Compounds > 9-((2-phosphonylmethoxy)ethyl)guanine
Page last updated: 2024-10-15

9-((2-phosphonylmethoxy)ethyl)guanine

Description

9-((2-phosphonylmethoxy)ethyl)guanine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID135409438
CHEMBL ID223737
CHEBI ID7880
SCHEMBL ID64567
MeSH IDM0174973

Synonyms (28)

Synonym
phosphonic acid, ((2-(2-amino-1,6-dihydro-6-oxo-9h-purin-9-yl)ethoxy)methyl)-
5-(3-hydroxy-2-phosphonomethoxypropylguanine)
((2-(2-amino-1,6-dihydro-6-oxo-9h-purin-9-yl)ethoxy)methyl)phosphonic acid
phosphonic acid, [[2-(2-amino-1,6-dihydro-6-oxo-9h-purin-9-yl)ethoxy]methyl]-
9-(2-phosphonylmethoxyethyl)guanine
2-(2-amino-6-oxo-1h-purin-9-yl)ethoxymethylphosphonic acid
2-(2-amino-6-hydroxy-purin-9-yl)ethoxymethylphosphonic acid
114088-58-3
9-((2-phosphonylmethoxy)ethyl)guanine
pmeg
chebi:7880 ,
9-[2-(phosphonomethoxy)ethyl]guanine
9-[3-(phosphonomethoxy)ethyl]guanine
CHEMBL223737
2-(2-amino-6-oxo-3h-purin-9-yl)ethoxymethylphosphonic acid
unii-n9yoi96lpp
n9yoi96lpp ,
SCHEMBL64567
NZVORGQIEFTOQZ-UHFFFAOYSA-N
9-(2-(phosphonomethoxy)ethyl)guanine
9-((2-phosphonylmethoxy)ethyl)guanine [mi]
phosphonic acid, p-((2-(2-amino-1,6-dihydro-6-oxo-9h-purin-9-yl)ethoxy)methyl)-
gs-438
(2-(2-amino-6-hydroxy-9h-purin-9-yl)ethoxy)methylphosphonic acid
DTXSID90150649
J291.906K ,
Q15424806
((2-(2-amino-6-oxo-1,6-dihydro-9h-purin-9-yl)ethoxy)methyl)phosphonic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
phosphoethanolamine
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (85)

Assay IDTitleYearJournalArticle
AID105344Protection of MT-4 cells against the cytopathic effect of HIV-1 (4 days)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines.
AID90790Tested in vitro against HCMV AD-169 strain in MRC-5 cells1993Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.
AID29185Second dissociation constant was determined1993Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
Novel acyclonucleotides: synthesis and antiviral activity of alkenylphosphonic acid derivatives of purines and a pyrimidine.
AID90942Tested in vitro against HCMV AD-169 strain in MRC-5 cells1993Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.
AID1714446Drug level in HFF cells treated with 1 uM [14C]-labelled ODE-Bn-PMEG assessed as compound levels incubated for 48 hrs by liquid scintillation counting2016Journal of medicinal chemistry, 12-08, Volume: 59, Issue:23
Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification.
AID104792Cytotoxic concentration required to reduce viability of mock-infected MT-4 cells (4 days)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines.
AID374203Cytotoxicity against HEL299 cells assessed as minimum cytotoxic concentration required for alteration in cell morphology after 4 days by microscopy2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID47260In vitro anti -HIV activity tested against CEM cells infected with HIV by XTT assay1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
AID26830Evaluated for the dissociation constant1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID560435Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 48 to 51 hrs by ELISA2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID18082Evaluated for the kinetic parameter Km, with bovine brain guanylate kinase.1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID560418Antiproliferative activity against human PHK after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID374199Antiviral activity against Camelpox virus CML14 infected in human PHK assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID106200Antiviral activity determined by plaque reduction assay of HCMV (AD-169) in MRC-5 cells1991Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
A new class of acyclic phosphonate nucleotide analogues: phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents.
AID235680Selectivity Index measured as the ratio of CC50 to that of EC50 (HIV-2) values.1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines.
AID217751Antiviral activity determined by plaque reduction assay of HSV-1 (BWS) in vero cells1991Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
A new class of acyclic phosphonate nucleotide analogues: phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents.
AID374200Cytotoxicity against human PHK after 4 days by Z1 Coulter counting analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID560413Antiproliferative activity against HPV-transformed human C4I cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID105588Cellular toxic effect was determined in MT-4 cells2001Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.
AID374204Cytotoxicity against human PHK assessed as minimum cytotoxic concentration required for alteration in cell morphology after 4 days by microscopy2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID106203In vitro cellular toxicity in MRC-5 cells1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
AID87815Tested in vitro against HSV 2 G strain in vero cells1993Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.
AID83262Inhibition of cytopathogenicity against human HIV-2(LAV-2) in MT-4 cells2001Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.
AID47615Toxic concentration, in CEM cells estimated by the XTT assay1993Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.
AID560433Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 6 to 9 hrs by ELISA2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID560432Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 to 6 hrs by ELISA2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID374193Antiviral activity against Camelpox virus CML1 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID229219In vitro cellular toxicity in vero cells1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
AID235868Ratio between TC50 against human immunodeficiency virus infected CEM cells and IC50 against CEM cells1993Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.
AID560417Antiproliferative activity against HPV-non-transformed human SCC9 cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID374201Selectivity index, ratio of CC50 for human PHK to EC50 for Camelpox virus CML1 infected in human PHK2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID83102Inhibition of cytopathogenicity against human HIV-1(IIIB) in MT-4 cells2001Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.
AID374197Selectivity index, ratio of CC50 for HEL299 cells to EC50 for Camelpox virus CML14 infected in HEL299 cells2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID560421Antiproliferative activity against human lung fibroblast after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID280941Cytotoxicity against mouse L1210/0 cells after 48 hrs2007Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
AID106724Inhibition of antiviral activity against moloney murine sarcoma virus(MSV)in CEM cells in cell protection assay2001Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.
AID47618Toxicity in vitro against CEM cells by XTT assay1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
AID47267Inhibition of human immunodeficiency virus type 2 (HIV-2) induced cytopathogenicity in CEM cells1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base.
AID47283Cellular toxic effect was determined in CEM cells2001Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.
AID105345Protection of MT-4 cells against the cytopathic effect of HIV-2 (8 days)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines.
AID215478Compound was evaluated for the inhibition of DNA synthesis in uninfected cells1993Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
Novel acyclonucleotides: synthesis and antiviral activity of alkenylphosphonic acid derivatives of purines and a pyrimidine.
AID44139Inhibitory activity against murine sarcoma virus induced transformation of murine C3H/3T3 embryo fibroblasts1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base.
AID83719Evaluated for the antiviral activity against Herpes simplex virus type 1 (HSV-1).1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID678820TP_TRANSPORTER: uptake in Xenopus laevis oocytes1999Molecular pharmacology, Sep, Volume: 56, Issue:3
The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.
AID81791Evaluated for the antiretroviral activity against Human immunodeficiency virus type 11990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID560410Antiproliferative activity against HPV-transformed human CaSki cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID560416Antiproliferative activity against HPV-non-transformed human SCC4 cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID560434Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 24 to 27 hrs by ELISA2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID636360Inhibition of Plasmodium vivax HGPRT2012Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2
Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.
AID560415Antiproliferative activity against HPV-non-transformed human HT3 cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID163321Evaluated for the antiretroviral activity against Rauscher-murine leukemia virus (R-MuLV)1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID46965Cell growth toxicity against CEM cells after treatment with compound for 72 hours1993Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.
AID83717Evaluated for the antiviral activity against Herpes simplex virus type 1 (HSV-1) strain BWS by the plaque reduction assay1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID105336Inhibitory activity against human immunodeficiency virus type 2 (HIV-2) induced cytopathogenicity in MT-4 cells1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base.
AID23335Evaluated for the rate of phosphorylation with bovine brain guanylate kinase.1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID229054In vitro antiherpesvirus activity against vero cells infected with HSV-2(G strain)[plaque reduction assay]1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
AID374196Selectivity index, ratio of CC50 for HEL299 cells to EC50 for Camelpox virus CML1 infected in HEL299 cells2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID79966Evaluated for the antiviral activity against Human cytomegalovirus (HCMV) strain AD-169 by the plaque reduction assay1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID374195Cytotoxicity against HEL299 cells after 4 days by Z1 Coulter counting analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID679147TP_TRANSPORTER: uptake in Xenopus laevis oocytes1999Molecular pharmacology, Sep, Volume: 56, Issue:3
The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.
AID105334Inhibitory activity of compound against human immunodeficiency virus type 1 (HIV-1) induced cytopathogenicity in MT-4 cells1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base.
AID560420Antiproliferative activity against NHBE cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID235561Selectivity Index is the ratio of the TC50 to EC501992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
AID560411Antiproliferative activity against HPV-transformed human HeLa cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID46969In vitro CEM cell growth inhibition by measuring the number of cells after treatment for 72 hours1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
AID47459Evaluated for the anticellular activity against CEM cells1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID374198Antiviral activity against Camelpox virus CML1 infected in human PHK assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID81623Tested in vitro against human immunodeficiency virus (HIV) infected CEM cells using XTT assay (LAV-BRU strain)1993Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.
AID560414Antiproliferative activity against HPV-transformed human ME180 cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID560409Antiproliferative activity against HPV-transformed human SiHa cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID87831Tested in vitro against HSV 2 G strain in vero cells1993Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.
AID217752Antiviral activity determined by plaque reduction assay of HSV-2 (G) in vero cells1991Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
A new class of acyclic phosphonate nucleotide analogues: phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents.
AID1714442Drug uptake in HFF cells at 1 uM incubated for 1 to 48 hrs using [14C]-labelled compound by liquid scintillation counting2016Journal of medicinal chemistry, 12-08, Volume: 59, Issue:23
Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification.
AID560436Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 72 to 75 hrs by ELISA2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID560412Antiproliferative activity against HPV-transformed human MS751 cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID560431Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 hrs by ELISA2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID217747Anticellular activity was determined by plaque reduction assay in vero cells.1991Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
A new class of acyclic phosphonate nucleotide analogues: phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents.
AID235679Selectivity Index measured as the ratio of CC50 to that of EC50 (HIV-1) values.1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines.
AID218248Evaluated for the antiviral activity against Vero cells by proliferation assays (in uninfected cells)1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID84951Evaluated for the antiviral activity against Herpes simplex virus type 2 (HSV-2) strain G by the plaque reduction assay1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID374194Antiviral activity against Camelpox virus CML14 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID560422Antiproliferative activity against PHF after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID560419Antiproliferative activity against human CK after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID374202Selectivity index, ratio of CC50 for human PHK to EC50 for Camelpox virus CML14 infected in human PHK2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID106179In vitro antiherpesvirus activity against MRC-5 cells infected with HCMV (AD-169 strain)1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (51)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's22 (43.14)18.2507
2000's11 (21.57)29.6817
2010's11 (21.57)24.3611
2020's7 (13.73)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (1.96%)5.53%
Reviews1 (1.96%)6.00%
Case Studies1 (1.96%)4.05%
Observational0 (0.00%)0.25%
Other48 (94.12%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
alpha-ketoglutaric acid
2-oxoglutaric acid : An oxo dicarboxylic acid that consists of glutaric acid bearing an oxo substituent at position 2. It is an intermediate metabolite in Krebs cycle.		210oxo dicarboxylic acidfundamental metabolite
adenine
[no description available]		5.411906-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
2,4-dichlorophenoxyacetic acid
2,4-Dichlorophenoxyacetic Acid: An herbicide with irritant effects on the eye and the gastrointestinal system.. 2,4-D : A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.		210chlorophenoxyacetic acid;
dichlorobenzene		agrochemical;
defoliant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
environmental contaminant;
phenoxy herbicide;
synthetic auxin
p-aminohippuric acid
p-Aminohippuric Acid: The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.. p-aminohippurate : A hippurate that is the conjugate base of p-aminohippuric acid, arising from deprotonation of the carboxy group.. p-aminohippuric acid : An N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow.		210N-acylglycineDaphnia magna metabolite
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.4520nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
tetraethylammonium
Tetraethylammonium: A potassium-selective ion channel blocker. (From J Gen Phys 1994;104(1):173-90)		210quaternary ammonium ion
thymidine
[no description available]		210pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
floxuridine
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.. floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.		2.0310nucleoside analogue;
organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
radiosensitizing agent
idoxuridine
[no description available]		2.0310organoiodine compound;
pyrimidine 2'-deoxyribonucleoside		antiviral drug;
DNA synthesis inhibitor
alanine
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.		5.4541alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
bromodeoxyuridine
Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.		2.0310pyrimidine 2'-deoxyribonucleosideantimetabolite;
antineoplastic agent
adenosine monophosphate
Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.		2.420adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
cytarabine
[no description available]		2.4120beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside		antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent
trifluridine
Trifluridine: An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557). trifluridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis.		2.0310nucleoside analogue;
organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
EC 2.1.1.45 (thymidylate synthase) inhibitor
bromcresol green
Bromcresol Green: An indicator and reagent. It has been used in serum albumin determinations and as a pH indicator.		210benzofurans
thymidine monophosphate
Thymidine Monophosphate: 5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety.. dTMP : The neutral species of thymidine 5'-monophosphate (2'-deoxythymidine 5'-monophosphate).		1.9710thymidine 5'-monophosphatefundamental metabolite
rhein
[no description available]		2.610dihydroxyanthraquinone
podophyllotoxin
Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.		2.0510furonaphthodioxole;
lignan;
organic heterotetracyclic compound		antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
2'-deoxyadenosine triphosphate
2'-deoxyadenosine triphosphate: RN given refers to unlabeled parent cpd		2.4202'-deoxyadenosine 5'-phosphate;
purine 2'-deoxyribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite
vidarabine
adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond.		210beta-D-arabinoside;
purine nucleoside		antineoplastic agent;
bacterial metabolite;
nucleoside antibiotic
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		3.0950azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
adefovir
adefovir: inhibitor of African swine fever virus. adefovir(1-) : A organophosphonate oxoanion obtained by removal of a proton from the phosphonate group of adefovir, a nucleoside reverse transcriptase inhibitor. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).. adefovir : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.		3.941306-aminopurines;
ether;
phosphonic acids		antiviral drug;
DNA synthesis inhibitor;
drug metabolite;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent
cidofovir anhydrous
Cidofovir: An acyclic nucleoside phosphonate that acts as a competitive inhibitor of viral DNA polymerases. It is used in the treatment of RETINITIS caused by CYTOMEGALOVIRUS INFECTIONS and may also be useful for treating HERPESVIRUS INFECTIONS.. cidofovir anhydrous : Cytosine substituted at the 1 position by a 3-hydroxy-2-(phosphonomethoxy)propyl group (S configuration). A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.		2.9540phosphonic acids;
pyrimidone		anti-HIV agent;
antineoplastic agent;
antiviral drug;
photosensitizing agent
9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine
[no description available]		5.31170
thymine arabinoside
thymine arabinoside: selectively inhibits replication of herpes simplex virus		2.0310N-glycosyl compound
edoxudin
[no description available]		2.0310pyrimidine 2'-deoxyribonucleoside
9-(s)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine
[no description available]		2.0310
9-(3-hydroxy-2-phosphonomethoxypropyl)-2,6-diaminopurine
9-(3-hydroxy-2-phosphonomethoxypropyl)-2,6-diaminopurine: RN refers to (S)-isomer		2.0310
n-(2-(hydroxyethoxy)methyl)-5-methyluracil
N-(2-(hydroxyethoxy)methyl)-5-methyluracil: structure given in first source		2.0310
5-fluoro-1-((2-hydroxyethoxy)methyl)uracil
5-fluoro-1-((2-hydroxyethoxy)methyl)uracil: structure given in first source		2.0310
5-hydroxymethyl-2'-deoxyuridine
[no description available]		2.0310pyrimidine 2'-deoxyribonucleoside
msh release-inhibiting hormone
[no description available]		2.0310oligopeptide
5-hydroxy-2'-deoxyuridine
5-hydroxy-2'-deoxyuridine: a major oxidation product of 2'-deoxycytidine		2.0310
5-formyl-2'-deoxyuridine
5-formyl-2'-deoxyuridine: structure given in first source		2.0310
cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine
cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine: prodrug for HPMPC; specific name and structure not given in first source		2.0310
5-nitro-2'-deoxyuridine
[no description available]		2.0310
5-vinyl-2'-deoxyuridine
5-vinyl-2'-deoxyuridine: structure		2.0310
5-propyl-2'-deoxyuridine
5-propyl-2'-deoxyuridine: RN given refers to parent cpd		2.0310
organophosphonates
hydrogenphosphite : A divalent inorganic anion resulting from the removal of a proton from two of the hydroxy groups of phosphorous acid.		4.89110divalent inorganic anion;
phosphite ion
cyclic-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine
cyclic-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine: specific name and structure not given in first source		2.0310
pentostatin
Pentostatin: A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.. pentostatin : A member of the class of coformycins that is coformycin in which the hydroxy group at position 2' is replaced with a hydrogen. It is a drug used for the treatment of hairy cell leukaemia.		210coformycinsantimetabolite;
antineoplastic agent;
Aspergillus metabolite;
bacterial metabolite;
EC 3.5.4.4 (adenosine deaminase) inhibitor
abacavir
abacavir: a carbocyclic nucleoside with potent selective anti-HIV activity. abacavir : A 2,6-diaminopurine that is (1S)-cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection.		2102,6-diaminopurinesantiviral drug;
drug allergen;
HIV-1 reverse transcriptase inhibitor
adenosine-5'-carboxaldehyde
adenosine-5'-carboxaldehyde: potent inhibitor of S-adenosyl-L-homocysteine hydrolase; structure given in first source. 5'-dehydroadenosine : A member of the class of adenosines that is 5'-dehydro derivative of adenosine.		2.0310adenosines
brivudine
brivudine: anti-herpes agent		2.0310
tenofovir
tenofovir (anhydrous) : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.		2.6830nucleoside analogue;
phosphonic acids		antiviral drug;
drug metabolite;
HIV-1 reverse transcriptase inhibitor
5-ethynyl-2'-deoxyuridine
5-ethynyl-2'-deoxyuridine: structure in first source		2.0310
6-phosphonylmethoxyethoxy-2,4-diaminopyrimidine
[no description available]		2.0310
5-cyano-2'-deoxyuridine
5-cyano-2'-deoxyuridine: structure in first source		2.0310
thioguanine anhydrous
Thioguanine: An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.. tioguanine : A 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia.		1.99102-aminopurinesanticoronaviral agent;
antimetabolite;
antineoplastic agent
5-(2-iodovinyl)-2'-deoxyuridine
[no description available]		2.0310
rabacfosadine
rabacfosadine: has potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma; structure in first source		5.4541
oligonucleotides
[no description available]		1.9910
epidermal growth factor
Epidermal Growth Factor: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.		2.0510
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		3.38702-aminopurines;
oxopurine		antimetabolite;
antiviral drug
2'-deoxyguanosine 5'-phosphate
2'-deoxyguanosine 5'-phosphate: RN given refers to parent cpd.. 2'-deoxyguanosine 5'-monophosphate : A purine 2'-deoxyribonucleoside 5'-monophosphate having guanine as the nucleobase.		1.9710deoxyguanosine phosphate;
guanyl deoxyribonucleotide;
purine 2'-deoxyribonucleoside 5'-monophosphate		Escherichia coli metabolite;
mouse metabolite
guanosine monophosphate
Guanosine Monophosphate: A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.. guanosine 5'-monophosphate : A purine ribonucleoside 5'-monophosphate having guanine as the nucleobase.		210guanosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		biomarker;
Escherichia coli metabolite;
metabolite;
mouse metabolite
guanine
[no description available]		7.33212-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ganciclovir
[no description available]		1.98102-aminopurines;
oxopurine		antiinfective agent;
antiviral drug
9-(3-hydroxy-2-phosphonomethoxypropyl)guanine
9-(3-hydroxy-2-phosphonomethoxypropyl)guanine: structure given in first source; RN given refers to (+-)-isomer; RN for cpd without isomeric designation not available 3/89		2.3920
ConditionIndicatedRelationship StrengthStudiesTrials
HIV
Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.		02.730
Cytomegalovirus
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.		02.420
Experimental Leukemia
[description not available]		02.3920
Infections, Retroviridae
[description not available]		02.420
Fibroma, Shope
[description not available]		02.3920
Retroviridae Infections
Virus diseases caused by the RETROVIRIDAE.		02.420
Cancer of Cervix
[description not available]		02.4620
Uterine Cervical Neoplasms
Tumors or cancer of the UTERINE CERVIX.		02.4620
Aneurysm, Thoracic Aortic
[description not available]		04.6250
Aortic Dissection
[description not available]		03.0120
Ache
[description not available]		02.610
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.		02.610
Aortic Aneurysm, Thoracic
An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.		04.4440
Abdominal Aortic Aneurysm
[description not available]		03.9320
Complication, Postoperative
[description not available]		02.610
Postoperative Complications
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.		02.610
Aortic Aneurysm, Abdominal
An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.		03.9320
Disease Exacerbation
[description not available]		02.610
Hepatocellular Carcinoma
[description not available]		02.610
Cirrhosis, Liver
[description not available]		02.610
Cancer of Liver
[description not available]		02.610
Angiogenesis, Pathologic
[description not available]		02.5320
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.610
Liver Cirrhosis
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.		02.610
Liver Neoplasms
Tumors or cancer of the LIVER.		02.610
Proliferative Vitreoretinopathy
[description not available]		02.1510
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.1510
Vitreoretinopathy, Proliferative
Vitreoretinal membrane shrinkage or contraction secondary to the proliferation of primarily retinal pigment epithelial cells and glial cells, particularly fibrous astrocytes, followed by membrane formation. The formation of fibrillar collagen and cellular proliferation appear to be the basis for the contractile properties of the epiretinal and vitreous membranes.		02.1510
Canine Diseases
[description not available]		03.8921
Benign Neoplasms
[description not available]		02.1110
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.1110
Kahler Disease
[description not available]		03.4811
Multiple Myeloma
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.		03.4811
Diffuse Mixed Small and Large Cell Lymphoma
[description not available]		03.3620
Lymphoma, Non-Hodgkin
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.		03.3620
T-Cell Lymphoma
[description not available]		02.0510
Lymphoma, T-Cell
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.		02.0510
B-Cell Chronic Lymphocytic Leukemia
[description not available]		02.0510
Leukemia, Lymphocytic, Chronic, B-Cell
A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.		02.0510
Leukemia L 1210
[description not available]		02.420
Granulocytic Leukemia
[description not available]		0210
Leukemia, Myeloid
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.		0210
Cancer of the Uterus
[description not available]		0210
Choriocarcinoma
A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).		0210
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		0210
Uterine Neoplasms
Tumors or cancer of the UTERUS.		0210
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		01.9710