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staurosporine aglycone and Pain

staurosporine aglycone has been researched along with Pain in 5 studies

staurosporine aglycone: metabolite from culture broth of Nocardiopsis sp.; a neurotrophin antag; inhibits BDNF TrkB receptor

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
" Von Frey filament testing of somatic referral regions was evaluated as a method to measure referred pain in a rat model of acute necrotizing pancreatitis induced by L-arginine."3.72Acute pancreatitis results in referred mechanical hypersensitivity and neuropeptide up-regulation that can be suppressed by the protein kinase inhibitor k252a. ( He, ZJ; Micci, MA; Pasricha, PJ; Shenoy, M; Toma, H; Winston, JH; Xiao, SY; Zou, L, 2003)
"Heat hyperalgesia induced by peripheral injection of CFA was significantly reversed by roscovitine, TrkB-IgG, and the TrkB inhibitor K252a, respectively."1.40The BDNF/TrkB signaling pathway is involved in heat hyperalgesia mediated by Cdk5 in rats. ( Huang, JL; Lu, H; Shao, HJ; Wang, WY; Xue, QS; Yu, BW; Zhang, HH; Zhang, S; Zhang, XQ, 2014)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, HH1
Zhang, XQ1
Xue, QS1
Huang, JL1
Zhang, S1
Shao, HJ1
Lu, H1
Wang, WY1
Yu, BW1
Tao, W1
Chen, Q1
Wang, L1
Zhou, W1
Wang, Y1
Zhang, Z1
Li, YQ1
Li, H1
Wei, J1
Qu, L1
Wu, LA1
Winston, JH1
Toma, H1
Shenoy, M1
He, ZJ1
Zou, L1
Xiao, SY1
Micci, MA1
Pasricha, PJ1
Obata, K1
Yamanaka, H1
Dai, Y1
Mizushima, T1
Fukuoka, T1
Tokunaga, A1
Noguchi, K1

Other Studies

5 other studies available for staurosporine aglycone and Pain

ArticleYear
The BDNF/TrkB signaling pathway is involved in heat hyperalgesia mediated by Cdk5 in rats.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Cyclin-Dependent Kinase 5; Freund's Adjuvant

2014
Brainstem brain-derived neurotrophic factor signaling is required for histone deacetylase inhibitor-induced pain relief.
    Molecular pharmacology, 2015, Volume: 87, Issue:6

    Topics: Analgesics; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; gamma-Aminobutyric Acid; Glutama

2015
Expression changes of K+-Cl- co-transporter 2 and Na+-K+-Cl- co-transporter1 in mouse trigeminal subnucleus caudalis following pulpal inflammation.
    Brain research bulletin, 2010, Apr-05, Volume: 81, Issue:6

    Topics: Analgesics; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Dental Pulp; Dental Pulp Disease

2010
Acute pancreatitis results in referred mechanical hypersensitivity and neuropeptide up-regulation that can be suppressed by the protein kinase inhibitor k252a.
    The journal of pain, 2003, Volume: 4, Issue:6

    Topics: Animals; Arginine; Calcitonin Gene-Related Peptide; Carbazoles; Cyclic AMP-Dependent Protein Kinases

2003
Activation of extracellular signal-regulated protein kinase in the dorsal root ganglion following inflammation near the nerve cell body.
    Neuroscience, 2004, Volume: 126, Issue:4

    Topics: Animals; Behavior, Animal; Blotting, Western; Brain-Derived Neurotrophic Factor; Butadienes; Carbazo

2004