fp 83 has been researched along with Pain in 9 studies
FP 83: structure given in first source
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The lidocaine/flurbiprofen axetil combination, compared with lidocaine 40 mg or flurbiprofen 50 mg, effectively reduces pain during the injection of propofol." | 9.15 | Efficacy of the lidocaine/flurbiprofen axetil combination for reducing pain during the injection of propofol. ( Fujii, Y; Itakura, M, 2011) |
| " The overall incidence of pain on injection of propofol was 92% (23 of 25 patients) in the control group versus 60% (15/ 25) in the flurbiprofen group (P = 0." | 9.14 | Pretreatment with flurbiprofen axetil, flurbiprofen axetil preceded by venous occlusion, and a mixture of flurbiprofen axetil and propofol in reducing pain on injection of propofol in adult Japanese surgical patients: a prospective, randomized, double-bli ( Fujii, Y; Itakura, M, 2009) |
| " The overall incidence of propofol-induced pain was 24% (6/25 patients) with lidocaine (P = 0." | 9.13 | Comparison of lidocaine, metoclopramide, and flurbiprofen axetil for reducing pain on injection of propofol in Japanese adult surgical patients: a prospective, randomized, double-blind, parallel-group, placebo-controlled study. ( Fujii, Y; Itakura, M, 2008) |
| "In this small clinical trial in Japanese surgical patients undergoing general anesthesia, flurbiprofen axetil requirements for the reduction of pain during injection of propofol were found to be 50 mg in young adults (age 20-40 years) and 25 or 50 mg in older adults (age 60-80 years), regardless of weight, preceded by venous occlusion for 2 minutes." | 9.12 | Influence of age on flurbiprofen axetil requirements for preventing pain on injection of propofol in Japanese adult surgical patients: a prospective, randomized, double-blind, vehicle-controlled, parallel-group, dose-ranging study. ( Fujii, Y; Nakayama, M, 2006) |
| "The findings suggest that the reduction of propofol injection pain by FA may be explained, at least in part, by a reduction in the free propofol concentration." | 9.12 | Emulsion of flurbiprofen axetil reduces propofol injection pain due to a decrease in free propofol concentration. ( Kaminoh, Y; Tanimoto, M; Tashiro, C; Tatara, T; Tsujimoto, S; Ueki, R, 2007) |
| "In this study of Japanese adult surgical patients, flurbiprofen axetil at doses of 50 and 75 mg, preceded by venous occlusion for 2 minutes, was found to be effective in reducing propofol-induced pain on injection." | 9.11 | Flurbiprofen axetil preceded by venous occlusion in the prevention of pain on propofol injection in the hand: a prospective, randomized, double-blind, vehicle-controlled, dose-finding study in Japanese adult surgical patients. ( Fujii, Y; Shiga, Y, 2005) |
| "Pain on injection is an acknowledged adverse effect (AE) of propofol administration for the induction of general anesthesia." | 8.90 | Efficacy and safety of flurbiprofen axetil in the prevention of pain on propofol injection: a systematic review and meta-analysis. ( Bao, H; Luo, Z; Shi, H; Wang, H; Xu, L; Yu, Y; Zhang, L; Zhang, X; Zhang, Y; Zhao, Y; Zhu, J, 2014) |
| "We examined the effects of U50,488, a kappa-opioid receptor agonist, and flurbiprofen axetil, a nonsteroidal antiinflammatory drug, in a visceral pain model using conscious rats." | 7.75 | The individual and combined effects of U50,488, and flurbiprofen axetil on visceral pain in conscious rats. ( Kitamura, T; Ogawa, M; Yamada, Y, 2009) |
| "The lidocaine/flurbiprofen axetil combination, compared with lidocaine 40 mg or flurbiprofen 50 mg, effectively reduces pain during the injection of propofol." | 5.15 | Efficacy of the lidocaine/flurbiprofen axetil combination for reducing pain during the injection of propofol. ( Fujii, Y; Itakura, M, 2011) |
| " The overall incidence of pain on injection of propofol was 92% (23 of 25 patients) in the control group versus 60% (15/ 25) in the flurbiprofen group (P = 0." | 5.14 | Pretreatment with flurbiprofen axetil, flurbiprofen axetil preceded by venous occlusion, and a mixture of flurbiprofen axetil and propofol in reducing pain on injection of propofol in adult Japanese surgical patients: a prospective, randomized, double-bli ( Fujii, Y; Itakura, M, 2009) |
| " The overall incidence of propofol-induced pain was 24% (6/25 patients) with lidocaine (P = 0." | 5.13 | Comparison of lidocaine, metoclopramide, and flurbiprofen axetil for reducing pain on injection of propofol in Japanese adult surgical patients: a prospective, randomized, double-blind, parallel-group, placebo-controlled study. ( Fujii, Y; Itakura, M, 2008) |
| "In this small clinical trial in Japanese surgical patients undergoing general anesthesia, flurbiprofen axetil requirements for the reduction of pain during injection of propofol were found to be 50 mg in young adults (age 20-40 years) and 25 or 50 mg in older adults (age 60-80 years), regardless of weight, preceded by venous occlusion for 2 minutes." | 5.12 | Influence of age on flurbiprofen axetil requirements for preventing pain on injection of propofol in Japanese adult surgical patients: a prospective, randomized, double-blind, vehicle-controlled, parallel-group, dose-ranging study. ( Fujii, Y; Nakayama, M, 2006) |
| "The findings suggest that the reduction of propofol injection pain by FA may be explained, at least in part, by a reduction in the free propofol concentration." | 5.12 | Emulsion of flurbiprofen axetil reduces propofol injection pain due to a decrease in free propofol concentration. ( Kaminoh, Y; Tanimoto, M; Tashiro, C; Tatara, T; Tsujimoto, S; Ueki, R, 2007) |
| "In this study of Japanese adult surgical patients, flurbiprofen axetil at doses of 50 and 75 mg, preceded by venous occlusion for 2 minutes, was found to be effective in reducing propofol-induced pain on injection." | 5.11 | Flurbiprofen axetil preceded by venous occlusion in the prevention of pain on propofol injection in the hand: a prospective, randomized, double-blind, vehicle-controlled, dose-finding study in Japanese adult surgical patients. ( Fujii, Y; Shiga, Y, 2005) |
| "Pain on injection is an acknowledged adverse effect (AE) of propofol administration for the induction of general anesthesia." | 4.90 | Efficacy and safety of flurbiprofen axetil in the prevention of pain on propofol injection: a systematic review and meta-analysis. ( Bao, H; Luo, Z; Shi, H; Wang, H; Xu, L; Yu, Y; Zhang, L; Zhang, X; Zhang, Y; Zhao, Y; Zhu, J, 2014) |
| "We examined the effects of U50,488, a kappa-opioid receptor agonist, and flurbiprofen axetil, a nonsteroidal antiinflammatory drug, in a visceral pain model using conscious rats." | 3.75 | The individual and combined effects of U50,488, and flurbiprofen axetil on visceral pain in conscious rats. ( Kitamura, T; Ogawa, M; Yamada, Y, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Dong, T | 1 |
| Cao, X | 1 |
| Zhang, Y | 2 |
| Wang, Z | 1 |
| Li, Y | 1 |
| Zhang, L | 1 |
| Zhu, J | 1 |
| Xu, L | 1 |
| Zhang, X | 1 |
| Wang, H | 1 |
| Luo, Z | 1 |
| Zhao, Y | 1 |
| Yu, Y | 1 |
| Shi, H | 1 |
| Bao, H | 1 |
| Fujii, Y | 5 |
| Itakura, M | 3 |
| Kitamura, T | 1 |
| Ogawa, M | 1 |
| Yamada, Y | 1 |
| Shiga, Y | 1 |
| Nakayama, M | 1 |
| Ueki, R | 1 |
| Tanimoto, M | 1 |
| Tatara, T | 1 |
| Tsujimoto, S | 1 |
| Kaminoh, Y | 1 |
| Tashiro, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Evaluation of the Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol.[NCT01342510] | Phase 4 | 200 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Ten seconds following injection of propofol, subjects were asked Are you having pain at your IV site? Any behavioral signs were noted. Injection pain was assessed using the following four point scale: 0 = no pain; 1 = mild pain (pain reported only in response to questioning and without behavioral signs); 2 = moderate pain (pain reported in response to questioning and accompanied by a behavioral sign, or pain reported spontaneously without questioning); and 3 = severe pain (strong vocal response or response accompanied by facial grimacing, arm withdrawal, or tears)." (NCT01342510)
Timeframe: < 1 minute.
| Intervention | participants reporting pain (Number) |
|---|---|
| Lidocaine | 11 |
| Magnesium | 25 |
| Lidocaine/Magnesium | 15 |
| Control | 18 |
Following injection of the study drug, 50 mg of propofol will be injected. Ten seconds after propofol, subjects will be asked a standard question about pain. Behavioral signs will be noted. Pain will be assessed using a four point scale: 0=no pain, 1=mild pain (pain reported only in response to questioning and without behavioral signs), 2=moderate pain (pain reported in response to questioning and a behavioral sign, or pain reported without questioning), 3=severe pain (strong vocal response or behavioral response). (NCT01342510)
Timeframe: Approximately 10 seconds following administration of propofol.
| Intervention | percentage of patients reporting pain (Number) |
|---|---|
| Lidocaine | 29 |
| Magnesium | 57 |
| Lidocaine/Magnesium | 41 |
| Control | 46 |
1 review available for fp 83 and Pain
| Article | Year |
|---|---|
Efficacy and safety of flurbiprofen axetil in the prevention of pain on propofol injection: a systematic review and meta-analysis.
Topics: Clinical Trials as Topic; Flurbiprofen; Humans; Pain; Propofol; Publication Bias; Risk Factors; Trea | 2014 |
6 trials available for fp 83 and Pain
2 other studies available for fp 83 and Pain
| Article | Year |
|---|---|
Effect of flurbiprofen axetil on pain and cognitive dysfunction after radical operation of cervical cancer in elderly patients.
Topics: Aged; Cognitive Dysfunction; Female; Flurbiprofen; Humans; Pain; Uterine Cervical Neoplasms | 2022 |
The individual and combined effects of U50,488, and flurbiprofen axetil on visceral pain in conscious rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Abdominal | 2009 |