Page last updated: 2024-12-09

yoda 1

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

yoda-1: small molecule activator of Piezo-1 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

yoda 1 : A member of the class of thiadiazoles that is 1,3,4-thiadiazole substituted by pyrazin-2-yl and (2,6-dichlorobenzyl)sulfanediyl groups at positions 2 and 5, respectively. It is a selective activator of mechanosensitive channel piezo1. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID2746822
CHEMBL ID4303374
CHEBI ID194079
SCHEMBL ID6490578

Synonyms (43)

Synonym
2-[(2,6-dichlorophenyl)methylsulfanyl]-5-pyrazin-2-yl-1,3,4-thiadiazole
CHEBI:194079
448947-81-7
S6678
AKOS025312144
BQNXBSYSQXSXPT-UHFFFAOYSA-N
5-[(2,6-dichlorophenyl)methylthio]-2-(pyrazin-2-yl)-1,3,4-thiadiazole
CS-5095
SCHEMBL6490578
yoda1
yoda 1
HY-18723
2-[(2,6-dichlorophenyl)methylthio]-5-(pyrazin-2-yl)-1,3,4-thiadiazole
glyt2-in-1 ,
2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine
2-((2,6-dichlorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole
gtpl9817
2-[5-[(2,6-dichlorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]pyrazine
AS-16891
unii-tw6gf9rw6s
BCP29380
yoda1; yoda-1; yoda 1
2-[5-(2,6-dichloro-benzylsulfanyl)-[1,3,4]thiadiazol-2-yl]-pyrazine
mfcd00833175
NCGC00476206-03
2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-pyrazine
CHEMBL4303374 ,
yoda-1
TW6GF9RW6S ,
2-(5-(((2,6-dichlorophenyl)methyl)sulfanyl)-1,3,4-thiadiazol-2-yl)pyrazine
pyrazine, (5-(((2,6-dichlorophenyl)methyl)thio)-1,3,4-thiadiazol-2-yl)-
2-(5-(((2,6-dichlorophenyl)methyl)thio)-1,3,4-thiadiazol-2-yl)pyrazine
EX-A1902
D83675
glyt2-in-1;yoda 1
A919056
BG168492
EN300-246893
2-(5-{[(2,6-dichlorophenyl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)pyrazine
DTXSID301337271
AC-36238
Z2193704533
bdbm50600401
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
glycine transporter 2 inhibitorAny glycine transporter inhibitor that interferes with the action of glycine 2 transporters.
piezo1 agonistAn agonist that binds to and activates piezo1 receptors.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
aromatic compoundA cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character.
pyrazines
thiadiazoles
organic sulfideCompounds having the structure RSR (R =/= H). Such compounds were once called thioethers.
dichlorobenzeneAny member of the class of chlorobenzenes carrying two chloro groups at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (8)

Processvia Protein(s)Taxonomy
monoatomic cation transportPiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
positive regulation of myotube differentiationPiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
positive regulation of integrin activationPiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
positive regulation of cell-cell adhesion mediated by integrinPiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
monoatomic cation transmembrane transportPiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
cellular response to mechanical stimulusPiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
regulation of membrane potentialPiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
detection of mechanical stimulusPiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
monoatomic cation channel activityPiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
protein bindingPiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
mechanosensitive monoatomic cation channel activityPiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
mechanosensitive monoatomic ion channel activityPiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Processvia Protein(s)Taxonomy
endoplasmic reticulumPiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
endoplasmic reticulum membranePiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
plasma membranePiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
lamellipodium membranePiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartment membranePiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
endoplasmic reticulumPiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
plasma membranePiezo-type mechanosensitive ion channel component 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID1891732Agonist activity at mouse Piezo1 transfected in human HEK293T cells by FLIPR assay2022Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9
Piezo-Type Mechanosensitive Ion Channel Component 1 (Piezo1): A Promising Therapeutic Target and Its Modulators.
AID1891733Agonist activity at human Piezo1 transfected in human HEK293T cells by FLIPR assay2022Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9
Piezo-Type Mechanosensitive Ion Channel Component 1 (Piezo1): A Promising Therapeutic Target and Its Modulators.
AID1891734Binding affinity to CM5 sensor chip-immobilized mouse Piezo1 (1 to 2190 residues) assessed as dissociation constant by real-time SPR assay2022Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9
Piezo-Type Mechanosensitive Ion Channel Component 1 (Piezo1): A Promising Therapeutic Target and Its Modulators.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (21.74)24.3611
2020's18 (78.26)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 50.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index50.38 (24.57)
Research Supply Index3.18 (2.92)
Research Growth Index4.91 (4.65)
Search Engine Demand Index77.94 (26.88)
Search Engine Supply Index2.06 (0.95)

This Compound (50.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.35%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (95.65%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]