Assay ID | Title | Year | Journal | Article |
AID105344 | Protection of MT-4 cells against the cytopathic effect of HIV-1 (4 days) | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
| Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines. |
AID90790 | Tested in vitro against HCMV AD-169 strain in MRC-5 cells | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues. |
AID29185 | Second dissociation constant was determined | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Novel acyclonucleotides: synthesis and antiviral activity of alkenylphosphonic acid derivatives of purines and a pyrimidine. |
AID90942 | Tested in vitro against HCMV AD-169 strain in MRC-5 cells | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues. |
AID1714446 | Drug level in HFF cells treated with 1 uM [14C]-labelled ODE-Bn-PMEG assessed as compound levels incubated for 48 hrs by liquid scintillation counting | 2016 | Journal of medicinal chemistry, 12-08, Volume: 59, Issue:23
| Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification. |
AID104792 | Cytotoxic concentration required to reduce viability of mock-infected MT-4 cells (4 days) | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
| Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines. |
AID374203 | Cytotoxicity against HEL299 cells assessed as minimum cytotoxic concentration required for alteration in cell morphology after 4 days by microscopy | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
| Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. |
AID47260 | In vitro anti -HIV activity tested against CEM cells infected with HIV by XTT assay | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine. |
AID26830 | Evaluated for the dissociation constant | 1990 | Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
| Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships. |
AID560435 | Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 48 to 51 hrs by ELISA | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID18082 | Evaluated for the kinetic parameter Km, with bovine brain guanylate kinase. | 1990 | Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
| Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships. |
AID560418 | Antiproliferative activity against human PHK after 7 days by SRB assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID374199 | Antiviral activity against Camelpox virus CML14 infected in human PHK assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
| Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. |
AID106200 | Antiviral activity determined by plaque reduction assay of HCMV (AD-169) in MRC-5 cells | 1991 | Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
| A new class of acyclic phosphonate nucleotide analogues: phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents. |
AID235680 | Selectivity Index measured as the ratio of CC50 to that of EC50 (HIV-2) values. | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
| Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines. |
AID217751 | Antiviral activity determined by plaque reduction assay of HSV-1 (BWS) in vero cells | 1991 | Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
| A new class of acyclic phosphonate nucleotide analogues: phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents. |
AID374200 | Cytotoxicity against human PHK after 4 days by Z1 Coulter counting analysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
| Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. |
AID560413 | Antiproliferative activity against HPV-transformed human C4I cells after 7 days by SRB assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID105588 | Cellular toxic effect was determined in MT-4 cells | 2001 | Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
| Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses. |
AID374204 | Cytotoxicity against human PHK assessed as minimum cytotoxic concentration required for alteration in cell morphology after 4 days by microscopy | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
| Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. |
AID106203 | In vitro cellular toxicity in MRC-5 cells | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine. |
AID87815 | Tested in vitro against HSV 2 G strain in vero cells | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues. |
AID83262 | Inhibition of cytopathogenicity against human HIV-2(LAV-2) in MT-4 cells | 2001 | Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
| Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses. |
AID47615 | Toxic concentration, in CEM cells estimated by the XTT assay | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues. |
AID560433 | Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 6 to 9 hrs by ELISA | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID560432 | Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 to 6 hrs by ELISA | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID374193 | Antiviral activity against Camelpox virus CML1 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
| Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. |
AID229219 | In vitro cellular toxicity in vero cells | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine. |
AID235868 | Ratio between TC50 against human immunodeficiency virus infected CEM cells and IC50 against CEM cells | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues. |
AID560417 | Antiproliferative activity against HPV-non-transformed human SCC9 cells after 7 days by SRB assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID374201 | Selectivity index, ratio of CC50 for human PHK to EC50 for Camelpox virus CML1 infected in human PHK | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
| Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. |
AID83102 | Inhibition of cytopathogenicity against human HIV-1(IIIB) in MT-4 cells | 2001 | Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
| Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses. |
AID374197 | Selectivity index, ratio of CC50 for HEL299 cells to EC50 for Camelpox virus CML14 infected in HEL299 cells | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
| Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. |
AID560421 | Antiproliferative activity against human lung fibroblast after 7 days by SRB assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID280941 | Cytotoxicity against mouse L1210/0 cells after 48 hrs | 2007 | Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
| Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set. |
AID106724 | Inhibition of antiviral activity against moloney murine sarcoma virus(MSV)in CEM cells in cell protection assay | 2001 | Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
| Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses. |
AID47618 | Toxicity in vitro against CEM cells by XTT assay | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine. |
AID47267 | Inhibition of human immunodeficiency virus type 2 (HIV-2) induced cytopathogenicity in CEM cells | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. |
AID47283 | Cellular toxic effect was determined in CEM cells | 2001 | Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
| Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses. |
AID105345 | Protection of MT-4 cells against the cytopathic effect of HIV-2 (8 days) | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
| Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines. |
AID215478 | Compound was evaluated for the inhibition of DNA synthesis in uninfected cells | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Novel acyclonucleotides: synthesis and antiviral activity of alkenylphosphonic acid derivatives of purines and a pyrimidine. |
AID44139 | Inhibitory activity against murine sarcoma virus induced transformation of murine C3H/3T3 embryo fibroblasts | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. |
AID83719 | Evaluated for the antiviral activity against Herpes simplex virus type 1 (HSV-1). | 1990 | Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
| Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships. |
AID678820 | TP_TRANSPORTER: uptake in Xenopus laevis oocytes | 1999 | Molecular pharmacology, Sep, Volume: 56, Issue:3
| The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. |
AID81791 | Evaluated for the antiretroviral activity against Human immunodeficiency virus type 1 | 1990 | Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
| Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships. |
AID560410 | Antiproliferative activity against HPV-transformed human CaSki cells after 7 days by SRB assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID560416 | Antiproliferative activity against HPV-non-transformed human SCC4 cells after 7 days by SRB assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID560434 | Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 24 to 27 hrs by ELISA | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID636360 | Inhibition of Plasmodium vivax HGPRT | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2
| Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. |
AID560415 | Antiproliferative activity against HPV-non-transformed human HT3 cells after 7 days by SRB assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID163321 | Evaluated for the antiretroviral activity against Rauscher-murine leukemia virus (R-MuLV) | 1990 | Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
| Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships. |
AID46965 | Cell growth toxicity against CEM cells after treatment with compound for 72 hours | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues. |
AID83717 | Evaluated for the antiviral activity against Herpes simplex virus type 1 (HSV-1) strain BWS by the plaque reduction assay | 1990 | Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
| Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships. |
AID105336 | Inhibitory activity against human immunodeficiency virus type 2 (HIV-2) induced cytopathogenicity in MT-4 cells | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. |
AID23335 | Evaluated for the rate of phosphorylation with bovine brain guanylate kinase. | 1990 | Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
| Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships. |
AID229054 | In vitro antiherpesvirus activity against vero cells infected with HSV-2(G strain)[plaque reduction assay] | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine. |
AID374196 | Selectivity index, ratio of CC50 for HEL299 cells to EC50 for Camelpox virus CML1 infected in HEL299 cells | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
| Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. |
AID79966 | Evaluated for the antiviral activity against Human cytomegalovirus (HCMV) strain AD-169 by the plaque reduction assay | 1990 | Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
| Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships. |
AID374195 | Cytotoxicity against HEL299 cells after 4 days by Z1 Coulter counting analysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
| Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. |
AID679147 | TP_TRANSPORTER: uptake in Xenopus laevis oocytes | 1999 | Molecular pharmacology, Sep, Volume: 56, Issue:3
| The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. |
AID105334 | Inhibitory activity of compound against human immunodeficiency virus type 1 (HIV-1) induced cytopathogenicity in MT-4 cells | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. |
AID560420 | Antiproliferative activity against NHBE cells after 7 days by SRB assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID235561 | Selectivity Index is the ratio of the TC50 to EC50 | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine. |
AID560411 | Antiproliferative activity against HPV-transformed human HeLa cells after 7 days by SRB assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID46969 | In vitro CEM cell growth inhibition by measuring the number of cells after treatment for 72 hours | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine. |
AID47459 | Evaluated for the anticellular activity against CEM cells | 1990 | Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
| Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships. |
AID374198 | Antiviral activity against Camelpox virus CML1 infected in human PHK assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
| Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. |
AID81623 | Tested in vitro against human immunodeficiency virus (HIV) infected CEM cells using XTT assay (LAV-BRU strain) | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues. |
AID560414 | Antiproliferative activity against HPV-transformed human ME180 cells after 7 days by SRB assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID560409 | Antiproliferative activity against HPV-transformed human SiHa cells after 7 days by SRB assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID87831 | Tested in vitro against HSV 2 G strain in vero cells | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues. |
AID217752 | Antiviral activity determined by plaque reduction assay of HSV-2 (G) in vero cells | 1991 | Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
| A new class of acyclic phosphonate nucleotide analogues: phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents. |
AID1714442 | Drug uptake in HFF cells at 1 uM incubated for 1 to 48 hrs using [14C]-labelled compound by liquid scintillation counting | 2016 | Journal of medicinal chemistry, 12-08, Volume: 59, Issue:23
| Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification. |
AID560436 | Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 72 to 75 hrs by ELISA | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID560412 | Antiproliferative activity against HPV-transformed human MS751 cells after 7 days by SRB assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID560431 | Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 hrs by ELISA | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID217747 | Anticellular activity was determined by plaque reduction assay in vero cells. | 1991 | Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
| A new class of acyclic phosphonate nucleotide analogues: phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents. |
AID235679 | Selectivity Index measured as the ratio of CC50 to that of EC50 (HIV-1) values. | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
| Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines. |
AID218248 | Evaluated for the antiviral activity against Vero cells by proliferation assays (in uninfected cells) | 1990 | Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
| Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships. |
AID84951 | Evaluated for the antiviral activity against Herpes simplex virus type 2 (HSV-2) strain G by the plaque reduction assay | 1990 | Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
| Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships. |
AID374194 | Antiviral activity against Camelpox virus CML14 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
| Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. |
AID560422 | Antiproliferative activity against PHF after 7 days by SRB assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID560419 | Antiproliferative activity against human CK after 7 days by SRB assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. |
AID374202 | Selectivity index, ratio of CC50 for human PHK to EC50 for Camelpox virus CML14 infected in human PHK | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
| Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. |
AID106179 | In vitro antiherpesvirus activity against MRC-5 cells infected with HCMV (AD-169 strain) | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |