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Prolyl endopeptidase
A prolyl endopeptidase that is encoded in the genome of pig. [OMA:P23687, PRO:DNx]
Synonyms
PE;
EC 3.4.21.26;
Post-proline cleaving enzyme
Research
Bioassay Publications (10)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Dicarboxylic acid bis(L-prolyl-pyrrolidine) amides as prolyl oligopeptidase inhibitors.Journal of medicinal chemistry, , Sep-26, Volume: 45, Issue:20, 2002
3-Oxo-hexahydro-1H-isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase Inhibitors.Journal of medicinal chemistry, , 05-12, Volume: 59, Issue:9, 2016
Synthesis and characterization of the novel fluorescent prolyl oligopeptidase inhibitor 4-fluoresceinthiocarbamoyl-6-aminocaproyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine.Journal of medicinal chemistry, , Nov-17, Volume: 48, Issue:23, 2005
Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Tetrazole as a Replacement of the Electrophilic Group in Characteristic Prolyl Oligopeptidase Inhibitors.ACS medicinal chemistry letters, , Dec-12, Volume: 10, Issue:12, 2019
P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors.Journal of medicinal chemistry, , May-13, Volume: 53, Issue:9, 2010
Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Dicarboxylic acid bis(L-prolyl-pyrrolidine) amides as prolyl oligopeptidase inhibitors.Journal of medicinal chemistry, , Sep-26, Volume: 45, Issue:20, 2002
2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors.ACS medicinal chemistry letters, , Oct-14, Volume: 12, Issue:10, 2021
Tetrazole as a Replacement of the Electrophilic Group in Characteristic Prolyl Oligopeptidase Inhibitors.ACS medicinal chemistry letters, , Dec-12, Volume: 10, Issue:12, 2019
Synthesis and biological evaluation of novel (123)I-labeled 4-(4-iodophenyl)butanoyl-L-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo.European journal of medicinal chemistry, , May-22, Volume: 79, 2014
P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors.Journal of medicinal chemistry, , May-13, Volume: 53, Issue:9, 2010
Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005