Page last updated: 2024-12-05

pentamethonium

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Pentamethonium is a quaternary ammonium compound that acts as a ganglion blocker. It was synthesized in the 1950s and was initially studied for its potential use as a treatment for hypertension. Pentamethonium works by blocking the transmission of nerve impulses at autonomic ganglia, which are clusters of nerve cells that control involuntary functions such as heart rate, blood pressure, and digestion. It was found to have a number of side effects, including hypotension, dizziness, and blurred vision. As a result, it is no longer commonly used clinically, but it is still studied as a research tool in pharmacology and physiology.'

pentamethonium: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

pentamethonium : A quarternary ammonium cation that is cadaverine in which the terminal amino hydrogens are substituted methyl groups. Its bromide and iodide salt exhibits ganglionic blocking activity and used in the treatment of hypertension. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID10920
CHEMBL ID2110996
CHEBI ID166825
SCHEMBL ID61798
MeSH IDM0062448

Synonyms (23)

Synonym
pentamethonum
2365-25-5
n(1),n(1),n(1),n(5),n(5),n(5)-hexamethylpentane-1,5-bis(aminium)
CHEBI:166825
1,5-pentanediylbis(trimethylaminium)
trimethyl-[5-(trimethylazaniumyl)pentyl]azanium
n,n,n,n',n',n'-hexamethylpentane-1,5-bis(aminium)
n,n,n,n',n',n'-hexamethyl-1,5-pentanediaminium
pentamethonium
trimethyl-[5-(trimethylazaniumyl)pentyl]azanium diiodide
trimethyl-(5-trimethylazaniumylpentyl)azanium dibromide
inchi=1/c11h28n2/c1-12(2,3)10-8-7-9-11-13(4,5)6/h7-11h2,1-6h3/q+2
xuspwdahgxsths-uhfffaoysa-
pentamethylenebis(trimethylammonium)
521ds2d2hb ,
unii-521ds2d2hb
pentamethonium [who-dd]
pentamethonium cation
pentamethonium ion
SCHEMBL61798
CHEMBL2110996
DTXSID30178322
Q27260943
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
antihypertensive agentAny drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
vasodilator agentA drug used to cause dilation of the blood vessels.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
quaternary ammonium ionA derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (44)

TimeframeStudies, This Drug (%)All Drugs %
pre-199039 (88.64)18.7374
1990's3 (6.82)18.2507
2000's0 (0.00)29.6817
2010's1 (2.27)24.3611
2020's1 (2.27)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 15.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index15.40 (24.57)
Research Supply Index3.89 (2.92)
Research Growth Index4.11 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (15.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (2.13%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other46 (97.87%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]