Compounds > pd 135158
Page last updated: 2024-09-25

pd 135158

Description

PD 135158: selective cholecystokinin type B receptor agonist; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID146156889
MeSH IDM0180349

Synonyms (3)

Synonym
cam 1028
pd 135158
130325-35-8

Research

Studies (50)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's40 (80.00)18.2507
2000's10 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other51 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
sincalide[no description available]medium140oligopeptide
proglumide[no description available]medium130benzamides;
dicarboxylic acid monoamide;
glutamine derivative;
racemate		anti-ulcer drug;
cholecystokinin antagonist;
cholinergic antagonist;
delta-opioid receptor agonist;
drug metabolite;
gastrointestinal drug;
opioid analgesic;
xenobiotic metabolite
tetrodotoxin[no description available]medium10azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid		animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker
atropine[no description available]medium10
meglumine[no description available]medium510hexosamine;
secondary amino compound
lorglumide[no description available]medium110benzamides;
dicarboxylic acid monoamide;
dichlorobenzene;
glutamic acid derivative
pd 140548[no description available]medium20
eticlopride[no description available]medium10salicylamides
cholecystokinin[no description available]medium200
cholecystokinin 9[no description available]medium10
sr 27897[no description available]medium20indolyl carboxylic acid
thiazoles[no description available]medium201,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
gastrins[no description available]medium80
diazepam[no description available]medium201,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic
sucrose[no description available]medium10glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
phencyclidine[no description available]medium10benzenes;
piperidines		anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug
devazepide[no description available]medium901,4-benzodiazepinone;
indolecarboxamide		antineoplastic agent;
apoptosis inducer;
cholecystokinin antagonist;
gastrointestinal drug
ci 988[no description available]medium60
l 365260[no description available]medium80benzodiazepine
gastrin 17[no description available]medium30gastrinantineoplastic agent
pd 136450[no description available]medium20
enkephalin, leucine[no description available]medium30pentapeptide;
peptide zwitterion		analgesic;
delta-opioid receptor agonist;
human metabolite;
mu-opioid receptor agonist;
neurotransmitter;
rat metabolite
medetomidine[no description available]medium10imidazoles
morphine[no description available]medium60morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
enkephalin, ala(2)-mephe(4)-gly(5)-[no description available]medium20
loxiglumide[no description available]medium20organic molecular entity
1-anilino-8-naphthalenesulfonate[no description available]medium10aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
tetragastrin[no description available]medium20peptidyl amide;
tetrapeptide		anxiogenic;
human metabolite
gamma-aminobutyric acid[no description available]medium20amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
beta-alanine[no description available]medium10amino acid zwitterion;
beta-amino acid		agonist;
fundamental metabolite;
human metabolite;
inhibitor;
neurotransmitter
benzotript[no description available]medium30
beta-endorphin[no description available]medium10
enkephalin, d-penicillamine (2,5)-[no description available]medium20heterodetic cyclic peptidedelta-opioid receptor agonist
u-50488[no description available]medium10dichlorobenzene;
monocarboxylic acid amide;
N-alkylpyrrolidine		analgesic;
antitussive;
calcium channel blocker;
diuretic;
kappa-opioid receptor agonist
fura-2[no description available]medium10
1,2-bis(2-aminophenoxy)ethane-n,n,n',n'-tetraacetic acid[no description available]medium10polyamino carboxylic acid;
tetracarboxylic acid		chelator
egtazic acid[no description available]medium10diether;
tertiary amino compound;
tetracarboxylic acid		chelator
pentagastrin[no description available]medium10organic molecular entity
1-(4-bromophenylaminocarbonyl)-4,5-diphenyl-3-pyrazolidinone[no description available]medium10
l 740093[no description available]medium10
3,4-dihydroxyphenylacetic acid[no description available]medium10catechols;
dihydroxyphenylacetic acid		human metabolite
pentobarbital[no description available]medium10barbituratesGABAA receptor agonist
n-methylaspartate[no description available]medium10amino dicarboxylic acid;
D-alpha-amino acid;
D-aspartic acid derivative;
secondary amino compound		neurotransmitter agent
glycine[no description available]medium10alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
alanine[no description available]medium10alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
taurine[no description available]medium10amino sulfonic acid;
zwitterion		antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite
glutamic acid[no description available]medium10glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
dynorphins[no description available]medium10
enkephalin, ser(2), leu(5), thr(6)-[no description available]medium10oligopeptide
neurotensin[no description available]medium10peptide hormonehuman metabolite;
mitogen;
neurotransmitter;
vulnerary
naloxone[no description available]medium10morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol		antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist
ym 022[no description available]medium10
haloperidol[no description available]medium10aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
lamotrigine[no description available]medium101,2,4-triazines;
dichlorobenzene;
primary arylamine		anticonvulsant;
antidepressant;
antimanic drug;
calcium channel blocker;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
excitatory amino acid antagonist;
geroprotector;
non-narcotic analgesic;
xenobiotic
sorbitol[no description available]medium10glucitolcathartic;
Escherichia coli metabolite;
food humectant;
human metabolite;
laxative;
metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite;
sweetening agent
ConditionIndicatedRelationship StrengthStudiesTrials
Absence Seizure0low10
Absence Seizures0low10
Ache0low20
Active Hyperemia0low10
Acute Post-Traumatic Stress Disorder0low20
Alcohol Abuse0low10
Alcohol Addiction0low10
Alcohol Dependence0low10
Alcohol Drinking0low20
Alcohol Use Disorder0low10
Alcoholic Intoxication, Chronic0low10
Alcoholism0low10
Allodynia0low10
Allodynia, Mechanical0low10
Allodynia, Tactile0low10
Allodynia, Thermal0low10
Anxiety0low90
Arterial Hyperemia0low10
Atonic Absence Seizure0low10
Atonic Absence Seizures0low10
Atonic Seizure0low10
Atonic Seizures0low10
Bilateral Wilms Tumor0low10
Bovine Diseases0low10
Cancer of Kidney0low10
Cancer of the Kidney0low10
Cattle Diseases0low10
Chronic Post-Traumatic Stress Disorder0low20
Clonic Seizure0low10
Clonic Seizures0low10
Cognition Disorders0low10
Complex Partial Seizure0low10
Complex Partial Seizures0low10
Convulsion0low10
Convulsion, Non-Epileptic0low10
Convulsions0low10
Convulsive Seizure0low10
Convulsive Seizures0low10
Delayed Onset Post-Traumatic Stress Disorder0low20
Dementia Praecox0low10
Disease Models, Animal0low20
Drug Withdrawal Symptoms0low30
Epileptic Seizure0low10
Epileptic Seizures0low10
Ethanol Abuse0low10
Experimental Hepatoma0low10
Experimental Hepatomas0low10
Experimental Liver Neoplasms0low10
Generalized Absence Seizure0low10
Generalized Absence Seizures0low10
Generalized Tonic-Clonic Seizures0low10
Hepatoma, Experimental0low10
Hepatoma, Morris0low10
Hepatoma, Novikoff0low10
Hepatomas, Experimental0low10
Hyperactivity, Motor0low10
Hyperalgesia0low10
Hyperalgesia, Mechanical0low10
Hyperalgesia, Primary0low10
Hyperalgesia, Secondary0low10
Hyperalgesia, Tactile0low10
Hyperalgesia, Thermal0low10
Hyperalgesic Sensations0low10
Hyperalgia0low10
Hyperalgia, Mechanical0low10
Hyperalgia, Primary0low10
Hyperalgia, Secondary0low10
Hyperemia0low10
Hyperkinesia0low10
Hyperkinesia, Generalized0low10
Hyperkinesis0low10
Hyperkinetic Movements0low10
Inflammation0low10
Innate Inflammatory Response0low10
Jacksonian Seizure0low10
Kidney Cancer0low10
Kidney Neoplasms0low10
Liver Neoplasms, Experimental0low10
Mechanical Allodynia0low10
Mechanical Hyperalgesia0low10
Moral Injury0low20
Muscle Contraction0low20
Myoclonic Seizure0low10
Myoclonic Seizures0low10
Neoplasms, Experimental Liver0low10
Neoplasms, Kidney0low10
Nephroblastoma0low10
Neuroses, Post-Traumatic0low20
Neuroses, Posttraumatic0low20
Non-Epileptic Seizure0low10
Non-Epileptic Seizures0low10
Nonepileptic Seizure0low10
Nonepileptic Seizures0low10
Overinclusion0low10
Pain0low20
Pain, Burning0low20
Pain, Crushing0low20
Pain, Migratory0low20
Pain, Radiating0low20
Pain, Splitting0low20
Panic Attacks0low20
Panic Disorder0low20
Partial Seizure0low10
Partial Seizures0low10
Passive Hyperemia0low10
Peripheral Nerve Diseases0low10
Peripheral Nervous System Disease0low10
Peripheral Nervous System Diseases0low10
Peripheral Nervous System Disorders0low10
Peripheral Neuropathies0low10
Petit Mal Convulsion0low10
PNS (Peripheral Nervous System) Diseases0low10
PNS Diseases0low10
Post Traumatic Stress Disorder0low20
Post-Traumatic Stress Disorders0low20
Posttraumatic Stress Disorders0low20
PTSD0low20
Reactive Hyperemia0low10
Renal Cancer0low10
Renal Neoplasms0low10
Schizophrenia0low10
Schizophrenic Disorders0low10
Seizure0low10
Seizures0low10
Seizures, Auditory0low10
Seizures, Clonic0low10
Seizures, Convulsive0low10
Seizures, Epileptic0low10
Seizures, Focal0low10
Seizures, Generalized0low10
Seizures, Gustatory0low10
Seizures, Motor0low10
Seizures, Olfactory0low10
Seizures, Sensory0low10
Seizures, Somatosensory0low10
Seizures, Tonic0low10
Seizures, Tonic-Clonic0low10
Seizures, Vertiginous0low10
Seizures, Vestibular0low10
Seizures, Visual0low10
Single Seizure0low10
Stress Disorder, Post Traumatic0low20
Stress Disorders, Post-Traumatic0low20
Stress Disorders, Posttraumatic0low20
Substance Withdrawal Syndrome0low30
Suffering, Physical0low20
Tactile Allodynia0low10
Thermal Allodynia0low10
Tonic Clonic Seizure0low10
Tonic Seizure0low10
Tonic Seizures0low10
Tonic-Clonic Seizure0low10
Tonic-Clonic Seizures0low10
Venous Congestion0low10
Venous Engorgement0low10
Wilms Tumor0low10
Wilms Tumor 10low10
Wilms' Tumor0low10
Withdrawal Symptoms0low30

Research Highlights

Long-term Use (1)

ArticleYear
Inhibition of gastric emptying and intestinal transit by amphetamine through a mechanism involving an increased secretion of CCK in male rats.
British journal of pharmacology, Volume: 124, Issue: 6		1998
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (3)

ArticleYear
Supraspinal neurotensin-induced antianalgesia in mice is mediated by spinal cholecystokinin.
Japanese journal of pharmacology, Volume: 79, Issue: 2		1999
Antianalgesic action of dynorphin A mediated by spinal cholecystokinin.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), Volume: 220, Issue: 3		1999
Pentobarbital antagonism of morphine analgesia mediated by spinal cholecystokinin.
The Journal of pharmacology and experimental therapeutics, Volume: 284, Issue: 3		1998
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]