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protriptyline and Pain

protriptyline has been researched along with Pain in 4 studies

Protriptyline: Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"In protriptyline (25 mg/kg) pretreated rats stereotactic 5,7-dihydroxytryptamine (5,7-DHT) lesions of the medial plus laternal 5-hydroxytryptamine (5-HE) bundles in the mesencephalon increased the 5-HT fluorescence in these bundles, and reduced the in vitro uptake of [3H] 5-HT in the hypothalamus to 16% of control values after 2 mug 5,7-DHT/4mul and 12% after 4 mug 5,7-DHT/4mul, and in the cortex cerebri to 35 and 34% of control values, respectively."1.26Behavioral effects of 5, 7-dihydroxytryptamine lesions of ascending 5-hydroxytryptamine pathways. ( Fuxe, K; Hole, K; Jonsson, G, 1976)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, H1
Altenbach, RJ2
Carr, TL2
Chandran, P1
Hsieh, GC2
Lewis, LG1
Manelli, AM2
Milicic, I1
Marsh, KC2
Miller, TR1
Strakhova, MI2
Vortherms, TA1
Wakefield, BD1
Wetter, JM2
Witte, DG1
Honore, P2
Esbenshade, TA1
Brioni, JD2
Cowart, MD2
Black, LA1
Wensink, EJ1
Garrison, TR1
Hole, K1
Fuxe, K1
Jonsson, G1
Cunha, UV1

Other Studies

4 other studies available for protriptyline and Pain

ArticleYear
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
    Journal of medicinal chemistry, 2008, Nov-27, Volume: 51, Issue:22

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal;

2008
Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain.
    Journal of medicinal chemistry, 2010, Nov-11, Volume: 53, Issue:21

    Topics: Animals; Histamine H3 Antagonists; Naphthols; Norepinephrine Plasma Membrane Transport Proteins; Ost

2010
Behavioral effects of 5, 7-dihydroxytryptamine lesions of ascending 5-hydroxytryptamine pathways.
    Brain research, 1976, May-07, Volume: 107, Issue:2

    Topics: Afferent Pathways; Animals; Apomorphine; Avoidance Learning; Behavior, Animal; Cerebral Cortex; Huma

1976
Antidepressants: their uses in nonpsychiatric disorders of aging.
    Geriatrics, 1986, Volume: 41, Issue:10

    Topics: Affective Symptoms; Aged; Antidepressive Agents; Chronic Disease; Colonic Diseases, Functional; Depr

1986