7-chlorokynurenic acid has been researched along with Pain in 7 studies
7-chlorokynurenic acid: selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex; structure given in first source
7-chlorokynurenic acid : A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the NMDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martins, MA | 1 |
| De Castro Bastos, L | 1 |
| Melo, NE | 1 |
| Tonussi, CR | 1 |
| Ren, WH | 1 |
| Guo, JD | 1 |
| Cao, H | 1 |
| Wang, H | 1 |
| Wang, PF | 1 |
| Sha, H | 1 |
| Ji, RR | 1 |
| Zhao, ZQ | 1 |
| Zhang, YQ | 1 |
| Tan-No, K | 1 |
| Esashi, A | 1 |
| Nakagawasai, O | 1 |
| Niijima, F | 1 |
| Furuta, S | 1 |
| Sato, T | 1 |
| Satoh, S | 1 |
| Yasuhara, H | 1 |
| Tadano, T | 1 |
| Chapman, V | 2 |
| Dickenson, AH | 3 |
| Chiang, CY | 1 |
| Hu, JW | 1 |
| Sessle, BJ | 1 |
| Reeve, AJ | 1 |
| Kerr, NC | 1 |
7 other studies available for 7-chlorokynurenic acid and Pain
| Article | Year |
|---|---|
Dependency of nociception facilitation or inhibition after periaqueductal gray matter stimulation on the context.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; | 2010 |
Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect?
Topics: Animals; Anxiety; D-Amino-Acid Oxidase; Excitatory Amino Acid Antagonists; Fear; Glycine; Gyrus Cing | 2006 |
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site.
Topics: 2-Amino-5-phosphonovalerate; Agmatine; Animals; Cycloserine; Dizocilpine Maleate; Dose-Response Rela | 2007 |
Time-related roles of excitatory amino acid receptors during persistent noxiously evoked responses of rat dorsal horn neurones.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Evoked Potentials; Excitatory Amino Acid Antagonists; | 1995 |
NMDA receptor involvement in neuroplastic changes induced by neonatal capsaicin treatment in trigeminal nociceptive neurons.
Topics: Animals; Animals, Newborn; Capsaicin; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Functi | 1997 |
Spinal effects of bicuculline: modulation of an allodynia-like state by an A1-receptor agonist, morphine, and an NMDA-receptor antagonist.
Topics: Adenosine; Animals; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; Kynurenic Acid; | 1998 |
The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn.
Topics: Afferent Pathways; Animals; Electric Stimulation; Hot Temperature; Injections, Spinal; Kynurenic Aci | 1992 |