Page last updated: 2024-11-03

protoporphyrin ix and Pain

protoporphyrin ix has been researched along with Pain in 18 studies

protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Although aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) photodynamic therapy (PDT) is an effective FDA-approved therapy for actinic keratosis (AK), a substantial fraction of patients (up to 25%) do not respond to treatment."9.20Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy. ( Chapman, MS; Davis, SC; Hasan, T; Kanick, SC; Maytin, EV; Pogue, BW; Sheehan, KL; Zhao, Y, 2015)
"To determine the impact of skin pretreatment with microneedles (MNs) on ALA- and MAL-induced protoporphyrin IX (PpIX) production, as well as MN impact on pain sensations during light exposure and erythema after PDT."9.14Microneedle pre-treatment of human skin improves 5-aminolevulininc acid (ALA)- and 5-aminolevulinic acid methyl ester (MAL)-induced PpIX production for topical photodynamic therapy without increase in pain or erythema. ( Donnelly, RF; Garland, MJ; Iani, V; Juzeniene, A; Mikolajewska, P; Moan, J; Morrow, DI; Singh, TR, 2010)
"We assessed whether PDT clinical outcome and pain during treatment were correlated with protoporphyrin IX fluorescence intensity and photobleaching."7.79Correlation between protoporphyrin IX fluorescence intensity, photobleaching, pain and clinical outcome of actinic keratosis treated by photodynamic therapy. ( Barge, J; Kasraee, B; Piffaretti, F; Salomon, D; van den Bergh, H; Wagnières, G; Zellweger, M, 2013)
"In superficial basal cell carcinomas treated with photodynamic therapy with topical delta-aminolevulinic acid, we examined effects of light irradiance on photodynamic efficiency and pain."7.74Irradiance-dependent photobleaching and pain in delta-aminolevulinic acid-photodynamic therapy of superficial basal cell carcinomas. ( Cottrell, WJ; Foster, TH; Keymel, KR; Oseroff, AR; Paquette, AD, 2008)
"To compare pain during PDT using two different fluence rates, and also to evaluate the association between pain and protoporphyrin IX (PpIX) fluorescence, lesion type, lesion preparation and lesion localization."7.74Pain during photodynamic therapy is associated with protoporphyrin IX fluorescence and fluence rate. ( Philipsen, PA; Skiveren, J; Wiegell, SR; Wulf, HC, 2008)
"Although aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) photodynamic therapy (PDT) is an effective FDA-approved therapy for actinic keratosis (AK), a substantial fraction of patients (up to 25%) do not respond to treatment."5.20Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy. ( Chapman, MS; Davis, SC; Hasan, T; Kanick, SC; Maytin, EV; Pogue, BW; Sheehan, KL; Zhao, Y, 2015)
" Objective and visual erythema, protoporphyrin IX (PpIX) fluorescence and pain were evaluated."5.19Topical corticosteroid reduces inflammation without compromising the efficacy of photodynamic therapy for actinic keratoses: a randomized clinical trial. ( Petersen, B; Wiegell, SR; Wulf, HC, 2014)
"To determine the impact of skin pretreatment with microneedles (MNs) on ALA- and MAL-induced protoporphyrin IX (PpIX) production, as well as MN impact on pain sensations during light exposure and erythema after PDT."5.14Microneedle pre-treatment of human skin improves 5-aminolevulininc acid (ALA)- and 5-aminolevulinic acid methyl ester (MAL)-induced PpIX production for topical photodynamic therapy without increase in pain or erythema. ( Donnelly, RF; Garland, MJ; Iani, V; Juzeniene, A; Mikolajewska, P; Moan, J; Morrow, DI; Singh, TR, 2010)
"To evaluate the efficacy and safety of LPDL alone versus LPDL in photodynamic therapy with methylaminolevulinic acid (MAL-LPDL) for acne vulgaris."5.13Long-pulsed dye laser versus long-pulsed dye laser-assisted photodynamic therapy for acne vulgaris: A randomized controlled trial. ( Haedersdal, M; Togsverd-Bo, K; Wiegell, SR; Wulf, HC, 2008)
"We assessed whether PDT clinical outcome and pain during treatment were correlated with protoporphyrin IX fluorescence intensity and photobleaching."3.79Correlation between protoporphyrin IX fluorescence intensity, photobleaching, pain and clinical outcome of actinic keratosis treated by photodynamic therapy. ( Barge, J; Kasraee, B; Piffaretti, F; Salomon, D; van den Bergh, H; Wagnières, G; Zellweger, M, 2013)
"Because of the retrospective study design not all factors that may influence pain (eg, protoporphyrin IX fluorescence) were recorded."3.76Factors influencing pain intensity during topical photodynamic therapy of complete cosmetic units for actinic keratoses. ( Denk, K; Enk, A; Gholam, P; Hartmann, M; Sehr, T, 2010)
"In superficial basal cell carcinomas treated with photodynamic therapy with topical delta-aminolevulinic acid, we examined effects of light irradiance on photodynamic efficiency and pain."3.74Irradiance-dependent photobleaching and pain in delta-aminolevulinic acid-photodynamic therapy of superficial basal cell carcinomas. ( Cottrell, WJ; Foster, TH; Keymel, KR; Oseroff, AR; Paquette, AD, 2008)
"To compare pain during PDT using two different fluence rates, and also to evaluate the association between pain and protoporphyrin IX (PpIX) fluorescence, lesion type, lesion preparation and lesion localization."3.74Pain during photodynamic therapy is associated with protoporphyrin IX fluorescence and fluence rate. ( Philipsen, PA; Skiveren, J; Wiegell, SR; Wulf, HC, 2008)
"Pain is the main acute adverse event during photodynamic therapy of skin lesions."2.74Cold water and pauses in illumination reduces pain during photodynamic therapy: a randomized clinical study. ( Haedersdal, M; Wiegell, SR; Wulf, HC, 2009)
"Post-treatment inflammation can often be severe and cause inconvenient down-time for the patients and their employers."1.48The background and philosophy behind daylight photodynamic therapy. ( Wulf, HC, 2018)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (27.78)29.6817
2010's13 (72.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wulf, HC8
Piffaretti, F1
Zellweger, M1
Kasraee, B1
Barge, J1
Salomon, D1
van den Bergh, H1
Wagnières, G1
Wiegell, SR6
Petersen, B2
Lerche, CM1
Fabricius, S1
Philipsen, PA2
Shen, Y1
Zhang, ZJ1
Zhu, MD1
Jiang, BC1
Yang, T1
Gao, YJ1
Kanick, SC1
Davis, SC1
Zhao, Y1
Sheehan, KL1
Hasan, T1
Maytin, EV1
Pogue, BW1
Chapman, MS1
Nissen, CV1
Heerfordt, IM1
Mikkelsen, CS1
Gandy, J1
Labadie, B1
Bierman, D1
Zachary, C1
Cottrell, WJ1
Paquette, AD1
Keymel, KR1
Foster, TH1
Oseroff, AR1
Haedersdal, M2
Mikolajewska, P2
Iani, V2
Juzeniene, A2
Moan, J2
Gholam, P1
Denk, K1
Sehr, T1
Enk, A1
Hartmann, M1
Donnelly, RF1
Garland, MJ1
Morrow, DI1
Singh, TR1
Tyrrell, J1
Campbell, SM1
Curnow, A1
Gaál, M1
Kui, R1
Hunyadi, Z1
Kemény, L1
Gyulai, R1
Togsverd-Bo, K1
Skiveren, J1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Indoor Daylight Photo Dynamic Therapy (PDT) for Actinic Keratosis[NCT03805737]43 participants (Actual)Interventional2019-11-01Completed
Portable Measurement of Protoporphyrin IX in the Skin[NCT04223570]218 participants (Anticipated)Observational2022-12-01Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for protoporphyrin ix and Pain

ArticleYear
[Fluorescence diagnosis of non-melanoma skin cancer].
    Orvosi hetilap, 2012, Aug-26, Volume: 153, Issue:34

    Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Basal Cell; Carcinoma, Basosquamous; Carcinoma, Squamous

2012

Trials

7 trials available for protoporphyrin ix and Pain

ArticleYear
Topical corticosteroid reduces inflammation without compromising the efficacy of photodynamic therapy for actinic keratoses: a randomized clinical trial.
    The British journal of dermatology, 2014, Volume: 171, Issue:6

    Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Aminolevulinic Acid; Anti-Inflammatory Agents; C

2014
Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy.
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:4

    Topics: Aminolevulinic Acid; Biomarkers; Dose-Response Relationship, Drug; Erythema; Female; Humans; Keratos

2015
Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy.
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:4

    Topics: Aminolevulinic Acid; Biomarkers; Dose-Response Relationship, Drug; Erythema; Female; Humans; Keratos

2015
Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy.
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:4

    Topics: Aminolevulinic Acid; Biomarkers; Dose-Response Relationship, Drug; Erythema; Female; Humans; Keratos

2015
Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy.
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:4

    Topics: Aminolevulinic Acid; Biomarkers; Dose-Response Relationship, Drug; Erythema; Female; Humans; Keratos

2015
Pulse photodynamic therapy reduces inflammation without compromising efficacy in the treatment of multiple mild actinic keratoses of the face and scalp: a randomized clinical trial.
    The British journal of dermatology, 2016, Volume: 174, Issue:5

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Erythema; Facial Dermatoses; Female; Fluorescence; Hum

2016
Increased protoporphyrin IX accumulation does not improve the effect of photodynamic therapy for actinic keratosis: a randomized controlled trial.
    The British journal of dermatology, 2017, Volume: 176, Issue:5

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Curettage; Drug Eruptions; Erythema; Female; Fluoresce

2017
Cold water and pauses in illumination reduces pain during photodynamic therapy: a randomized clinical study.
    Acta dermato-venereologica, 2009, Volume: 89, Issue:2

    Topics: Aged; Cold Temperature; Female; Fluorescence; Humans; Keratosis, Actinic; Male; Middle Aged; Pain; P

2009
Microneedle pre-treatment of human skin improves 5-aminolevulininc acid (ALA)- and 5-aminolevulinic acid methyl ester (MAL)-induced PpIX production for topical photodynamic therapy without increase in pain or erythema.
    Pharmaceutical research, 2010, Volume: 27, Issue:10

    Topics: Administration, Cutaneous; Adult; Aminolevulinic Acid; Erythema; Female; Humans; Light; Male; Needle

2010
Long-pulsed dye laser versus long-pulsed dye laser-assisted photodynamic therapy for acne vulgaris: A randomized controlled trial.
    Journal of the American Academy of Dermatology, 2008, Volume: 58, Issue:3

    Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Edema; Erythema; Female; Fluorescence; Humans; Laser Ther

2008

Other Studies

10 other studies available for protoporphyrin ix and Pain

ArticleYear
The background and philosophy behind daylight photodynamic therapy.
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2018, Volume: 153, Issue:6

    Topics: Apoptosis; Humans; Inflammation; Light; Pain; Photochemotherapy; Photosensitizing Agents; Protoporph

2018
Correlation between protoporphyrin IX fluorescence intensity, photobleaching, pain and clinical outcome of actinic keratosis treated by photodynamic therapy.
    Dermatology (Basel, Switzerland), 2013, Volume: 227, Issue:3

    Topics: Aged; Aminolevulinic Acid; Fluorescence; Humans; Keratosis, Actinic; Middle Aged; Pain; Pain Measure

2013
Correlation between treatment time, photobleaching, inflammation and pain after photodynamic therapy with methyl aminolevulinate on tape-stripped skin in healthy volunteers.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2015, Volume: 14, Issue:5

    Topics: Adult; Aminolevulinic Acid; Erythema; Fluorescence; Forearm; Humans; Inflammation; Male; Middle Aged

2015
Exogenous induction of HO-1 alleviates vincristine-induced neuropathic pain by reducing spinal glial activation in mice.
    Neurobiology of disease, 2015, Volume: 79

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Disease Models,

2015
Photodynamic Therapy Effectively Treats Actinic Keratoses Without Pre-Illumination Incubation Time.
    Journal of drugs in dermatology : JDD, 2017, Mar-01, Volume: 16, Issue:3

    Topics: Aminolevulinic Acid; Face; Humans; Keratosis, Actinic; Male; Middle Aged; Pain; Photochemotherapy; P

2017
Irradiance-dependent photobleaching and pain in delta-aminolevulinic acid-photodynamic therapy of superficial basal cell carcinomas.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Jul-15, Volume: 14, Issue:14

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Huma

2008
Topical aminolaevulinic acid- and aminolaevulinic acid methyl ester-based photodynamic therapy with red and violet light: influence of wavelength on pain and erythema.
    The British journal of dermatology, 2009, Volume: 161, Issue:5

    Topics: Administration, Topical; Adult; Aminolevulinic Acid; Animals; Erythema; Humans; Lasers; Mice; Mice,

2009
Factors influencing pain intensity during topical photodynamic therapy of complete cosmetic units for actinic keratoses.
    Journal of the American Academy of Dermatology, 2010, Volume: 63, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Cosmetic Techniques; Female; Humans; Keratosis,

2010
The effect of air cooling pain relief on protoporphyrin IX photobleaching and clinical efficacy during dermatological photodynamic therapy.
    Journal of photochemistry and photobiology. B, Biology, 2011, Apr-04, Volume: 103, Issue:1

    Topics: Aged; Air; Air Conditioning; Cold Temperature; Female; Humans; Light; Male; Oxygen; Pain; Pain Manag

2011
Pain during photodynamic therapy is associated with protoporphyrin IX fluorescence and fluence rate.
    The British journal of dermatology, 2008, Volume: 158, Issue:4

    Topics: Acne Vulgaris; Adult; Aged; Female; Humans; Keratosis; Male; Pain; Pain Measurement; Photochemothera

2008