trazodone and Pain
trazodone has been researched along with Pain in 19 studies
Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with trazodone significantly improved global fibromyalgia severity, sleep quality, and depression, as well as pain interference with daily activities although without showing a direct effect on bodily pain." | 9.15 | Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study. ( Calandre, EP; Molina-Barea, R; Morillas-Arques, P; Rico-Villademoros, F; Rodriguez-Lopez, CM, 2011) |
| "Trazodone was developed according to the mental pain hypothesis, which was postulated from studying patients and which proposes that depression is associated with a decreased pain threshold." | 8.77 | Trazodone: from the mental pain to the "dys-stress" hypothesis of depression. ( Silvestrini, B, 1989) |
| "Thirty-one adult diabetic patients with painful distal symmetrical polyneuropathy were treated with low doses of oral trazodone (50 or 100 mg/day)." | 7.70 | The use of low-dose trazodone in the treatment of painful diabetic neuropathy. ( Wilson, RC, 1999) |
| "Trazodone hydrochloride is a potent presynaptic serotonin reuptake blocker with few anticholinergic and cardiovascular side effects." | 6.66 | Trazodone hydrochloride in the treatment of dysesthetic pain in traumatic myelopathy: a randomized, double-blind, placebo-controlled study. ( Davidoff, G; Guarracini, M; Roth, E; Sliwa, J; Yarkony, G, 1987) |
| " First of all, once assessed that all drugs induced dose-related antinociceptive effects, they were mixed in fixed ratio (1:1) combinations and a synergistic drug-drug interaction was obtained in all circumstances." | 5.37 | Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain. ( Ciruela, F; Fernández, A; Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2011) |
| "Treatment with trazodone significantly improved global fibromyalgia severity, sleep quality, and depression, as well as pain interference with daily activities although without showing a direct effect on bodily pain." | 5.15 | Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study. ( Calandre, EP; Molina-Barea, R; Morillas-Arques, P; Rico-Villademoros, F; Rodriguez-Lopez, CM, 2011) |
| "A prospective single-blind study was conducted to compare flunitrazepam vs trazodone in the premedication of patients undergoing day-case surgery for termination of pregnancy, with particular regard to the degree of preoperative sedation, intraoperative analgesia and postoperative recovery." | 5.07 | [Trazodone versus flunitrazepam in premedication in day-care surgery]. ( Andriolli, A; Bonazzi, M; Laveneziana, D; Marsicano, M; Prampolini, F; Riva, A; Speranza, R, 1994) |
| "Forty-seven patients with definite rheumatoid arthritis (RA) were treated in a 32 week, double blind, crossover trial of amitriptyline, desipramine, trazodone, and placebo." | 5.06 | Antidepressant analgesia in rheumatoid arthritis. ( Atwood, C; Beck, NC; Brownlee-Duffeck, M; Elliott, TR; Frank, RG; Haut, AE; Kashani, JH; Kay, DR; Parker, JC; Smith, E, 1988) |
| "Trazodone was developed according to the mental pain hypothesis, which was postulated from studying patients and which proposes that depression is associated with a decreased pain threshold." | 4.77 | Trazodone: from the mental pain to the "dys-stress" hypothesis of depression. ( Silvestrini, B, 1989) |
| "Trazodone hydrochloride is used in the treatment of neuropathic pain." | 3.72 | Trazodone hydrochloride attenuates thermal hyperalgesia in a chronic constriction injury rat model. ( Okuda, K; Takanishi, T; Ueda, S; Yoshimoto, K, 2003) |
| " The non-selective noradrenaline (NA) and serotonin (5-HT) reuptake inhibitors imipramine, amitriptyline and clomipramine displayed anti-inflammatory activity in the carrageenan model of paw inflammation." | 3.72 | Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. ( Abdel-Salam, OM; El-Shenawy, SM; Nofal, SM, 2003) |
| "Thirty-one adult diabetic patients with painful distal symmetrical polyneuropathy were treated with low doses of oral trazodone (50 or 100 mg/day)." | 3.70 | The use of low-dose trazodone in the treatment of painful diabetic neuropathy. ( Wilson, RC, 1999) |
| "Chronic pain is refractory to most currently marketed regimens." | 2.66 | Chronic pain: hypothesized mechanism and rationale for treatment. ( Gershon, S, 1986) |
| "Trazodone hydrochloride is a potent presynaptic serotonin reuptake blocker with few anticholinergic and cardiovascular side effects." | 2.66 | Trazodone hydrochloride in the treatment of dysesthetic pain in traumatic myelopathy: a randomized, double-blind, placebo-controlled study. ( Davidoff, G; Guarracini, M; Roth, E; Sliwa, J; Yarkony, G, 1987) |
| "Female priapism is a rare condition that is not commonly described in the literature." | 1.40 | Female clitoral priapism: an over-the-counter option for management. ( Unger, CA; Walters, MD, 2014) |
| " First of all, once assessed that all drugs induced dose-related antinociceptive effects, they were mixed in fixed ratio (1:1) combinations and a synergistic drug-drug interaction was obtained in all circumstances." | 1.37 | Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain. ( Ciruela, F; Fernández, A; Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2011) |
| "Trazodone was frequently recommended for sleep problems." | 1.34 | Reasons for antidepressant prescriptions in Canada. ( Carter, B; Esposito, E; Patten, SB, 2007) |
Research
Studies (19)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (42.11) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Morinaga, Y | 1 |
| Nii, K | 1 |
| Hanada, H | 1 |
| Takemura, Y | 1 |
| Sakamoto, K | 1 |
| Inoue, R | 1 |
| Mitsutake, T | 1 |
| Tsugawa, J | 1 |
| Kurihara, K | 1 |
| Tateishi, Y | 1 |
| Higashi, T | 1 |
| Unger, CA | 1 |
| Walters, MD | 1 |
| Fernández-Dueñas, V | 1 |
| Poveda, R | 1 |
| Fernández, A | 1 |
| Sánchez, S | 1 |
| Planas, E | 1 |
| Ciruela, F | 1 |
| Calandre, EP | 1 |
| Morillas-Arques, P | 1 |
| Molina-Barea, R | 1 |
| Rodriguez-Lopez, CM | 1 |
| Rico-Villademoros, F | 1 |
| Okuda, K | 1 |
| Takanishi, T | 1 |
| Yoshimoto, K | 1 |
| Ueda, S | 1 |
| Abdel-Salam, OM | 1 |
| Nofal, SM | 1 |
| El-Shenawy, SM | 1 |
| Zhang, R | 1 |
| Nagata, T | 1 |
| Hayashi, T | 1 |
| Miyata, M | 1 |
| Kawakami, Y | 1 |
| Patten, SB | 1 |
| Esposito, E | 1 |
| Carter, B | 1 |
| Erickson, J | 1 |
| Fisher, A | 1 |
| Khurana, RC | 1 |
| Bonazzi, M | 1 |
| Riva, A | 1 |
| Marsicano, M | 1 |
| Prampolini, F | 1 |
| Speranza, R | 1 |
| Andriolli, A | 1 |
| Laveneziana, D | 1 |
| Rohet, F | 1 |
| Rubat, C | 1 |
| Coudert, P | 1 |
| Couquelet, J | 1 |
| Wilson, RC | 1 |
| Silvestrini, B | 1 |
| Fabre, LF | 1 |
| Gershon, S | 1 |
| Frank, RG | 1 |
| Kashani, JH | 1 |
| Parker, JC | 1 |
| Beck, NC | 1 |
| Brownlee-Duffeck, M | 1 |
| Elliott, TR | 1 |
| Haut, AE | 1 |
| Atwood, C | 1 |
| Smith, E | 1 |
| Kay, DR | 1 |
| Davidoff, G | 1 |
| Guarracini, M | 1 |
| Roth, E | 1 |
| Sliwa, J | 1 |
| Yarkony, G | 1 |
| Tyrer, SP | 1 |
| Matthews, JNS | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Open Label Trial Concerning the Effectiveness of Trazodone in the Treatment of Fibromyalgia (Phase I) and Its Augmentation With Pregabalin in Trazodone Partial Responders (Phase II)[NCT00791739] | Phase 4 | 66 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
2 reviews available for trazodone and Pain
| Article | Year |
|---|---|
Trazodone: from the mental pain to the "dys-stress" hypothesis of depression.
Topics: Adrenergic alpha-Antagonists; Depression; Humans; Pain; Sensory Thresholds; Trazodone | 1989 |
United States experience and perspectives with trazodone.
Topics: Aged; Bulimia; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Female; Humans; Male; | 1989 |
Trials
6 trials available for trazodone and Pain
| Article | Year |
|---|---|
Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study.
Topics: Adult; Analgesics; Analysis of Variance; Anti-Anxiety Agents; Antidepressive Agents, Second-Generati | 2011 |
[Trazodone versus flunitrazepam in premedication in day-care surgery].
Topics: Abortion, Induced; Adolescent; Adult; Ambulatory Surgical Procedures; Analgesia; Anesthesia Recovery | 1994 |
United States experience and perspectives with trazodone.
Topics: Aged; Bulimia; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Female; Humans; Male; | 1989 |
Chronic pain: hypothesized mechanism and rationale for treatment.
Topics: Antidepressive Agents; Brain; Chronic Disease; Clinical Trials as Topic; Depression; Humans; Neurotr | 1986 |
Antidepressant analgesia in rheumatoid arthritis.
Topics: Aged; Amitriptyline; Antidepressive Agents; Arthritis, Rheumatoid; Depression; Desipramine; Double-B | 1988 |
Trazodone hydrochloride in the treatment of dysesthetic pain in traumatic myelopathy: a randomized, double-blind, placebo-controlled study.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Pain; Pain Measurement; | 1987 |
Other Studies
12 other studies available for trazodone and Pain
| Article | Year |
|---|---|
Clinical features of Barré-Lièou syndrome and efficacy of trazodone for its treatment: A retrospective single center study.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Autonomic Nervous System; | 2021 |
Female clitoral priapism: an over-the-counter option for management.
Topics: Adult; Bupropion; Clitoris; Female; Humans; Male; Nonprescription Drugs; Pain; Priapism; Pseudoephed | 2014 |
Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain.
Topics: Acetaminophen; Analgesics; Animals; Disease Models, Animal; Drug Combinations; Fentanyl; Male; Mice; | 2011 |
Trazodone hydrochloride attenuates thermal hyperalgesia in a chronic constriction injury rat model.
Topics: Animals; Antidepressive Agents, Second-Generation; Disease Models, Animal; Hot Temperature; Hyperalg | 2003 |
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Carrageenan; Clomipramine; Dise | 2003 |
Intracerebroventricular injection of trazodone produces 5-HT receptor subtype mediated anti-nociception at the supraspinal and spinal levels.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraventricular; Injectio | 2004 |
Reasons for antidepressant prescriptions in Canada.
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Canada; Databases, Factual; Depression; Hum | 2007 |
Myalgia associated with trazodone.
Topics: Depressive Disorder; Humans; Male; Middle Aged; Muscles; Obsessive-Compulsive Disorder; Pain; Pipera | 1983 |
Treatment of painful diabetic neuropathy with trazodone.
Topics: Diabetic Neuropathies; Humans; Pain; Piperazines; Trazodone | 1983 |
Synthesis and analgesic effects of 3-substituted 4,6-diarylpyridazine derivatives of the arylpiperazine class.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non- | 1997 |
The use of low-dose trazodone in the treatment of painful diabetic neuropathy.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Diabetic Foot; Female; Humans; Male; Middle Aged; Pain; | 1999 |
Re, Trazodone in dysaesthesia.
Topics: Humans; Pain; Trazodone | 1988 |