ica-121431 profile

ICA-121431: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	998021
CHEMBL ID	3617053
SCHEMBL ID	15113469
MeSH ID	M0587955

Synonym
OPREA1_549338
OPREA1_750763
STK081225
2,2-diphenyl-n-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide
AKOS000487880
F0012-0842
2,2-diphenyl-n-(4-(n-(thiazol-2-yl)sulfamoyl)phenyl)acetamide
313254-51-2
ica 121431
SCHEMBL15113469
?-phenyl-n-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide
ica-121431
HY-16787
CHEMBL3617053 ,
bdbm50118516
SR-01000004656-1
sr-01000004656
NCGC00379252-02
F16058
2,2-diphenyl-~{n}-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]ethanamide
8de ,
Z30538253
2,2-diphenyl-n-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide
mfcd00992334
BCP28611
A13773
EN300-1212519
2,2-diphenyl-n-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}acetamide
2,2-diphenyl-n-[4-(thiazol-2-ylsulfamoyl
A924466
MS-28143

Excerpt	Reference	Relevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51

Protein Targets (17)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	4.7724	0.0123	7.9835	43.2770	AID1645841
G	Vesicular stomatitis virus	Potency	0.6741	0.0123	8.9648	39.8107	AID1645842
cytochrome P450 2D6	Homo sapiens (human)	Potency	18.9991	0.0010	8.3798	61.1304	AID1645840
Interferon beta	Homo sapiens (human)	Potency	0.6741	0.0033	9.1582	39.8107	AID1645842
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	0.6741	0.0123	8.9648	39.8107	AID1645842
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	0.6741	0.0123	8.9648	39.8107	AID1645842
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	0.6741	0.0123	8.9648	39.8107	AID1645842
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Sodium channel protein type 9 subunit alpha	Rattus norvegicus (Norway rat)	IC50 (µMol)	0.0680	0.0680	0.0680	0.0680	AID1411473
Sodium channel protein type 3 subunit alpha	Rattus norvegicus (Norway rat)	IC50 (µMol)	0.0060	0.0060	0.8605	2.9390	AID1411466
Sodium channel protein type 1 subunit alpha	Homo sapiens (human)	IC50 (µMol)	0.0260	0.0023	2.8296	9.0000	AID1246059; AID1411467
Sodium channel protein type 4 subunit alpha	Homo sapiens (human)	IC50 (µMol)	10.0000	0.0001	3.5075	10.0000	AID1246061; AID1411469
Sodium channel protein type 5 subunit alpha	Homo sapiens (human)	IC50 (µMol)	9.6000	0.0003	3.6484	9.2000	AID1246062; AID1411470
Sodium channel protein type 9 subunit alpha	Homo sapiens (human)	IC50 (µMol)	7.6000	0.0060	2.7749	9.0000	AID1246065; AID1411472
Sodium channel protein type 2 subunit alpha	Homo sapiens (human)	IC50 (µMol)	0.3165	0.0000	3.7401	10.0000	AID1246060; AID1411468
Sodium channel protein type 3 subunit alpha	Homo sapiens (human)	IC50 (µMol)	0.0185	0.0053	2.8085	9.0000	AID1246058; AID1411465
Sodium channel protein type 8 subunit alpha	Homo sapiens (human)	IC50 (µMol)	10.1500	0.0011	3.4705	9.0000	AID1246063; AID1411471
Sodium channel protein type 10 subunit alpha	Homo sapiens (human)	IC50 (µMol)	6.5000	0.0080	3.1752	9.0000	AID1246064; AID1411474
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (113)

Process	via Protein(s)	Taxonomy
cell surface receptor signaling pathway via JAK-STAT	Interferon beta	Homo sapiens (human)
response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
B cell activation involved in immune response	Interferon beta	Homo sapiens (human)
cell surface receptor signaling pathway	Interferon beta	Homo sapiens (human)
cell surface receptor signaling pathway via JAK-STAT	Interferon beta	Homo sapiens (human)
response to virus	Interferon beta	Homo sapiens (human)
positive regulation of autophagy	Interferon beta	Homo sapiens (human)
cytokine-mediated signaling pathway	Interferon beta	Homo sapiens (human)
natural killer cell activation	Interferon beta	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation of STAT protein	Interferon beta	Homo sapiens (human)
cellular response to interferon-beta	Interferon beta	Homo sapiens (human)
B cell proliferation	Interferon beta	Homo sapiens (human)
negative regulation of viral genome replication	Interferon beta	Homo sapiens (human)
innate immune response	Interferon beta	Homo sapiens (human)
positive regulation of innate immune response	Interferon beta	Homo sapiens (human)
regulation of MHC class I biosynthetic process	Interferon beta	Homo sapiens (human)
negative regulation of T cell differentiation	Interferon beta	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Interferon beta	Homo sapiens (human)
defense response to virus	Interferon beta	Homo sapiens (human)
type I interferon-mediated signaling pathway	Interferon beta	Homo sapiens (human)
neuron cellular homeostasis	Interferon beta	Homo sapiens (human)
cellular response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
cellular response to virus	Interferon beta	Homo sapiens (human)
negative regulation of Lewy body formation	Interferon beta	Homo sapiens (human)
negative regulation of T-helper 2 cell cytokine production	Interferon beta	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Interferon beta	Homo sapiens (human)
response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
B cell differentiation	Interferon beta	Homo sapiens (human)
natural killer cell activation involved in immune response	Interferon beta	Homo sapiens (human)
adaptive immune response	Interferon beta	Homo sapiens (human)
T cell activation involved in immune response	Interferon beta	Homo sapiens (human)
humoral immune response	Interferon beta	Homo sapiens (human)
positive regulation of T cell mediated cytotoxicity	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
adaptive immune response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of T cell anergy	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
defense response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
immune response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
detection of bacterium	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of interleukin-12 production	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of interleukin-6 production	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
protection from natural killer cell mediated cytotoxicity	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
innate immune response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of dendritic cell differentiation	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class Ib	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
sodium ion transport	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
adult walking behavior	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
determination of adult lifespan	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
neuronal action potential propagation	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
neuronal action potential	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
nerve development	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
neuromuscular process controlling posture	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of pain	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
establishment of localization in cell	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
cardiac muscle cell action potential involved in contraction	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
membrane depolarization during action potential	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
regulation of presynaptic membrane potential	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
sodium ion transmembrane transport	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
sodium ion transport	Sodium channel protein type 4 subunit alpha	Homo sapiens (human)
muscle contraction	Sodium channel protein type 4 subunit alpha	Homo sapiens (human)
sodium ion transmembrane transport	Sodium channel protein type 4 subunit alpha	Homo sapiens (human)
regulation of skeletal muscle contraction by action potential	Sodium channel protein type 4 subunit alpha	Homo sapiens (human)
cardiac muscle cell action potential involved in contraction	Sodium channel protein type 4 subunit alpha	Homo sapiens (human)
regulation of heart rate	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
cardiac conduction system development	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
cardiac ventricle development	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
brainstem development	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
sodium ion transport	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
positive regulation of sodium ion transport	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
response to denervation involved in regulation of muscle adaptation	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
telencephalon development	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
cerebellum development	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
sodium ion transmembrane transport	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
odontogenesis of dentin-containing tooth	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
positive regulation of action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
positive regulation of epithelial cell proliferation	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
membrane depolarization	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
cardiac muscle contraction	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
regulation of ventricular cardiac muscle cell membrane repolarization	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
regulation of atrial cardiac muscle cell membrane depolarization	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
regulation of atrial cardiac muscle cell membrane repolarization	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
regulation of ventricular cardiac muscle cell membrane depolarization	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
cellular response to calcium ion	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
cardiac muscle cell action potential involved in contraction	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
regulation of cardiac muscle cell contraction	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
ventricular cardiac muscle cell action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
membrane depolarization during action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
membrane depolarization during cardiac muscle cell action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
atrial cardiac muscle cell action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
SA node cell action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
AV node cell action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
bundle of His cell action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
membrane depolarization during AV node cell action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
membrane depolarization during SA node cell action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
membrane depolarization during Purkinje myocyte cell action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
membrane depolarization during bundle of His cell action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
AV node cell to bundle of His cell communication	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
regulation of heart rate by cardiac conduction	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
membrane depolarization during atrial cardiac muscle cell action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
regulation of sodium ion transmembrane transport	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
sodium ion transport	Sodium channel protein type 9 subunit alpha	Homo sapiens (human)
inflammatory response	Sodium channel protein type 9 subunit alpha	Homo sapiens (human)
circadian rhythm	Sodium channel protein type 9 subunit alpha	Homo sapiens (human)
response to toxic substance	Sodium channel protein type 9 subunit alpha	Homo sapiens (human)
post-embryonic development	Sodium channel protein type 9 subunit alpha	Homo sapiens (human)
sensory perception of pain	Sodium channel protein type 9 subunit alpha	Homo sapiens (human)
sodium ion transmembrane transport	Sodium channel protein type 9 subunit alpha	Homo sapiens (human)
behavioral response to pain	Sodium channel protein type 9 subunit alpha	Homo sapiens (human)
detection of temperature stimulus involved in sensory perception of pain	Sodium channel protein type 9 subunit alpha	Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception	Sodium channel protein type 9 subunit alpha	Homo sapiens (human)
cardiac muscle cell action potential involved in contraction	Sodium channel protein type 9 subunit alpha	Homo sapiens (human)
inositol phosphate metabolic process	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
negative regulation of cold-induced thermogenesis	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol phosphate biosynthetic process	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
sodium ion transport	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
nervous system development	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to osmotic stress	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
neuron apoptotic process	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
memory	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
determination of adult lifespan	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
neuronal action potential	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
dentate gyrus development	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
nerve development	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
myelination	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
cellular response to hypoxia	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
cardiac muscle cell action potential involved in contraction	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
sodium ion transmembrane transport	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
sodium ion transport	Sodium channel protein type 3 subunit alpha	Homo sapiens (human)
behavioral response to pain	Sodium channel protein type 3 subunit alpha	Homo sapiens (human)
cardiac muscle cell action potential involved in contraction	Sodium channel protein type 3 subunit alpha	Homo sapiens (human)
sodium ion transmembrane transport	Sodium channel protein type 3 subunit alpha	Homo sapiens (human)
sodium ion transport	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
nervous system development	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
peripheral nervous system development	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
neuronal action potential	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
optic nerve development	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
myelination	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
sodium ion transmembrane transport	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
cardiac muscle cell action potential involved in contraction	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
regulation of heart rate	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
sensory perception	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
regulation of monoatomic ion transmembrane transport	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
sodium ion transmembrane transport	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
odontogenesis of dentin-containing tooth	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
regulation of cardiac muscle contraction	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
regulation of atrial cardiac muscle cell membrane depolarization	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
membrane depolarization during action potential	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
AV node cell action potential	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
bundle of His cell action potential	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
regulation of presynaptic membrane potential	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
cardiac muscle cell action potential involved in contraction	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (36)

Process	via Protein(s)	Taxonomy
cytokine activity	Interferon beta	Homo sapiens (human)
cytokine receptor binding	Interferon beta	Homo sapiens (human)
type I interferon receptor binding	Interferon beta	Homo sapiens (human)
protein binding	Interferon beta	Homo sapiens (human)
chloramphenicol O-acetyltransferase activity	Interferon beta	Homo sapiens (human)
TAP binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
signaling receptor binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
protein binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
peptide antigen binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
TAP binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
protein-folding chaperone binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
voltage-gated sodium channel activity	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel activity	Sodium channel protein type 4 subunit alpha	Homo sapiens (human)
protein binding	Sodium channel protein type 4 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel activity	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
protein binding	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
calmodulin binding	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
fibroblast growth factor binding	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
enzyme binding	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
protein kinase binding	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
protein domain specific binding	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
ankyrin binding	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
ubiquitin protein ligase binding	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
transmembrane transporter binding	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
nitric-oxide synthase binding	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel activity involved in cardiac muscle cell action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel activity involved in AV node cell action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel activity involved in bundle of His cell action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel activity involved in Purkinje myocyte action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel activity involved in SA node cell action potential	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
scaffold protein binding	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel activity	Sodium channel protein type 9 subunit alpha	Homo sapiens (human)
protein binding	Sodium channel protein type 9 subunit alpha	Homo sapiens (human)
inositol-1,3,4,5,6-pentakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol heptakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate 5-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
protein binding	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
ATP binding	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate 1-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate 3-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol 5-diphosphate pentakisphosphate 5-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol diphosphate tetrakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
voltage-gated sodium channel activity	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
protein binding	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
calmodulin binding	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel activity	Sodium channel protein type 3 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel activity	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
protein binding	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
ATP binding	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
sodium ion binding	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel activity	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
transmembrane transporter binding	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (46)

Process	via Protein(s)	Taxonomy
extracellular space	Interferon beta	Homo sapiens (human)
extracellular region	Interferon beta	Homo sapiens (human)
Golgi membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
endoplasmic reticulum	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
Golgi apparatus	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
plasma membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
cell surface	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
ER to Golgi transport vesicle membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
secretory granule membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
phagocytic vesicle membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
early endosome membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
recycling endosome membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
extracellular exosome	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
lumenal side of endoplasmic reticulum membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
MHC class I protein complex	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
extracellular space	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
external side of plasma membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
plasma membrane	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
nucleoplasm	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
plasma membrane	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
intercalated disc	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
nuclear body	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
Z disc	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
T-tubule	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
node of Ranvier	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
neuronal cell body	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
axon initial segment	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel complex	Sodium channel protein type 1 subunit alpha	Homo sapiens (human)
plasma membrane	Sodium channel protein type 4 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel complex	Sodium channel protein type 4 subunit alpha	Homo sapiens (human)
caveola	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
nucleoplasm	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
nucleolus	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
endoplasmic reticulum	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
plasma membrane	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
caveola	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
cell surface	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
intercalated disc	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
membrane	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
lateral plasma membrane	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
Z disc	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
T-tubule	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
sarcolemma	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
perinuclear region of cytoplasm	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel complex	Sodium channel protein type 5 subunit alpha	Homo sapiens (human)
plasma membrane	Sodium channel protein type 9 subunit alpha	Homo sapiens (human)
axon	Sodium channel protein type 9 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel complex	Sodium channel protein type 9 subunit alpha	Homo sapiens (human)
fibrillar center	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
nucleoplasm	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
cytosol	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
nucleus	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
cytoplasm	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
plasma membrane	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
plasma membrane	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
intercalated disc	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
T-tubule	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
axon	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
node of Ranvier	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
paranode region of axon	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
presynaptic membrane	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
glutamatergic synapse	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel complex	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
membrane	Sodium channel protein type 2 subunit alpha	Homo sapiens (human)
sarcoplasm	Sodium channel protein type 3 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel complex	Sodium channel protein type 3 subunit alpha	Homo sapiens (human)
plasma membrane	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
membrane	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
Z disc	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
cell junction	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
axon	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
cytoplasmic vesicle	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
node of Ranvier	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
axon initial segment	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
presynaptic active zone membrane	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
parallel fiber to Purkinje cell synapse	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
postsynaptic density membrane	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
glutamatergic synapse	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel complex	Sodium channel protein type 8 subunit alpha	Homo sapiens (human)
plasma membrane	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
axon	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
presynaptic membrane	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
extracellular exosome	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
glutamatergic synapse	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
voltage-gated sodium channel complex	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
clathrin complex	Sodium channel protein type 10 subunit alpha	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (51)

Assay ID	Title	Year	Journal	Article
AID1411481	Selectivity ratio of IC50 for human NaV1.8 to IC50 for human NaV1.3	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1246035	Selectivity ratio of IC50 for human NaV1.5 channel to IC50 for human NaV1.3 channel	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.
AID1246058	Inhibition of human TTX-sensitive NaV1.3 channel expressed in HEK293 cells by patch clamp electrophysiology assay	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.
AID1411474	Inhibition of human NaV1.8	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1246064	Inhibition of human NaV1.8 channel by patch clamp electrophysiology assay	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.
AID1411470	Inhibition of human NaV1.5	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1411486	Lipophilicity, log D of the compound	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1411465	Inhibition of human NaV1.3 expressed in HEK cells by electrophysiological method	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1246037	Selectivity ratio of IC50 for human NaV1.5 channel to IC50 for human NaV1.7 channel	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.
AID1246060	Inhibition of human NaV1.2 channel by patch clamp electrophysiology assay	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.
AID1411480	Selectivity ratio of IC50 for human NaV1.7 to IC50 for human NaV1.3	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1411467	Inhibition of human NaV1.1	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1246063	Inhibition of human NaV1.6 channel by patch clamp electrophysiology assay	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.
AID1411466	Inhibition of rat NaV1.3 by electrophysiological method	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1411483	Inhibition of CYP2C9 (unknown origin) at 3 uM by high throughput assay relative to control	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1411479	Selectivity ratio of IC50 for human NaV1.6 to IC50 for human NaV1.3	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1411485	Efflux ratio of permeability across basolateral to apical over apical to basolateral side in RRCK cells expressing MDR1	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1411477	Selectivity ratio of IC50 for human NaV1.4 to IC50 for human NaV1.3	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1411476	Selectivity ratio of IC50 for human NaV1.2 to IC50 for human NaV1.3	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1246036	Selectivity ratio of IC50 for human NaV1.5 channel to IC50 for human NaV1.6 channel	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.
AID1246059	Inhibition of human NaV1.1 channel by patch clamp electrophysiology assay	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.
AID1246061	Inhibition of human NaV1.4 channel by patch clamp electrophysiology assay	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.
AID1246065	Inhibition of human NaV1.7 channel expressed in HEK293 cells by patch clamp electrophysiology assay	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.
AID1411482	Clearance in human liver microsomes	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1411468	Inhibition of human NaV1.2	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1411472	Inhibition of human NaV1.7	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1411478	Selectivity ratio of IC50 for human NaV1.5 to IC50 for human NaV1.3	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1246062	Inhibition of human NaV1.5 channel expressed in HEK293 cells by patch clamp electrophysiology assay	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.
AID1411471	Inhibition of human NaV1.6	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1411484	Aqueous solubility of compound	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1411473	Inhibition of rat NaV1.7	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1411475	Selectivity ratio of IC50 for human NaV1.1 to IC50 for human NaV1.3	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1411469	Inhibition of human NaV1.4	2017	MedChemComm, Jun-01, Volume: 8, Issue:6	The discovery of a potent Na
AID1246034	Selectivity ratio of IC50 for human NaV1.5 channel to IC50 for human NaV1.1 channel	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.
AID1347164	384 well plate NINDS Rhodamine confirmatory qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347158	ZIKV-mCherry secondary qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347156	DAPI mCherry counterscreen qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347153	Confirmatory screen GU AMC qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347149	Furin counterscreen qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347163	384 well plate NINDS AMC confirmatory qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347168	HepG2 cells viability qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347161	Confirmatory screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347167	Vero cells viability qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347169	Tertiary RLuc qRT-PCR qHTS assay for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347157	Confirmatory screen GU Rhodamine qHTS for Zika virus inhibitors qHTS	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347152	Confirmatory screen NINDS AMC qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347159	Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	5 (62.50)	24.3611
2020's	3 (37.50)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (12.50%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (87.50%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
veratridine [no description available]	3.21	1	steroid	sodium channel modulator
thiazoles [no description available]	2.52	2	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
lacosamide Lacosamide: An acetamide derivative that acts as a blocker of VOLTAGE-GATED SODIUM CHANNELS. It is used as an anticonvulsant, for adjunctive or monotherapy, in the treatment of PARTIAL SEIZURES.	2.15	1	N-acyl-amino acid
pregabalin Pregabalin: A gamma-aminobutyric acid (GABA) derivative that functions as a CALCIUM CHANNEL BLOCKER and is used as an ANTICONVULSANT as well as an ANTI-ANXIETY AGENT. It is also used as an ANALGESIC in the treatment of NEUROPATHIC PAIN and FIBROMYALGIA.. pregabalin : A gamma-amino acid that is gamma-aminobutyric acid (GABA) carrying an isobutyl substitutent at the beta-position (the S-enantiomer). Binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues.	2.15	1	gamma-amino acid	anticonvulsant; calcium channel blocker
antillatoxin antillatoxin: a neurotoxic lipopeptide from marine cyanobacterium, Lyngbya majuscula	3.21	1
zetekitoxin ab zetekitoxin AB: a sodium channel blocker; isolated from the frog Atelopus zeteki; structure in first source	3.21	1

Condition	Relationship Strength	Studies
Channelopathies A variety of neuromuscular conditions resulting from MUTATIONS in ION CHANNELS manifesting as episodes of EPILEPSY; HEADACHE DISORDERS; and DYSKINESIAS.	3.03	1
Aura [description not available]	4.36	5
Benign Neoplasms [description not available]	3.03	1
Amyotonia Congenita [description not available]	3.03	1
Ache [description not available]	3.03	1
Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.	3.03	1
Epilepsy A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)	4.36	5
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.03	1
Neuromuscular Diseases A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manifestations include MUSCLE WEAKNESS; FASCICULATION; muscle ATROPHY; SPASM; MYOKYMIA; MUSCLE HYPERTONIA, myalgias, and MUSCLE HYPOTONIA.	3.03	1
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	3.03	1
Respiratory Tract Diseases Diseases involving the RESPIRATORY SYSTEM.	3.03	1
Congenital Zika Syndrome [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.25	1
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.25	1

ica-121431

Description

Cross-References

Synonyms (31)

Research Excerpts

Bioavailability

Protein Targets (17)

Potency Measurements

Inhibition Measurements

Biological Processes (113)

Molecular Functions (36)

Ceullar Components (46)

Bioassays (51)

Research

Studies (8)

Market Indicators

Research Demand Index: 19.99

Study Types

ica-121431

Description

Cross-References

Synonyms (31)

Research Excerpts

Bioavailability

Protein Targets (17)

Potency Measurements

Inhibition Measurements

Biological Processes (113)

Molecular Functions (36)

Ceullar Components (46)

Bioassays (51)

Research

Studies (8)

Market Indicators

Research Demand Index: 19.99

Study Types

Related Drugs (6)

Related Conditions (14)