deltorphin i, ala(2)- profile

deltorphin I, Ala(2)-: isolated from skin extracts of frogs belonging to the genus Phyllomedusa; has affinity to opioid receptors [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	10055958
CHEMBL ID	317956
CHEBI ID	81500
MeSH ID	M0167363

Synonym
deltorphin i, ala(2)-
deltorphin i
glycinamide, l-tyrosyl-d-alanyl-l-phenylalanyl-l-alpha-aspartyl-l-valyl-l-valyl-
deltorphin c
NCGC00167304-01
CHEMBL317956 ,
chebi:81500 ,
C18097
122752-15-2
bdbm50001468
3-(2-{2-[2-amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-n-{1-[1-(carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propyl}-succinamic acid
(s)-3-((s)-2-{(r)-2-[(s)-2-amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-n-{(s)-1-[(s)-1-(carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propyl}-succinamic acid
tyr-d-ala-phe-asp-val-val-gly-nh2
h-tyr-d-ala-phe-asp-val-val-gly-nh2
AKOS024458238
deltorphin 1; deltorphin c
DTXSID10153692
mfcd00080071
J-004850
Q5254879
deltorphin c(9ci)
tyr-d-ala-phe-asp-val-val-gly-nh(2)
tyr-d-ala-phe-asp-val-val-glynh2
(s)-4-((s)-1-((s)-1-(2-amino-2-oxoethylamino)-3-methyl-1-oxobutan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-((s)-2-((r)-2-((s)-2-amino-3-(4-hydroxyphenyl)propanamido)propanamido)-3-phenylpropanamido)-4-oxobutanoic acid
HY-P1336
CS-0029459
(3s)-3-[[(2s)-2-[[(2r)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]-4-[[(2s)-1-[[(2s)-1-[(2-amino-2-oxoethyl)amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
deltorphin 1
deltorphin i(tfa)
MS-31392
deltophin 1

Excerpt	Relevance	Reference
"3 nmol/rat of DADELT II and shifted the dose-response curve to the right, without decreasing the maximum effect."	( Behavioural effects of deltorphins in rats. Angelucci, F; Negri, L; Noviello, V, 1991)	0.28
" Dose-response curves for 1DMe in the presence of naltrindole or naltrexone, delta- and mu-opioid selective antagonists respectively, indicate that 1DMe preferentially reversed mu-receptor-mediated but increased delta-receptor-mediated analgesia."	( Differential modulation of mu- and delta-opioid antinociception by neuropeptide FF receptors in young mice. Desprat, C; Zajac, JM, 1997)	0.3
" Endomorphin-1, endomorphin-2 and deltorphin I at the dosage of 1, 10, 100 nmol/embryo could stimulate angiogenesis dose-dependently, respectively."	( Endogenous opioid peptides, endomorphin-1 and -2 and deltorphin I, stimulate angiogenesis in the CAM assay. Cui, SG; Dai, X; Liu, Q; Song, HJ; Wang, R; Wang, T, 2008)	0.35

Class	Description
peptide	Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	21.1923	0.0316	22.3146	100.0000	AID588579
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	22.3872	0.2512	15.8432	39.8107	AID504327
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Delta-type opioid receptor	Mus musculus (house mouse)	IC50 (µMol)	0.0003	0.0001	0.7298	10.0000	AID132686; AID148639; AID148649
Delta-type opioid receptor	Mus musculus (house mouse)	Ki	0.0008	0.0000	0.5393	9.4000	AID149091
Delta-type opioid receptor	Rattus norvegicus (Norway rat)	IC50 (µMol)	0.0005	0.0003	0.3887	7.0000	AID147812
Delta-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	0.0003	0.0000	0.6068	9.2330	AID149344; AID149348; AID149350; AID149651; AID149812
Mu-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	0.2499	0.0000	0.3845	8.6000	AID149296; AID149301; AID149308; AID151595; AID151765
Mu-type opioid receptor	Homo sapiens (human)	IC50 (µMol)	0.2250	0.0001	0.8133	10.0000	AID152240
Delta-type opioid receptor	Homo sapiens (human)	IC50 (µMol)	0.0009	0.0002	0.7521	8.0140	AID147812; AID148079
Delta-type opioid receptor	Homo sapiens (human)	Ki	0.0017	0.0000	0.5978	9.9300	AID149777
Kappa-type opioid receptor	Cavia porcellus (domestic guinea pig)	Ki	10.0000	0.0000	0.2018	6.4240	AID149119
Kappa-type opioid receptor	Homo sapiens (human)	IC50 (µMol)	7.3300	0.0000	1.2011	10.0000	AID147860
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)	Ki	0.6770	0.0000	0.2786	9.0000	AID147905
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Mu-type opioid receptor	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0000	0.0000	0.0647	0.9320	AID277680
Mu-type opioid receptor	Homo sapiens (human)	EC50 (µMol)	1.1300	0.0000	0.3263	9.4000	AID152235
Delta-type opioid receptor	Homo sapiens (human)	EC50 (µMol)	0.0016	0.0000	0.4332	8.3000	AID147950; AID277680; AID314190
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)	EC50 (µMol)	0.0000	0.0000	0.0493	0.9320	AID277680
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Delta-type opioid receptor	Rattus norvegicus (Norway rat)	Activity	0.0810	0.0000	0.1193	1.2200	AID310939
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Mu-type opioid receptor	Homo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	Mu-type opioid receptor	Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathway	Mu-type opioid receptor	Homo sapiens (human)
sensory perception	Mu-type opioid receptor	Homo sapiens (human)
negative regulation of cell population proliferation	Mu-type opioid receptor	Homo sapiens (human)
sensory perception of pain	Mu-type opioid receptor	Homo sapiens (human)
G protein-coupled opioid receptor signaling pathway	Mu-type opioid receptor	Homo sapiens (human)
behavioral response to ethanol	Mu-type opioid receptor	Homo sapiens (human)
positive regulation of neurogenesis	Mu-type opioid receptor	Homo sapiens (human)
negative regulation of Wnt protein secretion	Mu-type opioid receptor	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Mu-type opioid receptor	Homo sapiens (human)
calcium ion transmembrane transport	Mu-type opioid receptor	Homo sapiens (human)
cellular response to morphine	Mu-type opioid receptor	Homo sapiens (human)
regulation of cellular response to stress	Mu-type opioid receptor	Homo sapiens (human)
regulation of NMDA receptor activity	Mu-type opioid receptor	Homo sapiens (human)
neuropeptide signaling pathway	Mu-type opioid receptor	Homo sapiens (human)
immune response	Delta-type opioid receptor	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Delta-type opioid receptor	Homo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Delta-type opioid receptor	Homo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	Delta-type opioid receptor	Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathway	Delta-type opioid receptor	Homo sapiens (human)
adult locomotory behavior	Delta-type opioid receptor	Homo sapiens (human)
negative regulation of gene expression	Delta-type opioid receptor	Homo sapiens (human)
negative regulation of protein-containing complex assembly	Delta-type opioid receptor	Homo sapiens (human)
positive regulation of CREB transcription factor activity	Delta-type opioid receptor	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Delta-type opioid receptor	Homo sapiens (human)
response to nicotine	Delta-type opioid receptor	Homo sapiens (human)
G protein-coupled opioid receptor signaling pathway	Delta-type opioid receptor	Homo sapiens (human)
eating behavior	Delta-type opioid receptor	Homo sapiens (human)
regulation of mitochondrial membrane potential	Delta-type opioid receptor	Homo sapiens (human)
regulation of calcium ion transport	Delta-type opioid receptor	Homo sapiens (human)
cellular response to growth factor stimulus	Delta-type opioid receptor	Homo sapiens (human)
cellular response to hypoxia	Delta-type opioid receptor	Homo sapiens (human)
cellular response to toxic substance	Delta-type opioid receptor	Homo sapiens (human)
neuropeptide signaling pathway	Delta-type opioid receptor	Homo sapiens (human)
immune response	Kappa-type opioid receptor	Homo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	Kappa-type opioid receptor	Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathway	Kappa-type opioid receptor	Homo sapiens (human)
chemical synaptic transmission	Kappa-type opioid receptor	Homo sapiens (human)
sensory perception	Kappa-type opioid receptor	Homo sapiens (human)
locomotory behavior	Kappa-type opioid receptor	Homo sapiens (human)
sensory perception of pain	Kappa-type opioid receptor	Homo sapiens (human)
adenylate cyclase-inhibiting opioid receptor signaling pathway	Kappa-type opioid receptor	Homo sapiens (human)
response to insulin	Kappa-type opioid receptor	Homo sapiens (human)
positive regulation of dopamine secretion	Kappa-type opioid receptor	Homo sapiens (human)
negative regulation of luteinizing hormone secretion	Kappa-type opioid receptor	Homo sapiens (human)
response to nicotine	Kappa-type opioid receptor	Homo sapiens (human)
G protein-coupled opioid receptor signaling pathway	Kappa-type opioid receptor	Homo sapiens (human)
maternal behavior	Kappa-type opioid receptor	Homo sapiens (human)
eating behavior	Kappa-type opioid receptor	Homo sapiens (human)
response to estrogen	Kappa-type opioid receptor	Homo sapiens (human)
estrous cycle	Kappa-type opioid receptor	Homo sapiens (human)
response to ethanol	Kappa-type opioid receptor	Homo sapiens (human)
regulation of saliva secretion	Kappa-type opioid receptor	Homo sapiens (human)
behavioral response to cocaine	Kappa-type opioid receptor	Homo sapiens (human)
sensory perception of temperature stimulus	Kappa-type opioid receptor	Homo sapiens (human)
defense response to virus	Kappa-type opioid receptor	Homo sapiens (human)
cellular response to lipopolysaccharide	Kappa-type opioid receptor	Homo sapiens (human)
cellular response to glucose stimulus	Kappa-type opioid receptor	Homo sapiens (human)
positive regulation of p38MAPK cascade	Kappa-type opioid receptor	Homo sapiens (human)
positive regulation of potassium ion transmembrane transport	Kappa-type opioid receptor	Homo sapiens (human)
response to acrylamide	Kappa-type opioid receptor	Homo sapiens (human)
positive regulation of eating behavior	Kappa-type opioid receptor	Homo sapiens (human)
conditioned place preference	Kappa-type opioid receptor	Homo sapiens (human)
neuropeptide signaling pathway	Kappa-type opioid receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
G-protein alpha-subunit binding	Mu-type opioid receptor	Homo sapiens (human)
G protein-coupled receptor activity	Mu-type opioid receptor	Homo sapiens (human)
beta-endorphin receptor activity	Mu-type opioid receptor	Homo sapiens (human)
voltage-gated calcium channel activity	Mu-type opioid receptor	Homo sapiens (human)
protein binding	Mu-type opioid receptor	Homo sapiens (human)
morphine receptor activity	Mu-type opioid receptor	Homo sapiens (human)
G-protein beta-subunit binding	Mu-type opioid receptor	Homo sapiens (human)
neuropeptide binding	Mu-type opioid receptor	Homo sapiens (human)
G protein-coupled opioid receptor activity	Delta-type opioid receptor	Homo sapiens (human)
protein binding	Delta-type opioid receptor	Homo sapiens (human)
receptor serine/threonine kinase binding	Delta-type opioid receptor	Homo sapiens (human)
G protein-coupled enkephalin receptor activity	Delta-type opioid receptor	Homo sapiens (human)
neuropeptide binding	Delta-type opioid receptor	Homo sapiens (human)
G protein-coupled opioid receptor activity	Kappa-type opioid receptor	Homo sapiens (human)
protein binding	Kappa-type opioid receptor	Homo sapiens (human)
receptor serine/threonine kinase binding	Kappa-type opioid receptor	Homo sapiens (human)
dynorphin receptor activity	Kappa-type opioid receptor	Homo sapiens (human)
neuropeptide binding	Kappa-type opioid receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
endosome	Mu-type opioid receptor	Homo sapiens (human)
endoplasmic reticulum	Mu-type opioid receptor	Homo sapiens (human)
Golgi apparatus	Mu-type opioid receptor	Homo sapiens (human)
plasma membrane	Mu-type opioid receptor	Homo sapiens (human)
axon	Mu-type opioid receptor	Homo sapiens (human)
dendrite	Mu-type opioid receptor	Homo sapiens (human)
perikaryon	Mu-type opioid receptor	Homo sapiens (human)
synapse	Mu-type opioid receptor	Homo sapiens (human)
plasma membrane	Mu-type opioid receptor	Homo sapiens (human)
neuron projection	Mu-type opioid receptor	Homo sapiens (human)
plasma membrane	Delta-type opioid receptor	Homo sapiens (human)
synaptic vesicle membrane	Delta-type opioid receptor	Homo sapiens (human)
dendrite membrane	Delta-type opioid receptor	Homo sapiens (human)
presynaptic membrane	Delta-type opioid receptor	Homo sapiens (human)
axon terminus	Delta-type opioid receptor	Homo sapiens (human)
spine apparatus	Delta-type opioid receptor	Homo sapiens (human)
postsynaptic density membrane	Delta-type opioid receptor	Homo sapiens (human)
neuronal dense core vesicle	Delta-type opioid receptor	Homo sapiens (human)
plasma membrane	Delta-type opioid receptor	Homo sapiens (human)
neuron projection	Delta-type opioid receptor	Homo sapiens (human)
nucleoplasm	Kappa-type opioid receptor	Homo sapiens (human)
mitochondrion	Kappa-type opioid receptor	Homo sapiens (human)
cytosol	Kappa-type opioid receptor	Homo sapiens (human)
plasma membrane	Kappa-type opioid receptor	Homo sapiens (human)
membrane	Kappa-type opioid receptor	Homo sapiens (human)
sarcoplasmic reticulum	Kappa-type opioid receptor	Homo sapiens (human)
T-tubule	Kappa-type opioid receptor	Homo sapiens (human)
dendrite	Kappa-type opioid receptor	Homo sapiens (human)
synaptic vesicle membrane	Kappa-type opioid receptor	Homo sapiens (human)
presynaptic membrane	Kappa-type opioid receptor	Homo sapiens (human)
perikaryon	Kappa-type opioid receptor	Homo sapiens (human)
axon terminus	Kappa-type opioid receptor	Homo sapiens (human)
postsynaptic membrane	Kappa-type opioid receptor	Homo sapiens (human)
plasma membrane	Kappa-type opioid receptor	Homo sapiens (human)
neuron projection	Kappa-type opioid receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (103)

Assay ID	Title	Year	Journal	Article
AID256772	Selectivity for rat mu opioid receptor over delta opioid receptor	2005	Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26	Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).
AID139793	Delta or Mu antagonist activity tested in mouse vas deferens (MVD) along with, naloxone	2002	Journal of medicinal chemistry, Jan-31, Volume: 45, Issue:3	Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.
AID235157	Selectivity ratio for mu and delta opioid receptors	1994	Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1	Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors.
AID149401	Inhibition of [3H][p-Cl-Phe-]DPDE binding to rat brain homogenate delta-opioid receptor	1994	Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1	Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors.
AID151609	Binding affinity against Opioid receptor mu 1 using [3H]DAMGO in rat brain synaptosomes was determined	2002	Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6	Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity.
AID148079	Binding affinity at cloned human delta-opioid receptor	2001	Journal of medicinal chemistry, Jul-19, Volume: 44, Issue:15	Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors.
AID224551	Concentration required to inhibit electrically induced twitch by 50% in mouse vas deferens(MVD).	1992	Journal of medicinal chemistry, Dec-11, Volume: 35, Issue:25	Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites.
AID256771	Displacement of [3H]DAMGO from rat mu opioid receptor in brain P2 synaptosomes	2005	Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26	Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).
AID148154	Agonist potency using GTP-gamma [35S]- binding assay for opioid receptor kappa 1; Inactive	2001	Journal of medicinal chemistry, Jul-19, Volume: 44, Issue:15	Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors.
AID149319	Ratio of the binding constant against opioid receptor mu and opioid receptor delta	1992	Journal of medicinal chemistry, Dec-11, Volume: 35, Issue:25	Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites.
AID233440	Selectivity ratio measured as the Ki value of mu receptor to that of delta receptor	1997	Journal of medicinal chemistry, Aug-01, Volume: 40, Issue:16	Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues.
AID398174	Displacement of [3H][Ile5,6]deltorphin-2 from delta opioid receptor in Wistar rat brain membrane	2009	Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11	Biological activity of endomorphin and [Dmt1]endomorphin analogs with six-membered proline surrogates in position 2.
AID148640	In vitro inhibition of electrically induced smooth muscle contractions of mouse vas deferens	1994	Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1	Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors.
AID149348	Inhibition of [3H]- ]DSLET binding to opioid receptor delta from rat brain membrane	1992	Journal of medicinal chemistry, Oct-16, Volume: 35, Issue:21	Conformationally restricted deltorphin analogues.
AID239304	Inhibition of [3H]naloxone binding to rat brain homogenate Opioid receptor delta	2005	Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10	6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides.
AID147905	Inhibition of [3H]DAMGO binding to Opioid receptor mu 1 of guinea pig brain	1995	Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7	Opioid receptor binding requirements for the delta-selective peptide deltorphin. I: Phe3 replacement with ring-substituted and heterocyclic amino acids.
AID234202	Ratio of the inhibitory concentrations against MVD and GPI.	1992	Journal of medicinal chemistry, Dec-11, Volume: 35, Issue:25	Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites.
AID132686	Inhibition of electrically evoked contractions in mouse vas deferens	1992	Journal of medicinal chemistry, Oct-16, Volume: 35, Issue:21	Conformationally restricted deltorphin analogues.
AID270135	Agonist activity at delta opioid receptor assessed as inhibition of electrically-evoked contraction of mouse vas deferens	2006	Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18	Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.
AID149301	Inhibition of [3H]- ]DAMGO binding to opioid receptor mu from rat brain membrane	1992	Journal of medicinal chemistry, Oct-16, Volume: 35, Issue:21	Conformationally restricted deltorphin analogues.
AID108533	Antinociceptive activity after subcutaneous administration in mice.	1999	Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3	Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic administration.
AID151765	Displacement of [3H]DAGO (1.28 nM) from Opioid receptor mu 1	1996	Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3	Design and synthesis of 1-aminocycloalkane-1-carboxylic acid-substituted deltorphin analogues: unique delta and mu opioid activity in modified peptides.
AID149357	Potency to inhibit [3H]- ]DSLET binding to delta receptor relative to [Leu]enkephalin	1992	Journal of medicinal chemistry, Oct-16, Volume: 35, Issue:21	Conformationally restricted deltorphin analogues.
AID224591	Tested for binding affinity against mu opioid receptor fby displacing [3H]- DAMGO radioligand from rat brain membrane preparations	1993	Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21	TIPP[psi]: a highly potent and stable pseudopeptide delta opioid receptor antagonist with extraordinary delta selectivity.
AID149729	Agonist activity was evaluated in guinea pig ileum (GPI) preparations at Opioid receptor mu 1	1997	Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5	Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80)
AID277680	Activity at delta opioid receptor assessed as increase in calcium level in CHO cells by aequorin luminescence based calcium assay	2007	Journal of medicinal chemistry, Feb-08, Volume: 50, Issue:3	Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2).
AID76378	Tested for inhibition of amplification of electrically induced twitch in guinea pig ileum (GPI)	1993	Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24	Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors.
AID141643	Inhibition of [3H]CTOP binding to rat brain homogenate mu-opioid receptor	1994	Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1	Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors.
AID148516	Agonist activity was evaluated in guinea pig ileum (GPI) preparations at Opioid receptor delta 1	1997	Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5	Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80)
AID149119	Inhibition of [3H]- U 69593 from Opioid receptor kappa 1 of guinea pig brain	1995	Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7	Opioid receptor binding requirements for the delta-selective peptide deltorphin. I: Phe3 replacement with ring-substituted and heterocyclic amino acids.
AID149796	Binding affinity was determined on delta [3H]DPDPE site in rat brain synaptosomes by radioreceptor assay	1993	Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24	Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors.
AID148532	Functional biological activity for Opioid receptor delta 1 was determined in vitro, on mouse vas deferens (MVD).	1997	Journal of medicinal chemistry, Aug-01, Volume: 40, Issue:16	Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues.
AID149316	Potency to inhibit 3H ]DAMGO binding to opioid receptor mu relative to [Leu]enkephalin	1992	Journal of medicinal chemistry, Oct-16, Volume: 35, Issue:21	Conformationally restricted deltorphin analogues.
AID149091	Displacement of [3H]NLT from Opioid receptor delta 1 of adult male mouse brain.	1999	Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3	Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic administration.
AID228359	Ratio of delta-Opioid receptor to the mu-opioid receptor	1997	Journal of medicinal chemistry, Aug-29, Volume: 40, Issue:18	Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.
AID148639	In vitro biological activity by electrically induced smooth muscle contractions in mouse vas deferens (Opioid receptor delta 1); inhibitory concentration was evaluated	2002	Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6	Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity.
AID138349	In vitro concentration required to inhibit electrically evoked twitch in isolated mouse vas deferens.	1999	Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3	Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic administration.
AID149350	Binding affinity against opioid receptor delta in rats by displacing [3H]DPDPE	1992	Journal of medicinal chemistry, Dec-11, Volume: 35, Issue:25	Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites.
AID149812	Displacement of [3H]DPDPE (0.63 nM) from Opioid receptor delta 1	1996	Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3	Design and synthesis of 1-aminocycloalkane-1-carboxylic acid-substituted deltorphin analogues: unique delta and mu opioid activity in modified peptides.
AID310939	Displacement of [3H]naltrindole from rat delta opioid receptor expressed in C6 cells	2007	Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8	Quantitative conformationally sampled pharmacophore for delta opioid ligands: reevaluation of hydrophobic moieties essential for biological activity.
AID152235	Agonist potency using GTP-gamma [35S]- binding assay for mu-opioid receptor	2001	Journal of medicinal chemistry, Jul-19, Volume: 44, Issue:15	Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors.
AID138857	In vitro inhibition of electrically evoked contractions in guinea pig ileum longitudinal muscle myenteric plexus	1994	Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1	Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors.
AID227065	IC50 ratio measured as the IC50 value of GPI to that of MVD.	1997	Journal of medicinal chemistry, Aug-01, Volume: 40, Issue:16	Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues.
AID314190	Antagonist activity at delta opioid receptor expressed in CHO cells assessed as release of intracellular calcium ions by aequorin luminescence-based calcium assay	2008	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 18, Issue:4	Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure.
AID235354	Relative binding to mu and delta opioid receptors (ratio of Ki)	1995	Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7	Opioid receptor binding requirements for the delta-selective peptide deltorphin. I: Phe3 replacement with ring-substituted and heterocyclic amino acids.
AID151611	Binding affinity for rat brain P2 synaptosome Opioid receptor mu 1	2002	Journal of medicinal chemistry, Jan-31, Volume: 45, Issue:3	Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.
AID147950	Agonist potency using GTP-gamma [35S]- binding assay for delta-opioid receptor	2001	Journal of medicinal chemistry, Jul-19, Volume: 44, Issue:15	Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors.
AID149308	Binding affinity against opioid receptor mu in rats by displacing [3H]-DAGO	1992	Journal of medicinal chemistry, Dec-11, Volume: 35, Issue:25	Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites.
AID23166	Half-life time of enzymatic breakdown in mouse brain.	1999	Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3	Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic administration.
AID149939	Tested for binding affinity against delta opioid receptor by displacing [3H]- DSLET radioligand from rat brain membrane preparations	1993	Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21	TIPP[psi]: a highly potent and stable pseudopeptide delta opioid receptor antagonist with extraordinary delta selectivity.
AID229963	IC50 ratio (GPI/MVD)	1992	Journal of medicinal chemistry, Oct-16, Volume: 35, Issue:21	Conformationally restricted deltorphin analogues.
AID229342	Ratio of inhibitory concentration of guinea pig ileum to mouse vas deferens was determined	2002	Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6	Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity.
AID151895	Opioid receptor mu 1 binding affinity by displacement of radioligand [3H][DAla,MePhe,Gly-ol]enkephalin (DAGO) from rat brain membrane synaptosomes	1997	Journal of medicinal chemistry, Aug-29, Volume: 40, Issue:18	Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.
AID223198	Concentration required to inhibit electrically induced twitch by 50% in guinea pig ileum(GPI).	1992	Journal of medicinal chemistry, Dec-11, Volume: 35, Issue:25	Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites.
AID149935	Opioid receptor delta 1 binding affinity by displacement of radioligand [3H][D-Pen]-enkephalin (DPDPE) from rat brain membrane synaptosomes	1997	Journal of medicinal chemistry, Aug-29, Volume: 40, Issue:18	Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.
AID224710	Relative potency to that of [Leu5]- enkephalin	1993	Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21	TIPP[psi]: a highly potent and stable pseudopeptide delta opioid receptor antagonist with extraordinary delta selectivity.
AID231652	Binding ratio between delta and mu receptor was determined	1993	Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24	Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors.
AID139792	Delta or Mu antagonist activity tested in mouse vas deferens (MVD) along with N,N-dimethyl-Dmt-Tic-OH	2002	Journal of medicinal chemistry, Jan-31, Volume: 45, Issue:3	Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.
AID149950	Relative potency to that of [Leu5]- enkephalin	1993	Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21	TIPP[psi]: a highly potent and stable pseudopeptide delta opioid receptor antagonist with extraordinary delta selectivity.
AID229970	IC50 ratio on Mu receptor of GPI to the delta receptor MVD	1997	Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5	Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80)
AID235155	Selectivity ratio against guinea pig ileum and mouse vas deferens contractions	1994	Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1	Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors.
AID151268	Displacement of [3H]-DAGO from Opioid receptor mu 1 of adult male mouse brain.	1999	Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3	Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic administration.
AID79023	In vitro concentration required to inhibit electrically evoked twitch in isolated guinea pig ileum.	1999	Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3	Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic administration.
AID230636	Ratio, binding to cloned human kappa-opioid versus delta-opioid receptor (IC50)	2001	Journal of medicinal chemistry, Jul-19, Volume: 44, Issue:15	Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors.
AID234886	Potency to inhibit MVD relative to [Leu]enkephalin	1992	Journal of medicinal chemistry, Oct-16, Volume: 35, Issue:21	Conformationally restricted deltorphin analogues.
AID149296	Inhibition of [3H]DAGO binding to trat brain opioid receptor mu in P2 membrane	1991	Journal of medicinal chemistry, Apr, Volume: 34, Issue:4	Function of negative charge in the "address domain" of deltorphins.
AID149651	Affinity was assessed using competitive binding assay labeled with [3H]DPDPE (6.3 nM) for Opioid receptor delta 1	1997	Journal of medicinal chemistry, Aug-01, Volume: 40, Issue:16	Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues.
AID78287	Functional biological activity for mu opioid receptor was determined in vitro, on guinea pig ileum (GPI).	1997	Journal of medicinal chemistry, Aug-01, Volume: 40, Issue:16	Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues.
AID138859	Inhibitory concentration against electrically evoked contractions of guinea pig ileum longitudinal muscle-myenteric plexus	1994	Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1	Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors.
AID149670	Binding affinity against Opioid receptor delta 1 using [3H]DT in rat brain synaptosomes was determined	2002	Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6	Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity.
AID152236	Compound was tested for maximum stimulation of mu opioid receptor by GTP-gamma [35S]- binding assay	2001	Journal of medicinal chemistry, Jul-19, Volume: 44, Issue:15	Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors.
AID149344	Inhibition of [3H]-DADLE binding to opioid receptor delta in P2 membrane preparation of rat brain	1991	Journal of medicinal chemistry, Apr, Volume: 34, Issue:4	Function of negative charge in the "address domain" of deltorphins.
AID239267	Inhibition of [3H]naloxone binding to rat brain homogenate Opioid receptor mu	2005	Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10	6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides.
AID149672	Binding affinity at Opioid receptor delta 1 using rat brain receptor (P2 synaptosome) assay	2002	Journal of medicinal chemistry, Jan-31, Volume: 45, Issue:3	Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.
AID149777	Inhibition of [3H]- DPDPE binding to delta opioid receptor of guinea pig brain	1995	Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7	Opioid receptor binding requirements for the delta-selective peptide deltorphin. I: Phe3 replacement with ring-substituted and heterocyclic amino acids.
AID256770	Displacement of [3H]deltorphin II from rat delta opioid receptor in brain P2 synaptosomes	2005	Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26	Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).
AID231661	Bioselectivity ratio of compound as guinea pig ileum to mouse vas deferens was determined	1993	Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24	Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors.
AID23167	Half-life time of enzymatic breakdown in mouse liver.	1999	Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3	Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic administration.
AID148071	Maximum stimulation of delta opioid receptor by GTP-gamma [35S]- binding assay	2001	Journal of medicinal chemistry, Jul-19, Volume: 44, Issue:15	Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors.
AID105933	Negative logarithm of the molar concentration required to produce 50% of the maximum effect in mu receptor from mouse vas deferens (MVD)	2002	Journal of medicinal chemistry, Jan-31, Volume: 45, Issue:3	Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.
AID310938	Agonist activity at rat delta opioid receptor expressed in C6 cells assessed as stimulation of [35S]GTP-gamma-S binding relative to BW373U86	2007	Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8	Quantitative conformationally sampled pharmacophore for delta opioid ligands: reevaluation of hydrophobic moieties essential for biological activity.
AID147812	Agonist activity for Opioid receptor delta 1	1997	Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19	Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.
AID76094	Inhibition of electrically evoked contractions in Guinea pig ileum	1992	Journal of medicinal chemistry, Oct-16, Volume: 35, Issue:21	Conformationally restricted deltorphin analogues.
AID151595	Affinity was assessed using competitive binding assay labeled with [3H]- DAGO (1.28 nM) for Opioid receptor mu 1	1997	Journal of medicinal chemistry, Aug-01, Volume: 40, Issue:16	Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues.
AID167727	Bioactivity in vitro in rabbit jejunum (RJ) isolated organ preparation	1997	Journal of medicinal chemistry, Aug-29, Volume: 40, Issue:18	Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.
AID256773	Functional bioactivity against delta opioid receptor in mouse vas deferens	2005	Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26	Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).
AID152240	Binding affinity at cloned human mu-opioid receptor	2001	Journal of medicinal chemistry, Jul-19, Volume: 44, Issue:15	Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors.
AID228347	Ratio of Ki values for mu and delta opioid receptors.	1991	Journal of medicinal chemistry, Apr, Volume: 34, Issue:4	Function of negative charge in the "address domain" of deltorphins.
AID256774	Functional bioactivity against mu opioid receptor in guinea-pig ileum	2005	Journal of medicinal chemistry, Dec-29, Volume: 48, Issue:26	Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).
AID234885	Potency to inhibit GPI relative to [Leu]enkephalin	1992	Journal of medicinal chemistry, Oct-16, Volume: 35, Issue:21	Conformationally restricted deltorphin analogues.
AID131044	Compound was tested in vivo by a mouse tail-flick assay after intracerebroventricular (icv) injection	1997	Journal of medicinal chemistry, Aug-29, Volume: 40, Issue:18	Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.
AID147860	Binding affinity at cloned human opioid receptor kappa 1	2001	Journal of medicinal chemistry, Jul-19, Volume: 44, Issue:15	Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors.
AID149736	Compound was evaluated for its inhibitory activity towards Opioid receptor mu 1 of guinea pig ileum (GPI)	1996	Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3	Design and synthesis of 1-aminocycloalkane-1-carboxylic acid-substituted deltorphin analogues: unique delta and mu opioid activity in modified peptides.
AID314186	Displacement of [3H]naltrindole from delta opioid receptor in rat brain membranes	2008	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 18, Issue:4	Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure.
AID231027	Ratio, binding to cloned human mu-opioid versus delta-opioid receptor (IC50)	2001	Journal of medicinal chemistry, Jul-19, Volume: 44, Issue:15	Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors.
AID224589	Binding affinity was determined on mu [3H]DAGO site in rat brain synaptosomes by radioreceptor assay	1993	Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24	Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors.
AID152083	The selectivity ratio as the ratio of Ki of Opioid receptor mu 1 to Ki of Opioid receptor delta 1	2002	Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6	Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity.
AID148525	Inhibitory activity against Opioid receptor delta 1 of mouse vas deferens (MVD)	1996	Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3	Design and synthesis of 1-aminocycloalkane-1-carboxylic acid-substituted deltorphin analogues: unique delta and mu opioid activity in modified peptides.
AID149314	Selectivity ratio against Opioid receptor mu and delta binding	1992	Journal of medicinal chemistry, Oct-16, Volume: 35, Issue:21	Conformationally restricted deltorphin analogues.
AID148649	Inhibitory concentration against delta opioid receptor of electrically induced smooth muscle contraction of mouse vas deferens	1994	Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1	Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors.
AID149743	In vitro biological activity by electrically induced smooth muscle contractions in guinea pig ileum (Opioid receptor mu 1); inhibitory concentration was evaluated	2002	Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6	Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity.
AID132850	Tested for inhibition of amplification of electrically induced twitch in mouse vas deferens (MVD)	1993	Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24	Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors.
AID235156	Selectivity ratio (GPI/MVD) of the compound	1994	Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1	Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (0.86)	18.7374
1990's	66 (56.90)	18.2507
2000's	45 (38.79)	29.6817
2010's	4 (3.45)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	122 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
gamma-aminobutyric acid gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.	2.41	2	amino acid zwitterion; gamma-amino acid; monocarboxylic acid	human metabolite; neurotransmitter; Saccharomyces cerevisiae metabolite; signalling molecule
formaldehyde paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy	1.99	1	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
glycine [no description available]	2.13	1	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
melatonin [no description available]	2.02	1	acetamides; tryptamines	anticonvulsant; central nervous system depressant; geroprotector; hormone; human metabolite; immunological adjuvant; mouse metabolite; radical scavenger
phosphorylcholine Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.. phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.	1.98	1	phosphocholines	allergen; epitope; hapten; human metabolite; mouse metabolite
1,3-dipropyl-8-cyclopentylxanthine DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.	2.02	1	oxopurine	adenosine A1 receptor antagonist; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide: cyclic somatostatin octapeptide analog with high affinity & selectivity toward mu opioid receptors	2.4	2
thymidine [no description available]	1.99	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
carbachol Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.	2.03	1	ammonium salt; carbamate ester	cardiotonic drug; miotic; muscarinic agonist; nicotinic acetylcholine receptor agonist; non-narcotic analgesic
alanine Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.	2	1	alanine zwitterion; alanine; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid	EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; fundamental metabolite
aspartic acid Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.. aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent. L-aspartic acid : The L-enantiomer of aspartic acid.	2.38	2	aspartate family amino acid; aspartic acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; mouse metabolite; neurotransmitter
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	2.91	4	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
valine Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.. valine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group.. L-valine : The L-enantiomer of valine.	2.01	1	L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid; valine	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
isoleucine Isoleucine: An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.. isoleucine : A 2-amino-3-methylpentanoic acid having either (2R,3R)- or (2S,3S)-configuration.. L-isoleucine : The L-enantiomer of isoleucine.	1.99	1	aspartate family amino acid; isoleucine; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
2-naphthylamine 2-Naphthylamine: A naphthalene derivative with carcinogenic action.. 2-naphthylamine : A naphthylamine carrying the amino group at position 2.	1.99	1	naphthylamine	carcinogenic agent
etorphine Etorphine: A narcotic analgesic morphinan used as a sedative in veterinary practice.	3.27	6
azides Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.	2	1	pseudohalide anion	mitochondrial respiratory-chain inhibitor
substance p [no description available]	1.98	1	peptide	neurokinin-1 receptor agonist; neurotransmitter; vasodilator agent
enkephalin, methionine Enkephalin, Methionine: One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.	2.03	1
colforsin Colforsin: Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.	2	1	acetate ester; cyclic ketone; labdane diterpenoid; organic heterotricyclic compound; tertiary alpha-hydroxy ketone; triol	adenylate cyclase agonist; anti-HIV agent; antihypertensive agent; plant metabolite; platelet aggregation inhibitor; protein kinase A agonist
enadoline enadoline: kappa-opioid receptor agonist; RN given refers to cpd without isomeric designation; PD 129290 (CAM 570; CI 977) is the S,S(-)-enantiomer; PD 129289 (CAM 569) is the corresponding R,R(+)-enantiomer	2.41	2
2-amino-3-phenylbutanoic acid [no description available]	1.99	1
1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid: used as a substitute for amino acids in synthetic peptides	1.98	1
n-succinimidyl-3-(4-hydroxyphenyl)propionate N-succinimidyl-3-(4-hydroxyphenyl)propionate: acylates free amino groups on proteins	1.99	1
enkephalin, d-penicillamine (2,5)- Enkephalin, D-Penicillamine (2,5)-: A disulfide opioid pentapeptide that selectively binds to the DELTA OPIOID RECEPTOR. It possesses antinociceptive activity.. DPDPE : A heterodetic cyclic peptide that is a cyclic enkephalin analogue, having D-penicillaminyl residues located at positions 2 and 5, which form the heterocycle via a disulfide bond.	4.3	19	heterodetic cyclic peptide	delta-opioid receptor agonist
u 69593 U 69593: selective ligand for opioid K-receptor. U69593 : A monocarboxylic acid amide obtained by formal condensation between the carboxy group of phenylacetic acid and the secodary amino group of (5R,7S,8S)-N-methyl-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-amine.	1.99	1	monocarboxylic acid amide; N-alkylpyrrolidine; organic heterobicyclic compound; oxaspiro compound	anti-inflammatory agent; diuretic; kappa-opioid receptor agonist
n,n-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine [no description available]	2.4	2
bremazocine bremazocine: potent, log-acting opiate kappa-agonist & centrally acting analgesic; RN given refers to (2R)-isomer; structure given in first source	2.01	1
enkephalin, ser(2), leu(5), thr(6)- enkephalin, Ser(2), Leu(5), Thr(6)-: specific probe for the delta-opiate receptor subtype in brain membranes	2.69	3	oligopeptide
bw 373u86 BW 373U86: a nonpeptidic delta opioid receptor agonist	2.41	2	diarylmethane
enkephalin-met, arg(6)-phe(7)- [no description available]	2.03	1	organic molecular entity
deltorphin ii, ala(2)- deltorphin II, Ala(2)-: isolated from skin extracts of frogs belonging to the genus Phyllomedusa; has affinity to opioid receptors	5.26	20
phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide: endogenous opioid antagonist octapeptide from bovine brain	1.99	1
4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide: a highly-selective, nonpeptide delta opioid receptor agonist; structure given in first source	2.71	3	diarylmethane
salvinorin a salvinorin A: from the herb, Salvia divinorum	2.04	1	organic heterotricyclic compound; organooxygen compound	metabolite; oneirogen
tyrosyl-seryl(o-tert-butyl)-glycyl-phenylalanyl-leucyl-threonine tyrosyl-seryl(O-tert-butyl)-glycyl-phenylalanyl-leucyl-threonine: has good selectivity & high affinity for delta opioid receptors	1.97	1
tyrosyl-seryl(o-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(o-t-butyl) tyrosyl-seryl(O-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(O-t-butyl): RN given refers to L-Thr-L-Tyr-D-Ser-Gly-L-Phe-L-Leu cpd; RN for cpd without isomeric designation not available 3/90	2	1
tyrosyl-leucyl-n-methylphenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide tyrosyl-leucyl-N-methylphenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide: exerts effect similar to opiate agonists on intestinal myoelectrical activity & on nociception in rats	1.99	1
ethylketocyclazocine Ethylketocyclazocine: A kappa opioid receptor agonist. The compound has analgesic action and shows positive inotropic effects on the electrically stimulated left atrium. It also affects various types of behavior in mammals such as locomotion, rearing, and grooming.	2.04	1
2-aminocyclohexanecarboxylic acid 2-aminocyclohexanecarboxylic acid: RN given for (trans)-isomer; structure in first source	2	1
4-aminocyclohexanecarboxylic acid 4-aminocyclohexanecarboxylic acid: RN for cpd without isomeric designation not in Chemline 12/6/82	2	1
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	2.41	2
dihydropyridines Dihydropyridines: Pyridine moieties which are partially saturated by the addition of two hydrogen atoms in any position.	2.01	1
strychnine Strychnine: An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.. strychnine : A monoterpenoid indole alkaloid that is strychnidine bearing a keto substituent at the 10-position.	2.02	1	monoterpenoid indole alkaloid; organic heteroheptacyclic compound	avicide; cholinergic antagonist; glycine receptor antagonist; neurotransmitter agent; rodenticide
diprenorphine Diprenorphine: A narcotic antagonist similar in action to NALOXONE. It is used to remobilize animals after ETORPHINE neuroleptanalgesia and is considered a specific antagonist to etorphine.	2.03	1	morphinane alkaloid
betadex beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.	2.02	1	cyclodextrin
cocaine Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.. cocaine : A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.	2.01	1	benzoate ester; methyl ester; tertiary amino compound; tropane alkaloid	adrenergic uptake inhibitor; central nervous system stimulant; dopamine uptake inhibitor; environmental contaminant; local anaesthetic; mouse metabolite; plant metabolite; serotonin uptake inhibitor; sodium channel blocker; sympathomimetic agent; vasoconstrictor agent; xenobiotic
h 89 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide: structure given in first source. N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide : A member of the class of isoquinolines that is the sulfonamide obtained by formal condensation of the sulfo group of isoquinoline-5-sulfonic acid with the primary amino group of N(1)-[3-(4-bromophenyl)prop-2-en-1-yl]ethane-1,2-diamine. It is a protein kinase A inhibitor.. (E)-N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide : A N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide in which the double bond adopts a trans-configuration.	2.02	1	N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide
enkephalin, leucine Enkephalin, Leucine: One of the endogenous pentapeptides with morphine-like activity. It differs from MET-ENKEPHALIN in the LEUCINE at position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.. Leu-enkephalin : A pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-leucine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide produced in vertebrate species, including rodents, primates and humans that results from decomposition of proenkephalin or dynorphin and exhibits antinociceptive properties.	4.43	22	pentapeptide; peptide zwitterion	analgesic; delta-opioid receptor agonist; human metabolite; mu-opioid receptor agonist; neurotransmitter; rat metabolite
3-aminocyclohexanecarboxylic acid 3-aminocyclohexanecarboxylic acid: GABA analog; RN given refers to cis-(+-)-isomer; structure	2	1
etorphine [no description available]	2.03	1	alcohol; morphinane alkaloid	opioid analgesic; opioid receptor agonist; sedative
tyrosyl-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-phenylalanyl-phenylalanine tyrosyl-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-phenylalanyl-phenylalanine: a delta opioid antagonist	1.98	1
dodecylphosphocholine dodecylphosphocholine: phospholipase A2 inhibitor; RN refers to chloride. dodecylphosphocholine : A phosphocholine that is the monododecyl ester of phosphocholine	1.98	1	phosphocholines	detergent
deltorphin deltorphin: isolated from skin of Phyllomedusa sauvagei; has affinity to opioid receptor; note deltorphin I and deltorphin II are available, they have Ala in position 2	4.01	14	peptide
u-50488 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer: A non-peptide, kappa-opioid receptor agonist which has also been found to stimulate the release of adrenocorticotropin (ADRENOCORTICOTROPIC HORMONE) via the release of hypothalamic arginine vasopressin (ARGININE VASOPRESSIN) and CORTICOTROPIN-RELEASING HORMONE. (From J Pharmacol Exp Ther 1997;280(1):416-21). U50488 : A monocarboxylic acid amide obtained by formal condensation between the carboxy group of 3,4-dichlorophenylacetic acid and the secondary amino group of (1R,2R)-N-methyl-2-(pyrrolidin-1-yl)cyclohexanamine	2.41	2	dichlorobenzene; monocarboxylic acid amide; N-alkylpyrrolidine	analgesic; antitussive; calcium channel blocker; diuretic; kappa-opioid receptor agonist
h-tyrosyl-cyclo(cysteinyl-phenylalanyl-penicillaminyl)-oh H-tyrosyl-cyclo(cysteinyl-phenylalanyl-penicillaminyl)-OH: a cyclic delta receptor selective tetrapeptide; RN given is for D-penicillamine	1.98	1
6-cyano-7-nitroquinoxaline-2,3-dione 6-Cyano-7-nitroquinoxaline-2,3-dione: A potent excitatory amino acid antagonist with a preference for non-NMDA iontropic receptors. It is used primarily as a research tool.	2.02	1	quinoxaline derivative
naloxone Naloxone: A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.. naloxone : A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.	3.39	7	morphinane alkaloid; organic heteropentacyclic compound; tertiary alcohol	antidote to opioid poisoning; central nervous system depressant; mu-opioid receptor antagonist
morphine Meconium: The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.	3.72	10	morphinane alkaloid; organic heteropentacyclic compound; tertiary amino compound	anaesthetic; drug allergen; environmental contaminant; geroprotector; mu-opioid receptor agonist; opioid analgesic; plant metabolite; vasodilator agent; xenobiotic
7-benzylidenenaltrexone 7-benzylidenenaltrexone: structure given in first source; a highly selective delta1-opioid receptor antagonist	2.7	3	phenanthrenes
endomorphin 1 endomorphin 1: isolated from bovine brain	2.73	3	oligopeptide
endomorphin 2 endomorphin 2: isolated from bovine brain	3.29	6
naltrexone Naltrexone: Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.. naltrexone : An organic heteropentacyclic compound that is naloxone substituted in which the allyl group attached to the nitrogen is replaced by a cyclopropylmethyl group. A mu-opioid receptor antagonist, it is used to treat alcohol dependence.	3.78	11	cyclopropanes; morphinane-like compound; organic heteropentacyclic compound	antidote to opioid poisoning; central nervous system depressant; environmental contaminant; mu-opioid receptor antagonist; xenobiotic
enkephalin, ala(2)-mephe(4)-gly(5)- [no description available]	1.97	1	peptide
dermorphin dermorphin: opiate-like peptide present in amphibian skin	4.86	13	oligopeptide
enkephalin, ala(2)-mephe(4)-gly(5)- Enkephalin, Ala(2)-MePhe(4)-Gly(5)-: An enkephalin analog that selectively binds to the MU OPIOID RECEPTOR. It is used as a model for drug permeability experiments.	3.94	13
naltrindole benzofuran naltrindole benzofuran: structure given in first source	2.41	2	morphinane alkaloid
oxymorphindole oxymorphindole: no other info avail 9/91	2.47	2
naltrindole naltrindole: delta opioid receptor antagonist	3.87	12	isoquinolines
morphinans Morphinans: Compounds based on a partially saturated iminoethanophenanthrene, which can be described as ethylimino-bridged benzo-decahydronaphthalenes. They include some of the OPIOIDS found in PAPAVER that are used as ANALGESICS.	2.38	2	isoquinoline alkaloid fundamental parent; morphinane alkaloid
enkephalin, leucine-2-alanine Enkephalin, Leucine-2-Alanine: A delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.	2.9	4
milameline milameline: a candidate drug for the treatment of age-related disorders of cognition; RN refers to the E-isomer; structure given in first source	2.01	1
tan 67 [no description available]	2.03	1	quinolines
g(m1) ganglioside G(M1) Ganglioside: A specific monosialoganglioside that accumulates abnormally within the nervous system due to a deficiency of GM1-b-galactosidase, resulting in GM1 gangliosidosis.. ganglioside GM1 : A sialotetraosylceramide consisting of a branched pentasaccharide made up from one sialyl residue, two galactose residues, one N-acetylgalactosamine residue and a glucose residue at the reducing end attached to N-stearoylsphingosine via a beta-linkage.	2.03	1	alpha-N-acetylneuraminosyl-(2->3)-[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphingosine; sialotetraosylceramide
ufp-502 [no description available]	2.42	2
h-dmt-tic-gly-nh-bzl H-Dmt-Tic-Gly-NH-Bzl: bifunctional opioid ligand;structure in first source	2.01	1
9-(benzoyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2h-naphtho(2,1-c)pyran-7-carboxylic acid methyl ester 9-(benzoyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho(2,1-c)pyran-7-carboxylic acid methyl ester: structure in first source	2.04	1
dynorphins Dynorphins: A class of opioid peptides including dynorphin A, dynorphin B, and smaller fragments of these peptides. Dynorphins prefer kappa-opioid receptors (RECEPTORS, OPIOID, KAPPA) and have been shown to play a role as central nervous system transmitters.	2.01	1
dermaseptin s dermaseptin: 34 amino acid residues given in first source; antimicrobial peptide of amphibian skin	2.03	1
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene [no description available]	1.99	1	BODIPY compound
ici 174865 ICI 174865: delta opioid receptor antagonist	2.03	1
7-spiroindanyloxymorphone 7-spiroindanyloxymorphone: a delta opioid receptor agonist; structure given in first source	2.03	1
d-ala(2),mephe(4),met(0)-ol-enkephalin D-Ala(2),MePhe(4),Met(0)-ol-enkephalin: A stable synthetic analog of methionine enkephalin (ENKEPHALIN, METHIONINE). Actions are similar to those of methionine enkephalin. Its effects can be reversed by narcotic antagonists such as naloxone.	2.67	3
guanosine triphosphate Guanosine Triphosphate: Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.	2	1	guanosine 5'-phosphate; purine ribonucleoside 5'-triphosphate	Escherichia coli metabolite; mouse metabolite; uncoupling protein inhibitor
guanosine 5'-o-(3-thiotriphosphate) Guanosine 5'-O-(3-Thiotriphosphate): Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes.	2.43	2	nucleoside triphosphate analogue
guanylyl imidodiphosphate Guanylyl Imidodiphosphate: A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of ADENYLYL CYCLASES.. guanosine 5'-[beta,gamma-imido]triphosphate : A nucleoside triphosphate analogue that is GTP in which the oxygen atom bridging the beta- to the gamma- phosphate is replaced by a nitrogen atom A non-hydrolyzable analog of GTP, it binds tightly to G-protein in the presence of Mg(2+).	1.99	1	nucleoside triphosphate analogue
gtp gamma-4-azidoanilide [no description available]	2	1

Condition	Relationship Strength	Studies
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	5.05	16
Ache [description not available]	2.92	4
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	2.92	4
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	3.11	5
Bradyarrhythmia [description not available]	2.03	1
Bradycardia Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.	2.03	1
Autism [description not available]	2.03	1
Autistic Disorder A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)	2.03	1
Alloxan Diabetes [description not available]	1.98	1
Cadaver A dead body, usually a human body.	1.99	1
Recrudescence [description not available]	1.99	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	1.99	1

deltorphin i, ala(2)-

Description

Cross-References

Synonyms (31)

Research Excerpts

Dosage Studied

Drug Classes (1)

Protein Targets (10)

Potency Measurements

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Other Measurements

Biological Processes (52)

Molecular Functions (12)

Ceullar Components (23)

Bioassays (103)

Research

Studies (116)

Study Types

deltorphin i, ala(2)-

Description

Cross-References

Synonyms (31)

Research Excerpts

Dosage Studied

Drug Classes (1)

Protein Targets (10)

Potency Measurements

Inhibition Measurements

Activation Measurements

Other Measurements

Biological Processes (52)

Molecular Functions (12)

Ceullar Components (23)

Bioassays (103)

Research

Studies (116)

Study Types

Related Drugs (87)

Related Conditions (12)