7-nitroindazole has been researched along with Pain in 12 studies
7-nitroindazole: an inhibitor of nitric oxide synthase; exhibits anti-nociceptive activity without increasing blood pressure
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response for each NSAIDs were created before and after 5 mg/kg of L-NAME i." | 1.56 | Involvement of NO in Antinociception of NSAIDS in Murine Formalin Hind Paw Assay. ( Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Sotomayor-Zárate, R, 2020) |
| "Modafinil was administered in the doses of 50, 100 or 200 mg/kg once in acute study and it showed significantly increased tail-flick latency (tfl) and paw-licking latency." | 1.40 | Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole. ( Bhattacharya, SK; Gupta, LK; Gupta, R, 2014) |
| "Compound 16 was shown to reverse thermal hyperalgesia in vivo in the Chung model of neuropathic pain." | 1.37 | Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain. ( Andrews, JS; Annedi, SC; Bunton, D; Christie, L; Lee, DK; Maddaford, SP; Mladenova, G; Porreca, F; Rakhit, S; Ramnauth, J; Zhang, D, 2011) |
| "morphine." | 1.34 | Extracellular signal-regulated kinase (ERK) and nitric oxide synthase mediate intrathecal morphine-induced nociceptive behavior. ( Bagetta, G; Komatsu, T; Sakurada, C; Sakurada, S; Sakurada, T; Sanai, K; Sasaki, M; Tsuzuki, M, 2007) |
| "Pinacidil activity was not blocked by L-NAME, D-NAME, 7-nitroindazole, ODQ, KT-5823 or okadaic acid." | 1.33 | The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin. ( Flores-Murrieta, FJ; Granados-Soto, V; Mixcoatl-Zecuatl, T, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 7 (58.33) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Annedi, SC | 1 |
| Maddaford, SP | 1 |
| Mladenova, G | 1 |
| Ramnauth, J | 1 |
| Rakhit, S | 1 |
| Andrews, JS | 1 |
| Lee, DK | 1 |
| Zhang, D | 1 |
| Porreca, F | 1 |
| Bunton, D | 1 |
| Christie, L | 1 |
| Noriega, V | 1 |
| Miranda, HF | 1 |
| Prieto, JC | 1 |
| Sotomayor-Zárate, R | 1 |
| Sierralta, F | 1 |
| Gupta, R | 1 |
| Gupta, LK | 1 |
| Bhattacharya, SK | 1 |
| Yilmaz, I | 1 |
| Ulugol, A | 1 |
| Doursout, MF | 1 |
| Liang, Y | 1 |
| Chelly, JE | 1 |
| Zanchet, EM | 1 |
| Longo, I | 1 |
| Cury, Y | 1 |
| Dal, D | 1 |
| Salman, MA | 1 |
| Salman, AE | 1 |
| Iskit, AB | 1 |
| Aypar, U | 1 |
| Mixcoatl-Zecuatl, T | 1 |
| Flores-Murrieta, FJ | 1 |
| Granados-Soto, V | 1 |
| Komatsu, T | 1 |
| Sakurada, C | 1 |
| Sasaki, M | 1 |
| Sanai, K | 1 |
| Tsuzuki, M | 1 |
| Bagetta, G | 1 |
| Sakurada, S | 1 |
| Sakurada, T | 1 |
| Hao, JX | 1 |
| Xu, XJ | 1 |
| Fukuda, T | 1 |
| Saito, S | 1 |
| Sato, S | 1 |
| Harukuni, I | 1 |
| Toyooka, H | 1 |
| Kuroda, R | 1 |
| Kawao, N | 1 |
| Yoshimura, H | 1 |
| Umeda, W | 1 |
| Takemura, M | 1 |
| Shigenaga, Y | 1 |
| Kawabata, A | 1 |
12 other studies available for 7-nitroindazole and Pain
| Article | Year |
|---|---|
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.
Topics: Analgesics; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Hot Temperature; Humans; Hyperalge | 2011 |
Involvement of NO in Antinociception of NSAIDS in Murine Formalin Hind Paw Assay.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Formaldehyde; Humans; Inda | 2020 |
Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole.
Topics: Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Central Nervous System Stimulants; Form | 2014 |
The effect of nitric oxide synthase inhibitors on the development of analgesic tolerance to dipyrone in mice.
Topics: Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Drug T | 2009 |
NOS inhibitors exhibit antinociceptive properties in the rat formalin test.
Topics: Analgesics; Animals; Arginine; Blood Pressure; Enzyme Inhibitors; Formaldehyde; Guanidines; Heart Ra | 2003 |
Involvement of spinal neurokinins, excitatory amino acids, proinflammatory cytokines, nitric oxide and prostanoids in pain facilitation induced by Phoneutria nigriventer spider venom.
Topics: Animals; Antibodies; Calcitonin Gene-Related Peptide Receptor Antagonists; Celecoxib; Citrates; Cycl | 2004 |
The involvement of nitric oxide on the analgesic effect of tramadol.
Topics: Analgesics; Analgesics, Opioid; Animals; Drug Synergism; Female; Indazoles; Mice; NG-Nitroarginine M | 2006 |
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.
Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Pro | 2006 |
Extracellular signal-regulated kinase (ERK) and nitric oxide synthase mediate intrathecal morphine-induced nociceptive behavior.
Topics: Amidines; Analgesics, Opioid; Animals; Behavior, Animal; Benzylamines; Blotting, Western; Butadienes | 2007 |
Treatment of a chronic allodynia-like response in spinally injured rats: effects of systemically administered nitric oxide synthase inhibitors.
Topics: Adrenergic Agonists; Analgesics; Animals; Arousal; Blood Pressure; Chronic Disease; Dose-Response Re | 1996 |
Halothane minimum alveolar anesthetic concentration and neuronal nitric oxide synthase activity of the dorsal horn and the locus ceruleus in rats.
Topics: Anesthetics, Inhalation; Animals; Axons; Coloring Agents; Dose-Response Relationship, Drug; Enzyme I | 1999 |
Secondary somatosensory cortex stimulation facilitates the antinociceptive effect of the NO synthase inhibitor through suppression of spinal nociceptive neurons in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Electric Stimulation; Enzyme Inhibitors; Indazoles; Injection | 2001 |