Page last updated: 2024-12-11

sun n8075

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

SUN N8075: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9852813
SCHEMBL ID3041578
MeSH IDM0370560

Synonyms (8)

Synonym
SCHEMBL3041578
unii-dm2asgkfm4
sun n8075
sun-n 8075
224450-56-0
DM2ASGKFM4 ,
1-piperazineethanol, .alpha.-((4-amino-2,3,5-trimethylphenoxy)methyl)-4-(4-((4-fluorophenyl)methyl)phenyl)-, (.alpha.s)-, methanesulfonate (1:2)
(2s)-1-(4-amino-2,3,5-trimethylphenoxy)-3-[4-[4-[(4-fluorophenyl)methyl]phenyl]piperazin-1-yl]propan-2-ol;methanesulfonic acid

Research Excerpts

Overview

SUN N8075 is a novel antioxidant with neuroprotective properties.

ExcerptReferenceRelevance
"SUN N8075 is a novel antioxidant with neuroprotective properties. "( Protective effects of SUN N8075, a novel agent with antioxidant properties, in in vitro and in vivo models of Parkinson's disease.
Adachi, T; Hara, H; Izuta, H; Matsunaga, N; Oida, Y; Oyagi, A; Shimazawa, M, 2008
)
2.1
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
D(2) dopamine receptorRattus norvegicus (Norway rat)IC50 (µMol)10.00000.00010.54948.4000AID64281
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID227648Inhibition of low-threshold (T-type) Calcium [Ca2+] currents in primary cultured rat cerebrocortical neurons using whole-cell voltage-clamp recording technique2000Journal of medicinal chemistry, Sep-07, Volume: 43, Issue:18
Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity.
AID64281Concentration required for 50% inhibitory effect on Dopamine receptor D2 determined in competition experiments with [3H]raclopride2000Journal of medicinal chemistry, Sep-07, Volume: 43, Issue:18
Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity.
AID53441Tested for anticonvulsant effects on audiogenic seizures in DBA/2 mice; administered intra peritonealy2000Journal of medicinal chemistry, Sep-07, Volume: 43, Issue:18
Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity.
AID179394Concentration required for 50% inhibitory effect on automatic oxidation in plasma membrane of rat brain homogenates by measuring malondialdehyde and 4-hydroxyalkenals using peroxidized lipid colorimetric assay kit2000Journal of medicinal chemistry, Sep-07, Volume: 43, Issue:18
Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity.
AID227650Inhibition of veratridine-induced depolarization of rat cerebrocortical synaptosomes using a membrane potential sensitive fluorescent dye, rhodamine 6G2000Journal of medicinal chemistry, Sep-07, Volume: 43, Issue:18
Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (44.44)29.6817
2010's3 (33.33)24.3611
2020's2 (22.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.75

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.75 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index5.05 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.75)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]