indoprofen and Pain
indoprofen has been researched along with Pain in 17 studies
Indoprofen: A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p21)
indoprofen : A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a double-blind, randomized, parallel-group study involving sixty patients with severe pain due to fractures, the analgesic activity of indoprofen and pentazocine was evaluated." | 9.05 | Indoprofen and pentazocine in post-traumatic pain. A double-blind, parallel-group comparative trial. ( Ferrati, G; Lavezzari, M; Sacchetti, G; Soave, G, 1983) |
| "In a double-blind, parallel-group study indoprofen 800 mg daily was compared with indomethacin 100 mg daily in forty patients suffering from acute painful shoulder and other soft-tissue rheumatic complaints." | 9.05 | Indoprofen versus indomethacin in acute painful shoulder and other soft-tissue rheumatic complaints. ( Bruni, G; Lavezzari, M; Parrinello, L; Soave, G, 1982) |
| " indoprofen induced no clinically significant changes in hemodynamic parameters of patients with acute myocardial infarction (AMI), a double-blind randomized trial was carried out in 40 AMI patients to evaluate the analgesic activity of 400 mg i." | 9.05 | Analgesic treatment in acute myocardial infarction: a comparison between indoprofen and morphine by a double-blind randomized pilot study. ( Battaglia, A; Bressan, MA; Bruni, G; Costantini, M; Klersy, C; Marangoni, E; Meardi, G; Panciroli, C; Sacchetti, G, 1985) |
| "Indoprofen and morphine were not significantly different as regards pain relief, but both were significantly more effective than placebo." | 6.65 | Effect of i.v. indoprofen on cancer pain and serum prolactin and growth hormone levels--a controlled pharmacologic study vs i. m. morphine and placebo. ( Bruni, G; Defraia, E; Massidda, B; Parrinello, L; Pellegrini, A; Pellegrini, P; Rigamonti, G; Sacchetti, G; Usai, A, 1983) |
| "In a double-blind, randomized, parallel-group study involving sixty patients with severe pain due to fractures, the analgesic activity of indoprofen and pentazocine was evaluated." | 5.05 | Indoprofen and pentazocine in post-traumatic pain. A double-blind, parallel-group comparative trial. ( Ferrati, G; Lavezzari, M; Sacchetti, G; Soave, G, 1983) |
| "In a double-blind, parallel-group study indoprofen 800 mg daily was compared with indomethacin 100 mg daily in forty patients suffering from acute painful shoulder and other soft-tissue rheumatic complaints." | 5.05 | Indoprofen versus indomethacin in acute painful shoulder and other soft-tissue rheumatic complaints. ( Bruni, G; Lavezzari, M; Parrinello, L; Soave, G, 1982) |
| "1 Twenty-four patients suffering from severe pain due to chronic occlusive arterial disease of the legs were given oral doses of indoprofen (200 mg), ibuprofen (300 mg) and placebo." | 5.05 | Response of pathological ischaemic muscle pain to analgesics. ( Battistini, C; Lampugnani, R; Mandelli, V; Sacchetti, G, 1980) |
| " indoprofen induced no clinically significant changes in hemodynamic parameters of patients with acute myocardial infarction (AMI), a double-blind randomized trial was carried out in 40 AMI patients to evaluate the analgesic activity of 400 mg i." | 5.05 | Analgesic treatment in acute myocardial infarction: a comparison between indoprofen and morphine by a double-blind randomized pilot study. ( Battaglia, A; Bressan, MA; Bruni, G; Costantini, M; Klersy, C; Marangoni, E; Meardi, G; Panciroli, C; Sacchetti, G, 1985) |
| "Flunarizine, a Ca-antagonist with demonstrated antimigraine properties, and indoprofen, an anti-inflammatory non-steroidal agent, were used in the treatment of daily chronic headache." | 5.05 | Antimigraine drugs in the management of daily chronic headaches: clinical profiles of responsive patients. ( Cavallini, A; Gabellini, S; Mancuso, A; Micieli, G; Pacchetti, C; Piazza, D; Sinforiani, E; Trucco, M, 1985) |
| "A double-blind, controlled trial is described in which a total of forty hospital in-patients suffering from severe post-operative pain were randomly allocated to treatment with one of two non-steroidal anti-inflammatory drugs, namely, either indoprofen which has a short half-life (two-hours) or naproxen which has a long half-life (thirteen hours)." | 5.04 | Kinetics of analgesic response in man; an example with two non-steroidal anti-inflammatory analgesic drugs. ( Ferrati, GC; Parrinello, L; Sacchetti, G; Salami, A, 1978) |
| " The double-blind cross-over trial was carried out in 18 patients of both sexes suffering from pain due to malignant tumours who received single doses of 200 mg indoprofen and 250 mg naproxen p." | 5.04 | A controlled study of the analgetic effect of two non-steroidal anti-inflammatory drugs in cancer pain. ( Emanueli, A; Mandelli, V; Martino, G; Ventafridda, V, 1978) |
| "Diclofenac was preferred to naproxen, aspirin and indomethacin, while piroxicam and placebo were preferred only to aspirin." | 2.66 | Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment. ( Bassi, GP; Borghi, C; Camarri, E; Cocco, F; Francucci, BM; Giannini, R; Giordano, N; Marcolongo, R; Mordini, M; Neri, D, 1985) |
| "Indoprofen and morphine were not significantly different as regards pain relief, but both were significantly more effective than placebo." | 2.65 | Effect of i.v. indoprofen on cancer pain and serum prolactin and growth hormone levels--a controlled pharmacologic study vs i. m. morphine and placebo. ( Bruni, G; Defraia, E; Massidda, B; Parrinello, L; Pellegrini, A; Pellegrini, P; Rigamonti, G; Sacchetti, G; Usai, A, 1983) |
| "Indoprofen was well tolerated, and no side-effects were observed." | 2.65 | Indoprofen versus ibuprofen in osteoarthrosis: a short-term, double-blind, crossover trial. ( Bruni, G; Ferrati, GC; Innocenti, PF; Mandelli, V, 1979) |
Research
Studies (17)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Bonavita, E | 1 |
| Cooper, SA | 1 |
| Pellegrini, A | 1 |
| Massidda, B | 1 |
| Pellegrini, P | 1 |
| Defraia, E | 1 |
| Usai, A | 1 |
| Parrinello, L | 3 |
| Bruni, G | 5 |
| Rigamonti, G | 1 |
| Sacchetti, G | 8 |
| Soave, G | 2 |
| Lavezzari, M | 3 |
| Ferrati, G | 1 |
| Marcolongo, R | 2 |
| Giordano, N | 2 |
| Mattara, L | 1 |
| Leardini, G | 1 |
| Gruni, G | 1 |
| Mandelli, V | 5 |
| Egsmose, C | 1 |
| Lund, B | 1 |
| Bach Andersen, R | 1 |
| Rubegni, M | 1 |
| De Mauro, G | 1 |
| Provvedi, D | 1 |
| Battaglia, A | 2 |
| Medici, A | 1 |
| Salerno, JA | 1 |
| Previtali, M | 1 |
| Chimienti, M | 1 |
| Bobba, P | 1 |
| Lampugnani, R | 1 |
| Battistini, C | 1 |
| Ferrati, GC | 2 |
| Salami, A | 1 |
| Innocenti, PF | 1 |
| Martino, G | 1 |
| Emanueli, A | 2 |
| Ventafridda, V | 1 |
| Mascellani, G | 1 |
| Bassi, GP | 1 |
| Giannini, R | 1 |
| Borghi, C | 1 |
| Francucci, BM | 1 |
| Camarri, E | 1 |
| Mordini, M | 1 |
| Cocco, F | 1 |
| Neri, D | 1 |
| Bressan, MA | 1 |
| Costantini, M | 1 |
| Klersy, C | 1 |
| Marangoni, E | 1 |
| Meardi, G | 1 |
| Panciroli, C | 1 |
| Micieli, G | 1 |
| Piazza, D | 1 |
| Sinforiani, E | 1 |
| Cavallini, A | 1 |
| Trucco, M | 1 |
| Gabellini, S | 1 |
| Mancuso, A | 1 |
| Pacchetti, C | 1 |
Reviews
1 review available for indoprofen and Pain
| Article | Year |
|---|---|
New peripherally-acting oral analgesic agents.
Topics: Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials | 1983 |
Trials
14 trials available for indoprofen and Pain
| Article | Year |
|---|---|
New peripherally-acting oral analgesic agents.
Topics: Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials | 1983 |
Effect of i.v. indoprofen on cancer pain and serum prolactin and growth hormone levels--a controlled pharmacologic study vs i. m. morphine and placebo.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Growth Hormone; Humans; Indoprof | 1983 |
Indoprofen and pentazocine in post-traumatic pain. A double-blind, parallel-group comparative trial.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indoprofen; | 1983 |
A short-term, double-blind comparison between indoprofen and diclofenac in osteoarthritis.
Topics: Adult; Aged; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Female; Humans; Indoprofen; | 1983 |
Hip joint distension in osteoarthrosis. A triple-blind controlled study comparing the effect of intra-articular indoprofen with placebo.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Hip Joint; Humans; Indoprofen; Injections, Intra-Arti | 1984 |
Indoprofen versus indomethacin in acute painful shoulder and other soft-tissue rheumatic complaints.
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Indomethacin; Indoprofen; Male; Middle Aged; Pain; | 1982 |
A double-blind evaluation of oral indoprofen versus ASA in osteoarthritic patients: influence on haemostatic parameters and clinical effects.
Topics: Adult; Aged; Aspirin; Bleeding Time; Clinical Trials as Topic; Double-Blind Method; Female; Heartbur | 1981 |
Response of pathological ischaemic muscle pain to analgesics.
Topics: Aged; Analgesics; Female; Humans; Ibuprofen; Indoprofen; Ischemia; Male; Middle Aged; Muscles; Muscu | 1980 |
Kinetics of analgesic response in man; an example with two non-steroidal anti-inflammatory analgesic drugs.
Topics: Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indoprofen; Kineti | 1978 |
Indoprofen versus ibuprofen in osteoarthrosis: a short-term, double-blind, crossover trial.
Topics: Adult; Aged; Bone Diseases; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ibuprofen | 1979 |
A controlled study of the analgetic effect of two non-steroidal anti-inflammatory drugs in cancer pain.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indoprofen; Male; Middle | 1978 |
Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Administration | 1985 |
Analgesic treatment in acute myocardial infarction: a comparison between indoprofen and morphine by a double-blind randomized pilot study.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indoprofen; Male; Middle | 1985 |
Antimigraine drugs in the management of daily chronic headaches: clinical profiles of responsive patients.
Topics: Adult; Anti-Inflammatory Agents; Calcium Channel Blockers; Cinnarizine; Endorphins; Female; Flunariz | 1985 |
Other Studies
3 other studies available for indoprofen and Pain
| Article | Year |
|---|---|
[The salmon calcitonin-antiinflammatory association in the treatment of painful spondyloarthrosis. Clinico-experimental study].
Topics: Aged; Calcitonin; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Indoprofen; Male; Midd | 1984 |
[Hemodynamic and pharmacokinetic effects of indoprofen in patients with acute myocardial infarct].
Topics: Adult; Aged; Female; Humans; Indoprofen; Male; Middle Aged; Myocardial Infarction; Pain; Phenylpropi | 1981 |
Indoprofen, a new non-steroidal anti-inflammatory drug, in the treatment of osteoarthrosis: report on a multi-centre study in 1629 patients.
Topics: Adult; Aged; Constipation; Diarrhea; Digestive System; Drug Evaluation; Drug Tolerance; Female; Hear | 1979 |