Compounds > caulerpin
Page last updated: 2024-12-11

caulerpin

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Description

caulerpin: pigment from green algae, Caulerpa lamourouxii; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5326018
CHEMBL ID377236
CHEBI ID80923
SCHEMBL ID13808752
MeSH IDM0040489

Synonyms (16)

Synonym
caulerpin
26612-48-6
nsc-719624
nsc719624
bdbm50184688
C17097
chebi:80923 ,
CHEMBL377236 ,
cycloocta(1,2-b:5,6-b')diindole-6,13-dicarboxylic acid, 5,12-dihydro-, dimethyl ester
SCHEMBL13808752
cycloocta[1,2-b:5,6-b']diindole-6,13-dicarboxylic acid, 5,12-dihydro-, dimethyl ester
Q27151423
dimethyl (1z,3z,12z,14z)-11,22-diazapentacyclo[13.7.0.04,12.05,10.016,21]docosa-1,3,5,7,9,12,14,16,18,20-decaene-2,13-dicarboxylate
dimethyl 5,12-dihydrocycloocta[1,2-b:5,6-b']diindole-6,13-dicarboxylate
dimethyl-6,13-dihydrodibenzo[b,i]phenazine-5,12-dicarboxylate
STARBLD0001353

Research Excerpts

Overview

Caulerpin is a bisindolic alkaloid that has been obtained from many species of the genus.

ExcerptReferenceRelevance
"Caulerpin is a bisindolic alkaloid that has been obtained from many species of the genus "( Microwave irradiation is a suitable method for caulerpin extraction from the green algae
Cantarino, SJ; Coutinho, R; Duarte, HM; Martinez, ST; Soares, AR, 2022)		2.42
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pathways (1)

PathwayProteinsCompounds
CAMKK2 pathway011

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC50 (µMol)3.77000.00053.49849.7600AID264979
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (27)

Processvia Protein(s)Taxonomy
positive regulation of JUN kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
actin cytoskeleton organizationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of endocytosisTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of vascular endothelial growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulum unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of intracellular protein transportTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cellular response to unfolded proteinTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
platelet-derived growth factor receptor-beta signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor recyclingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of MAP kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of type I interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
growth hormone receptor signaling pathway via JAK-STATTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of protein tyrosine kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of hepatocyte growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of PERK-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of receptor catabolic processTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (12)

Processvia Protein(s)Taxonomy
RNA bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
zinc ion bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
enzyme bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
receptor tyrosine kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cadherin bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
ephrin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein phosphatase 2A bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (11)

Processvia Protein(s)Taxonomy
plasma membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial matrixTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial cristaTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endosome lumenTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
sorting endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmic side of endoplasmic reticulum membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein-containing complexTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (44)

Assay IDTitleYearJournalArticle
AID468785Inhibition of cell migration in human MDA-MB-231 cells under hypoxic conditions after 22 hrs by wound-healing assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468784Inhibition of cell migration in human MDA-MB-231 cells under normoxic conditions after 22 hrs by wound-healing assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468802Inhibition of electron transport protein complex 3 in human T47D cells assessed as decrease in oxygen consumption at 30 uM pretreated for 2 hrs before succinate addition by mitochondrial respiration assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468221Inhibition of 1,10-phenanthroline-induced HIF1 activation in human T47D cells at 1 uM after 16 hrs by pTK-HRE3-luciferase reporter gene assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468235Antiangiogenic activity in human HUVEC cells assessed as inhibition of normoxic T47D cell-conditioned media-induced tube formation at 30 uM after 18 hrs by Matrigel based tube formation assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468219Inhibition of electron transport protein complex 1 in digitonin-permeabilized human T47D cells assessed as decrease in oxygen consumption at 30 uM by mitochondrial respiration assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468795Inhibition of hypoxia-induced nuclear HIF1beta accumulation in human T47D cells at 10 uM after 4 hrs by Western blot analysis2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468803Inhibition of electron transport protein complex 4 in human T47D cells assessed as decrease in oxygen consumption at 30 uM pretreated for 2 hrs before TMPD/ascorbate addition by mitochondrial respiration assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468786Cytotoxicity against human MDA-MB-231 cells under hypoxic conditions up to 30 uM after 22 hrs by neutral red method2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468800Inhibition of electron transport protein complex 1 in human T47D cells assessed as decrease in oxygen consumption at 30 uM pretreated for 2 hrs before malate and pyruvate addition by mitochondrial respiration assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468229Inhibition of 1,10-phenanthroline-induced VEGF mRNA expression in human T47D cells at 30 uM after 16 hrs by RT-PCR2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468225Inhibition of hypoxia-induced VEGF mRNA expression in human T47D cells at 30 uM after 16 hrs by RT-PCR2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468793Inhibition of hypoxia-induced nuclear HIF1alpha accumulation in human T47D cells at 10 uM after 4 hrs by Western blot analysis2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468216Cytotoxicity against human MDA-MB-231 cells up to 30 uM after 22 hrs by neutral red method2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468218Antiangiogenic activity in human HUVEC cells assessed as decrease in tube length up to 30 uM after 18 hrs by Matrigel based tube formation assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468798Inhibition of electron transport protein complex 1 in human T47D cells assessed as reduction of oxygen consumption at 30 uM pretreated for 2 hrs relative to untreated control2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468220Inhibition of 1,10-phenanthroline-induced HIF1 activation in human T47D cells after 16 hrs by pTK-HRE3-luciferase reporter gene assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468217Inhibition of hypoxia-induced HIF1 activation in human T47D cells after 16 hrs by pTK-HRE3-luciferase reporter gene assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID264979Inhibition of human PTP1B2006Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia.
AID468801Inhibition of electron transport protein complex 2 in human T47D cells assessed as decrease in oxygen consumption at 30 uM pretreated for 2 hrs before succinate addition by mitochondrial respiration assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468234Antiangiogenic activity in human HUVEC cells assessed as inhibition of hypoxic T47D cell-conditioned media-induced tube formation at 30 uM after 18 hrs by Matrigel based tube formation assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468222Inhibition of hypoxia-induced HIF1 activation in human T47D cells at 1 uM after 16 hrs by pTK-HRE3-luciferase reporter gene assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468790Growth inhibition of human MCF7 cells at 1 uM to 30 uM after 48 hrs by sulforhodamine B assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468226Inhibition of hypoxia-induced GLUT1 mRNA expression in human T47D cells at 30 uM after 16 hrs by RT-PCR2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468791Growth inhibition of human PC3 cells at 30 uM after 48 hrs by sulforhodamine B assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468787Growth inhibition of human MDA-MB-231 cells at 1 uM to 30 uM after 48 hrs by sulforhodamine B assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468804Inhibition of cellular respiration in human T47D cells assessed as oxygen consumption2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468797Inhibition of electron transport protein complex 1 in human T47D cells assessed as reduction of oxygen consumption at 30 uM2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468223Cytotoxicity against human T47D cells under hypoxic conditions at 30 uM after 16 hrs2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468789Growth inhibition of human T47D cells at 1 uM to 30 uM after 48 hrs by sulforhodamine B assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468788Growth inhibition of human DU145 cells at 1 uM to 30 uM after 48 hrs by sulforhodamine B assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468227Inhibition of hypoxia-induced VEGF mRNA expression in human T47D cells at 10 uM after 16 hrs by RT-PCR2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468232Inhibition of secreted VEGF protein level in human T47D cells under normoxic conditions at 10 uM after 16 hrs by ELISA2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468459Antiangiogenic activity in human HUVEC cells assessed as decrease in branch point number up to 30 uM after 18 hrs by Matrigel based tube formation assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468228Inhibition of hypoxia-induced GLUT1 mRNA expression in human T47D cells at 10 uM after 16 hrs by RT-PCR2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID1601819Antimycobacterial activity against Mycobacterium tuberculosis H37Rv2019European journal of medicinal chemistry, Mar-01, Volume: 165Marine natural products as potential anti-tubercular agents.
AID468233Antiangiogenic activity in human HUVEC cells assessed as inhibition of hypoxic T47D cell-conditioned media-induced tube formation at 10 uM after 18 hrs by Matrigel based tube formation assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468231Inhibition of hypoxia-induced secreted VEGF protein level in human T47D cells at 10 uM after 16 hrs by ELISA2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468794Inhibition of 1,10-phenanthroline-induced nuclear HIF1alpha accumulation in human T47D cells at 10 uM after 4 hrs by Western blot analysis2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468224Effect on luciferase expression in hypoxia-stimulated human T47D cells expressing pGL3 construct at 30 uM after 16 hrs by reporter gene assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468792Growth inhibition of human HMEC cells up to 30 uM after 48 hrs by sulforhodamine B assay2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468230Inhibition of 1,10-phenanthroline-induced GLUT1 mRNA expression in human T47D cells at 30 uM after 16 hrs by RT-PCR2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468799Inhibition of electron transport protein complex 1 in digitonin-induced permeable human T47D cells assessed as reduction of oxygen consumption at 30 uM relative to control2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
AID468796Inhibition of electron transport protein complex 1 in human T47D cells assessed as reduction of oxygen consumption at 10 uM2009Journal of natural products, Dec, Volume: 72, Issue:12
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (25)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (20.00)29.6817
2010's16 (64.00)24.3611
2020's4 (16.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 30.48

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index30.48 (24.57)
Research Supply Index3.26 (2.92)
Research Growth Index5.38 (4.65)
Search Engine Demand Index36.71 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (30.48)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (12.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (88.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
formaldehyde
paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy		2.0510aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
histamine
[no description available]		2.0810aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
1,10-phenanthroline
1,10-phenanthroline: RN given refers to parent cpd; inhibits Zn-dependent metalloproteinases		2.0510phenanthrolineEC 2.7.1.1 (hexokinase) inhibitor;
EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		3.3110carbohydrazideantitubercular agent;
drug allergen
carbachol
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.		2.0810ammonium salt;
carbamate ester		cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic
gliotoxin
Gliotoxin: A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an immunosuppressive agent.. gliotoxin : A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi.		3.3110dipeptide;
organic disulfide;
organic heterotetracyclic compound;
pyrazinoindole		antifungal agent;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor;
immunosuppressive agent;
mycotoxin;
proteasome inhibitor
yohimbine
Yohimbine: A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION.. yohimbine : An indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina.		2.110methyl 17-hydroxy-20xi-yohimban-16-carboxylatealpha-adrenergic antagonist;
dopamine receptor D2 antagonist;
serotonergic antagonist
pyrazines
Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.		2.4220diazine;
pyrazines		Daphnia magna metabolite
hentriacontane
[no description available]		210long-chain alkaneantitubercular agent
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		2.1710D-glucopyranoseepitope;
mouse metabolite
puupehenone
[no description available]		3.3110
24-methylenecholesterol
24-methylenecholesterol: RN given refers to (3beta)-isomer; structure. 24-methylenecholesterol : A 3beta-sterol having the structure of cholesterol with a methylene group at C-24.		3.31103beta-hydroxy-Delta(5)-steroid;
3beta-sterol		mouse metabolite
brevianamide f
brevianamide F: isolated from the endophyte from Aspergillus fumigatus associated with Melia azedarach L that could be used to develop a natural eco-friendly herbicide.structure in first source. brevianamide F : A pyrrolopyrazine that is hexahydropyrrolo[1,2-a]pyrazine-1,4-dione bearing an indol-3-ylmethyl substituent at position 3 (the 3S,8aS-diastereomer, obtained by formal cyclocondensation of L-tryptophan and L-proline).		3.3110dipeptide;
indoles;
pyrrolopyrazine		metabolite
tropisetron
Tropisetron: An indole derivative and 5-HT3 RECEPTOR antagonist that is used for the prevention of nausea and vomiting.. tropisetron : An indolyl carboxylate ester obtained by formal condensation of the carboxy group of indole-3-carboxylic acid with the hydroxy group of tropine.		2.110indolyl carboxylic acid
sesquiterpenes
[no description available]		3.5820
capsaicin
ALGRX-4975: an injectable capsaicin (TRPV1 receptor agonist) formulation for longlasting pain relief. capsaicinoid : A family of aromatic fatty amides produced as secondary metabolites by chilli peppers.		2.0510capsaicinoidnon-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker
epinephrine
ircinal A: from an Indonesian Acanthostrongylophora sponge with activity against infectious, tropical parasitic, and Alzheimer's diseases; structure in first source		3.3110
naloxone
Naloxone: A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.. naloxone : A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.		2.110morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol		antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist
caulerpenyne
caulerpenyne: from the marine algae Caulerpa taxifolia; structure in first source		3.5820
sclerotiorin
sclerotiorin: isolated from monoverticillate Penicillia; RN given for (R-(R*,S*-(E,E)))-isomer; structure in first source		3.3110azaphilone
pseudopteroxazole
pseudopteroxazole: structure in first source		3.3110tetralinsmetabolite
manzamine a
manzamine A: RN given refers to (1R-(1R*,9Z,13S*,13aR*,20aR*,21aR*)-isomer; RN for cpd without isomeric designation not avail 12/92. manzamine A : An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).		3.3110alkaloid;
beta-carbolines;
isoquinolines		animal metabolite;
anti-HSV-1 agent;
antimalarial;
antineoplastic agent;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
marine metabolite
halicyclamine a
halicyclamine A: structure in first source		3.3110
1,4-dihydroxy-2-methoxy-7-methylanthraquinone
[no description available]		3.3110
neuropeptide y
Neuropeptide Y: A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones.		7.2110
proximicin b
proximicin B: antineoplastic agent isolated from Verrucosispora; structure in first source		3.3110
sch 419560
Sch 419560: isolated from Pseudomonas fluorescens; structure in first source		3.3110
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)		3.3110cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
4-deoxybostrycin
4-deoxybostrycin: crystalline red pigment from culture filtrate of Alternaria eichhorniae with antibacterial & phytotoxic activity; structure given in first source		3.3110
ConditionIndicatedRelationship StrengthStudiesTrials
Koch's Disease
[description not available]		03.1210
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.		03.1210
Infections, Helicobacter
[description not available]		02.3110
Helicobacter Infections
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.		02.3110
Colorectal Cancer
[description not available]		02.6320
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		02.6320
Colitis Gravis
[description not available]		02.1710
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.1710
Primary Peritonitis
[description not available]		02.4920
Colitis, Ulcerative
Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.		02.1710
Peritonitis
INFLAMMATION of the PERITONEUM lining the ABDOMINAL CAVITY as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the PERITONEAL CAVITY via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the ABDOMINAL CAVITY itself through RUPTURE or ABSCESS of intra-abdominal organs.		02.4920
Fish Diseases
Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).		02.1710
Benign Neoplasms
[description not available]		03.1210
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.1210
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		02.0810
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)		02.0810
Nociceptive Pain
Dull or sharp aching pain caused by stimulated NOCICEPTORS due to tissue injury, inflammation or diseases. It can be divided into somatic or tissue pain and VISCERAL PAIN.		02.110
Cancer of Ovary
[description not available]		02.1310
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.1310
Anasarca
[description not available]		02.0510
Ache
[description not available]		02.0510
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.0510
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.		02.0510