Proteins > Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Page last updated: 2024-08-07 13:37:22
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
[no definition available]
Synonyms
ENR;
EC 1.3.1.39;
NADPH-dependent enoyl-ACP reductase
Research
Bioassay Publications (9)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| triclosan | Staphylococcus aureus subsp. aureus MRSA252 | IC50 | 2.6049 | 10 | 14 |
| triclosan | Staphylococcus aureus subsp. aureus MRSA252 | Ki | 0.0000 | 1 | 1 |
| 2-phenoxyphenol | Staphylococcus aureus subsp. aureus MRSA252 | Ki | 0.0189 | 1 | 1 |
| moracin c | Staphylococcus aureus subsp. aureus MRSA252 | IC50 | 83.8000 | 1 | 1 |
| afn 1252 | Staphylococcus aureus subsp. aureus MRSA252 | IC50 | 0.0290 | 1 | 1 |
Discovery of a potent enoyl-acyl carrier protein reductase (FabI) inhibitor suitable for antistaphylococcal agent.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 25, Issue:20, 2015
Rational optimization of drug-target residence time: insights from inhibitor binding to the Staphylococcus aureus FabI enzyme-product complex.Biochemistry, , Jun-18, Volume: 52, Issue:24, 2013
From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK.Journal of medicinal chemistry, , Apr-24, Volume: 46, Issue:9, 2003
Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI).Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents.Bioorganic & medicinal chemistry letters, , Sep-03, Volume: 11, Issue:17, 2001
1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).Bioorganic & medicinal chemistry letters, , Aug-20, Volume: 11, Issue:16, 2001