| Assay ID | Title | Year | Journal | Article |
|---|
| AID235352 | Selectivity ratio (Ki value towards kappa receptor compared to that of delta receptor). | 2002 | Journal of medicinal chemistry, Nov-21, Volume: 45, Issue:24
| Synthesis and biological evaluation of 14-alkoxymorphinans. 17. Highly delta opioid receptor selective 14-alkoxy-substituted indolo- and benzofuromorphinans. |
| AID310938 | Agonist activity at rat delta opioid receptor expressed in C6 cells assessed as stimulation of [35S]GTP-gamma-S binding relative to BW373U86 | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Quantitative conformationally sampled pharmacophore for delta opioid ligands: reevaluation of hydrophobic moieties essential for biological activity. |
| AID152379 | Displacement of [3H]DAMGO at mu-opioid receptor | 2001 | Journal of medicinal chemistry, Apr-26, Volume: 44, Issue:9
| Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy. |
| AID148220 | Displacement of [3H]C1-DPDPE from human recombinant Opioid receptor delta 1 on CHO cell membranes. | 2003 | Journal of medicinal chemistry, Apr-10, Volume: 46, Issue:8
| 14-amino, 14-alkylamino, and 14-acylamino analogs of oxymorphindole. Differential effects on opioid receptor binding and functional profiles. |
| AID147964 | Opioid receptor kappa antagonistic activity was measured by the displacement of ethylketazocine in the guinea pig ileum at a concentration of 100 nM | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. |
| AID132269 | The compound was evaluated for antinociceptive potency using abdominal stretch assay in mice. | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Opioid agonist and antagonist activities of morphindoles related to naltrindole. |
| AID148693 | Opioid receptor kappa 1 antagonistic activity was measured by the displacement of ethylketazocine in the guinea pig ileum at a concentration of 100 nM | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. |
| AID234369 | Selectivity ratio (mu opioid receptors vs. delta opioid receptors). | 2001 | Journal of medicinal chemistry, Apr-26, Volume: 44, Issue:9
| Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy. |
| AID148662 | Opioid receptor delta 1 antagonistic activity was measured by the displacement of DADLE in the mouse vas deferens at a concentration of 100 nM | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. |
| AID309548 | Antinociceptive effect in mouse at 30 mg/kg by morphine assay | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21
| 5'-halogenated analogs of oxymorphindole. |
| AID149937 | Opioid receptor delta 1 binding affinity was determined by inhibition of binding of [3H]DADLE to rat brain membrane | 2002 | Journal of medicinal chemistry, Nov-21, Volume: 45, Issue:24
| Synthesis and biological evaluation of 14-alkoxymorphinans. 17. Highly delta opioid receptor selective 14-alkoxy-substituted indolo- and benzofuromorphinans. |
| AID149544 | Binding affinity at kappa opioid receptor 1 in guinea pig brain by [3H]U-69593 displacement. | 2002 | Journal of medicinal chemistry, Nov-21, Volume: 45, Issue:24
| Synthesis and biological evaluation of 14-alkoxymorphinans. 17. Highly delta opioid receptor selective 14-alkoxy-substituted indolo- and benzofuromorphinans. |
| AID309544 | Selectivity for delta opioid receptor over mu opioid receptor | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21
| 5'-halogenated analogs of oxymorphindole. |
| AID147987 | Displacement of [3H]U-69593 from human recombinant Opioid receptor kappa 1 on CHO cell membranes. | 2003 | Journal of medicinal chemistry, Apr-10, Volume: 46, Issue:8
| 14-amino, 14-alkylamino, and 14-acylamino analogs of oxymorphindole. Differential effects on opioid receptor binding and functional profiles. |
| AID148998 | Opioid receptor mu antagonistic activity was measured by the displacement of morphine in the guinea pig ileum at a concentration of 100 nM | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. |
| AID148835 | Antagonist potency was determined as the ratio of [antagonist] to (IC50 ratio-1) for Opioid receptor kappa 1 | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. |
| AID149279 | Binding affinity was measured by the displacement of [3H]- EK in guinea pig brain membrane of Opioid receptor kappa 1 | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. |
| AID147978 | Binding affinity was measured by the displacement of [3H]- EK in guinea pig brain membrane of opioid receptor kappa | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. |
| AID148040 | Binding affinity was measured by the displacement of [3H]- DAMGO in guinea pig brain membrane of Opioid receptor mu 1 | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. |
| AID151151 | Binding affinity against Opioid receptor mu 1 using [3H][D-Ala2, MePhe4, Gly-ol5]-enkephalin as radioligand | 1997 | Journal of medicinal chemistry, Sep-26, Volume: 40, Issue:20
| Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept. |
| AID149074 | Binding affinity against Opioid receptor delta 1 using [3H][D-Ala2, D-Leu5]-enkephalin as radioligand | 1997 | Journal of medicinal chemistry, Sep-26, Volume: 40, Issue:20
| Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept. |
| AID309546 | Antinociceptive effect in mouse at 30 mg/kg by hot plate assay | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21
| 5'-halogenated analogs of oxymorphindole. |
| AID76531 | Antagonistic activity against EK in guinea pig ileal longitudinal muscle (GPI) | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Opioid agonist and antagonist activities of morphindoles related to naltrindole. |
| AID76532 | Antagonistic activity against morphine in guinea pig ileal longitudinal muscle (GPI) | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Opioid agonist and antagonist activities of morphindoles related to naltrindole. |
| AID150043 | The compound was evaluated for binding affinity against Opioid receptor delta 1 in guinea pig brain membrane using [3H]- DPDPE as ligand | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Opioid agonist and antagonist activities of morphindoles related to naltrindole. |
| AID149011 | Binding affinity was measured by the displacement of [3H]- DAMGO in guinea pig brain membrane of opioid receptor mu | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. |
| AID309542 | Displacement of [3H]p-Cl-DPDPE from delta opioid receptor | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21
| 5'-halogenated analogs of oxymorphindole. |
| AID147839 | Selectivity for kappa to delta opioid receptors was determined | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Opioid agonist and antagonist activities of morphindoles related to naltrindole. |
| AID395145 | Binding affinity to delta opioid receptor in rat brain membrane | 2008 | European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
| Ligand binding to nucleic acids and proteins: Does selectivity increase with strength? |
| AID148810 | Antagonist potency was determined as the ratio of [antagonist] to (IC50 ratio-1) for opioid receptor delta 1 | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. |
| AID309541 | Displacement of [3H]DAMGO from mu opioid receptor | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21
| 5'-halogenated analogs of oxymorphindole. |
| AID148102 | The compound was evaluated for binding affinity against the opioid receptor kappa in guinea pig brain membranes using [3H]- U-69,593 | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Opioid agonist and antagonist activities of morphindoles related to naltrindole. |
| AID395146 | Ratio of Ki for kappa opioid receptor in rat brain membrane to Ki for mu opioid receptor in rat brain membrane | 2008 | European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
| Ligand binding to nucleic acids and proteins: Does selectivity increase with strength? |
| AID309543 | Displacement of [3H]U-69593 from cloned kappa opioid receptor | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21
| 5'-halogenated analogs of oxymorphindole. |
| AID149907 | Binding affinity was measured by the displacement of [3H]- DADLE in guinea pig brain membrane of Opioid receptor delta 1 | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. |
| AID132874 | Antagonistic activity against morphine in smooth muscle preparation (MVD) | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Opioid agonist and antagonist activities of morphindoles related to naltrindole. |
| AID233862 | Selectivity between mu opioid receptor and delta opioid receptor. | 2003 | Journal of medicinal chemistry, Apr-10, Volume: 46, Issue:8
| 14-amino, 14-alkylamino, and 14-acylamino analogs of oxymorphindole. Differential effects on opioid receptor binding and functional profiles. |
| AID233684 | Selectivity ratio of the affinity for kappa and delta opioid receptors (Ki mu/Ki delta) | 1997 | Journal of medicinal chemistry, Sep-26, Volume: 40, Issue:20
| Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept. |
| AID148317 | Binding affinity against Opioid receptor kappa 1 using [3H]-U-69,593 as radioligand | 1997 | Journal of medicinal chemistry, Sep-26, Volume: 40, Issue:20
| Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept. |
| AID395144 | Binding affinity to kappa opioid receptor in rat brain membrane | 2008 | European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
| Ligand binding to nucleic acids and proteins: Does selectivity increase with strength? |
| AID78079 | The compound was tested for opioid agonist activity against guinea pig ileal longitudinal muscle (GPI) | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Opioid agonist and antagonist activities of morphindoles related to naltrindole. |
| AID310939 | Displacement of [3H]naltrindole from rat delta opioid receptor expressed in C6 cells | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Quantitative conformationally sampled pharmacophore for delta opioid ligands: reevaluation of hydrophobic moieties essential for biological activity. |
| AID149206 | Opioid receptor delta antagonistic activity was measured by the displacement of DADLE in the mouse vas deferens at a concentration of 100 nM | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. |
| AID149192 | Binding affinity was measured by the displacement of [3H]- DADLE in guinea pig brain membrane of opioid receptor delta | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. |
| AID233860 | Selectivity between kappa opioid receptor and delta opioid receptor. | 2003 | Journal of medicinal chemistry, Apr-10, Volume: 46, Issue:8
| 14-amino, 14-alkylamino, and 14-acylamino analogs of oxymorphindole. Differential effects on opioid receptor binding and functional profiles. |
| AID150010 | Antagonist potency was determined as the ratio of [antagonist] to (IC50 ratio-1) for Opioid receptor mu 1 | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. |
| AID149023 | Selectivity for mu to delta opioid receptors was determined | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Opioid agonist and antagonist activities of morphindoles related to naltrindole. |
| AID149075 | Displacement of [3H]DADLE at delta-opioid receptor | 2001 | Journal of medicinal chemistry, Apr-26, Volume: 44, Issue:9
| Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy. |
| AID309547 | Antinociceptive effect in mouse at 30 mg/kg by antiwrithing assay | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21
| 5'-halogenated analogs of oxymorphindole. |
| AID395147 | Ratio of Ki for delta opioid receptor in rat brain membrane to Ki for mu opioid receptor in rat brain membrane | 2008 | European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
| Ligand binding to nucleic acids and proteins: Does selectivity increase with strength? |
| AID149872 | Opioid receptor mu 1 antagonistic activity was measured by the displacement of morphine in the guinea pig ileum at a concentration of 100 nM | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. |
| AID149020 | The compound was evaluated for binding affinity against opioid receptor mu in guinea pig brain membranes using [3H]- DAMGO as ligand | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Opioid agonist and antagonist activities of morphindoles related to naltrindole. |
| AID133921 | The compound was tested for opioid agonist activity against mouse vas deferens (MVD) | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Opioid agonist and antagonist activities of morphindoles related to naltrindole. |
| AID150841 | Displacement of [3H]DAMGO from human recombinant Opioid receptor mu 1 on CHO cell membranes. | 2003 | Journal of medicinal chemistry, Apr-10, Volume: 46, Issue:8
| 14-amino, 14-alkylamino, and 14-acylamino analogs of oxymorphindole. Differential effects on opioid receptor binding and functional profiles. |
| AID151896 | Binding affinity at mu opioid receptor 1 in rat brain membrane by [3H]DAMGO displacement. | 2002 | Journal of medicinal chemistry, Nov-21, Volume: 45, Issue:24
| Synthesis and biological evaluation of 14-alkoxymorphinans. 17. Highly delta opioid receptor selective 14-alkoxy-substituted indolo- and benzofuromorphinans. |
| AID132873 | Antagonistic activity against DADLE in smooth muscle preparation (MVD) | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Opioid agonist and antagonist activities of morphindoles related to naltrindole. |
| AID233685 | Selectivity ratio of the affinity for mu and delta opioid receptors (Ki mu/Ki delta) | 1997 | Journal of medicinal chemistry, Sep-26, Volume: 40, Issue:20
| Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept. |
| AID395143 | Binding affinity to mu opioid receptor in rat brain membrane | 2008 | European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
| Ligand binding to nucleic acids and proteins: Does selectivity increase with strength? |
| AID309545 | Antinociceptive effect in mouse at 30 mg/kg by tail flick assay | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21
| 5'-halogenated analogs of oxymorphindole. |
| AID235355 | Selectivity ratio (Ki value towards mu receptor compared to that of delta receptor). | 2002 | Journal of medicinal chemistry, Nov-21, Volume: 45, Issue:24
| Synthesis and biological evaluation of 14-alkoxymorphinans. 17. Highly delta opioid receptor selective 14-alkoxy-substituted indolo- and benzofuromorphinans. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |