A cytosolic beta-glucosidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H227]
EC 3.2.1.21;
Cytosolic beta-glucosidase-like protein 1;
Cytosolic glycosylceramidase;
Cytosolic GCase;
Glucosidase beta acid 3;
Glucosylceramidase beta 3;
Klotho-related protein;
KLrP
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 1-deoxynojirimycin | Homo sapiens (human) | IC50 | 160.0000 | 2 | 2 |
| 2,5-dideoxy-2,5-imino-d-glucitol | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| validamine | Homo sapiens (human) | IC50 | 130,000,000.0000 | 1 | 1 |
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| galactosylceramidase activity | molecular function | Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine. [EC:3.2.1.46] |
| glucosylceramidase activity | molecular function | Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. [EC:3.2.1.45] |
| beta-galactosidase activity | molecular function | Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. [EC:3.2.1.23] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| beta-glucosidase activity | molecular function | Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. [EC:3.2.1.21, PMID:12594539] |
| glycosylceramidase activity | molecular function | Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine. [PMID:10692580, PMID:9762914] |
| scopolin beta-glucosidase activity | molecular function | Catalysis of the reaction: H2O + scopolin = beta-D-glucose + scopoletin. [EC:3.2.1.21, GOC:pz] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| catalytic complex | cellular component | A protein complex which is capable of catalytic activity. [GOC:bhm, GOC:TermGenie, PMID:8077207] |
This protein is involved in 9 target(s):
| Target | Category | Definition |
|---|---|---|
| glucosylceramide catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. [GOC:ai] |
| galactosylceramide catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group. [GOC:ai] |
| oligosaccharide catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [ISBN:0198506732] |
| glycoside catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. [GOC:go_curators] |
| glycosphingolipid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. [ISBN:0198506732] |
| protein stabilization | biological process | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai] |
| beta-glucoside catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of beta-glucoside. [GOC:TermGenie, GOC:yaf, PMID:15205427, PMID:16390337, PMID:8990303, Unipathway:UPA00237] |
| positive regulation of exo-alpha-sialidase activity | biological process | Any process that activates or increases the frequency, rate or extent of exo-alpha-sialidase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] |
| glycosylceramide catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. [GOC:ai] |