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carbachol and Pain

carbachol has been researched along with Pain in 38 studies

Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Carbachol was found to have an analgesic effect."5.27Inhibition of the response to pain by the action of serotonin and carbachol topically applied to the area postrema of conscious guinea pigs. ( Lico, MC; Menescal-de-Oliveira, L, 1985)
"Carbachol attenuated formalin-induced biphasic pain responses and SB-334867 or TCS OX2 29 administration dose-dependently antagonized the LH-induced analgesia during both phases."3.83Differential contribution of orexin receptors within the ventral tegmental area to modulation of persistent inflammatory pain. ( Babapour, V; Ezzatpanah, S; Haghparast, A, 2016)
"Chemical stimulation of the lateral hypothalamus (LH) with carbachol induces antinociception which is antagonized by blockade of orexin receptors in some pain modulatory sites in the tail-flick test."3.83Functional interaction between orexin-1 and CB1 receptors in the periaqueductal gray matter during antinociception induced by chemical stimulation of the lateral hypothalamus in rats. ( Esmaeili, MH; Ezzatpanah, S; Haghparast, A; Reisi, Z, 2016)
"A single gene deletion causes lack of leptin and obesity in B6."3.75Leptin replacement restores supraspinal cholinergic antinociception in leptin-deficient obese mice. ( Baghdoyan, HA; Lydic, R; Wang, W, 2009)
"Intra-arterial injection of increasing doses of acetylcholine, nicotine, carbachol and pilocarpine into the pain reflex ear of the rabbit dose-dependently caused a reflex fall in mean arterial blood pressure."3.66Nicotinic nociceptors on perivascular sensory nerve endings. ( Juan, H, 1982)
"Muscle strips from the body and neck of the gallbladder were suspended in organ baths and dose-response curves were constructed for CCK-8 and carbachol."2.69In vitro responses of gallbladder muscle from patients with acalculous biliary pain. ( Ahmed, R; Bird, NC; Chess-Williams, R; Johnson, AG; Thomas, WE, 2000)
"3-10 microg) and clonidine (1-30 microg) were administered to obtain the dose-response curves and the 50% effective dose (ED(50)) for each drug."1.31Intrathecal carbachol and clonidine produce a synergistic antiallodynic effect in rats with a nerve ligation injury. ( Han, SM; Hwang, JH; Lee, EJ; Park, JY; Park, PH; Sim, JY, 2002)
"Carbachol was found to have an analgesic effect."1.27Inhibition of the response to pain by the action of serotonin and carbachol topically applied to the area postrema of conscious guinea pigs. ( Lico, MC; Menescal-de-Oliveira, L, 1985)
"Carbachol has the strongest side effects (maximal change of the anterior chamber 0."1.26Ultrasonographic study of the effect of different miotics on the eye components. ( François, J; Goes, F, 1977)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199012 (31.58)18.7374
1990's3 (7.89)18.2507
2000's13 (34.21)29.6817
2010's9 (23.68)24.3611
2020's1 (2.63)2.80

Authors

AuthorsStudies
Torkamand, F1
Aghakhani-Lobnani, AM1
Khaleghzadeh-Ahangar, H1
Rashvand, M1
Rahban, M1
Haghparast, A10
Siahposht-Khachaki, A1
Pourreza, P1
Ezzatpanah, S5
Zugaib, J1
Menescal-de-Oliveira, L2
Rezaee, L1
Salehi, S1
Alizadeh, AM1
Fazli-Tabaei, S1
Azhdari-Zarmehri, H1
Reisi, Z3
Vaziri, A1
Shaigani, P1
Moradi, M1
Fatahi, Z1
Babapour, V1
Yazdi, F1
Jahangirvand, M1
Esmaeili, MH2
Jeong, Y4
Holden, JE5
Pizzi, JA1
Wang, W1
Baghdoyan, HA2
Lydic, R2
Lograsso, M1
Nadeson, R1
Goodchild, CS1
Demarco, GJ1
Farah, EN1
Ebersberger, A1
Takac, H1
Richter, F1
Schaible, HG1
Hayes, RL1
Katayama, Y2
Watkins, LR1
Becker, DP1
Brodie, MS2
Proudfit, HK3
Juan, H1
Taylor, JE1
Yaksh, TL1
Richelson, E1
Nuseir, K1
Heidenreich, BA1
Ahn, DK1
Kim, YS1
Park, JS1
Ahmed, R1
Bird, NC1
Chess-Williams, R1
Thomas, WE1
Johnson, AG1
Guimarães, AP1
Guimarães, FS1
Prado, WA2
Kanda, T1
Naleway, E1
Lee, EJ1
Sim, JY1
Park, JY1
Hwang, JH1
Park, PH1
Han, SM1
François, J1
Goes, F1
Khayutin, VM1
Baraz, LA1
Lukoshkova, EV1
Sonina, RS1
Chernilovskaya, PE1
Klamt, JG1
Tsubokawa, T1
Maejima, S1
Yamamoto, T1
Lico, MC1
Huang, TF1
Liu, HM1
Vahlensieck, W1
Fabian, K1
Mörsdorf, K1
Kanski, JJ1

Trials

1 trial available for carbachol and Pain

ArticleYear
In vitro responses of gallbladder muscle from patients with acalculous biliary pain.
    Digestion, 2000, Volume: 61, Issue:2

    Topics: Adult; Aged; Carbachol; Cholecystitis; Cholelithiasis; Dose-Response Relationship, Drug; Female; Gal

2000

Other Studies

37 other studies available for carbachol and Pain

ArticleYear
The role of dentate gyrus dopaminergic receptors in the lateral hypothalamic-induced antinociception during persistent inflammatory pain in male rats.
    Behavioural brain research, 2021, 08-27, Volume: 412

    Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Benzazepines; Carbachol; Dentate Gyrus; Dopamine Anta

2021
Nucleus accumbens dopamine receptors mediate hypothalamus-induced antinociception in the rat formalin test.
    European journal of pain (London, England), 2017, Volume: 21, Issue:7

    Topics: Analgesia; Animals; Benzazepines; Carbachol; Hypothalamus; Male; Nucleus Accumbens; Pain; Pain Measu

2017
Cholinergic/opioid interaction in anterior cingulate cortex reduces the nociceptive response of vocalization in guinea pigs.
    Brain research, 2017, Sep-15, Volume: 1671

    Topics: Acetylcholine; Analgesics, Opioid; Animals; Atropine; Carbachol; Cholinergic Agents; Guinea Pigs; Gy

2017
Spinal Orexin-2 Receptors are Involved in Modulation of the Lateral Hypothalamic Stimulation-Induced Analgesia.
    Neurochemical research, 2019, Volume: 44, Issue:5

    Topics: Analgesia; Animals; Carbachol; Hypothalamic Area, Lateral; Male; Nucleus Accumbens; Orexin Receptors

2019
Involvement of orexin-2 receptors in the ventral tegmental area and nucleus accumbens in the antinociception induced by the lateral hypothalamus stimulation in rats.
    Peptides, 2013, Volume: 47

    Topics: Analgesics, Non-Narcotic; Animals; Carbachol; Catheterization; Hot Temperature; Hypothalamus; Inject

2013
Blockade of D1-like dopamine receptors within the ventral tegmental area and nucleus accumbens attenuates antinociceptive responses induced by chemical stimulation of the lateral hypothalamus.
    Neuroscience letters, 2015, Jul-10, Volume: 599

    Topics: Analgesics; Animals; Benzazepines; Carbachol; Hypothalamus; Intracellular Signaling Peptides and Pro

2015
Differential contribution of orexin receptors within the ventral tegmental area to modulation of persistent inflammatory pain.
    European journal of pain (London, England), 2016, Volume: 20, Issue:7

    Topics: Animals; Benzoxazoles; Carbachol; Hypothalamic Area, Lateral; Isoquinolines; Male; Naphthyridines; N

2016
Role of orexin-2 receptors in the nucleus accumbens in antinociception induced by carbachol stimulation of the lateral hypothalamus in formalin test.
    Behavioural pharmacology, 2016, Volume: 27, Issue:5

    Topics: Analgesics, Non-Narcotic; Animals; Carbachol; Disease Models, Animal; Dose-Response Relationship, Dr

2016
Functional interaction between orexin-1 and CB1 receptors in the periaqueductal gray matter during antinociception induced by chemical stimulation of the lateral hypothalamus in rats.
    European journal of pain (London, England), 2016, Volume: 20, Issue:10

    Topics: Animals; Benzoxazoles; Carbachol; Disease Models, Animal; Hypothalamic Area, Lateral; Male; Microinj

2016
Role of orexin-2 and CB1 receptors within the periaqueductal gray matter in lateral hypothalamic-induced antinociception in rats.
    Behavioural pharmacology, 2017, Volume: 28, Issue:1

    Topics: Animals; Carbachol; Disease Models, Animal; Dose-Response Relationship, Drug; Hypothalamic Area, Lat

2017
Lateral hypothalamic-induced alpha-adrenoceptor modulation occurs in a model of inflammatory pain in rats.
    Biological research for nursing, 2009, Volume: 10, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Carbachol; Cholinergic Agonists; Disease Models, Animal; Fema

2009
An NK1 receptor antagonist microinjected into the periaqueductal gray blocks lateral hypothalamic-induced antinociception in rats.
    Neuroscience letters, 2009, Apr-03, Volume: 453, Issue:2

    Topics: Animals; Behavior, Animal; Carbachol; Cholinergic Agonists; Cobalt; Female; Foot; Hypothalamic Area,

2009
Leptin replacement restores supraspinal cholinergic antinociception in leptin-deficient obese mice.
    The journal of pain, 2009, Volume: 10, Issue:8

    Topics: Acetylcholine; Adenosine; Animals; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Hot T

2009
The role of spinal orexin-1 receptors in posterior hypothalamic modulation of neuropathic pain.
    Neuroscience, 2009, Apr-10, Volume: 159, Issue:4

    Topics: Analgesics; Animals; Benzoxazoles; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug

2009
The spinal antinociceptive effects of cholinergic drugs in rats: receptor subtype specificity in different nociceptive tests.
    BMC pharmacology, 2002, Nov-19, Volume: 2

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Carbachol; Cholinergi

2002
Differential cholinergic activation of G proteins in rat and mouse brainstem: relevance for sleep and nociception.
    The Journal of comparative neurology, 2003, Mar-03, Volume: 457, Issue:2

    Topics: Animals; Autoradiography; Brain Stem; Carbachol; Cats; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiot

2003
Stimulation of the lateral hypothalamus produces antinociception mediated by 5-HT1A, 5-HT1B and 5-HT3 receptors in the rat spinal cord dorsal horn.
    Neuroscience, 2005, Volume: 135, Issue:4

    Topics: Animals; Carbachol; Cholinergic Agonists; Efferent Pathways; Female; Hypothalamus; Injections, Intra

2005
Effect of sympathetic and parasympathetic mediators on the release of calcitonin gene-related peptide and prostaglandin E from rat dura mater, in vitro.
    Cephalalgia : an international journal of headache, 2006, Volume: 26, Issue:3

    Topics: Animals; Calcitonin Gene-Related Peptide; Carbachol; Cholinergic Agonists; Dinoprostone; Dura Mater;

2006
Bilateral lesions of the dorsolateral funiculus of the cat spinal cord: effects on basal nociceptive reflexes and nociceptive suppression produced by cholinergic activation of the pontine parabrachial region.
    Brain research, 1984, Oct-08, Volume: 311, Issue:2

    Topics: Acetylcholine; Analgesia; Animals; Carbachol; Cats; Female; Male; Nociceptors; Pain; Pons; Reflex; S

1984
Hypoalgesia induced by the local injection of carbachol into the nucleus raphe magnus.
    Brain research, 1984, Jan-23, Volume: 291, Issue:2

    Topics: Acetylcholine; Animals; Atropine; Brain Mapping; Brain Stem; Carbachol; Cholinergic Fibers; Dose-Res

1984
Nicotinic nociceptors on perivascular sensory nerve endings.
    Pain, 1982, Volume: 12, Issue:3

    Topics: Acetylcholine; Analgesics; Animals; Atropine; Carbachol; Dose-Response Relationship, Drug; Morphine;

1982
Agonist regulation of muscarinic acetylcholine receptors in rat spinal cord.
    Journal of neurochemistry, 1982, Volume: 39, Issue:2

    Topics: Animals; Atropine; Carbachol; Kinetics; Male; Nociceptors; Pain; Quinuclidinyl Benzilate; Rats; Rats

1982
The antinociception produced by microinjection of a cholinergic agonist in the ventromedial medulla is mediated by noradrenergic neurons in the A7 catecholamine cell group.
    Brain research, 1999, Mar-20, Volume: 822, Issue:1-2

    Topics: Anesthetics, Local; Animals; Antimutagenic Agents; Carbachol; Cholinergic Agonists; Cobalt; Female;

1999
Central-amygdaloid carbachol suppressed nociceptive jaw opening reflex in freely moving rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 1999, Volume: 23, Issue:4

    Topics: Amygdala; Animals; Carbachol; Dental Pulp; Electromyography; Electroshock; Jaw; Male; Microinjection

1999
Modulation of carbachol-induced antinociception from the rat periaqueductal gray.
    Brain research bulletin, 2000, Volume: 51, Issue:6

    Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Anxiety; Bethanechol; Carbachol; Cholinergic Agon

2000
[Effects of cholinergic drugs and noradrenaline on the activity of neurons in the rat nucleus raphe magnus in vitro].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 2000, Volume: 75, Issue:4

    Topics: Action Potentials; Animals; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cholinergic Agonists

2000
Microinjection of carbachol in the lateral hypothalamus produces opposing actions on nociception mediated by alpha(1)- and alpha(2)-adrenoceptors.
    Brain research, 2001, Aug-17, Volume: 911, Issue:1

    Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Carbachol; Cholinergic Agonists; Dose-Response Rel

2001
Intrathecal carbachol and clonidine produce a synergistic antiallodynic effect in rats with a nerve ligation injury.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2002, Volume: 49, Issue:2

    Topics: Animals; Carbachol; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Ligation; Male; Pai

2002
Ultrasonographic study of the effect of different miotics on the eye components.
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1977, Volume: 175, Issue:6

    Topics: Administration, Topical; Adult; Anterior Chamber; Carbachol; Epinephrine; Eye; Humans; Lens, Crystal

1977
Chemosensitive spinal afferents: thresholds of specific and nociceptive reflexes as compared with thresholds of excitation for receptors and axons.
    Progress in brain research, 1976, Volume: 43

    Topics: Acetylcholine; Animals; Blood Pressure; Bradykinin; Carbachol; Cats; Chemoreceptor Cells; Histamine;

1976
Antinociception and behavioral changes induced by carbachol microinjected into identified sites of the rat brain.
    Brain research, 1991, May-17, Volume: 549, Issue:1

    Topics: Animals; Brain; Brain Mapping; Carbachol; Male; Microinjections; Organ Specificity; Pain; Rats; Rats

1991
Antinociception induced by local injections of carbachol into the nucleus raphe magnus in rats: alteration by intrathecal injection of monoaminergic antagonists.
    Brain research, 1986, Apr-16, Volume: 371, Issue:1

    Topics: Animals; Brain Mapping; Carbachol; Efferent Pathways; Norepinephrine; Pain; Raphe Nuclei; Rats; Rats

1986
Responses of raphe-spinal neurons to stimulation of the pontine parabrachial region producing behavioral nociceptive suppression in the cat.
    Applied neurophysiology, 1986, Volume: 49, Issue:3

    Topics: Animals; Blood Pressure; Carbachol; Cats; Electric Stimulation; Naloxone; Neural Pathways; Pain; Per

1986
Inhibition of the response to pain by the action of serotonin and carbachol topically applied to the area postrema of conscious guinea pigs.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1985, Volume: 18, Issue:1

    Topics: Analgesia; Animals; Carbachol; Cerebral Ventricles; Electric Stimulation; Guinea Pigs; Lysergic Acid

1985
Algesic actions of the polypeptides and other agents.
    The Chinese journal of physiology, 1972, Dec-31, Volume: 21, Issue:2

    Topics: Angiotensin II; Animals; Arecoline; Bradykinin; Carbachol; Catecholamines; Dogs; Dopamine; Epinephri

1972
[Induction and control of spasmo-analgesia].
    Zeitschrift fur Urologie und Nephrologie, 1971, Volume: 64, Issue:12

    Topics: Analgesics; Antipyrine; Carbachol; Colic; Dioxoles; Humans; Methylamines; Pain; Parasympatholytics;

1971
Miotics.
    The British journal of ophthalmology, 1968, Volume: 52, Issue:12

    Topics: Acetylcholine; Anterior Chamber; Carbachol; Cataract; Cholinesterase Inhibitors; Cysts; Echothiophat

1968