donepezil and Pain
donepezil has been researched along with Pain in 17 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "A new series of indanone and aurone derivatives have been synthesized and tested for in vitro AChE inhibitory activity by modified Ellman method." | 7.75 | Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives. ( He, Q; Hu, C; Hu, Y; Li, J; Lin, X; Sheng, R; Xu, Y; Yang, B; Zhang, J, 2009) |
| "Although gabapentin may relieve neuropathic pain by actions at many sites, these results suggest that its actions in the brain to cause spinal cholinergic activation predominate after oral administration." | 7.74 | Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. ( Eisenach, JC; Hayashida, K; Parker, R, 2007) |
| "Donepezil 5 mg was given every morning for 7 days." | 6.71 | The effect of donepezil on sedation and other symptoms in patients receiving opioids for cancer pain: a pilot study. ( Bruera, E; Burton, AW; Driver, LC; Palmer, JL; Shen, L; Strasser, F; Willey, J, 2003) |
| "Donepezil is an anti-inflammatory and neuroprotective drug that is thought to alleviate morphine tolerance." | 5.62 | Donepezil attenuates the development of morphine tolerance in rats with cancer-induced bone pain: The role of cortical N-methyl-D-aspartate receptors. ( Dong, Y; Sun, L; Wu, L; Zhang, B; Zhu, Q, 2021) |
| "Donepezil is a drug that is used to treat Alzheimer's disease." | 5.40 | A brief report on the efficacy of donepezil in pain management in Alzheimer's disease. ( Gharaei, H; Shadlou, H, 2014) |
| " Symptoms, interventions, and treatment-related adverse events addressed in this issue are management of Alzheimer's agitation with donepezil; needle-free lidocaine powder for minor painful procedures; psychostimulants in depression; anticoagulation for cancer-related venous thromboembolism; effect of waiting for acute pain treatment on risk of chronic pain; and an update on severe cutaneous reactions associated with medications." | 4.85 | Pain and palliative care pharmacotherapy literature summaries and analyses. ( Abernethy, AP; Farrell, TW, 2009) |
| "A new series of indanone and aurone derivatives have been synthesized and tested for in vitro AChE inhibitory activity by modified Ellman method." | 3.75 | Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives. ( He, Q; Hu, C; Hu, Y; Li, J; Lin, X; Sheng, R; Xu, Y; Yang, B; Zhang, J, 2009) |
| "Donepezil, a well-tolerated cholinesterase inhibitor used in the treatment of Alzheimer dementia, reduces hypersensitivity in this rat model of neuropathic pain by actions on muscarinic receptors in the spinal cord." | 3.74 | Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism. ( Childers, SR; Clayton, BA; Eisenach, JC; Hayashida, K; Xiao, R, 2007) |
| "Although gabapentin may relieve neuropathic pain by actions at many sites, these results suggest that its actions in the brain to cause spinal cholinergic activation predominate after oral administration." | 3.74 | Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. ( Eisenach, JC; Hayashida, K; Parker, R, 2007) |
| "Donepezil, an oral acetylcholinesterase inhibitor approved for the treatment of Alzheimer's disease, was given to 6 cancer pain patients having sedation related to the analgesic use of opioids." | 3.71 | Donepezil in the treatment of opioid-induced sedation: report of six cases. ( Bolton, TM; Rhiner, M; Slatkin, NE, 2001) |
| "Donepezil 5 mg was given every morning for 7 days." | 2.71 | The effect of donepezil on sedation and other symptoms in patients receiving opioids for cancer pain: a pilot study. ( Bruera, E; Burton, AW; Driver, LC; Palmer, JL; Shen, L; Strasser, F; Willey, J, 2003) |
| "Donepezil is an anti-inflammatory and neuroprotective drug that is thought to alleviate morphine tolerance." | 1.62 | Donepezil attenuates the development of morphine tolerance in rats with cancer-induced bone pain: The role of cortical N-methyl-D-aspartate receptors. ( Dong, Y; Sun, L; Wu, L; Zhang, B; Zhu, Q, 2021) |
| "Donepezil is a drug that is used to treat Alzheimer's disease." | 1.40 | A brief report on the efficacy of donepezil in pain management in Alzheimer's disease. ( Gharaei, H; Shadlou, H, 2014) |
| "Ventilatory depression is a serious side-effect of opioid analgesics." | 1.39 | Effects of cholinesterase inhibitors and serotonin-1A receptor agonists on morphine-induced ventilatory depression and antinociception in rats. ( Haji, A; Kimura, S; Ohi, Y, 2013) |
| "Remarkably, acetylcholinesterase (AChE) inhibitors that act on the brain AChE suppressed both cocaine- and morphine-induced conditioned place preference and blocked the induction and persistence of cocaine-evoked hyperlocomotion." | 1.32 | Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine. ( Hikida, T; Kitabatake, Y; Nakanishi, S; Pastan, I, 2003) |
Research
Studies (17)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (52.94) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Sheng, R | 1 |
| Xu, Y | 1 |
| Hu, C | 1 |
| Zhang, J | 1 |
| Lin, X | 1 |
| Li, J | 1 |
| Yang, B | 1 |
| He, Q | 1 |
| Hu, Y | 1 |
| Al-Rifai, NM | 1 |
| Al-Khalileh, NM | 1 |
| Zahra, JA | 1 |
| El-Barghouthi, MI | 1 |
| Darras, FH | 1 |
| Zhang, B | 1 |
| Wu, L | 1 |
| Zhu, Q | 1 |
| Dong, Y | 1 |
| Sun, L | 1 |
| Kimura, S | 1 |
| Ohi, Y | 1 |
| Haji, A | 1 |
| Gharaei, H | 1 |
| Shadlou, H | 1 |
| Boyle, Y | 1 |
| Fernando, D | 1 |
| Kurz, H | 1 |
| Miller, SR | 1 |
| Zucchetto, M | 1 |
| Storey, J | 1 |
| Shafie, A | 1 |
| Moradi, F | 1 |
| Izadpanah, E | 1 |
| Mokarizadeh, A | 1 |
| Moloudi, MR | 1 |
| Nikzaban, M | 1 |
| Hassanzadeh, K | 1 |
| Matias, M | 1 |
| Silvestre, S | 1 |
| Falcao, A | 1 |
| Alves, G | 1 |
| Gawel, K | 1 |
| Gibula-Bruzda, E | 1 |
| Dziedzic, M | 1 |
| Jenda-Wojtanowska, M | 1 |
| Marszalek-Grabska, M | 1 |
| Silberring, J | 1 |
| Kotlinska, JH | 1 |
| Hayashida, K | 3 |
| Eisenach, JC | 3 |
| Abernethy, AP | 1 |
| Farrell, TW | 1 |
| Hikida, T | 1 |
| Kitabatake, Y | 1 |
| Pastan, I | 1 |
| Nakanishi, S | 1 |
| Bruera, E | 1 |
| Strasser, F | 1 |
| Shen, L | 1 |
| Palmer, JL | 1 |
| Willey, J | 1 |
| Driver, LC | 1 |
| Burton, AW | 1 |
| Kuloor, CB | 1 |
| Puranik, A | 1 |
| Clayton, BA | 1 |
| Childers, SR | 1 |
| Xiao, R | 1 |
| Parker, R | 1 |
| Slatkin, NE | 1 |
| Rhiner, M | 1 |
| Bolton, TM | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double Blind, Placebo Controlled Study to Investigate the Effect of Donepezil and Gabapentin Combination on an Experimental Pain Model in Healthy Subjects[NCT01485185] | Phase 1 | 48 participants (Actual) | Interventional | 2011-10-11 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
2 reviews available for donepezil and Pain
| Article | Year |
|---|---|
Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders.
Topics: Analgesics; Central Nervous System Diseases; Choline; Donepezil; Epilepsy; gamma-Aminobutyric Acid; | 2017 |
Pain and palliative care pharmacotherapy literature summaries and analyses.
Topics: Alzheimer Disease; Amphetamines; Anesthetics, Local; Anticoagulants; Antidepressive Agents; Depressi | 2009 |
Trials
2 trials available for donepezil and Pain
| Article | Year |
|---|---|
The effect of a combination of gabapentin and donepezil in an experimental pain model in healthy volunteers: Results of a randomized controlled trial.
Topics: Adolescent; Adult; Amines; Analgesics, Non-Narcotic; Cross-Over Studies; Cyclohexanecarboxylic Acids | 2014 |
The effect of donepezil on sedation and other symptoms in patients receiving opioids for cancer pain: a pilot study.
Topics: Adult; Aged; Analgesics, Opioid; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neoplasms; No | 2003 |
Other Studies
13 other studies available for donepezil and Pain
| Article | Year |
|---|---|
Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives.
Topics: Animals; Benzofurans; Cholinesterase Inhibitors; Drug Design; Indans; Memory; Mice; Pain; Structure- | 2009 |
Synthesis, biological evaluation, and computational studies of
Topics: Acetylcholinesterase; Alzheimer Disease; Antioxidants; Cholinesterase Inhibitors; Curcumin; Donepezi | 2023 |
Donepezil attenuates the development of morphine tolerance in rats with cancer-induced bone pain: The role of cortical N-methyl-D-aspartate receptors.
Topics: Analgesics, Opioid; Animals; Cancer Pain; Donepezil; Drug Tolerance; Morphine; Neuroprotective Agent | 2021 |
Effects of cholinesterase inhibitors and serotonin-1A receptor agonists on morphine-induced ventilatory depression and antinociception in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesia; Animals; Buspirone; Cholinesterase Inhibitors; Do | 2013 |
A brief report on the efficacy of donepezil in pain management in Alzheimer's disease.
Topics: Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; | 2014 |
Neuroprotection of donepezil against morphine-induced apoptosis is mediated through Toll-like receptors.
Topics: Analgesics, Opioid; Animals; Apoptosis; bcl-2-Associated X Protein; Donepezil; Drug Tolerance; Front | 2015 |
Cholinergic activation affects the acute and chronic antinociceptive effects of morphine.
Topics: Acetylcholine; Analgesics, Opioid; Analysis of Variance; Animals; Area Under Curve; Cholinesterase I | 2017 |
Multiplicative interactions to enhance gabapentin to treat neuropathic pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Donepezil; Dose-Response Relationship, Dru | 2008 |
Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine.
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Cocaine; Cocaine-Related Disorders; Conditioning, | 2003 |
Pain with donepezil.
Topics: Aged, 80 and over; Alzheimer Disease; Caregivers; Donepezil; Female; Humans; Indans; Nootropic Agent | 2006 |
Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism.
Topics: Administration, Oral; Animals; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Dru | 2007 |
Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil.
Topics: Administration, Oral; Amines; Analgesics; Animals; Cholinesterase Inhibitors; Cyclohexanecarboxylic | 2007 |
Donepezil in the treatment of opioid-induced sedation: report of six cases.
Topics: Adult; Aged; Analgesics, Opioid; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; | 2001 |