Compounds > teroxirone
Page last updated: 2024-11-11

teroxirone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID6917771
MeSH IDM0092302

Synonyms (40)

Synonym
alpha-tgt
alpha-tgi
teroxirone
nsc-296934
teroxirone (usan)
59653-73-5
D06080
nsc 296934
1,3,5-triazine-2,4,6-(1h,3h,5h)-trione, 1,3,5-tris(oxiranylmethyl)-, (alpha)-
teroxironum [inn-latin]
teroxirone [usan:inn]
teroxirona [inn-spanish]
henkel's compound
s-triazine-2,4,6(1h,3h,5h)-trione, 1,3,5-tris(2,3-epoxypropyl)-, alpha-
alpha-triglycidyl isocyanurate
1,3,5-triazine-2,4,6(1h,3h,5h)-trione, 1,3,5-tris(oxiranylmethyl)-, (1(r*),3(r*),5(s*))-(+-)-
alpha-1,3,5-tris(2,3-epoxypropyl)-s-triazine-2,4,6-(1h,3h,5h)-trione
(rs,rs,sr)-1,3,5-tris(2,3-epoxypropyl)-s-triazine-2,4,6(1h,3h,5h)-trione
alphatgi
.alpha.-triglycidyl isocyanurate
gatgi
456v4159sl ,
unii-456v4159sl
teroxirona
teroxironum
teroxirone [usan]
triglycidyl isocyanurate, .alpha.-
1,3,5-triazine-2,4,6(1h,3h,5h)-trione, 1,3,5-tris(oxiranylmethyl)-, (1(r*),3(r*),5(s*))-(+/-)-
triglycidyl isocyanurate .alpha.-form [mi]
teroxirone [inn]
1,3,5-triazine-2,4,6(1h,3h,5h)-trione, 1,3-bis((2r)-2-oxiranylmethyl)-5-((2s)-2-oxiranylmethyl)-, rel-
1,3,5-triazine-2,4,6(1h,3h,5h)-trione, 1,3-bis((2r)-oxiranylmethyl)-5-((2s)-oxiranylmethyl)-
1,3-bis((2r)-2-oxiranylmethyl)-5-((2s)-2-oxiranylmethyl)-1,3,5-triazine-2,4,6(1h,3h,5h)-trione
24N3OU2YDR ,
triglycidyl isocyanurate, (r,r,s)-
1,3,5-triazine-2,4,6(1h,3h,5h)-trione, 1,3-bis((2r)-2-oxiranylmethyl)-5-((2s)-2-oxiranylmethyl)-
240408-79-1
unii-24n3ou2ydr
1,5-bis[[(2r)-oxiran-2-yl]methyl]-3-[[(2s)-oxiran-2-yl]methyl]-1,3,5-triazinane-2,4,6-trione
DTXSID301318560

Research Excerpts

Overview

Teroxirone is a novel triepoxide, synthesized as an alkylator and showing a broad spectrum of preclinical activity.

ExcerptReferenceRelevance
"Teroxirone is a novel triepoxide, synthesized as an alkylator and showing a broad spectrum of preclinical activity. "( Phase I trial of teroxirone.
Derocher, D; Grever, MR; Kraut, EH; Malspeis, L; Neidhart, JA, 1984)		2.05
"Teroxirone is an experimental triepoxide antitumor agent currently undergoing evaluation in clinical trials. "( Pharmacological characterization of teroxirone, a triepoxide antitumor agent, in rats, rabbits, and humans.
Ames, MM; Kovach, JS; Rubin, J, 1984)		1.99
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (35)

TimeframeStudies, This Drug (%)All Drugs %
pre-199014 (40.00)18.7374
1990's7 (20.00)18.2507
2000's6 (17.14)29.6817
2010's8 (22.86)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 16.08

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index16.08 (24.57)
Research Supply Index3.58 (2.92)
Research Growth Index4.48 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (16.08)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies14 (40.00%)4.05%
Observational0 (0.00%)0.25%
Other21 (60.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
formaldehyde
paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy		2.0210aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
histamine
[no description available]		1.9910aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
haloperidol
Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279). haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.		210aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
bromodeoxyuridine
Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.		2.1710pyrimidine 2'-deoxyribonucleosideantimetabolite;
antineoplastic agent
methacholine chloride
Methacholine Chloride: A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)		2.0610quaternary ammonium salt
phencyclidine
Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.. phencyclidine : A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.		2.0210benzenes;
piperidines		anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug
4,4'-diaminodiphenylmethane
4,4'-diaminodiphenylmethane: RN given refers to parent cpd; structure. 4,4'-diaminodiphenylmethane : An aromatic amine that is diphenylmethane substituted at the 4-position of each benzene ring by an amino group.		1.9810aromatic amineallergen;
carcinogenic agent
hydroxyethyl methacrylate
hydroxyethyl methacrylate: many of cited refs are for gel which refers to polymeric form of above cpd: POLYHYDROXYETHYL METHACRYLATE. 2-hydroxyethyl methacrylate : An enoate ester that is the monomethacryloyl derivative of ethylene glycol.		1.9810enoate esterallergen;
polymerisation monomer
titanium
Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.		2.0210titanium group element atom
cobalt
Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.		2.1310cobalt group element atom;
metal allergen		micronutrient
barium
Barium: An element of the alkaline earth group of metals. It has an atomic symbol Ba, atomic number 56, and atomic weight 138. All of its acid-soluble salts are poisonous.		2.0210alkaline earth metal atom;
elemental barium
cytochrome c-t
Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.		2.5220
ConditionIndicatedRelationship StrengthStudiesTrials
Hepatocellular Carcinoma
[description not available]		07.1710
Cancer of Liver
[description not available]		02.1710
Invasiveness, Neoplasm
[description not available]		02.1710
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.1710
Liver Neoplasms
Tumors or cancer of the LIVER.		02.1710
Carcinoma, Non-Small Cell Lung
[description not available]		02.5220
Cancer of Lung
[description not available]		02.420
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.		02.5220
Lung Neoplasms
Tumors or cancer of the LUNG.		02.420
Asthma, Occupational
Asthma attacks caused, triggered, or exacerbated by OCCUPATIONAL EXPOSURE.		02.2110
Airway Hyper-Responsiveness
[description not available]		02.2110
Allergic Contact Dermatitis
[description not available]		03.3970
Facial Dermatoses
Skin diseases involving the FACE.		02.730
Dermatitis, Occupational
A recurrent contact dermatitis caused by substances found in the work place.		03.69100
Hand Dermatosis
[description not available]		02.1310
Hand Dermatoses
Skin diseases involving the HANDS.		02.1310
Dermatitis, Allergic Contact
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.		03.3970
Asthma, Bronchial
[description not available]		02.9440
Diseases, Occupational
[description not available]		02.9440
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).		02.9440
Ache
[description not available]		02.0210
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.		02.0210
Allergic Alveolitis, Extrinsic
[description not available]		02.0210
Alveolitis, Extrinsic Allergic
A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.		02.0210
Leukemia L 1210
[description not available]		02.3720
Blood Diseases
[description not available]		01.9610
Benign Neoplasms
[description not available]		03.0650
Phlegmasia Alba Dolens
Inflammation that is characterized by swollen, pale, and painful limb. It is usually caused by DEEP VEIN THROMBOSIS in a FEMORAL VEIN, following PARTURITION or an illness. This condition is also called milk leg or white leg.		02.6530
Hematologic Diseases
Disorders of the blood and blood forming tissues.		01.9610
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.0650
Thrombophlebitis
Inflammation of a vein associated with a blood clot (THROMBUS).		02.6530
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.3720
Leukocytopenia
[description not available]		02.6530
Emesis
[description not available]		02.3620
Leukopenia
A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).		02.6530
Vomiting
The forcible expulsion of the contents of the STOMACH through the MOUTH.		02.3620
Alopecia Cicatrisata
[description not available]		01.9610
Alopecia
Absence of hair from areas where it is normally present.		01.9610
Nausea
An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.		01.9610
Experimental Leukemia
[description not available]		01.9510
Experimental Neoplasms
[description not available]		02.3620
Adenocarcinoma, Basal Cell
[description not available]		01.9510
Carcinoma, Anaplastic
[description not available]		01.9510
Cancer of Colon
[description not available]		01.9510
Germinoblastoma
[description not available]		01.9510
Cancer of Ovary
[description not available]		01.9510
Anaplastic Ependymoma
[description not available]		01.9510
Experimental Mammary Neoplasms
[description not available]		01.9510
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		01.9510
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		01.9510
Colonic Neoplasms
Tumors or cancer of the COLON.		01.9510
Ependymoma
Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)		01.9510
Fibrosarcoma
A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)		01.9510
Lymphoma
A general term for various neoplastic diseases of the lymphoid tissue.		01.9510
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		01.9510
Dermatitis, Eczematous
[description not available]		01.9910
Eosinophilia, Tropical
[description not available]		01.9910
Eczema
A pruritic papulovesicular dermatitis occurring as a reaction to many endogenous and exogenous agents (Dorland, 27th ed).		01.9910
Eosinophilia
Abnormal increase of EOSINOPHILS in the blood, tissues or organs.		01.9910
Contact Dermatitis
[description not available]		02.6630
Dermatitis, Contact
A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.		02.6630
Allergic Reaction
[description not available]		01.9710
Hypersensitivity
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.		01.9710