Page last updated: 2024-08-07 13:13:29

Vasoactive intestinal polypeptide receptor 1

A vasoactive intestinal polypeptide receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32241]

Synonyms

VIP-R-1;
Pituitary adenylate cyclase-activating polypeptide type II receptor;
PACAP type II receptor;
PACAP-R-2;
PACAP-R2;
VPAC1

Research

Bioassay Publications (3)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Compounds (2)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
mk-0893Homo sapiens (human)IC5011.580011
pituitary adenylate cyclase activating polypeptide 38Homo sapiens (human)IC500.000022

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
vasoactive intestinal polypeptide receptor activitymolecular functionCombining with vasoactive intestinal polypeptide to initiate a change in cell activity. [GOC:mah]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
peptide hormone bindingmolecular functionBinding to a peptide with hormonal activity in animals. [GOC:jl, ISBN:0198506732]
G protein-coupled peptide receptor activitymolecular functionCombining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:dph, GOC:tb]

Located In

This protein is located in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
receptor complexcellular componentAny protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]

Involved In

This protein is involved in 5 target(s):

TargetCategoryDefinition
cell surface receptor signaling pathwaybiological processThe series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]
G protein-coupled receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerbiological processA G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. [GOC:mah, GOC:signaling, ISBN:0815316194]
positive regulation of cell population proliferationbiological processAny process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
adenylate cyclase-modulating G protein-coupled receptor signaling pathwaybiological processA G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP). [GOC:mah, GOC:signaling, ISBN:0815316194]