vanoxerine has been researched along with Pain in 2 studies
vanoxerine: structure given in first source
vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Initial pharmacokinetics evaluation indicated an excellent brain exposure following oral dosing in mice, suggesting that further investigation into the use of alkoxyisoxazoles as σ1 ligands for antinociception is warranted." | 1.43 | Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy. ( Gao, ZB; Gunosewoyo, H; Liu, T; Pang, T; Shi, JJ; Shi, M; Sun, H; Tang, J; Xu, YZ; Yang, F; Yu, LF; Zhang, W; Zheng, YM, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, H | 1 |
| Shi, M | 1 |
| Zhang, W | 1 |
| Zheng, YM | 1 |
| Xu, YZ | 1 |
| Shi, JJ | 1 |
| Liu, T | 1 |
| Gunosewoyo, H | 1 |
| Pang, T | 1 |
| Gao, ZB | 1 |
| Yang, F | 1 |
| Tang, J | 1 |
| Yu, LF | 1 |
| Damaj, MI | 1 |
| Slemmer, JE | 1 |
| Carroll, FI | 1 |
| Martin, BR | 1 |
2 other studies available for vanoxerine and Pain
| Article | Year |
|---|---|
Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Injecti | 2016 |
Pharmacological characterization of nicotine's interaction with cocaine and cocaine analogs.
Topics: Animals; Body Temperature; Bupropion; Cocaine; Discrimination, Psychological; Female; Male; Membrane | 1999 |