A glycogen debranching enzyme that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35573]
Glycogen debrancher
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 1-deoxynojirimycin | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| miglustat | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine | Homo sapiens (human) | IC50 | 9.8000 | 1 | 1 |
| 1,4-dideoxy-1,4-iminoarabinitol | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| migalastat | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| 2,5-dideoxy-2,5-imino-d-glucitol | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| 1,4-dideoxy-1,4-imino-d-arabinitol | Homo sapiens (human) | IC50 | 8.4000 | 2 | 2 |
| salacinol | Homo sapiens (human) | IC50 | 48.0000 | 1 | 1 |
| n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| l-altro-1-deoxynojirimycin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| neosalacinol | Homo sapiens (human) | IC50 | 16.0000 | 1 | 1 |
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| glycogen debranching enzyme activity | molecular function | Catalysis of the cleavage of branch points in branched glycogen polymers. [ISBN:0198506732] |
| 4-alpha-glucanotransferase activity | molecular function | Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan. [EC:2.4.1.25] |
| amylo-alpha-1,6-glucosidase activity | molecular function | Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present. [EC:3.2.1.33, ISBN:0198506732] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| polysaccharide binding | molecular function | Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [GOC:mah] |
| polyubiquitin modification-dependent protein binding | molecular function | Binding to a protein upon poly-ubiquitination of the target protein. [GOC:pg] |
| beta-maltose 4-alpha-glucanotransferase activity | molecular function | Catalysis of the reaction: beta-D-glucose + a plant soluble heteroglycan = a plant soluble heteroglycan + maltose. [EC:2.4.1.25, GOC:pz] |
This protein is located in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| inclusion body | cellular component | A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers. [GOC:mah, PMID:11121744] |
| sarcoplasmic reticulum | cellular component | A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage. [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684] |
| secretory granule lumen | cellular component | The volume enclosed by the membrane of a secretory granule. [GOC:rph] |
| ficolin-1-rich granule lumen | cellular component | Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| isoamylase complex | cellular component | A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. [GOC:jl, PMID:10333591] |
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| glycogen biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. [ISBN:0198506732] |
| glycogen catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. [ISBN:0198506732] |
| response to nutrient | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. [GOC:go_curators] |
| response to glucocorticoid | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [GOC:ai, PMID:9884123] |