Page last updated: 2024-11-13
bullatine a
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
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Protein Interactions
Research Growth
Description
bullatine A: isolated from Aconitum [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Related Flora
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Aconitum | genus | A plant genus of the family RANUNCULACEAE. Members contain a number of diterpenoid alkaloids including: aconitans, hypaconitine, ACONITINE, jesaconitine, ignavine, napelline, and mesaconitine. The common name of Wolfbane is similar to the common name for ARNICA.[MeSH] | Ranunculaceae | The buttercup plant family of the order RANUNCULALES, class MAGNOLIOPSIDA. The leaves are usually alternate and stalkless. The flowers usually have two to five free sepals and may be radially symmetrical or irregular.[MeSH] |
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 102004922 |
| CHEMBL ID | 4918659 |
| MeSH ID | M0592494 |
Synonyms (5)
| Synonym |
|---|
| 1354-84-3 |
| bullatine a |
| AC-35141 |
| AKOS037514572 |
| CHEMBL4918659 |
Research Excerpts
Overview
Bullatine A is a diterpenoid alkaloid of Xue-Shang-Yi-Zhi-Hao (Aconitum brachypodum) Used in traditional Chinese medicine for the treatment of rheumatism and pain.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Bullatine A is a diterpenoid alkaloid of Xue-Shang-Yi-Zhi-Hao (Aconitum brachypodum), which is widely used in traditional Chinese medicine for the treatment of rheumatism and pain. " | ( Development and validation of an LC-MS/MS method for the determination of bullatine A in rat plasma: application to a pharmacokinetic study. Niu, K; Teng, SY; Wang, SJ; Zhai, LJ; Zhang, SX, 2015) | 2.09 |
Actions
| Excerpt | Reference | Relevance |
|---|---|---|
| "Bullatine A can also inhibit the activation of PERK-elF-2α unfolded protein response (UPR), lysosome production and the increase of NLRP3 inflammasome protein expression in BV2-cells Both intragastric administration and intra-hippocampal microinjection of Bullatine A can significantly improve the despair behavior but not anhedonia of Chronic chronic social defeat stress (CSDS) mice." | ( Bullatine A has an antidepressant effect in chronic social defeat stress mice; Implication of microglial inflammasome. Li, B; Shen, ZQ; Yin, SY; Yu, J; Zhang, JR; Zhang, YQ, 2023) | 3.07 |
Pharmacokinetics
| Excerpt | Reference | Relevance |
|---|---|---|
| "In this study, the changes of bullatine A in plasma and skin of mice with time in microemulsion gel and ordinary gel of Aconitum brachypodum total alkaloids were compared through UPLC-MS/MS, and their pharmacokinetic parameters were also compared and analyzed, to investigate the feasibility of microemulsion agent in the transdermal drug delivery." | ( [Pharmacokinetics of bullatine A in Aconitum brachypodum total alkaloids gel in transdermal delivery]. Chen, XL; Dai, YJ; Liu, W; Tang, HY; Wu, YM; Yang, FF, 2016) | 1.04 |
Bioavailability
| Excerpt | Reference | Relevance |
|---|---|---|
| " The results showed that the microemulsion gel had more stable transdermal absorption, longer duration of action and higher bioavailability than ordinary gel, indicating that the microemulsion gel had a good and stable transdermal effect." | ( [Pharmacokinetics of bullatine A in Aconitum brachypodum total alkaloids gel in transdermal delivery]. Chen, XL; Dai, YJ; Liu, W; Tang, HY; Wu, YM; Yang, FF, 2016) | 0.75 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Research
Studies (7)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||