carbachol and Pain
carbachol has been researched along with Pain in 38 studies
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Carbachol was found to have an analgesic effect." | 5.27 | Inhibition of the response to pain by the action of serotonin and carbachol topically applied to the area postrema of conscious guinea pigs. ( Lico, MC; Menescal-de-Oliveira, L, 1985) |
| "Carbachol attenuated formalin-induced biphasic pain responses and SB-334867 or TCS OX2 29 administration dose-dependently antagonized the LH-induced analgesia during both phases." | 3.83 | Differential contribution of orexin receptors within the ventral tegmental area to modulation of persistent inflammatory pain. ( Babapour, V; Ezzatpanah, S; Haghparast, A, 2016) |
| "Chemical stimulation of the lateral hypothalamus (LH) with carbachol induces antinociception which is antagonized by blockade of orexin receptors in some pain modulatory sites in the tail-flick test." | 3.83 | Functional interaction between orexin-1 and CB1 receptors in the periaqueductal gray matter during antinociception induced by chemical stimulation of the lateral hypothalamus in rats. ( Esmaeili, MH; Ezzatpanah, S; Haghparast, A; Reisi, Z, 2016) |
| "A single gene deletion causes lack of leptin and obesity in B6." | 3.75 | Leptin replacement restores supraspinal cholinergic antinociception in leptin-deficient obese mice. ( Baghdoyan, HA; Lydic, R; Wang, W, 2009) |
| "Intra-arterial injection of increasing doses of acetylcholine, nicotine, carbachol and pilocarpine into the pain reflex ear of the rabbit dose-dependently caused a reflex fall in mean arterial blood pressure." | 3.66 | Nicotinic nociceptors on perivascular sensory nerve endings. ( Juan, H, 1982) |
| "Muscle strips from the body and neck of the gallbladder were suspended in organ baths and dose-response curves were constructed for CCK-8 and carbachol." | 2.69 | In vitro responses of gallbladder muscle from patients with acalculous biliary pain. ( Ahmed, R; Bird, NC; Chess-Williams, R; Johnson, AG; Thomas, WE, 2000) |
| "3-10 microg) and clonidine (1-30 microg) were administered to obtain the dose-response curves and the 50% effective dose (ED(50)) for each drug." | 1.31 | Intrathecal carbachol and clonidine produce a synergistic antiallodynic effect in rats with a nerve ligation injury. ( Han, SM; Hwang, JH; Lee, EJ; Park, JY; Park, PH; Sim, JY, 2002) |
| "Carbachol was found to have an analgesic effect." | 1.27 | Inhibition of the response to pain by the action of serotonin and carbachol topically applied to the area postrema of conscious guinea pigs. ( Lico, MC; Menescal-de-Oliveira, L, 1985) |
| "Carbachol has the strongest side effects (maximal change of the anterior chamber 0." | 1.26 | Ultrasonographic study of the effect of different miotics on the eye components. ( François, J; Goes, F, 1977) |
Research
Studies (38)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (31.58) | 18.7374 |
| 1990's | 3 (7.89) | 18.2507 |
| 2000's | 13 (34.21) | 29.6817 |
| 2010's | 9 (23.68) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Torkamand, F | 1 |
| Aghakhani-Lobnani, AM | 1 |
| Khaleghzadeh-Ahangar, H | 1 |
| Rashvand, M | 1 |
| Rahban, M | 1 |
| Haghparast, A | 10 |
| Siahposht-Khachaki, A | 1 |
| Pourreza, P | 1 |
| Ezzatpanah, S | 5 |
| Zugaib, J | 1 |
| Menescal-de-Oliveira, L | 2 |
| Rezaee, L | 1 |
| Salehi, S | 1 |
| Alizadeh, AM | 1 |
| Fazli-Tabaei, S | 1 |
| Azhdari-Zarmehri, H | 1 |
| Reisi, Z | 3 |
| Vaziri, A | 1 |
| Shaigani, P | 1 |
| Moradi, M | 1 |
| Fatahi, Z | 1 |
| Babapour, V | 1 |
| Yazdi, F | 1 |
| Jahangirvand, M | 1 |
| Esmaeili, MH | 2 |
| Jeong, Y | 4 |
| Holden, JE | 5 |
| Pizzi, JA | 1 |
| Wang, W | 1 |
| Baghdoyan, HA | 2 |
| Lydic, R | 2 |
| Lograsso, M | 1 |
| Nadeson, R | 1 |
| Goodchild, CS | 1 |
| Demarco, GJ | 1 |
| Farah, EN | 1 |
| Ebersberger, A | 1 |
| Takac, H | 1 |
| Richter, F | 1 |
| Schaible, HG | 1 |
| Hayes, RL | 1 |
| Katayama, Y | 2 |
| Watkins, LR | 1 |
| Becker, DP | 1 |
| Brodie, MS | 2 |
| Proudfit, HK | 3 |
| Juan, H | 1 |
| Taylor, JE | 1 |
| Yaksh, TL | 1 |
| Richelson, E | 1 |
| Nuseir, K | 1 |
| Heidenreich, BA | 1 |
| Ahn, DK | 1 |
| Kim, YS | 1 |
| Park, JS | 1 |
| Ahmed, R | 1 |
| Bird, NC | 1 |
| Chess-Williams, R | 1 |
| Thomas, WE | 1 |
| Johnson, AG | 1 |
| Guimarães, AP | 1 |
| Guimarães, FS | 1 |
| Prado, WA | 2 |
| Kanda, T | 1 |
| Naleway, E | 1 |
| Lee, EJ | 1 |
| Sim, JY | 1 |
| Park, JY | 1 |
| Hwang, JH | 1 |
| Park, PH | 1 |
| Han, SM | 1 |
| François, J | 1 |
| Goes, F | 1 |
| Khayutin, VM | 1 |
| Baraz, LA | 1 |
| Lukoshkova, EV | 1 |
| Sonina, RS | 1 |
| Chernilovskaya, PE | 1 |
| Klamt, JG | 1 |
| Tsubokawa, T | 1 |
| Maejima, S | 1 |
| Yamamoto, T | 1 |
| Lico, MC | 1 |
| Huang, TF | 1 |
| Liu, HM | 1 |
| Vahlensieck, W | 1 |
| Fabian, K | 1 |
| Mörsdorf, K | 1 |
| Kanski, JJ | 1 |
Trials
1 trial available for carbachol and Pain
| Article | Year |
|---|---|
In vitro responses of gallbladder muscle from patients with acalculous biliary pain.
Topics: Adult; Aged; Carbachol; Cholecystitis; Cholelithiasis; Dose-Response Relationship, Drug; Female; Gal | 2000 |
Other Studies
37 other studies available for carbachol and Pain
| Article | Year |
|---|---|
The role of dentate gyrus dopaminergic receptors in the lateral hypothalamic-induced antinociception during persistent inflammatory pain in male rats.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Benzazepines; Carbachol; Dentate Gyrus; Dopamine Anta | 2021 |
Nucleus accumbens dopamine receptors mediate hypothalamus-induced antinociception in the rat formalin test.
Topics: Analgesia; Animals; Benzazepines; Carbachol; Hypothalamus; Male; Nucleus Accumbens; Pain; Pain Measu | 2017 |
Cholinergic/opioid interaction in anterior cingulate cortex reduces the nociceptive response of vocalization in guinea pigs.
Topics: Acetylcholine; Analgesics, Opioid; Animals; Atropine; Carbachol; Cholinergic Agents; Guinea Pigs; Gy | 2017 |
Spinal Orexin-2 Receptors are Involved in Modulation of the Lateral Hypothalamic Stimulation-Induced Analgesia.
Topics: Analgesia; Animals; Carbachol; Hypothalamic Area, Lateral; Male; Nucleus Accumbens; Orexin Receptors | 2019 |
Involvement of orexin-2 receptors in the ventral tegmental area and nucleus accumbens in the antinociception induced by the lateral hypothalamus stimulation in rats.
Topics: Analgesics, Non-Narcotic; Animals; Carbachol; Catheterization; Hot Temperature; Hypothalamus; Inject | 2013 |
Blockade of D1-like dopamine receptors within the ventral tegmental area and nucleus accumbens attenuates antinociceptive responses induced by chemical stimulation of the lateral hypothalamus.
Topics: Analgesics; Animals; Benzazepines; Carbachol; Hypothalamus; Intracellular Signaling Peptides and Pro | 2015 |
Differential contribution of orexin receptors within the ventral tegmental area to modulation of persistent inflammatory pain.
Topics: Animals; Benzoxazoles; Carbachol; Hypothalamic Area, Lateral; Isoquinolines; Male; Naphthyridines; N | 2016 |
Role of orexin-2 receptors in the nucleus accumbens in antinociception induced by carbachol stimulation of the lateral hypothalamus in formalin test.
Topics: Analgesics, Non-Narcotic; Animals; Carbachol; Disease Models, Animal; Dose-Response Relationship, Dr | 2016 |
Functional interaction between orexin-1 and CB1 receptors in the periaqueductal gray matter during antinociception induced by chemical stimulation of the lateral hypothalamus in rats.
Topics: Animals; Benzoxazoles; Carbachol; Disease Models, Animal; Hypothalamic Area, Lateral; Male; Microinj | 2016 |
Role of orexin-2 and CB1 receptors within the periaqueductal gray matter in lateral hypothalamic-induced antinociception in rats.
Topics: Animals; Carbachol; Disease Models, Animal; Dose-Response Relationship, Drug; Hypothalamic Area, Lat | 2017 |
Lateral hypothalamic-induced alpha-adrenoceptor modulation occurs in a model of inflammatory pain in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Carbachol; Cholinergic Agonists; Disease Models, Animal; Fema | 2009 |
An NK1 receptor antagonist microinjected into the periaqueductal gray blocks lateral hypothalamic-induced antinociception in rats.
Topics: Animals; Behavior, Animal; Carbachol; Cholinergic Agonists; Cobalt; Female; Foot; Hypothalamic Area, | 2009 |
Leptin replacement restores supraspinal cholinergic antinociception in leptin-deficient obese mice.
Topics: Acetylcholine; Adenosine; Animals; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Hot T | 2009 |
The role of spinal orexin-1 receptors in posterior hypothalamic modulation of neuropathic pain.
Topics: Analgesics; Animals; Benzoxazoles; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug | 2009 |
The spinal antinociceptive effects of cholinergic drugs in rats: receptor subtype specificity in different nociceptive tests.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Carbachol; Cholinergi | 2002 |
Differential cholinergic activation of G proteins in rat and mouse brainstem: relevance for sleep and nociception.
Topics: Animals; Autoradiography; Brain Stem; Carbachol; Cats; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiot | 2003 |
Stimulation of the lateral hypothalamus produces antinociception mediated by 5-HT1A, 5-HT1B and 5-HT3 receptors in the rat spinal cord dorsal horn.
Topics: Animals; Carbachol; Cholinergic Agonists; Efferent Pathways; Female; Hypothalamus; Injections, Intra | 2005 |
Effect of sympathetic and parasympathetic mediators on the release of calcitonin gene-related peptide and prostaglandin E from rat dura mater, in vitro.
Topics: Animals; Calcitonin Gene-Related Peptide; Carbachol; Cholinergic Agonists; Dinoprostone; Dura Mater; | 2006 |
Bilateral lesions of the dorsolateral funiculus of the cat spinal cord: effects on basal nociceptive reflexes and nociceptive suppression produced by cholinergic activation of the pontine parabrachial region.
Topics: Acetylcholine; Analgesia; Animals; Carbachol; Cats; Female; Male; Nociceptors; Pain; Pons; Reflex; S | 1984 |
Hypoalgesia induced by the local injection of carbachol into the nucleus raphe magnus.
Topics: Acetylcholine; Animals; Atropine; Brain Mapping; Brain Stem; Carbachol; Cholinergic Fibers; Dose-Res | 1984 |
Nicotinic nociceptors on perivascular sensory nerve endings.
Topics: Acetylcholine; Analgesics; Animals; Atropine; Carbachol; Dose-Response Relationship, Drug; Morphine; | 1982 |
Agonist regulation of muscarinic acetylcholine receptors in rat spinal cord.
Topics: Animals; Atropine; Carbachol; Kinetics; Male; Nociceptors; Pain; Quinuclidinyl Benzilate; Rats; Rats | 1982 |
The antinociception produced by microinjection of a cholinergic agonist in the ventromedial medulla is mediated by noradrenergic neurons in the A7 catecholamine cell group.
Topics: Anesthetics, Local; Animals; Antimutagenic Agents; Carbachol; Cholinergic Agonists; Cobalt; Female; | 1999 |
Central-amygdaloid carbachol suppressed nociceptive jaw opening reflex in freely moving rats.
Topics: Amygdala; Animals; Carbachol; Dental Pulp; Electromyography; Electroshock; Jaw; Male; Microinjection | 1999 |
Modulation of carbachol-induced antinociception from the rat periaqueductal gray.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Anxiety; Bethanechol; Carbachol; Cholinergic Agon | 2000 |
[Effects of cholinergic drugs and noradrenaline on the activity of neurons in the rat nucleus raphe magnus in vitro].
Topics: Action Potentials; Animals; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cholinergic Agonists | 2000 |
Microinjection of carbachol in the lateral hypothalamus produces opposing actions on nociception mediated by alpha(1)- and alpha(2)-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Carbachol; Cholinergic Agonists; Dose-Response Rel | 2001 |
Intrathecal carbachol and clonidine produce a synergistic antiallodynic effect in rats with a nerve ligation injury.
Topics: Animals; Carbachol; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Ligation; Male; Pai | 2002 |
Ultrasonographic study of the effect of different miotics on the eye components.
Topics: Administration, Topical; Adult; Anterior Chamber; Carbachol; Epinephrine; Eye; Humans; Lens, Crystal | 1977 |
Chemosensitive spinal afferents: thresholds of specific and nociceptive reflexes as compared with thresholds of excitation for receptors and axons.
Topics: Acetylcholine; Animals; Blood Pressure; Bradykinin; Carbachol; Cats; Chemoreceptor Cells; Histamine; | 1976 |
Antinociception and behavioral changes induced by carbachol microinjected into identified sites of the rat brain.
Topics: Animals; Brain; Brain Mapping; Carbachol; Male; Microinjections; Organ Specificity; Pain; Rats; Rats | 1991 |
Antinociception induced by local injections of carbachol into the nucleus raphe magnus in rats: alteration by intrathecal injection of monoaminergic antagonists.
Topics: Animals; Brain Mapping; Carbachol; Efferent Pathways; Norepinephrine; Pain; Raphe Nuclei; Rats; Rats | 1986 |
Responses of raphe-spinal neurons to stimulation of the pontine parabrachial region producing behavioral nociceptive suppression in the cat.
Topics: Animals; Blood Pressure; Carbachol; Cats; Electric Stimulation; Naloxone; Neural Pathways; Pain; Per | 1986 |
Inhibition of the response to pain by the action of serotonin and carbachol topically applied to the area postrema of conscious guinea pigs.
Topics: Analgesia; Animals; Carbachol; Cerebral Ventricles; Electric Stimulation; Guinea Pigs; Lysergic Acid | 1985 |
Algesic actions of the polypeptides and other agents.
Topics: Angiotensin II; Animals; Arecoline; Bradykinin; Carbachol; Catecholamines; Dogs; Dopamine; Epinephri | 1972 |
[Induction and control of spasmo-analgesia].
Topics: Analgesics; Antipyrine; Carbachol; Colic; Dioxoles; Humans; Methylamines; Pain; Parasympatholytics; | 1971 |
Miotics.
Topics: Acetylcholine; Anterior Chamber; Carbachol; Cataract; Cholinesterase Inhibitors; Cysts; Echothiophat | 1968 |