diamide and Pain

diamide has been researched along with Pain* in 1 studies

Other Studies

1 other study(ies) available for diamide and Pain

Article	Year
Synthesis and bradykinin inhibitory activity of novel non-peptide compounds, and evaluation of in vivo analgesic activity. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 A series of novel non-peptide diamide compounds was synthesized and evaluated as antibradykinin agents by utilizing guinea-pig ileum smooth muscle. Among the final compounds, (Z)-4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-oxo-N-(4-phenylbutan-2-yl)but-2-enamide showed most favorable bradykinin inhibitory activity and demonstrated analgesic efficacies in the rat models of inflammatory and neuropathic pain. Topics: Analgesics; Animals; Anti-Inflammatory Agents; Bradykinin; Diamide; Disease Models, Animal; Guinea Pigs; Ileum; Inflammation; Molecular Structure; Muscle, Smooth; Pain; Rats; Stereoisomerism; Structure-Activity Relationship	2010

Article

Year

Synthesis and bradykinin inhibitory activity of novel non-peptide compounds, and evaluation of in vivo analgesic activity.

Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

A series of novel non-peptide diamide compounds was synthesized and evaluated as antibradykinin agents by utilizing guinea-pig ileum smooth muscle. Among the final compounds, (Z)-4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-oxo-N-(4-phenylbutan-2-yl)but-2-enamide showed most favorable bradykinin inhibitory activity and demonstrated analgesic efficacies in the rat models of inflammatory and neuropathic pain.

Topics: Analgesics; Animals; Anti-Inflammatory Agents; Bradykinin; Diamide; Disease Models, Animal; Guinea Pigs; Ileum; Inflammation; Molecular Structure; Muscle, Smooth; Pain; Rats; Stereoisomerism; Structure-Activity Relationship

2010