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7-nitroindazole and Pain

7-nitroindazole has been researched along with Pain in 12 studies

7-nitroindazole: an inhibitor of nitric oxide synthase; exhibits anti-nociceptive activity without increasing blood pressure

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
" Dose-response for each NSAIDs were created before and after 5 mg/kg of L-NAME i."1.56Involvement of NO in Antinociception of NSAIDS in Murine Formalin Hind Paw Assay. ( Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Sotomayor-Zárate, R, 2020)
"Modafinil was administered in the doses of 50, 100 or 200 mg/kg once in acute study and it showed significantly increased tail-flick latency (tfl) and paw-licking latency."1.40Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole. ( Bhattacharya, SK; Gupta, LK; Gupta, R, 2014)
"Compound 16 was shown to reverse thermal hyperalgesia in vivo in the Chung model of neuropathic pain."1.37Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain. ( Andrews, JS; Annedi, SC; Bunton, D; Christie, L; Lee, DK; Maddaford, SP; Mladenova, G; Porreca, F; Rakhit, S; Ramnauth, J; Zhang, D, 2011)
"morphine."1.34Extracellular signal-regulated kinase (ERK) and nitric oxide synthase mediate intrathecal morphine-induced nociceptive behavior. ( Bagetta, G; Komatsu, T; Sakurada, C; Sakurada, S; Sakurada, T; Sanai, K; Sasaki, M; Tsuzuki, M, 2007)
"Pinacidil activity was not blocked by L-NAME, D-NAME, 7-nitroindazole, ODQ, KT-5823 or okadaic acid."1.33The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin. ( Flores-Murrieta, FJ; Granados-Soto, V; Mixcoatl-Zecuatl, T, 2006)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (16.67)18.2507
2000's7 (58.33)29.6817
2010's2 (16.67)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Annedi, SC1
Maddaford, SP1
Mladenova, G1
Ramnauth, J1
Rakhit, S1
Andrews, JS1
Lee, DK1
Zhang, D1
Porreca, F1
Bunton, D1
Christie, L1
Noriega, V1
Miranda, HF1
Prieto, JC1
Sotomayor-Zárate, R1
Sierralta, F1
Gupta, R1
Gupta, LK1
Bhattacharya, SK1
Yilmaz, I1
Ulugol, A1
Doursout, MF1
Liang, Y1
Chelly, JE1
Zanchet, EM1
Longo, I1
Cury, Y1
Dal, D1
Salman, MA1
Salman, AE1
Iskit, AB1
Aypar, U1
Mixcoatl-Zecuatl, T1
Flores-Murrieta, FJ1
Granados-Soto, V1
Komatsu, T1
Sakurada, C1
Sasaki, M1
Sanai, K1
Tsuzuki, M1
Bagetta, G1
Sakurada, S1
Sakurada, T1
Hao, JX1
Xu, XJ1
Fukuda, T1
Saito, S1
Sato, S1
Harukuni, I1
Toyooka, H1
Kuroda, R1
Kawao, N1
Yoshimura, H1
Umeda, W1
Takemura, M1
Shigenaga, Y1
Kawabata, A1

Other Studies

12 other studies available for 7-nitroindazole and Pain

ArticleYear
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.
    Journal of medicinal chemistry, 2011, Oct-27, Volume: 54, Issue:20

    Topics: Analgesics; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Hot Temperature; Humans; Hyperalge

2011
Involvement of NO in Antinociception of NSAIDS in Murine Formalin Hind Paw Assay.
    Drug research, 2020, Volume: 70, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Formaldehyde; Humans; Inda

2020
Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole.
    European journal of pharmacology, 2014, Aug-05, Volume: 736

    Topics: Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Central Nervous System Stimulants; Form

2014
The effect of nitric oxide synthase inhibitors on the development of analgesic tolerance to dipyrone in mice.
    The International journal of neuroscience, 2009, Volume: 119, Issue:6

    Topics: Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Drug T

2009
NOS inhibitors exhibit antinociceptive properties in the rat formalin test.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:9

    Topics: Analgesics; Animals; Arginine; Blood Pressure; Enzyme Inhibitors; Formaldehyde; Guanidines; Heart Ra

2003
Involvement of spinal neurokinins, excitatory amino acids, proinflammatory cytokines, nitric oxide and prostanoids in pain facilitation induced by Phoneutria nigriventer spider venom.
    Brain research, 2004, Sep-17, Volume: 1021, Issue:1

    Topics: Animals; Antibodies; Calcitonin Gene-Related Peptide Receptor Antagonists; Celecoxib; Citrates; Cycl

2004
The involvement of nitric oxide on the analgesic effect of tramadol.
    European journal of anaesthesiology, 2006, Volume: 23, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Animals; Drug Synergism; Female; Indazoles; Mice; NG-Nitroarginine M

2006
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.
    European journal of pharmacology, 2006, Feb-15, Volume: 531, Issue:1-3

    Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Pro

2006
Extracellular signal-regulated kinase (ERK) and nitric oxide synthase mediate intrathecal morphine-induced nociceptive behavior.
    Neuropharmacology, 2007, Volume: 52, Issue:5

    Topics: Amidines; Analgesics, Opioid; Animals; Behavior, Animal; Benzylamines; Blotting, Western; Butadienes

2007
Treatment of a chronic allodynia-like response in spinally injured rats: effects of systemically administered nitric oxide synthase inhibitors.
    Pain, 1996, Volume: 66, Issue:2-3

    Topics: Adrenergic Agonists; Analgesics; Animals; Arousal; Blood Pressure; Chronic Disease; Dose-Response Re

1996
Halothane minimum alveolar anesthetic concentration and neuronal nitric oxide synthase activity of the dorsal horn and the locus ceruleus in rats.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:4

    Topics: Anesthetics, Inhalation; Animals; Axons; Coloring Agents; Dose-Response Relationship, Drug; Enzyme I

1999
Secondary somatosensory cortex stimulation facilitates the antinociceptive effect of the NO synthase inhibitor through suppression of spinal nociceptive neurons in the rat.
    Brain research, 2001, Jun-08, Volume: 903, Issue:1-2

    Topics: Adrenergic alpha-Antagonists; Animals; Electric Stimulation; Enzyme Inhibitors; Indazoles; Injection

2001