| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|
Ataxia
Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions. | 0 | 3.26 | 6 | 0 |
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. | 0 | 3.65 | 9 | 0 |
Ataxias, Hereditary
[description not available] | 0 | 2.25 | 1 | 0 |
Cancer of Colon
[description not available] | 0 | 2.15 | 1 | 0 |
Lassitude
[description not available] | 0 | 2.58 | 2 | 0 |
Colonic Neoplasms
Tumors or cancer of the COLON. | 0 | 2.15 | 1 | 0 |
Fatigue
The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli. | 0 | 2.58 | 2 | 0 |
Acute Hypercapnic Respiratory Failure
[description not available] | 0 | 2.17 | 1 | 0 |
Anesthesia
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures. | 0 | 2.42 | 2 | 0 |
Respiratory Insufficiency
Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed) | 0 | 2.17 | 1 | 0 |
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. | 0 | 3.39 | 7 | 0 |
Hypercapnia
A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood. | 0 | 2.11 | 1 | 0 |
Chronic Illness
[description not available] | 0 | 2.11 | 1 | 0 |
Depression, Endogenous
[description not available] | 0 | 2.11 | 1 | 0 |
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). | 0 | 2.11 | 1 | 0 |
Depressive Disorder
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent. | 0 | 2.11 | 1 | 0 |
HMN (Hereditary Motor Neuropathy) Proximal Type I
[description not available] | 0 | 2.05 | 1 | 0 |
Spinal Muscular Atrophies of Childhood
A group of recessive inherited diseases that feature progressive muscular atrophy and hypotonia. They are classified as type I (Werdnig-Hoffman disease), type II (intermediate form), and type III (Kugelberg-Welander disease). Type I is fatal in infancy, type II has a late infantile onset and is associated with survival into the second or third decade. Type III has its onset in childhood, and is slowly progressive. (J Med Genet 1996 Apr:33(4):281-3) | 0 | 2.05 | 1 | 0 |
Allodynia
[description not available] | 0 | 2.06 | 1 | 0 |
Innate Inflammatory Response
[description not available] | 0 | 2.06 | 1 | 0 |
Ache
[description not available] | 0 | 2.06 | 1 | 0 |
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. | 0 | 2.06 | 1 | 0 |
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. | 0 | 2.06 | 1 | 0 |
Hypovolemic
[description not available] | 0 | 2.06 | 1 | 0 |
Hemorrhagic Shock
[description not available] | 0 | 2.06 | 1 | 0 |
Hypovolemia
An abnormally low volume of blood circulating through the body. It may result in hypovolemic shock (see SHOCK). | 0 | 2.06 | 1 | 0 |
Anterior Circulation Transient Ischemic Attack
[description not available] | 0 | 2.01 | 1 | 0 |
Injury, Ischemia-Reperfusion
[description not available] | 0 | 2.01 | 1 | 0 |
Ischemic Attack, Transient
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6) | 0 | 2.01 | 1 | 0 |
Reperfusion Injury
Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA. | 0 | 2.01 | 1 | 0 |
Autosomal Dominant Striatonigral Degeneration
[description not available] | 0 | 3.4 | 1 | 1 |
Machado-Joseph Disease
A dominantly-inherited ATAXIA first described in people of Azorean and Portuguese descent, and subsequently identified in Brazil, Japan, China, and Australia. This disorder is classified as one of the SPINOCEREBELLAR ATAXIAS (Type 3) and has been associated with a mutation of the MJD1 gene on chromosome 14. Clinical features include progressive ataxia, DYSARTHRIA, postural instability, nystagmus, eyelid retraction, and facial FASCICULATIONS. DYSTONIA is prominent in younger patients (referred to as Type I Machado-Joseph Disease). Type II features ataxia and ocular signs; Type III features MUSCULAR ATROPHY and a sensorimotor neuropathy; and Type IV features extrapyramidal signs combined with a sensorimotor neuropathy. (From Clin Neurosci 1995;3(1):17-22; Ann Neurol 1998 Mar;43(3):288-96) | 0 | 3.4 | 1 | 1 |
Autosomal Dominant Cerebellar Ataxia, Type II
[description not available] | 0 | 2.02 | 1 | 0 |
Spinocerebellar Ataxias
A group of predominately late-onset, cerebellar ataxias which have been divided into multiple subtypes based on clinical features and genetic mapping. Progressive ataxia is a central feature of these conditions, and in certain subtypes POLYNEUROPATHY; DYSARTHRIA; visual loss; and other disorders may develop. (From Joynt, Clinical Neurology, 1997, Ch65, pp 12-17; J Neuropathol Exp Neurol 1998 Jun;57(6):531-43) | 0 | 2.02 | 1 | 0 |
Adiadochokinesis
[description not available] | 0 | 2.39 | 2 | 0 |
Cerebellar Ataxia
Incoordination of voluntary movements that occur as a manifestation of CEREBELLAR DISEASES. Characteristic features include a tendency for limb movements to overshoot or undershoot a target (dysmetria), a tremor that occurs during attempted movements (intention TREMOR), impaired force and rhythm of diadochokinesis (rapidly alternating movements), and GAIT ATAXIA. (From Adams et al., Principles of Neurology, 6th ed, p90) | 0 | 2.39 | 2 | 0 |
Conus Medullaris Syndrome
[description not available] | 0 | 1.98 | 1 | 0 |
Alcohol Abuse
[description not available] | 0 | 2.39 | 2 | 0 |
Alcohol Drinking
Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking. | 0 | 3.24 | 6 | 0 |
Alcoholism
A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4) | 0 | 2.39 | 2 | 0 |
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments. | 0 | 1.98 | 1 | 0 |
Brain Vascular Disorders
[description not available] | 0 | 1.98 | 1 | 0 |
Cerebrovascular Disorders
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others. | 0 | 1.98 | 1 | 0 |
Amentia
[description not available] | 0 | 3.37 | 1 | 1 |
Dementia
An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness. | 0 | 3.37 | 1 | 1 |
Cataleptic Attacks
[description not available] | 0 | 1.99 | 1 | 0 |
Hyperactivity, Motor
[description not available] | 0 | 3.09 | 5 | 0 |
Tachyarrhythmia
[description not available] | 0 | 1.99 | 1 | 0 |
Action Tremor
[description not available] | 0 | 1.99 | 1 | 0 |
Emesis
[description not available] | 0 | 2.4 | 2 | 0 |
Tachycardia
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia. | 0 | 1.99 | 1 | 0 |
Tremor
Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE. | 0 | 1.99 | 1 | 0 |
Vomiting
The forcible expulsion of the contents of the STOMACH through the MOUTH. | 0 | 2.4 | 2 | 0 |
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. | 0 | 3.09 | 5 | 0 |
Delayed Effects, Prenatal Exposure
[description not available] | 0 | 2.4 | 2 | 0 |
Adenoma, Basal Cell
[description not available] | 0 | 1.99 | 1 | 0 |
Cancer of Pituitary
[description not available] | 0 | 1.99 | 1 | 0 |
Cancer of the Thyroid
[description not available] | 0 | 1.99 | 1 | 0 |
Adenoma
A benign epithelial tumor with a glandular organization. | 0 | 1.99 | 1 | 0 |
Pituitary Neoplasms
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA. | 0 | 1.99 | 1 | 0 |
Thyroid Neoplasms
Tumors or cancer of the THYROID GLAND. | 0 | 1.99 | 1 | 0 |
Amnesia-Memory Loss
[description not available] | 0 | 1.97 | 1 | 0 |
Amnesia
Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7) | 0 | 1.97 | 1 | 0 |
Hypothermia, Accidental
[description not available] | 0 | 1.97 | 1 | 0 |
Hypothermia
Lower than normal body temperature, especially in warm-blooded animals. | 0 | 1.97 | 1 | 0 |