| Assay ID | Title | Year | Journal | Article |
|---|
| AID1476821 | Agonist activity at recombinant human MOR expressed in CHO cell membranes after 60 mins by [35S]GTPgammaS binding assay | 2017 | Journal of medicinal chemistry, 11-22, Volume: 60, Issue:22
| Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists. |
| AID239441 | Inhibition of [3H][Ile5,6]deltorphin II binding to opioid receptor delta from rat brain membranes | 2005 | Journal of medicinal chemistry, May-05, Volume: 48, Issue:9
| Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities. |
| AID1680658 | Displacement of [3H]U69,593 from kappa opioid receptor in guinea-pig brain membranes incubated for 30 mins by liquid scintillation counting method | 2019 | Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2
| Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14- O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives. |
| AID514207 | Selectivity ratio of Ki for delta opioid receptor in rat brain to mu opioid receptor in rat brain | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors. |
| AID1476824 | Antinociceptive activity in sc dosed CD1 mouse assessed as increase in latency in response to heat stimulus by hot plate assay | 2017 | Journal of medicinal chemistry, 11-22, Volume: 60, Issue:22
| Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists. |
| AID245887 | Antinociceptive potencie was assessed after subcutaneous administration of compound by hotplate test (HP) in mice | 2005 | Journal of medicinal chemistry, May-05, Volume: 48, Issue:9
| Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities. |
| AID239358 | Inhibition of [3H]U-69593 binding to opioid receptor kappa from guinea pig brain membranes | 2005 | Journal of medicinal chemistry, May-05, Volume: 48, Issue:9
| Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities. |
| AID1680660 | Selectivity index, ratio of Ki for displacement of [3H]U69,593 from kappa opioid receptor in guinea-pig brain membranes to Ki for displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes | 2019 | Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2
| Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14- O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives. |
| AID1476822 | Agonist activity at recombinant human MOR expressed in CHO cell membranes after 60 mins by [35S]GTPgammaS binding assay relative to MOR full agonist DAMGO | 2017 | Journal of medicinal chemistry, 11-22, Volume: 60, Issue:22
| Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists. |
| AID1476818 | Displacement of [3H]-HS665 from recombinant human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting | 2017 | Journal of medicinal chemistry, 11-22, Volume: 60, Issue:22
| Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists. |
| AID1476826 | Potency index, ratio of moprhine ED50 for antinociceptive activity in sc dosed ICR mouse to compound ED50 for antinociceptive activity in sc dosed CD1 mouse | 2017 | Journal of medicinal chemistry, 11-22, Volume: 60, Issue:22
| Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists. |
| AID1680659 | Selectivity index, ratio of Ki for displacement of [3H][Ile5,6]deltorphin II from delta opioid receptor in rat brain membranes to Ki for displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes | 2019 | Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2
| Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14- O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives. |
| AID1476823 | Antinociceptive activity in sc dosed CD1 mouse assessed as increase in latency in response to heat stimulus at 30 mins by hot plate assay | 2017 | Journal of medicinal chemistry, 11-22, Volume: 60, Issue:22
| Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists. |
| AID244113 | Ratio of binding affinities for opioid receptors delta and mu | 2005 | Journal of medicinal chemistry, May-05, Volume: 48, Issue:9
| Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities. |
| AID249430 | Ratios of colonic bead expulsion to that of antinociceptive potencie by hotplate test in mice | 2005 | Journal of medicinal chemistry, May-05, Volume: 48, Issue:9
| Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities. |
| AID241046 | In vitro agonistic activity against opioid receptor mu of guinea pig ileum | 2005 | Journal of medicinal chemistry, May-05, Volume: 48, Issue:9
| Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities. |
| AID1680664 | Agonist activity at human DOR expressed in CHO cell membranes incubated for 60 mins scintillation counting assay relative to DPDPE | 2019 | Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2
| Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14- O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives. |
| AID1680667 | Antinociceptive activity in sc dosed CD1 mouse assessed as inhibition of the writhing response after 30 mins post dose by acetic acid-induced writhing assay | 2019 | Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2
| Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14- O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives. |
| AID1680663 | Agonist activity at human MOR expressed in CHO cell membranes incubated for 60 mins scintillation counting assay relative to DAMGO | 2019 | Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2
| Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14- O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives. |
| AID514204 | Displacement of [3H]DAMGO from mu opioid receptor in rat brain membrane | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors. |
| AID239182 | Inhibition of [3H]DAMGO binding to opioid receptor mu from rat brain membranes | 2005 | Journal of medicinal chemistry, May-05, Volume: 48, Issue:9
| Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities. |
| AID1680655 | Displacement of [3H]diprenorphine from human DOR expressed in CHO cell membranes incubated for 60 mins liquid scintillation counting assay | 2019 | Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2
| Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14- O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives. |
| AID241773 | In vitro agonistic activity against opioid receptor delta of mouse vas deferens | 2005 | Journal of medicinal chemistry, May-05, Volume: 48, Issue:9
| Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities. |
| AID514205 | Displacement of [3H][Ile5,6]deltorphin2 from delta opioid receptor in rat brain membrane | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors. |
| AID1680661 | Agonist activity at human MOR expressed in CHO cell membranes incubated for 60 mins scintillation counting assay | 2019 | Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2
| Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14- O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives. |
| AID1476816 | Displacement of [3H]-DAMGO from recombinant human MOR expressed in CHO cell membranes after 60 mins by liquid scintillation counting | 2017 | Journal of medicinal chemistry, 11-22, Volume: 60, Issue:22
| Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists. |
| AID247018 | Gastrointestinal (GI) motility was assessed by colonic bead expulsion after subcutaneous administration in mice | 2005 | Journal of medicinal chemistry, May-05, Volume: 48, Issue:9
| Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities. |
| AID243120 | Relative agonistic activity against opioid receptor delta in mouse vas deferens and opioid receptor mu in guinea pig ileum | 2005 | Journal of medicinal chemistry, May-05, Volume: 48, Issue:9
| Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities. |
| AID514208 | Selectivity ratio of Ki for kappa opioid receptor in guinea pig brain to mu opioid receptor in rat brain | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors. |
| AID514206 | Displacement of [3H]U69593 from kappa opioid receptor in guinea pig brain membrane | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors. |
| AID1680662 | Agonist activity at human DOR expressed in CHO cell membranes incubated for 60 mins scintillation counting assay | 2019 | Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2
| Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14- O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives. |
| AID1680665 | Agonist activity at human KOR expressed in CHO cell membranes incubated for 60 mins scintillation counting assay | 2019 | Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2
| Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14- O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives. |
| AID244114 | Ratio of binding affinities for opioid receptors kappa and mu | 2005 | Journal of medicinal chemistry, May-05, Volume: 48, Issue:9
| Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities. |
| AID1680656 | Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes incubated for 45 mins by liquid scintillation counting method | 2019 | Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2
| Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14- O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives. |
| AID1476817 | Displacement of [3H]-diprenorphine from recombinant human DOR expressed in CHO cell membranes after 60 mins by liquid scintillation counting | 2017 | Journal of medicinal chemistry, 11-22, Volume: 60, Issue:22
| Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists. |
| AID514209 | Inhibition of electric eel AChE at 500 uM by Ellman's method | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors. |
| AID1680657 | Displacement of [3H][Ile5,6]deltorphin II from delta opioid receptor in rat brain membranes incubated for 45 mins by liquid scintillation counting method | 2019 | Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2
| Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14- O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives. |
| AID1680666 | Agonist activity at human KOR expressed in CHO cell membranes incubated for 60 mins scintillation counting assay relative to U69,593 | 2019 | Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2
| Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14- O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives. |
| AID1476820 | Selectivity ratio of Ki for recombinant human KOR expressed in CHO cell membranes to Ki for recombinant human MOR expressed in CHO cell membranes | 2017 | Journal of medicinal chemistry, 11-22, Volume: 60, Issue:22
| Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists. |
| AID1476819 | Selectivity ratio of Ki for recombinant human DOR expressed in CHO cell membranes to Ki for recombinant human MOR expressed in CHO cell membranes | 2017 | Journal of medicinal chemistry, 11-22, Volume: 60, Issue:22
| Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |