pralidoxime has been researched along with Pain* in 1 studies
1 other study(ies) available for pralidoxime and Pain
| Article | Year |
|---|---|
Differential effects of di-isopropylfluorophosphate poisoning and its treatment on opioid antinociception in the mouse.
Compounds which enhance cholinergic activity have been reported to interact with opioid drugs. We have shown, using the hot-plate test in mice that di-isopropylfluorophosphate potentiates the antinociceptive activity of alfentanil but has no effect on the activity of morphine or fentanyl. Administration of atropine and pralidoxime as a treatment for DFP poisoning does not reverse this effect, and itself potentiates morphine antinociception. The results suggest that a cholinergic/opioid interaction is dependent on the opioid studied, and may have clinical importance when opioid drugs are required in patients poisoned by irreversible anticholinesterases. Topics: Animals; Atropine; Cholinesterase Reactivators; Isoflurophate; Male; Mice; Narcotics; Nociceptors; Pain; Pralidoxime Compounds | 1983 |