Page last updated: 2024-10-15

9-((2-phosphonylmethoxy)ethyl)guanine

Description

9-((2-phosphonylmethoxy)ethyl)guanine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID135409438
CHEMBL ID223737
CHEBI ID7880
SCHEMBL ID64567
MeSH IDM0174973

Synonyms (28)

Synonym
phosphonic acid, ((2-(2-amino-1,6-dihydro-6-oxo-9h-purin-9-yl)ethoxy)methyl)-
5-(3-hydroxy-2-phosphonomethoxypropylguanine)
((2-(2-amino-1,6-dihydro-6-oxo-9h-purin-9-yl)ethoxy)methyl)phosphonic acid
phosphonic acid, [[2-(2-amino-1,6-dihydro-6-oxo-9h-purin-9-yl)ethoxy]methyl]-
9-(2-phosphonylmethoxyethyl)guanine
2-(2-amino-6-oxo-1h-purin-9-yl)ethoxymethylphosphonic acid
2-(2-amino-6-hydroxy-purin-9-yl)ethoxymethylphosphonic acid
114088-58-3
9-((2-phosphonylmethoxy)ethyl)guanine
pmeg
chebi:7880 ,
9-[2-(phosphonomethoxy)ethyl]guanine
9-[3-(phosphonomethoxy)ethyl]guanine
CHEMBL223737
2-(2-amino-6-oxo-3h-purin-9-yl)ethoxymethylphosphonic acid
unii-n9yoi96lpp
n9yoi96lpp ,
SCHEMBL64567
NZVORGQIEFTOQZ-UHFFFAOYSA-N
9-(2-(phosphonomethoxy)ethyl)guanine
9-((2-phosphonylmethoxy)ethyl)guanine [mi]
phosphonic acid, p-((2-(2-amino-1,6-dihydro-6-oxo-9h-purin-9-yl)ethoxy)methyl)-
gs-438
(2-(2-amino-6-hydroxy-9h-purin-9-yl)ethoxy)methylphosphonic acid
DTXSID90150649
J291.906K ,
Q15424806
((2-(2-amino-6-oxo-1,6-dihydro-9h-purin-9-yl)ethoxy)methyl)phosphonic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
phosphoethanolamine
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (85)

Assay IDTitleYearJournalArticle
AID105344Protection of MT-4 cells against the cytopathic effect of HIV-1 (4 days)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines.
AID90790Tested in vitro against HCMV AD-169 strain in MRC-5 cells1993Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.
AID29185Second dissociation constant was determined1993Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
Novel acyclonucleotides: synthesis and antiviral activity of alkenylphosphonic acid derivatives of purines and a pyrimidine.
AID90942Tested in vitro against HCMV AD-169 strain in MRC-5 cells1993Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.
AID1714446Drug level in HFF cells treated with 1 uM [14C]-labelled ODE-Bn-PMEG assessed as compound levels incubated for 48 hrs by liquid scintillation counting2016Journal of medicinal chemistry, 12-08, Volume: 59, Issue:23
Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification.
AID104792Cytotoxic concentration required to reduce viability of mock-infected MT-4 cells (4 days)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines.
AID374203Cytotoxicity against HEL299 cells assessed as minimum cytotoxic concentration required for alteration in cell morphology after 4 days by microscopy2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID47260In vitro anti -HIV activity tested against CEM cells infected with HIV by XTT assay1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
AID26830Evaluated for the dissociation constant1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID560435Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 48 to 51 hrs by ELISA2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID18082Evaluated for the kinetic parameter Km, with bovine brain guanylate kinase.1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID560418Antiproliferative activity against human PHK after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID374199Antiviral activity against Camelpox virus CML14 infected in human PHK assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID106200Antiviral activity determined by plaque reduction assay of HCMV (AD-169) in MRC-5 cells1991Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
A new class of acyclic phosphonate nucleotide analogues: phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents.
AID235680Selectivity Index measured as the ratio of CC50 to that of EC50 (HIV-2) values.1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines.
AID217751Antiviral activity determined by plaque reduction assay of HSV-1 (BWS) in vero cells1991Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
A new class of acyclic phosphonate nucleotide analogues: phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents.
AID374200Cytotoxicity against human PHK after 4 days by Z1 Coulter counting analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID560413Antiproliferative activity against HPV-transformed human C4I cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID105588Cellular toxic effect was determined in MT-4 cells2001Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.
AID374204Cytotoxicity against human PHK assessed as minimum cytotoxic concentration required for alteration in cell morphology after 4 days by microscopy2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID106203In vitro cellular toxicity in MRC-5 cells1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
AID87815Tested in vitro against HSV 2 G strain in vero cells1993Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.
AID83262Inhibition of cytopathogenicity against human HIV-2(LAV-2) in MT-4 cells2001Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.
AID47615Toxic concentration, in CEM cells estimated by the XTT assay1993Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.
AID560433Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 6 to 9 hrs by ELISA2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID560432Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 to 6 hrs by ELISA2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID374193Antiviral activity against Camelpox virus CML1 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID229219In vitro cellular toxicity in vero cells1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
AID235868Ratio between TC50 against human immunodeficiency virus infected CEM cells and IC50 against CEM cells1993Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.
AID560417Antiproliferative activity against HPV-non-transformed human SCC9 cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID374201Selectivity index, ratio of CC50 for human PHK to EC50 for Camelpox virus CML1 infected in human PHK2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID83102Inhibition of cytopathogenicity against human HIV-1(IIIB) in MT-4 cells2001Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.
AID374197Selectivity index, ratio of CC50 for HEL299 cells to EC50 for Camelpox virus CML14 infected in HEL299 cells2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID560421Antiproliferative activity against human lung fibroblast after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID280941Cytotoxicity against mouse L1210/0 cells after 48 hrs2007Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
AID106724Inhibition of antiviral activity against moloney murine sarcoma virus(MSV)in CEM cells in cell protection assay2001Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.
AID47618Toxicity in vitro against CEM cells by XTT assay1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
AID47267Inhibition of human immunodeficiency virus type 2 (HIV-2) induced cytopathogenicity in CEM cells1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base.
AID47283Cellular toxic effect was determined in CEM cells2001Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.
AID105345Protection of MT-4 cells against the cytopathic effect of HIV-2 (8 days)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines.
AID215478Compound was evaluated for the inhibition of DNA synthesis in uninfected cells1993Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
Novel acyclonucleotides: synthesis and antiviral activity of alkenylphosphonic acid derivatives of purines and a pyrimidine.
AID44139Inhibitory activity against murine sarcoma virus induced transformation of murine C3H/3T3 embryo fibroblasts1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base.
AID83719Evaluated for the antiviral activity against Herpes simplex virus type 1 (HSV-1).1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID678820TP_TRANSPORTER: uptake in Xenopus laevis oocytes1999Molecular pharmacology, Sep, Volume: 56, Issue:3
The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.
AID81791Evaluated for the antiretroviral activity against Human immunodeficiency virus type 11990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID560410Antiproliferative activity against HPV-transformed human CaSki cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID560416Antiproliferative activity against HPV-non-transformed human SCC4 cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID560434Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 24 to 27 hrs by ELISA2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID636360Inhibition of Plasmodium vivax HGPRT2012Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2
Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.
AID560415Antiproliferative activity against HPV-non-transformed human HT3 cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID163321Evaluated for the antiretroviral activity against Rauscher-murine leukemia virus (R-MuLV)1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID46965Cell growth toxicity against CEM cells after treatment with compound for 72 hours1993Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.
AID83717Evaluated for the antiviral activity against Herpes simplex virus type 1 (HSV-1) strain BWS by the plaque reduction assay1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID105336Inhibitory activity against human immunodeficiency virus type 2 (HIV-2) induced cytopathogenicity in MT-4 cells1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base.
AID23335Evaluated for the rate of phosphorylation with bovine brain guanylate kinase.1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID229054In vitro antiherpesvirus activity against vero cells infected with HSV-2(G strain)[plaque reduction assay]1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
AID374196Selectivity index, ratio of CC50 for HEL299 cells to EC50 for Camelpox virus CML1 infected in HEL299 cells2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID79966Evaluated for the antiviral activity against Human cytomegalovirus (HCMV) strain AD-169 by the plaque reduction assay1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID374195Cytotoxicity against HEL299 cells after 4 days by Z1 Coulter counting analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID679147TP_TRANSPORTER: uptake in Xenopus laevis oocytes1999Molecular pharmacology, Sep, Volume: 56, Issue:3
The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.
AID105334Inhibitory activity of compound against human immunodeficiency virus type 1 (HIV-1) induced cytopathogenicity in MT-4 cells1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base.
AID560420Antiproliferative activity against NHBE cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID235561Selectivity Index is the ratio of the TC50 to EC501992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
AID560411Antiproliferative activity against HPV-transformed human HeLa cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID46969In vitro CEM cell growth inhibition by measuring the number of cells after treatment for 72 hours1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
AID47459Evaluated for the anticellular activity against CEM cells1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID374198Antiviral activity against Camelpox virus CML1 infected in human PHK assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID81623Tested in vitro against human immunodeficiency virus (HIV) infected CEM cells using XTT assay (LAV-BRU strain)1993Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.
AID560414Antiproliferative activity against HPV-transformed human ME180 cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID560409Antiproliferative activity against HPV-transformed human SiHa cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID87831Tested in vitro against HSV 2 G strain in vero cells1993Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.
AID217752Antiviral activity determined by plaque reduction assay of HSV-2 (G) in vero cells1991Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
A new class of acyclic phosphonate nucleotide analogues: phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents.
AID1714442Drug uptake in HFF cells at 1 uM incubated for 1 to 48 hrs using [14C]-labelled compound by liquid scintillation counting2016Journal of medicinal chemistry, 12-08, Volume: 59, Issue:23
Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification.
AID560436Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 72 to 75 hrs by ELISA2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID560412Antiproliferative activity against HPV-transformed human MS751 cells after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID560431Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 hrs by ELISA2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID217747Anticellular activity was determined by plaque reduction assay in vero cells.1991Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
A new class of acyclic phosphonate nucleotide analogues: phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents.
AID235679Selectivity Index measured as the ratio of CC50 to that of EC50 (HIV-1) values.1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines.
AID218248Evaluated for the antiviral activity against Vero cells by proliferation assays (in uninfected cells)1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID84951Evaluated for the antiviral activity against Herpes simplex virus type 2 (HSV-2) strain G by the plaque reduction assay1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
AID374194Antiviral activity against Camelpox virus CML14 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID560422Antiproliferative activity against PHF after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID560419Antiproliferative activity against human CK after 7 days by SRB assay2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
AID374202Selectivity index, ratio of CC50 for human PHK to EC50 for Camelpox virus CML14 infected in human PHK2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID106179In vitro antiherpesvirus activity against MRC-5 cells infected with HCMV (AD-169 strain)1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (51)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's22 (43.14)18.2507
2000's11 (21.57)29.6817
2010's11 (21.57)24.3611
2020's7 (13.73)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (1.96%)5.53%
Reviews1 (1.96%)6.00%
Case Studies1 (1.96%)4.05%
Observational0 (0.00%)0.25%
Other48 (94.12%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]