inositol and Pain
inositol has been researched along with Pain in 6 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "We tested the ability of lithium (Li(+)) to block heat hyperalgesia, cold allodynia, mechanical allodynia and mechanical hyperalgesia in rats experimentally subjected to painful peripheral neuropathy." | 7.70 | Intrathecal lithium reduces neuropathic pain responses in a rat model of peripheral neuropathy. ( Inoue, T; Mashimo, T; Shibata, M; Shimizu, T; Wakisaka, S; Yoshiya, I, 2000) |
| "We tested the ability of lithium (Li(+)) to block heat hyperalgesia, cold allodynia, mechanical allodynia and mechanical hyperalgesia in rats experimentally subjected to painful peripheral neuropathy." | 3.70 | Intrathecal lithium reduces neuropathic pain responses in a rat model of peripheral neuropathy. ( Inoue, T; Mashimo, T; Shibata, M; Shimizu, T; Wakisaka, S; Yoshiya, I, 2000) |
| "Inositol was also significantly reduced in the spinal stenosis group when age matched to controls." | 1.31 | Metabolic changes in the cerebrospinal fluid of patients with lumbar disc herniation or spinal stenosis. ( Gårseth, M; Nygaard, Ø; Rød, M; Sonnewald, U; White, LR; Zwart, JA, 2002) |
| "Erythromelalgia is a syndrome characterized by erythema, burning pain and increased skin temperature of the affected extremities." | 1.27 | Erythromelalgia associated with acute diabetic neuropathy: an unusual condition. ( Bosch, X; Esmatjes, E; Goday, A; Gomis, R; Nubiola, A; Vendrell, J; Vilardell, E, 1988) |
Research
Studies (6)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Fayed, N | 1 |
| Garcia-Campayo, J | 1 |
| Magallón, R | 1 |
| Andrés-Bergareche, H | 1 |
| Luciano, JV | 1 |
| Andres, E | 1 |
| Beltrán, J | 1 |
| Gutzeit, A | 1 |
| Meier, D | 1 |
| Meier, ML | 1 |
| von Weymarn, C | 1 |
| Ettlin, DA | 1 |
| Graf, N | 1 |
| Froehlich, JM | 1 |
| Binkert, CA | 1 |
| Brügger, M | 1 |
| Gårseth, M | 1 |
| Sonnewald, U | 1 |
| White, LR | 1 |
| Rød, M | 1 |
| Nygaard, Ø | 1 |
| Zwart, JA | 1 |
| Raffa, RB | 1 |
| Martinez, RP | 1 |
| Shimizu, T | 1 |
| Shibata, M | 1 |
| Wakisaka, S | 1 |
| Inoue, T | 1 |
| Mashimo, T | 1 |
| Yoshiya, I | 1 |
| Vendrell, J | 1 |
| Nubiola, A | 1 |
| Goday, A | 1 |
| Bosch, X | 1 |
| Esmatjes, E | 1 |
| Gomis, R | 1 |
| Vilardell, E | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Chronic Pain Brain: Structural White and Gray Matter Correlates of Impaired Muscle Control and Deficient Pain Processing[NCT06143319] | 80 participants (Actual) | Observational | 2015-10-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Other Studies
6 other studies available for inositol and Pain
| Article | Year |
|---|---|
Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate.
Topics: Adult; Aspartic Acid; Brain; Cholic Acid; Cross-Sectional Studies; Diffusion Tensor Imaging; Female; | 2010 |
Insula-specific responses induced by dental pain. A proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Cerebral Cortex; Electrodes; Female; Glutamic Acid; Glutamine; Humans; Inosito | 2011 |
Metabolic changes in the cerebrospinal fluid of patients with lumbar disc herniation or spinal stenosis.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Cerebrospinal Fluid; Creatinine; Female; Glucose; Hum | 2002 |
Antinociceptive defect of beige-J mice reversed by i.c.v. IP3 or myo-inositol.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Inositol; Inosi | 1995 |
Intrathecal lithium reduces neuropathic pain responses in a rat model of peripheral neuropathy.
Topics: Animals; Chronic Disease; Cold Temperature; Drug Interactions; Hot Temperature; Hyperalgesia; Inject | 2000 |
Erythromelalgia associated with acute diabetic neuropathy: an unusual condition.
Topics: Acute Disease; Adult; Carbamazepine; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Erythromelalg | 1988 |