesics. 3. m-Hydroxyphenyl derivates. |
| AID114564 | Tested for sedation using inclined screen test in mice | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4
| 4-Amino-4-arylcyclohexanones and their derivatives, a novel class of analgesics. 1. Modification of the aryl ring. |
| AID131761 | Tested for effective dose required to produce morphine antagonist activity in mice | 1982 | Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
| Benzeneacetamide amines: structurally novel non-m mu opioids. |
| AID150402 | Compound was evaluated for the inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the presence of Na | 1981 | Journal of medicinal chemistry, Jul, Volume: 24, Issue:7
| Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1508627 | Counterscreen qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: GLuc-NoTag assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1508628 | Confirmatory qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347424 | RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
| Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1508629 | Cell Viability qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347407 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347425 | Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
| Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1135666 | Analgesic activity in sc dosed mouse assessed as inhibition of phenylquinone-induced writhing | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7
| Conformation of 2,9-dimethyl-3'-hydroxy-5-phenyl-6,7-genzomorphan and its relation to other analgetics and enkephalin. |
| AID1669069 | Induction of spontaneous withdrawal in naloxone-induced CD-1 mouse assessed as increase in urine output at 10 mg/kg, ip administered twice daily at 9 am and 5 pm for 3 days pretreated followed by naloxone challenge on day 4 at 4 hrs post compound dose and | | | |
| AID1135665 | Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation counting | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7
| Conformation of 2,9-dimethyl-3'-hydroxy-5-phenyl-6,7-genzomorphan and its relation to other analgetics and enkephalin. |
| AID1669073 | Induction of physical dependence/precipitated withdrawal in naloxone-induced CD-1 mouse assessed as overall withdrawal score at 10 mg/kg, ip administered twice daily at 9 am and 5 pm for 3 days pretreated followed by naloxone challenge on day 4 at 4 hrs p | | | |
| AID1669059 | Ratio of ED50 for antinociceptive activity in CD-1 mouse measured on day 1 to ED50 for antinociceptive activity in CD-1 mouse measured on day 4 | | | |
| AID1669052 | Antinociceptive activity in CD-1 mouse at 1 to 32 mg/kg, sc measured after 15 to 180 mins by warm water tail-flick assay | | | |
| AID1669057 | Antinociceptive activity in CD-1 mouse measured on day 1 by warm water tail-flick assay | | | |
| AID1669076 | Induction of respiratory depression in CD-1 mouse assessed as reduction in respiratory rate at 10 mg/kg, ip administered via bolus measured after 40 to 45 mins by plethysmography | | | |
| AID1669071 | Induction of spontaneous withdrawal in naloxone-induced CD-1 mouse assessed as increase in fecal pellets at 10 mg/kg, ip administered twice daily at 9 am and 5 pm for 3 days pretreated followed by naloxone challenge on day 4 at 4 hrs post compound dose an | | | |
| AID1669082 | Reward liability in CD-1 mouse assessed as increase in conditioned place preference at 10 mg/kg, sc administered for 5 days and measured on day 5 for 15 mins | | | |
| AID1669077 | Induction of respiratory depression in CD-1 mouse assessed as reduction in tidal volume at 10 mg/kg, ip administered via bolus measured after 42 to 45 mins by whole body plethysmography | | | |
| AID1669058 | Antinociceptive activity in CD-1 mouse administered twice daily at 9 am and 5 pm for 3 days measured on day 4 by warm water tail-flick assay | | | |
| AID1669078 | Induction of respiratory depression in CD-1 mouse assessed as reduction in minute ventilation at 10 mg/kg, ip administered via bolus under 5% CO2 exposure for 7 mins and measured after 40 to 45 mins by whole body plethysmography | | | |
| AID1669072 | Induction of physical dependence in naloxone-induced CD-1 mouse assessed as increase in jumping behavior at 10 mg/kg, ip administered twice daily at 9 am and 5 pm for 3 days pretreated followed by naloxone challenge on day 4 at 4 hrs post compound dose an | | | |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |