Page last updated: 2024-12-11
sun n8075
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
SUN N8075: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 9852813 |
SCHEMBL ID | 3041578 |
MeSH ID | M0370560 |
Synonyms (8)
Synonym |
---|
SCHEMBL3041578 |
unii-dm2asgkfm4 |
sun n8075 |
sun-n 8075 |
224450-56-0 |
DM2ASGKFM4 , |
1-piperazineethanol, .alpha.-((4-amino-2,3,5-trimethylphenoxy)methyl)-4-(4-((4-fluorophenyl)methyl)phenyl)-, (.alpha.s)-, methanesulfonate (1:2) |
(2s)-1-(4-amino-2,3,5-trimethylphenoxy)-3-[4-[4-[(4-fluorophenyl)methyl]phenyl]piperazin-1-yl]propan-2-ol;methanesulfonic acid |
Research Excerpts
Overview
SUN N8075 is a novel antioxidant with neuroprotective properties.
Excerpt | Reference | Relevance |
---|---|---|
"SUN N8075 is a novel antioxidant with neuroprotective properties. " | ( Protective effects of SUN N8075, a novel agent with antioxidant properties, in in vitro and in vivo models of Parkinson's disease. Adachi, T; Hara, H; Izuta, H; Matsunaga, N; Oida, Y; Oyagi, A; Shimazawa, M, 2008) | 2.1 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (1)
Inhibition Measurements
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 (µMol) | 10.0000 | 0.0001 | 0.5494 | 8.4000 | AID64281 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Bioassays (5)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID227648 | Inhibition of low-threshold (T-type) Calcium [Ca2+] currents in primary cultured rat cerebrocortical neurons using whole-cell voltage-clamp recording technique | 2000 | Journal of medicinal chemistry, Sep-07, Volume: 43, Issue:18 | Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity. |
AID64281 | Concentration required for 50% inhibitory effect on Dopamine receptor D2 determined in competition experiments with [3H]raclopride | 2000 | Journal of medicinal chemistry, Sep-07, Volume: 43, Issue:18 | Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity. |
AID53441 | Tested for anticonvulsant effects on audiogenic seizures in DBA/2 mice; administered intra peritonealy | 2000 | Journal of medicinal chemistry, Sep-07, Volume: 43, Issue:18 | Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity. |
AID179394 | Concentration required for 50% inhibitory effect on automatic oxidation in plasma membrane of rat brain homogenates by measuring malondialdehyde and 4-hydroxyalkenals using peroxidized lipid colorimetric assay kit | 2000 | Journal of medicinal chemistry, Sep-07, Volume: 43, Issue:18 | Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity. |
AID227650 | Inhibition of veratridine-induced depolarization of rat cerebrocortical synaptosomes using a membrane potential sensitive fluorescent dye, rhodamine 6G | 2000 | Journal of medicinal chemistry, Sep-07, Volume: 43, Issue:18 | Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (9)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 4 (44.44) | 29.6817 |
2010's | 3 (33.33) | 24.3611 |
2020's | 2 (22.22) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.75
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.75) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 9 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |