Page last updated: 2024-10-26

donepezil and Pain

donepezil has been researched along with Pain in 17 studies

Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"A new series of indanone and aurone derivatives have been synthesized and tested for in vitro AChE inhibitory activity by modified Ellman method."7.75Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives. ( He, Q; Hu, C; Hu, Y; Li, J; Lin, X; Sheng, R; Xu, Y; Yang, B; Zhang, J, 2009)
"Although gabapentin may relieve neuropathic pain by actions at many sites, these results suggest that its actions in the brain to cause spinal cholinergic activation predominate after oral administration."7.74Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. ( Eisenach, JC; Hayashida, K; Parker, R, 2007)
"Donepezil 5 mg was given every morning for 7 days."6.71The effect of donepezil on sedation and other symptoms in patients receiving opioids for cancer pain: a pilot study. ( Bruera, E; Burton, AW; Driver, LC; Palmer, JL; Shen, L; Strasser, F; Willey, J, 2003)
"Donepezil is an anti-inflammatory and neuroprotective drug that is thought to alleviate morphine tolerance."5.62Donepezil attenuates the development of morphine tolerance in rats with cancer-induced bone pain: The role of cortical N-methyl-D-aspartate receptors. ( Dong, Y; Sun, L; Wu, L; Zhang, B; Zhu, Q, 2021)
"Donepezil is a drug that is used to treat Alzheimer's disease."5.40A brief report on the efficacy of donepezil in pain management in Alzheimer's disease. ( Gharaei, H; Shadlou, H, 2014)
" Symptoms, interventions, and treatment-related adverse events addressed in this issue are management of Alzheimer's agitation with donepezil; needle-free lidocaine powder for minor painful procedures; psychostimulants in depression; anticoagulation for cancer-related venous thromboembolism; effect of waiting for acute pain treatment on risk of chronic pain; and an update on severe cutaneous reactions associated with medications."4.85Pain and palliative care pharmacotherapy literature summaries and analyses. ( Abernethy, AP; Farrell, TW, 2009)
"A new series of indanone and aurone derivatives have been synthesized and tested for in vitro AChE inhibitory activity by modified Ellman method."3.75Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives. ( He, Q; Hu, C; Hu, Y; Li, J; Lin, X; Sheng, R; Xu, Y; Yang, B; Zhang, J, 2009)
"Donepezil, a well-tolerated cholinesterase inhibitor used in the treatment of Alzheimer dementia, reduces hypersensitivity in this rat model of neuropathic pain by actions on muscarinic receptors in the spinal cord."3.74Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism. ( Childers, SR; Clayton, BA; Eisenach, JC; Hayashida, K; Xiao, R, 2007)
"Although gabapentin may relieve neuropathic pain by actions at many sites, these results suggest that its actions in the brain to cause spinal cholinergic activation predominate after oral administration."3.74Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. ( Eisenach, JC; Hayashida, K; Parker, R, 2007)
"Donepezil, an oral acetylcholinesterase inhibitor approved for the treatment of Alzheimer's disease, was given to 6 cancer pain patients having sedation related to the analgesic use of opioids."3.71Donepezil in the treatment of opioid-induced sedation: report of six cases. ( Bolton, TM; Rhiner, M; Slatkin, NE, 2001)
"Donepezil 5 mg was given every morning for 7 days."2.71The effect of donepezil on sedation and other symptoms in patients receiving opioids for cancer pain: a pilot study. ( Bruera, E; Burton, AW; Driver, LC; Palmer, JL; Shen, L; Strasser, F; Willey, J, 2003)
"Donepezil is an anti-inflammatory and neuroprotective drug that is thought to alleviate morphine tolerance."1.62Donepezil attenuates the development of morphine tolerance in rats with cancer-induced bone pain: The role of cortical N-methyl-D-aspartate receptors. ( Dong, Y; Sun, L; Wu, L; Zhang, B; Zhu, Q, 2021)
"Donepezil is a drug that is used to treat Alzheimer's disease."1.40A brief report on the efficacy of donepezil in pain management in Alzheimer's disease. ( Gharaei, H; Shadlou, H, 2014)
"Ventilatory depression is a serious side-effect of opioid analgesics."1.39Effects of cholinesterase inhibitors and serotonin-1A receptor agonists on morphine-induced ventilatory depression and antinociception in rats. ( Haji, A; Kimura, S; Ohi, Y, 2013)
"Remarkably, acetylcholinesterase (AChE) inhibitors that act on the brain AChE suppressed both cocaine- and morphine-induced conditioned place preference and blocked the induction and persistence of cocaine-evoked hyperlocomotion."1.32Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine. ( Hikida, T; Kitabatake, Y; Nakanishi, S; Pastan, I, 2003)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (52.94)29.6817
2010's6 (35.29)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Sheng, R1
Xu, Y1
Hu, C1
Zhang, J1
Lin, X1
Li, J1
Yang, B1
He, Q1
Hu, Y1
Al-Rifai, NM1
Al-Khalileh, NM1
Zahra, JA1
El-Barghouthi, MI1
Darras, FH1
Zhang, B1
Wu, L1
Zhu, Q1
Dong, Y1
Sun, L1
Kimura, S1
Ohi, Y1
Haji, A1
Gharaei, H1
Shadlou, H1
Boyle, Y1
Fernando, D1
Kurz, H1
Miller, SR1
Zucchetto, M1
Storey, J1
Shafie, A1
Moradi, F1
Izadpanah, E1
Mokarizadeh, A1
Moloudi, MR1
Nikzaban, M1
Hassanzadeh, K1
Matias, M1
Silvestre, S1
Falcao, A1
Alves, G1
Gawel, K1
Gibula-Bruzda, E1
Dziedzic, M1
Jenda-Wojtanowska, M1
Marszalek-Grabska, M1
Silberring, J1
Kotlinska, JH1
Hayashida, K3
Eisenach, JC3
Abernethy, AP1
Farrell, TW1
Hikida, T1
Kitabatake, Y1
Pastan, I1
Nakanishi, S1
Bruera, E1
Strasser, F1
Shen, L1
Palmer, JL1
Willey, J1
Driver, LC1
Burton, AW1
Kuloor, CB1
Puranik, A1
Clayton, BA1
Childers, SR1
Xiao, R1
Parker, R1
Slatkin, NE1
Rhiner, M1
Bolton, TM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double Blind, Placebo Controlled Study to Investigate the Effect of Donepezil and Gabapentin Combination on an Experimental Pain Model in Healthy Subjects[NCT01485185]Phase 148 participants (Actual)Interventional2011-10-11Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for donepezil and Pain

ArticleYear
Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders.
    Mini reviews in medicinal chemistry, 2017, Volume: 17, Issue:6

    Topics: Analgesics; Central Nervous System Diseases; Choline; Donepezil; Epilepsy; gamma-Aminobutyric Acid;

2017
Pain and palliative care pharmacotherapy literature summaries and analyses.
    Journal of pain & palliative care pharmacotherapy, 2009, Volume: 23, Issue:1

    Topics: Alzheimer Disease; Amphetamines; Anesthetics, Local; Anticoagulants; Antidepressive Agents; Depressi

2009

Trials

2 trials available for donepezil and Pain

ArticleYear
The effect of a combination of gabapentin and donepezil in an experimental pain model in healthy volunteers: Results of a randomized controlled trial.
    Pain, 2014, Volume: 155, Issue:12

    Topics: Adolescent; Adult; Amines; Analgesics, Non-Narcotic; Cross-Over Studies; Cyclohexanecarboxylic Acids

2014
The effect of donepezil on sedation and other symptoms in patients receiving opioids for cancer pain: a pilot study.
    Journal of pain and symptom management, 2003, Volume: 26, Issue:5

    Topics: Adult; Aged; Analgesics, Opioid; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neoplasms; No

2003

Other Studies

13 other studies available for donepezil and Pain

ArticleYear
Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:1

    Topics: Animals; Benzofurans; Cholinesterase Inhibitors; Drug Design; Indans; Memory; Mice; Pain; Structure-

2009
Synthesis, biological evaluation, and computational studies of
    Journal of enzyme inhibition and medicinal chemistry, 2023, Volume: 38, Issue:1

    Topics: Acetylcholinesterase; Alzheimer Disease; Antioxidants; Cholinesterase Inhibitors; Curcumin; Donepezi

2023
Donepezil attenuates the development of morphine tolerance in rats with cancer-induced bone pain: The role of cortical N-methyl-D-aspartate receptors.
    Neuroscience letters, 2021, 03-16, Volume: 747

    Topics: Analgesics, Opioid; Animals; Cancer Pain; Donepezil; Drug Tolerance; Morphine; Neuroprotective Agent

2021
Effects of cholinesterase inhibitors and serotonin-1A receptor agonists on morphine-induced ventilatory depression and antinociception in rats.
    European journal of pharmacology, 2013, Mar-05, Volume: 703, Issue:1-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesia; Animals; Buspirone; Cholinesterase Inhibitors; Do

2013
A brief report on the efficacy of donepezil in pain management in Alzheimer's disease.
    Journal of pain & palliative care pharmacotherapy, 2014, Volume: 28, Issue:1

    Topics: Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans;

2014
Neuroprotection of donepezil against morphine-induced apoptosis is mediated through Toll-like receptors.
    European journal of pharmacology, 2015, Oct-05, Volume: 764

    Topics: Analgesics, Opioid; Animals; Apoptosis; bcl-2-Associated X Protein; Donepezil; Drug Tolerance; Front

2015
Cholinergic activation affects the acute and chronic antinociceptive effects of morphine.
    Physiology & behavior, 2017, 02-01, Volume: 169

    Topics: Acetylcholine; Analgesics, Opioid; Analysis of Variance; Animals; Area Under Curve; Cholinesterase I

2017
Multiplicative interactions to enhance gabapentin to treat neuropathic pain.
    European journal of pharmacology, 2008, Nov-19, Volume: 598, Issue:1-3

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Donepezil; Dose-Response Relationship, Dru

2008
Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, May-13, Volume: 100, Issue:10

    Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Cocaine; Cocaine-Related Disorders; Conditioning,

2003
Pain with donepezil.
    Age and ageing, 2006, Volume: 35, Issue:6

    Topics: Aged, 80 and over; Alzheimer Disease; Caregivers; Donepezil; Female; Humans; Indans; Nootropic Agent

2006
Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism.
    Anesthesiology, 2007, Volume: 106, Issue:5

    Topics: Administration, Oral; Animals; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Dru

2007
Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil.
    Anesthesiology, 2007, Volume: 106, Issue:6

    Topics: Administration, Oral; Amines; Analgesics; Animals; Cholinesterase Inhibitors; Cyclohexanecarboxylic

2007
Donepezil in the treatment of opioid-induced sedation: report of six cases.
    Journal of pain and symptom management, 2001, Volume: 21, Issue:5

    Topics: Adult; Aged; Analgesics, Opioid; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male;

2001