| Assay ID | Title | Year | Journal | Article |
|---|
| AID1830049 | Displacement of [125I](+/-)DOI from human recombinant 5-HT2C receptor expressed in CHO cells at 100 nM measured after 60 mins by radioligand completion assay relative to control | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Activity of |
| AID1581714 | Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK293 cell membranes at 100 nM incubated for 60 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1581713 | Displacement of [3H]U69,593 from human recombinant kappa opioid receptor expressed in rat RBL cell membranes at 100 nM incubated for 60 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1581722 | Displacement of [3H]U69,593 from human recombinant kappa opioid receptor expressed in rat RBL cell membranes at 1000 nM incubated for 60 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1581726 | Displacement of [3H]U69,593 from human recombinant kappa opioid receptor expressed in rat RBL cell membranes incubated for 60 mins | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1581725 | Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in rat Chem-1 (RBL) cell membranes incubated for 60 mins | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1872150 | Inhibition of DOP (unknown origin) | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3
| Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources. |
| AID1581738 | Agonist activity at human recombinant kappa opioid receptor expressed in rat RBL cells assessed as stimulation of intracellular calcium levels incubated at room temperature by fluorimetry | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1775314 | Dose normalized Cmax in Sprague-Dawley rat plasma at 2.03 mg/kg, po administered as LKT formulation measured for 24 hrs by UPLC-MS/MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1581727 | Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK293 cell membranes incubated for 60 mins | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1775278 | Stability of the compound in rat plasma assessed as proportion of compound deviation from nominal concentration at 2.5 ng/ml measured in autosampler for 24 hrs by UPLC-MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1775315 | Dose normalized AUC(0 to 24 hrs) in Sprague-Dawley rat plasma at 2.03 mg/kg, po administered as LKT formulation measured for 24 hrs by UPLC-MS/MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1581750 | Metabolic stability in human liver microsomes assessed as elimination rate constant in presence of NADPH incubated up to 60 mins by UPLC-MS/MS analysis | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1749821 | Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK293 cells incubated for 120 mins by radiometric scintillation analysis | | | |
| AID1581707 | Displacement of [3H]prazosin from human recombinant adrenergic alpha-1A receptor expressed in CHO cell membranes at 100 nM incubated for 60 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1775282 | Stability of the compound in rat plasma assessed as proportion of compound deviation from nominal concentration at 2.5 ng/ml measured at -80 degC for 4 weeks by UPLC-MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1830051 | Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells at 100 nM measured after 60 mins by radioligand completion assay relative to control | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Activity of |
| AID1830052 | Displacement of [125I](+/-)DOI from human recombinant 5-HT2A receptor expressed in HEK293 cells at 10 uM measured after 60 to 90 mins by radioligand completion assay relative to control | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Activity of |
| AID1581718 | Displacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes at 10000 nM incubated for 60 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1581755 | Metabolic stability in human liver microsomes assessed as hepatic clearance in presence of NADPH incubated up to 60 mins by UPLC-MS/MS analysis | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1872032 | Binding affinity to DOP (unknown origin) | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3
| Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources. |
| AID1872031 | Binding affinity to MOP (unknown origin) | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3
| Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources. |
| AID1581746 | Antinociceptive activity in Sprague-Dawley rat dosed intravenously using cumulative dosing every 5 mins until rat maxed-out on hot plate by hot plate test relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1775318 | AUC(0 to 24 hrs) in Sprague-Dawley rat plasma at 2.24 mg/kg, po administered as OPMS liquid formulation measured for 24 hrs by UPLC-MS/MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1830047 | Displacement of [3H]BRL43694 from human recombinant 5-HT3 receptor expressed in CHO cells at 100 nM measured after 120 mins by radioligand completion assay relative to control | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Activity of |
| AID1775341 | Stability of the compound in rat plasma assessed as drug recovery | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1581754 | Metabolic stability in human liver microsomes assessed as intrinsic clearance in presence of NADPH incubated up to 60 mins by UPLC-MS/MS analysis | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1581724 | Displacement of radioligand from ORL1 (unknown origin) at 10000 nM incubated for 120 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1581719 | Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes at 10000 nM incubated for 60 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1830050 | Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells at 10 uM measured after 60 mins by radioligand completion assay relative to control | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Activity of |
| AID1581715 | Displacement of radioligand from ORL1 (unknown origin) at 100 nM incubated for 120 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1872149 | Inhibition of MOP (unknown origin) | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3
| Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources. |
| AID1830048 | Displacement of [125I](+/-)DOI from human recombinant 5-HT2C receptor expressed in CHO cells at 10 uM measured after 60 mins by radioligand completion assay relative to control | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Activity of |
| AID1775317 | Cmax in Sprague-Dawley rat plasma at 2.24 mg/kg, po administered as OPMS liquid formulation measured for 24 hrs by UPLC-MS/MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1581723 | Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK293 cell membranes at 10000 nM incubated for 60 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1830033 | Displacement of [3H]8-OH-DAPT from human recombinant 5-HT1A receptor expressed in cells at 100 nM measured after 60 to 90 mins by radioligand completion assay relative to control | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Activity of |
| AID1581756 | Metabolic stability in human liver microsomes assessed as hepatic extraction ratio in presence of NADPH incubated up to 60 mins by UPLC-MS/MS analysis | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1775311 | Tmax in Sprague-Dawley rat plasma at 2.03 mg/kg, po administered as LKT formulation measured for 24 hrs by UPLC-MS/MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1581751 | Metabolic stability in human liver microsomes assessed as half life in presence of NADPH incubated up to 60 mins by UPLC-MS/MS analysis | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1581747 | Antinociceptive activity in Sprague-Dawley rat dosed intravenously using cumulative dosing every 5 mins until rat maxed-out on hot plate co-treated with 0.1 mg/kg naltrexone by hot plate test | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1581710 | Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes at 100 nM incubated for 60 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1581711 | Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes at 100 nM incubated for 60 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1775313 | AUC(0 to 24 hrs) in Sprague-Dawley rat plasma at 2.03 mg/kg, po administered as LKT formulation measured for 24 hrs by UPLC-MS/MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1581709 | Displacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes at 100 nM incubated for 60 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1581716 | Displacement of [3H]prazosin from human recombinant adrenergic alpha-1A receptor expressed in CHO cell membranes at 10000 nM incubated for 60 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1830053 | Displacement of [125I](+/-)DOI from human recombinant 5-HT2A receptor expressed in HEK293 cells at 100 nM measured after 60 to 90 mins by radioligand completion assay relative to control | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Activity of |
| AID1872033 | Binding affinity to KOP (unknown origin) | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3
| Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources. |
| AID1872151 | Inhibition of KOP (unknown origin) | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3
| Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources. |
| AID1581749 | Toxicity in Sprague-Dawley rat assessed as induction of hypothermia at 0.0032 to 10 mg/kg, iv | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1581720 | Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes at 10000 nM incubated for 60 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1775275 | Stability of the compound in rat plasma assessed as proportion of compound deviation from nominal concentration at 2.5 ng/ml measured on the bench-top for 2 hrs by UPLC-MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1581708 | Displacement of [3H]prazosin from human recombinant adrenergic alpha-1B receptor expressed in CHO cell membranes at 100 nM incubated for 60 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1775279 | Stability of the compound in rat plasma assessed as proportion of compound deviation from nominal concentration at 160 ng/ml measured in autosampler for 24 hrs by UPLC-MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1775277 | Stability of the compound in rat plasma assessed as proportion of compound deviation from nominal concentration at 160 ng/ml measured on the bench-top for 2 hrs by UPLC-MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1830035 | Displacement of [125I]CYP from rat cerebral cortex 5-HT1B receptor at 100 nM measured after 120 mins by radioligand completion assay relative to control | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Activity of |
| AID1775342 | Stability of the compound in water-methanol mixture (1:1) assessed as drug recovery | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1581734 | Agonist activity at human recombinant mu opioid receptor expressed in CHO cells assessed as stimulation of cAMP accumulation incubated for 10 mins by HTRF assay | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1775320 | Dose normalized AUC(0 to 24 hrs) in Sprague-Dawley rat plasma at 2.24 mg/kg, po administered as OPMS liquid formulation measured for 24 hrs by UPLC-MS/MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1830032 | Displacement of [125I]CYP from rat cerebral cortex 5-HT1B receptor at 10 uM measured after 120 mins by radioligand completion assay relative to control | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Activity of |
| AID1830046 | Displacement of [3H]BRL43694 from human recombinant 5-HT3 receptor expressed in CHO cells at 10 uM measured after 120 mins by radioligand completion assay relative to control | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Activity of |
| AID1775312 | Cmax in Sprague-Dawley rat plasma at 2.03 mg/kg, po administered as LKT formulation measured for 24 hrs by UPLC-MS/MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1581736 | Antagonist activity at human recombinant kappa opioid receptor expressed in rat RBL cells assessed as inhibition of U50,488 -induced intracellular calcium levels incubated at room temperature by fluorimetry | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1581721 | Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in rat Chem-1 (RBL) cell membranes at 10000 nM incubated for 60 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1581753 | Fraction unbound in human liver microsomes at 1 uM by equilibrium dialysis | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1830034 | Displacement of [3H]8-OH-DAPT from human recombinant 5-HT1A receptor expressed in cells at 10 uM measured after 60 to 90 mins by radioligand completion assay relative to control | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Activity of |
| AID1775321 | Ratio of Dose normalized AUC(0 to 24 hrs) in Sprague-Dawley rat plasma at 2.24 mg/kg, po administered as OPMS liquid formulation to Dose normalized AUC(0 to 24 hrs) in Sprague-Dawley rat plasma at 2.03 mg/kg, po administered as LKT formulation | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1581717 | Displacement of [3H]prazosin from human recombinant adrenergic alpha-1B receptor expressed in CHO cell membranes at 10000 nM incubated for 60 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1581752 | Fraction unbound in human plasma at 1 uM by equilibrium dialysis | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1775280 | Stability of the compound in rat plasma assessed as proportion of compound deviation from nominal concentration at 2.5 ng/ml measured under freeze-thaw conditions for 3 cycles by UPLC-MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1775283 | Stability of the compound in rat plasma assessed as proportion of compound deviation from nominal concentration at 160 ng/ml measured at -80 degC for 4 weeks by UPLC-MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1581712 | Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in rat Chem-1 (RBL) cell membranes at 100 nM incubated for 60 mins relative to control | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| AID1775316 | Tmax in Sprague-Dawley rat plasma at 2.24 mg/kg, po administered as OPMS liquid formulation measured for 24 hrs by UPLC-MS/MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1830058 | Antinociceptive activity against Sprague-Dawley rats assessed as lower lip retraction at 17.8 mg/kg, ip measured for 15 mins in presence of WAY100635 | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Activity of |
| AID1775319 | Dose normalized Cmax in Sprague-Dawley rat plasma at 2.24 mg/kg, po administered as OPMS liquid formulation measured for 24 hrs by UPLC-MS/MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1775281 | Stability of the compound in rat plasma assessed as proportion of compound deviation from nominal concentration at 160 ng/ml measured under freeze-thaw conditions for 3 cycles by UPLC-MS analysis | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4
| Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. |
| AID1581745 | Antinociceptive activity in Sprague-Dawley rat dosed intravenously using cumulative dosing every 5 mins until rat maxed-out on hot plate by hot plate test | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
| Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |