Interleukin-6

An interleukin-6 that is encoded in the genome of human. [PRO:JAN, UniProtKB:P05231]

Synonyms

IL-6;
B-cell stimulatory factor 2;
BSF-2;
CTL differentiation factor;
CDF;
Hybridoma growth factor;
Interferon beta-2;
IFN-beta-2

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (2)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bergenin	Homo sapiens (human)	IC50	0.2080	1	1
bi 653048 bs h3po4	Homo sapiens (human)	IC50	0.0230	1	0

Enables

This protein enables 4 target(s):

Target	Category	Definition
cytokine activity	molecular function	The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. [ISBN:0198599471, PMID:11530802]
interleukin-6 receptor binding	molecular function	Binding to an interleukin-6 receptor. [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
growth factor activity	molecular function	The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. [ISBN:0815316194]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
endoplasmic reticulum lumen	cellular component	The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
interleukin-6 receptor complex	cellular component	A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130. [PMID:8083235]

Involved In

This protein is involved in 80 target(s):

Target	Category	Definition
neutrophil apoptotic process	biological process	Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. [CL:0000775, GOC:add, GOC:mtg_apoptosis, PMID:12752675, PMID:12960266]
germinal center B cell differentiation	biological process	The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA). [GOC:jal, ISBN:0781735149]
hepatic immune response	biological process	An immune response taking place in the liver. [GO_REF:0000022, GOC:jal, ISBN:0781735149]
neutrophil mediated immunity	biological process	Any process involved in the carrying out of an immune response by a neutrophil. [GO_REF:0000022, GOC:add, ISBN:0781735149]
monocyte chemotaxis	biological process	The movement of a monocyte in response to an external stimulus. [GOC:add, PMID:11696603, PMID:15173832]
positive regulation of immunoglobulin production	biological process	Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. [GOC:add]
positive regulation of acute inflammatory response	biological process	Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response. [GOC:add]
positive regulation of leukocyte chemotaxis	biological process	Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. [GOC:add]
acute-phase response	biological process	An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals. [ISBN:0198506732]
inflammatory response	biological process	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
humoral immune response	biological process	An immune response mediated through a body fluid. [GOC:hb, ISBN:0198506732]
positive regulation of cell population proliferation	biological process	Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
negative regulation of cell population proliferation	biological process	Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]
vascular endothelial growth factor production	biological process	The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:rl]
regulation of vascular endothelial growth factor production	biological process	Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor. [GOC:rl]
positive regulation of vascular endothelial growth factor production	biological process	Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor. [GOC:BHF, GOC:rl]
positive regulation of gene expression	biological process	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
positive regulation of epithelial to mesenchymal transition	biological process	Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:BHF, GOC:dph, GOC:tb]
negative regulation of lipid storage	biological process	Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. [GOC:BHF, GOC:dph, GOC:tb]
response to activity	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. [GOC:mtg_muscle]
cytokine-mediated signaling pathway	biological process	The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:19295629]
platelet activation	biological process	A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. [http://www.graylab.ac.uk/omd/]
endocrine pancreas development	biological process	The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. [GOC:cvs]
neuron projection development	biological process	The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:mah]
response to peptidoglycan	biological process	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule. [GOC:add, ISBN:0721601464]
negative regulation of chemokine production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production. [GOC:mah]
positive regulation of chemokine production	biological process	Any process that activates or increases the frequency, rate, or extent of chemokine production. [GOC:mah]
positive regulation of interleukin-1 beta production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. [GOC:mah]
positive regulation of interleukin-10 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. [GOC:mah]
positive regulation of interleukin-17 production	biological process	Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. [GOC:add, GOC:mah, PMID:16482511]
positive regulation of interleukin-21 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-21 production. [GOC:mah]
positive regulation of interleukin-6 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. [GOC:mah]
positive regulation of interleukin-8 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. [GOC:mah]
positive regulation of tumor necrosis factor production	biological process	Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. [GO_REF:0000058, GOC:TermGenie, PMID:10891884, PMID:15560120]
negative regulation of collagen biosynthetic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. [GOC:mah]
positive regulation of T cell proliferation	biological process	Any process that activates or increases the rate or extent of T cell proliferation. [GOC:ai]
positive regulation of tyrosine phosphorylation of STAT protein	biological process	Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:jl, PMID:11426647]
glucose homeostasis	biological process	Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. [GOC:go_curators]
positive regulation of apoptotic process	biological process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
negative regulation of apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
positive regulation of MAPK cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators]
negative regulation of fat cell differentiation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. [GOC:go_curators]
positive regulation of osteoblast differentiation	biological process	Any process that activates or increases the frequency, rate or extent of osteoblast differentiation. [GOC:go_curators]
positive regulation of translation	biological process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. [GOC:dph, GOC:go_curators, GOC:tb]
regulation of angiogenesis	biological process	Any process that modulates the frequency, rate or extent of angiogenesis. [GOC:go_curators]
negative regulation of bone resorption	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption. [GOC:go_curators]
positive regulation of DNA-templated transcription	biological process	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
positive regulation of receptor signaling pathway via JAK-STAT	biological process	Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity. [GOC:bf]
positive regulation of smooth muscle cell proliferation	biological process	Any process that activates or increases the rate or extent of smooth muscle cell proliferation. [CL:0000192, GOC:ebc]
negative regulation of neurogenesis	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. [GOC:ai]
regulation of insulin secretion	biological process	Any process that modulates the frequency, rate or extent of the regulated release of insulin. [GOC:ai]
defense response to Gram-negative bacterium	biological process	Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. [GOC:ai]
defense response to Gram-positive bacterium	biological process	Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. [GOC:ai]
positive regulation of B cell activation	biological process	Any process that activates or increases the frequency, rate or extent of B cell activation. [GOC:ai]
positive regulation of DNA-binding transcription factor activity	biological process	Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:ai]
response to glucocorticoid	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [GOC:ai, PMID:9884123]
defense response to virus	biological process	Reactions triggered in response to the presence of a virus that act to protect the cell or organism. [GOC:ai]
positive regulation of glial cell proliferation	biological process	Any process that activates or increases the rate or extent of glial cell proliferation. [GOC:dph, GOC:sl, GOC:tb]
T follicular helper cell differentiation	biological process	The process in which a relatively unspecialized T cell acquires specialized features of a mature T follicular helper cell. [GOC:dph, PMID:21572431]
regulation of astrocyte activation	biological process	Any process that modulates the frequency, rate or extent of astrocyte activation. [GOC:aruk, GOC:bc, PMID:20005821]
neuron cellular homeostasis	biological process	The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. [GOC:BHF, GOC:mah]
glucagon secretion	biological process	The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans). [GOC:BHF, GOC:rl]
regulation of glucagon secretion	biological process	Any process that modulates the frequency, rate or extent of the regulated release of glucagon. [GOC:BHF, GOC:mah]
interleukin-6-mediated signaling pathway	biological process	The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:add, GOC:BHF, GOC:mah, GOC:signaling]
cellular response to hydrogen peroxide	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. [CHEBI:16240, GOC:mah]
T-helper 17 cell lineage commitment	biological process	The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17. [CL:0000899, GOC:BHF, GOC:ebc]
hepatocyte proliferation	biological process	The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. [CL:0000182, GOC:BHF, GOC:mah]
positive regulation of extracellular matrix disassembly	biological process	Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. [GOC:dph, GOC:tb]
inflammatory response to wounding	biological process	The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents. [GOC:add]
liver regeneration	biological process	The regrowth of lost or destroyed liver. [GOC:gap, PMID:19447520]
cellular response to virus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. [GOC:dos]
regulation of neuroinflammatory response	biological process	Any process that modulates the frequency, rate or extent of neuroinflammatory response. [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423]
positive regulation of neuroinflammatory response	biological process	Any process that activates or increases the frequency, rate or extent of neuroinflammatory response. [GOC:aruk, GOC:bc]
positive regulation of cytokine production involved in inflammatory response	biological process	Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response. [GOC:TermGenie]
positive regulation of apoptotic DNA fragmentation	biological process	Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation. [GOC:hjd, GOC:TermGenie, PMID:15572351]
regulation of microglial cell activation	biological process	Any process that modulates the frequency, rate or extent of microglial cell activation. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
positive regulation of T-helper 2 cell cytokine production	biological process	Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production. [GOC:obol]
negative regulation of interleukin-1-mediated signaling pathway	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-1-mediated signaling pathway. [GOC:obol]
positive regulation of type B pancreatic cell apoptotic process	biological process	Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process. [GOC:mtg_apoptosis, GOC:obol]