nafamostat has been researched along with Pain in 3 studies
nafamostat: inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To elucidate the mechanism of propofol-induced pain on injection, we performed several studies using nafamostat mesilate, a kallikrein inhibitor, or lidocaine." | 9.09 | A potential mechanism of propofol-induced pain on injection based on studies using nafamostat mesilate. ( Iwama, H; Nakane, M, 1999) |
| "We have examined the preventative effect of nafamostat mesilate, a kallikrein inhibitor, on pain on injection with propofol in a randomized, double-blind study." | 9.08 | Nafamostat mesilate, a kallikrein inhibitor, prevents pain on injection with propofol. ( Iwama, H; Kaneko, T; Kato, M; Nakane, M; Ohmori, S; Okuaki, A; Watanabe, K, 1998) |
| "To elucidate the mechanism of propofol-induced pain on injection, we performed several studies using nafamostat mesilate, a kallikrein inhibitor, or lidocaine." | 5.09 | A potential mechanism of propofol-induced pain on injection based on studies using nafamostat mesilate. ( Iwama, H; Nakane, M, 1999) |
| "We have examined the preventative effect of nafamostat mesilate, a kallikrein inhibitor, on pain on injection with propofol in a randomized, double-blind study." | 5.08 | Nafamostat mesilate, a kallikrein inhibitor, prevents pain on injection with propofol. ( Iwama, H; Kaneko, T; Kato, M; Nakane, M; Ohmori, S; Okuaki, A; Watanabe, K, 1998) |
| "The established referred allodynia/hyperalgesia following cerulein treatment was abolished by post-treatment with nafamostat mesilate, a proteinase inhibitor, and with capsazepine, a TRPV1 antagonist, in mice." | 3.76 | The proteinase/proteinase-activated receptor-2/transient receptor potential vanilloid-1 cascade impacts pancreatic pain in mice. ( Akashi, R; Ishikura, H; Kawabata, A; Kitamura, T; Matsumura, K; Matsunami, M; Naruse, M; Nishimura, S; Sekiguchi, F; Shinozaki, Y, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nishimura, S | 1 |
| Ishikura, H | 1 |
| Matsunami, M | 1 |
| Shinozaki, Y | 1 |
| Sekiguchi, F | 1 |
| Naruse, M | 1 |
| Kitamura, T | 1 |
| Akashi, R | 1 |
| Matsumura, K | 1 |
| Kawabata, A | 1 |
| Iwama, H | 2 |
| Nakane, M | 2 |
| Ohmori, S | 1 |
| Kaneko, T | 1 |
| Kato, M | 1 |
| Watanabe, K | 1 |
| Okuaki, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Large Antecubital Vein Versus Small Vein on Dorsum of Hand for the Prevention of Propofol Injection Pain[NCT04673500] | 160 participants (Actual) | Interventional | 2013-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for nafamostat and Pain
| Article | Year |
|---|---|
Nafamostat mesilate, a kallikrein inhibitor, prevents pain on injection with propofol.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Benzamidines; Double-Blind Met | 1998 |
A potential mechanism of propofol-induced pain on injection based on studies using nafamostat mesilate.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Anesthetics, Local; Benzamidin | 1999 |
1 other study available for nafamostat and Pain
| Article | Year |
|---|---|
The proteinase/proteinase-activated receptor-2/transient receptor potential vanilloid-1 cascade impacts pancreatic pain in mice.
Topics: Acute Disease; Animals; Benzamidines; Capsaicin; Ceruletide; Disease Models, Animal; Gene Expression | 2010 |