Page last updated: 2024-11-05

trazodone and Pain

trazodone has been researched along with Pain in 19 studies

Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Treatment with trazodone significantly improved global fibromyalgia severity, sleep quality, and depression, as well as pain interference with daily activities although without showing a direct effect on bodily pain."9.15Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study. ( Calandre, EP; Molina-Barea, R; Morillas-Arques, P; Rico-Villademoros, F; Rodriguez-Lopez, CM, 2011)
"Trazodone was developed according to the mental pain hypothesis, which was postulated from studying patients and which proposes that depression is associated with a decreased pain threshold."8.77Trazodone: from the mental pain to the "dys-stress" hypothesis of depression. ( Silvestrini, B, 1989)
"Thirty-one adult diabetic patients with painful distal symmetrical polyneuropathy were treated with low doses of oral trazodone (50 or 100 mg/day)."7.70The use of low-dose trazodone in the treatment of painful diabetic neuropathy. ( Wilson, RC, 1999)
"Trazodone hydrochloride is a potent presynaptic serotonin reuptake blocker with few anticholinergic and cardiovascular side effects."6.66Trazodone hydrochloride in the treatment of dysesthetic pain in traumatic myelopathy: a randomized, double-blind, placebo-controlled study. ( Davidoff, G; Guarracini, M; Roth, E; Sliwa, J; Yarkony, G, 1987)
" First of all, once assessed that all drugs induced dose-related antinociceptive effects, they were mixed in fixed ratio (1:1) combinations and a synergistic drug-drug interaction was obtained in all circumstances."5.37Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain. ( Ciruela, F; Fernández, A; Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2011)
"Treatment with trazodone significantly improved global fibromyalgia severity, sleep quality, and depression, as well as pain interference with daily activities although without showing a direct effect on bodily pain."5.15Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study. ( Calandre, EP; Molina-Barea, R; Morillas-Arques, P; Rico-Villademoros, F; Rodriguez-Lopez, CM, 2011)
"A prospective single-blind study was conducted to compare flunitrazepam vs trazodone in the premedication of patients undergoing day-case surgery for termination of pregnancy, with particular regard to the degree of preoperative sedation, intraoperative analgesia and postoperative recovery."5.07[Trazodone versus flunitrazepam in premedication in day-care surgery]. ( Andriolli, A; Bonazzi, M; Laveneziana, D; Marsicano, M; Prampolini, F; Riva, A; Speranza, R, 1994)
"Forty-seven patients with definite rheumatoid arthritis (RA) were treated in a 32 week, double blind, crossover trial of amitriptyline, desipramine, trazodone, and placebo."5.06Antidepressant analgesia in rheumatoid arthritis. ( Atwood, C; Beck, NC; Brownlee-Duffeck, M; Elliott, TR; Frank, RG; Haut, AE; Kashani, JH; Kay, DR; Parker, JC; Smith, E, 1988)
"Trazodone was developed according to the mental pain hypothesis, which was postulated from studying patients and which proposes that depression is associated with a decreased pain threshold."4.77Trazodone: from the mental pain to the "dys-stress" hypothesis of depression. ( Silvestrini, B, 1989)
"Trazodone hydrochloride is used in the treatment of neuropathic pain."3.72Trazodone hydrochloride attenuates thermal hyperalgesia in a chronic constriction injury rat model. ( Okuda, K; Takanishi, T; Ueda, S; Yoshimoto, K, 2003)
" The non-selective noradrenaline (NA) and serotonin (5-HT) reuptake inhibitors imipramine, amitriptyline and clomipramine displayed anti-inflammatory activity in the carrageenan model of paw inflammation."3.72Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. ( Abdel-Salam, OM; El-Shenawy, SM; Nofal, SM, 2003)
"Thirty-one adult diabetic patients with painful distal symmetrical polyneuropathy were treated with low doses of oral trazodone (50 or 100 mg/day)."3.70The use of low-dose trazodone in the treatment of painful diabetic neuropathy. ( Wilson, RC, 1999)
"Chronic pain is refractory to most currently marketed regimens."2.66Chronic pain: hypothesized mechanism and rationale for treatment. ( Gershon, S, 1986)
"Trazodone hydrochloride is a potent presynaptic serotonin reuptake blocker with few anticholinergic and cardiovascular side effects."2.66Trazodone hydrochloride in the treatment of dysesthetic pain in traumatic myelopathy: a randomized, double-blind, placebo-controlled study. ( Davidoff, G; Guarracini, M; Roth, E; Sliwa, J; Yarkony, G, 1987)
"Female priapism is a rare condition that is not commonly described in the literature."1.40Female clitoral priapism: an over-the-counter option for management. ( Unger, CA; Walters, MD, 2014)
" First of all, once assessed that all drugs induced dose-related antinociceptive effects, they were mixed in fixed ratio (1:1) combinations and a synergistic drug-drug interaction was obtained in all circumstances."1.37Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain. ( Ciruela, F; Fernández, A; Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2011)
"Trazodone was frequently recommended for sleep problems."1.34Reasons for antidepressant prescriptions in Canada. ( Carter, B; Esposito, E; Patten, SB, 2007)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19908 (42.11)18.7374
1990's3 (15.79)18.2507
2000's4 (21.05)29.6817
2010's3 (15.79)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Morinaga, Y1
Nii, K1
Hanada, H1
Takemura, Y1
Sakamoto, K1
Inoue, R1
Mitsutake, T1
Tsugawa, J1
Kurihara, K1
Tateishi, Y1
Higashi, T1
Unger, CA1
Walters, MD1
Fernández-Dueñas, V1
Poveda, R1
Fernández, A1
Sánchez, S1
Planas, E1
Ciruela, F1
Calandre, EP1
Morillas-Arques, P1
Molina-Barea, R1
Rodriguez-Lopez, CM1
Rico-Villademoros, F1
Okuda, K1
Takanishi, T1
Yoshimoto, K1
Ueda, S1
Abdel-Salam, OM1
Nofal, SM1
El-Shenawy, SM1
Zhang, R1
Nagata, T1
Hayashi, T1
Miyata, M1
Kawakami, Y1
Patten, SB1
Esposito, E1
Carter, B1
Erickson, J1
Fisher, A1
Khurana, RC1
Bonazzi, M1
Riva, A1
Marsicano, M1
Prampolini, F1
Speranza, R1
Andriolli, A1
Laveneziana, D1
Rohet, F1
Rubat, C1
Coudert, P1
Couquelet, J1
Wilson, RC1
Silvestrini, B1
Fabre, LF1
Gershon, S1
Frank, RG1
Kashani, JH1
Parker, JC1
Beck, NC1
Brownlee-Duffeck, M1
Elliott, TR1
Haut, AE1
Atwood, C1
Smith, E1
Kay, DR1
Davidoff, G1
Guarracini, M1
Roth, E1
Sliwa, J1
Yarkony, G1
Tyrer, SP1
Matthews, JNS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Open Label Trial Concerning the Effectiveness of Trazodone in the Treatment of Fibromyalgia (Phase I) and Its Augmentation With Pregabalin in Trazodone Partial Responders (Phase II)[NCT00791739]Phase 466 participants (Actual)Interventional2008-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for trazodone and Pain

ArticleYear
Trazodone: from the mental pain to the "dys-stress" hypothesis of depression.
    Clinical neuropharmacology, 1989, Volume: 12 Suppl 1

    Topics: Adrenergic alpha-Antagonists; Depression; Humans; Pain; Sensory Thresholds; Trazodone

1989
United States experience and perspectives with trazodone.
    Clinical neuropharmacology, 1989, Volume: 12 Suppl 1

    Topics: Aged; Bulimia; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Female; Humans; Male;

1989

Trials

6 trials available for trazodone and Pain

ArticleYear
Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study.
    BMC musculoskeletal disorders, 2011, May-16, Volume: 12

    Topics: Adult; Analgesics; Analysis of Variance; Anti-Anxiety Agents; Antidepressive Agents, Second-Generati

2011
[Trazodone versus flunitrazepam in premedication in day-care surgery].
    Minerva anestesiologica, 1994, Volume: 60, Issue:3

    Topics: Abortion, Induced; Adolescent; Adult; Ambulatory Surgical Procedures; Analgesia; Anesthesia Recovery

1994
United States experience and perspectives with trazodone.
    Clinical neuropharmacology, 1989, Volume: 12 Suppl 1

    Topics: Aged; Bulimia; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Female; Humans; Male;

1989
Chronic pain: hypothesized mechanism and rationale for treatment.
    Neuropsychobiology, 1986, Volume: 15 Suppl 1

    Topics: Antidepressive Agents; Brain; Chronic Disease; Clinical Trials as Topic; Depression; Humans; Neurotr

1986
Antidepressant analgesia in rheumatoid arthritis.
    The Journal of rheumatology, 1988, Volume: 15, Issue:11

    Topics: Aged; Amitriptyline; Antidepressive Agents; Arthritis, Rheumatoid; Depression; Desipramine; Double-B

1988
Trazodone hydrochloride in the treatment of dysesthetic pain in traumatic myelopathy: a randomized, double-blind, placebo-controlled study.
    Pain, 1987, Volume: 29, Issue:2

    Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Pain; Pain Measurement;

1987

Other Studies

12 other studies available for trazodone and Pain

ArticleYear
Clinical features of Barré-Lièou syndrome and efficacy of trazodone for its treatment: A retrospective single center study.
    Drug discoveries & therapeutics, 2021, May-11, Volume: 15, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Autonomic Nervous System;

2021
Female clitoral priapism: an over-the-counter option for management.
    The journal of sexual medicine, 2014, Volume: 11, Issue:9

    Topics: Adult; Bupropion; Clitoris; Female; Humans; Male; Nonprescription Drugs; Pain; Priapism; Pseudoephed

2014
Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 98, Issue:3

    Topics: Acetaminophen; Analgesics; Animals; Disease Models, Animal; Drug Combinations; Fentanyl; Male; Mice;

2011
Trazodone hydrochloride attenuates thermal hyperalgesia in a chronic constriction injury rat model.
    European journal of anaesthesiology, 2003, Volume: 20, Issue:5

    Topics: Animals; Antidepressive Agents, Second-Generation; Disease Models, Animal; Hot Temperature; Hyperalg

2003
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat.
    Pharmacological research, 2003, Volume: 48, Issue:2

    Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Carrageenan; Clomipramine; Dise

2003
Intracerebroventricular injection of trazodone produces 5-HT receptor subtype mediated anti-nociception at the supraspinal and spinal levels.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2004, Volume: 14, Issue:5

    Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraventricular; Injectio

2004
Reasons for antidepressant prescriptions in Canada.
    Pharmacoepidemiology and drug safety, 2007, Volume: 16, Issue:7

    Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Canada; Databases, Factual; Depression; Hum

2007
Myalgia associated with trazodone.
    The American journal of psychiatry, 1983, Volume: 140, Issue:9

    Topics: Depressive Disorder; Humans; Male; Middle Aged; Muscles; Obsessive-Compulsive Disorder; Pain; Pipera

1983
Treatment of painful diabetic neuropathy with trazodone.
    JAMA, 1983, Sep-16, Volume: 250, Issue:11

    Topics: Diabetic Neuropathies; Humans; Pain; Piperazines; Trazodone

1983
Synthesis and analgesic effects of 3-substituted 4,6-diarylpyridazine derivatives of the arylpiperazine class.
    Bioorganic & medicinal chemistry, 1997, Volume: 5, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-

1997
The use of low-dose trazodone in the treatment of painful diabetic neuropathy.
    Journal of the American Podiatric Medical Association, 1999, Volume: 89, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Analgesics; Diabetic Foot; Female; Humans; Male; Middle Aged; Pain;

1999
Re, Trazodone in dysaesthesia.
    Pain, 1988, Volume: 33, Issue:1

    Topics: Humans; Pain; Trazodone

1988