Compounds > nsc-287088
Page last updated: 2024-12-08

nsc-287088

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID11613161
CHEMBL ID504404
MeSH IDM0103303

Synonyms (8)

Synonym
nsc-287088
CHEMBL504404 ,
bdbm50378034
MS-29476
DTXSID901318463
CS-0135227
HY-N7695
AKOS040760627
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Isocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)IC50 (µMol)100.63000.00350.52745.1760AID1709395; AID1709396
Zinc finger protein GLI1Homo sapiens (human)IC50 (µMol)0.62000.62002.54507.1000AID351770
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Isocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)Kd45.30002.81002.81002.8100AID1709397
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (67)

Processvia Protein(s)Taxonomy
glyoxylate cycleIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
tricarboxylic acid cycleIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
isocitrate metabolic processIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
2-oxoglutarate metabolic processIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
glutathione metabolic processIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
response to oxidative stressIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
female gonad developmentIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
response to steroid hormoneIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
regulation of phospholipid catabolic processIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
regulation of phospholipid biosynthetic processIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
NADP metabolic processIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIZinc finger protein GLI1Homo sapiens (human)
osteoblast differentiationZinc finger protein GLI1Homo sapiens (human)
regulation of DNA-templated transcriptionZinc finger protein GLI1Homo sapiens (human)
smoothened signaling pathwayZinc finger protein GLI1Homo sapiens (human)
spermatid developmentZinc finger protein GLI1Homo sapiens (human)
ventral midline developmentZinc finger protein GLI1Homo sapiens (human)
positive regulation of cell population proliferationZinc finger protein GLI1Homo sapiens (human)
regulation of smoothened signaling pathwayZinc finger protein GLI1Homo sapiens (human)
response to woundingZinc finger protein GLI1Homo sapiens (human)
epidermal cell differentiationZinc finger protein GLI1Homo sapiens (human)
dorsal/ventral pattern formationZinc finger protein GLI1Homo sapiens (human)
proximal/distal pattern formationZinc finger protein GLI1Homo sapiens (human)
cerebellar cortex morphogenesisZinc finger protein GLI1Homo sapiens (human)
pituitary gland developmentZinc finger protein GLI1Homo sapiens (human)
lung developmentZinc finger protein GLI1Homo sapiens (human)
prostate gland developmentZinc finger protein GLI1Homo sapiens (human)
regulation of osteoblast differentiationZinc finger protein GLI1Homo sapiens (human)
positive regulation of DNA replicationZinc finger protein GLI1Homo sapiens (human)
positive regulation of smoothened signaling pathwayZinc finger protein GLI1Homo sapiens (human)
positive regulation of DNA-templated transcriptionZinc finger protein GLI1Homo sapiens (human)
positive regulation of transcription by RNA polymerase IIZinc finger protein GLI1Homo sapiens (human)
digestive tract morphogenesisZinc finger protein GLI1Homo sapiens (human)
notochord regressionZinc finger protein GLI1Homo sapiens (human)
positive regulation of cardiac muscle cell proliferationZinc finger protein GLI1Homo sapiens (human)
negative regulation of canonical Wnt signaling pathwayZinc finger protein GLI1Homo sapiens (human)
liver regenerationZinc finger protein GLI1Homo sapiens (human)
positive regulation of cell cycle G1/S phase transitionZinc finger protein GLI1Homo sapiens (human)
regulation of hepatocyte proliferationZinc finger protein GLI1Homo sapiens (human)
regulation of transcription by RNA polymerase IIZinc finger protein GLI1Homo sapiens (human)
negative regulation of NF-kappaB transcription factor activityNF-kappa-B inhibitor alphaHomo sapiens (human)
protein import into nucleusNF-kappa-B inhibitor alphaHomo sapiens (human)
Notch signaling pathwayNF-kappa-B inhibitor alphaHomo sapiens (human)
canonical NF-kappaB signal transductionNF-kappa-B inhibitor alphaHomo sapiens (human)
cytoplasmic sequestering of NF-kappaBNF-kappa-B inhibitor alphaHomo sapiens (human)
negative regulation of macrophage derived foam cell differentiationNF-kappa-B inhibitor alphaHomo sapiens (human)
positive regulation of cholesterol effluxNF-kappa-B inhibitor alphaHomo sapiens (human)
negative regulation of lipid storageNF-kappa-B inhibitor alphaHomo sapiens (human)
lipopolysaccharide-mediated signaling pathwayNF-kappa-B inhibitor alphaHomo sapiens (human)
response to muramyl dipeptideNF-kappa-B inhibitor alphaHomo sapiens (human)
tumor necrosis factor-mediated signaling pathwayNF-kappa-B inhibitor alphaHomo sapiens (human)
toll-like receptor 4 signaling pathwayNF-kappa-B inhibitor alphaHomo sapiens (human)
response to muscle stretchNF-kappa-B inhibitor alphaHomo sapiens (human)
non-canonical NF-kappaB signal transductionNF-kappa-B inhibitor alphaHomo sapiens (human)
regulation of cell population proliferationNF-kappa-B inhibitor alphaHomo sapiens (human)
negative regulation of canonical NF-kappaB signal transductionNF-kappa-B inhibitor alphaHomo sapiens (human)
response to exogenous dsRNANF-kappa-B inhibitor alphaHomo sapiens (human)
negative regulation of myeloid cell differentiationNF-kappa-B inhibitor alphaHomo sapiens (human)
negative regulation of Notch signaling pathwayNF-kappa-B inhibitor alphaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IINF-kappa-B inhibitor alphaHomo sapiens (human)
positive regulation of inflammatory responseNF-kappa-B inhibitor alphaHomo sapiens (human)
B cell receptor signaling pathwayNF-kappa-B inhibitor alphaHomo sapiens (human)
positive regulation of protein metabolic processNF-kappa-B inhibitor alphaHomo sapiens (human)
positive regulation of transcription initiation by RNA polymerase IINF-kappa-B inhibitor alphaHomo sapiens (human)
cellular response to coldNF-kappa-B inhibitor alphaHomo sapiens (human)
nucleotide-binding oligomerization domain containing 1 signaling pathwayNF-kappa-B inhibitor alphaHomo sapiens (human)
nucleotide-binding oligomerization domain containing 2 signaling pathwayNF-kappa-B inhibitor alphaHomo sapiens (human)
interleukin-1-mediated signaling pathwayNF-kappa-B inhibitor alphaHomo sapiens (human)
cellular response to tumor necrosis factorNF-kappa-B inhibitor alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (24)

Processvia Protein(s)Taxonomy
magnesium ion bindingIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
isocitrate dehydrogenase (NADP+) activityIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
protein bindingIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
identical protein bindingIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
protein homodimerization activityIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
cadherin bindingIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
NADP bindingIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
NAD bindingIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
transcription cis-regulatory region bindingZinc finger protein GLI1Homo sapiens (human)
RNA polymerase II transcription regulatory region sequence-specific DNA bindingZinc finger protein GLI1Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificZinc finger protein GLI1Homo sapiens (human)
DNA bindingZinc finger protein GLI1Homo sapiens (human)
chromatin bindingZinc finger protein GLI1Homo sapiens (human)
protein bindingZinc finger protein GLI1Homo sapiens (human)
microtubule bindingZinc finger protein GLI1Homo sapiens (human)
metal ion bindingZinc finger protein GLI1Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificZinc finger protein GLI1Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingZinc finger protein GLI1Homo sapiens (human)
protein bindingNF-kappa-B inhibitor alphaHomo sapiens (human)
nuclear localization sequence bindingNF-kappa-B inhibitor alphaHomo sapiens (human)
enzyme bindingNF-kappa-B inhibitor alphaHomo sapiens (human)
ubiquitin protein ligase bindingNF-kappa-B inhibitor alphaHomo sapiens (human)
identical protein bindingNF-kappa-B inhibitor alphaHomo sapiens (human)
NF-kappaB bindingNF-kappa-B inhibitor alphaHomo sapiens (human)
protein sequestering activityNF-kappa-B inhibitor alphaHomo sapiens (human)
molecular sequestering activityNF-kappa-B inhibitor alphaHomo sapiens (human)
transcription regulator inhibitor activityNF-kappa-B inhibitor alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (18)

Processvia Protein(s)Taxonomy
extracellular regionIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
cytoplasmIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
peroxisomeIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
peroxisomal matrixIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
cytosolIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
secretory granule lumenIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
extracellular exosomeIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
tertiary granule lumenIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
ficolin-1-rich granule lumenIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
cytosolIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
mitochondrionIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
peroxisomeIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)
cytoplasmZinc finger protein GLI1Homo sapiens (human)
nucleusZinc finger protein GLI1Homo sapiens (human)
nucleoplasmZinc finger protein GLI1Homo sapiens (human)
cytoplasmZinc finger protein GLI1Homo sapiens (human)
cytosolZinc finger protein GLI1Homo sapiens (human)
axonemeZinc finger protein GLI1Homo sapiens (human)
ciliary tipZinc finger protein GLI1Homo sapiens (human)
ciliary baseZinc finger protein GLI1Homo sapiens (human)
GLI-SUFU complexZinc finger protein GLI1Homo sapiens (human)
nucleusZinc finger protein GLI1Homo sapiens (human)
cytoplasmNF-kappa-B inhibitor alphaHomo sapiens (human)
nucleusNF-kappa-B inhibitor alphaHomo sapiens (human)
nucleoplasmNF-kappa-B inhibitor alphaHomo sapiens (human)
cytoplasmNF-kappa-B inhibitor alphaHomo sapiens (human)
cytosolNF-kappa-B inhibitor alphaHomo sapiens (human)
plasma membraneNF-kappa-B inhibitor alphaHomo sapiens (human)
I-kappaB/NF-kappaB complexNF-kappa-B inhibitor alphaHomo sapiens (human)
cytosolNF-kappa-B inhibitor alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (64)

Assay IDTitleYearJournalArticle
AID380127Cytotoxicity against human HeLa cells at 100 uM2006Journal of natural products, Mar, Volume: 69, Issue:3
Physalins from Witheringia solanacea as modulators of the NF-kappaB cascade.
AID399455In vivo cytotoxicity against mouse 3PS cells at 300 mg/kg
AID640523Inhibition of peptide-glutamyl-peptide-hydrolyzing activity of 20S proteasome in human DLD1 cells transfected with 4Ub-Luc gene using Z-Leu-Leu-Glu-AMC as substrate at 40 uM after 6 hrs by spectrofluorometric analysis2012Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2
Semisynthetic neoboutomellerone derivatives as ubiquitin-proteasome pathway inhibitors.
AID291866Antitumor activity against human 1A9 cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata.
AID1869152Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-stimulated NO production pretreated with LPS followed by compund addition by Griess reagent based microplate reader assay
AID351776Selectivity for human PANC1 cells over mouse C3H10/T1/2 cells2009Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
AID1171135Antiinflammatory activity in Swiss Webster mouse assessed as reduction in hyperalgesia at 100 mg/kg, ip dosed 40 mins before CFA injection and measured 2 to 6 hrs post CFA stimulus2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Antinociceptive properties of physalins from Physalis angulata.
AID380116Inhibition of PMA-induced NF-kappaB activation in human HeLa cells at 8 uM after 7 hrs by IL6/luciferase reporter gene assay2006Journal of natural products, Mar, Volume: 69, Issue:3
Physalins from Witheringia solanacea as modulators of the NF-kappaB cascade.
AID1171137Antiinflammatory activity in Swiss Webster mouse assessed as reduction in paw edema at 100 mg/kg, ip dosed 40 mins before CFA injection and measured 2 hrs post CFA stimulus2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Antinociceptive properties of physalins from Physalis angulata.
AID760306Inhibition of TNFalpha-induced NF-kappaB activation (unknown origin) expressed in human HeLa cells pretreated 30 mins before TNFalpha addition after 7 hrs by luciferase reporter gene assay2013ACS medicinal chemistry letters, Aug-08, Volume: 4, Issue:8
Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Activation.
AID291865Antitumor activity against human DU145 cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata.
AID1869148Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
AID291872Antitumor activity against human A549 cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata.
AID1709395Inhibition of C-terminal His6-tagged IDH1 R132H mutant (unknown origin) expressed in Escherichia coli BL21 (DE) using alpha-ketoglutarate as substrate preincubated for 10 mins followed by substrate addition and measured at 1 min interval for 20 mins in pr2021Bioorganic & medicinal chemistry, 04-15, Volume: 36Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1.
AID623329Cytotoxicity against BALB/c mouse splenocytes assessed as [3H]thymidine incorporation after 24 hrs by beta counting2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Antimalarial activity of physalins B, D, F, and G.
AID380124Induction of apoptosis in human Jurkat T cells assessed as sub-G0/G1 fraction at 1 uM after 24 hrs by flow cytometry2006Journal of natural products, Mar, Volume: 69, Issue:3
Physalins from Witheringia solanacea as modulators of the NF-kappaB cascade.
AID760298Inhibition of NF-kappaB (unknown origin) expressed in human HeLa cells assessed as inhibition of TNFalpha-induced DNA binding of RelA pretreated 15 mins before TNFalpha addition measured after 30 mins by EMSA2013ACS medicinal chemistry letters, Aug-08, Volume: 4, Issue:8
Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Activation.
AID380115Inhibition of PMA-induced NF-kappaB activation in human HeLa cells at 16 uM after 7 hrs by IL6/luciferase reporter gene assay2006Journal of natural products, Mar, Volume: 69, Issue:3
Physalins from Witheringia solanacea as modulators of the NF-kappaB cascade.
AID380122Induction of apoptosis in human Jurkat T cells assessed as sub-G0/G1 fraction at 10 uM after 6 hrs by flow cytometry2006Journal of natural products, Mar, Volume: 69, Issue:3
Physalins from Witheringia solanacea as modulators of the NF-kappaB cascade.
AID291870Antitumor activity against human KB-VIN cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata.
AID351775Selectivity for Gli over Gli22009Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
AID291867Antitumor activity against human HCT116 cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata.
AID623328Antimalarial activity against chloroquine-resistant and mefloquine-sensitive Plasmodium falciparum W2 infected in human O-positive erythrocytes assessed as inhibition of parasite growth by [3H]hypoxanthine incorporation assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Antimalarial activity of physalins B, D, F, and G.
AID291874Antitumor activity against human PC3 cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata.
AID291869Antitumor activity against human KB cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata.
AID1869146Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
AID1709396Inhibition of wild-type IDH1 (unknown origin) in presence of sodium(D)-isocitrate and NADP+2021Bioorganic & medicinal chemistry, 04-15, Volume: 36Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1.
AID380114Cytotoxicity against human HeLa cells after 72 hrs by MTT assay2006Journal of natural products, Mar, Volume: 69, Issue:3
Physalins from Witheringia solanacea as modulators of the NF-kappaB cascade.
AID380125Induction of apoptosis in human Jurkat T cells assessed as sub-G0/G1 fraction at 10 uM after 24 hrs by flow cytometry2006Journal of natural products, Mar, Volume: 69, Issue:3
Physalins from Witheringia solanacea as modulators of the NF-kappaB cascade.
AID760305Inhibition of TNFalpha-induced IkappaBalpha (unknown origin) phosphorylation expressed in human HeLa cells pretreated 30 mins before TNFalpha addition measured up to 120 mins by ELISA in presence of proteasome inhibitor MG-1322013ACS medicinal chemistry letters, Aug-08, Volume: 4, Issue:8
Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Activation.
AID623330Selectivity index, ratio of LC50 for mouse splenocytes to IC50 for chloroquine-resistant and mefloquine-sensitive Plasmodium falciparum W22011Journal of natural products, Oct-28, Volume: 74, Issue:10
Antimalarial activity of physalins B, D, F, and G.
AID291875Antitumor activity against human ZR751 cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata.
AID760297Inhibition of NF-kappaB (unknown origin) expressed in human HeLa cells assessed as inhibition of TNFalpha-induced DNA binding of p50 pretreated 15 mins before TNFalpha addition measured after 30 mins by EMSA2013ACS medicinal chemistry letters, Aug-08, Volume: 4, Issue:8
Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Activation.
AID399453Cytotoxicity against human 9KB cells
AID1869151Cytotoxicity against human L02 cells assessed as cell viability at 10 uM incubated for 48 hrs by CCK8 assay
AID760303Inhibition of TNFalpha-induced IkappaBalpha (unknown origin) degradation expressed in human HeLa cells at 50 uM pretreated 12.5 mins before TNFalpha addition measured after 30 mins by ELISA2013ACS medicinal chemistry letters, Aug-08, Volume: 4, Issue:8
Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Activation.
AID1171145Antinociceptive activity in Swiss Webster mouse assessed as increase in reaction time at 100 mg/kg, ip measured after 3 hrs by tail flick test2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Antinociceptive properties of physalins from Physalis angulata.
AID1171121Antinociceptive activity in Swiss Webster mouse assessed as inhibition of formalin-induced late phase pain response at 25 to 100 mg/kg, ip dosed 40 mins before formalin injection2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Antinociceptive properties of physalins from Physalis angulata.
AID380123Induction of apoptosis in human Jurkat T cells assessed as sub-G0/G1 fraction at 20 uM after 6 hrs by flow cytometry2006Journal of natural products, Mar, Volume: 69, Issue:3
Physalins from Witheringia solanacea as modulators of the NF-kappaB cascade.
AID291871Antitumor activity against human A431 cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata.
AID1869150Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 10 uM incubated for 48 hrs by CCK8 assay
AID640445Inhibition of 20S proteasome in human DLD1 cells transfected with 4Ub-Luc gene assessed as bioluminescence induction factor at 5 uM after 8 hrs by luciferase reporter gene assay relative to epoxomicin2012Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2
Semisynthetic neoboutomellerone derivatives as ubiquitin-proteasome pathway inhibitors.
AID291868Antitumor activity against human LNCAP cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata.
AID760301Inhibition of NF-kappaB (unknown origin) expressed in human HeLa cells assessed as inhibition of TNFalpha-induced p50 nuclear translocation pretreated 15 mins before TNFalpha addition measured after 30 mins by Western blot analysis2013ACS medicinal chemistry letters, Aug-08, Volume: 4, Issue:8
Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Activation.
AID380128Cytotoxicity against human HeLa cells after 7 hrs2006Journal of natural products, Mar, Volume: 69, Issue:3
Physalins from Witheringia solanacea as modulators of the NF-kappaB cascade.
AID291873Antitumor activity against human HCT8 cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata.
AID1756816Cytotoxicity against human PC-3 cells assessed as cell growth inhibition measured after 24 to 72 hrs by MTT assay2021Journal of natural products, 02-26, Volume: 84, Issue:2
Cytotoxic Physalins from Aeroponically Grown
AID1756818Cytotoxicity against human NCI-H460 cells assessed as cell growth inhibition measured after 24 to 72 hrs by MTT assay2021Journal of natural products, 02-26, Volume: 84, Issue:2
Cytotoxic Physalins from Aeroponically Grown
AID383419Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite formation2008Journal of natural products, Apr, Volume: 71, Issue:4
Steroids and flavonoids from Physalis alkekengi var. franchetii and their inhibitory effects on nitric oxide production.
AID640524Inhibition of chymotrypsin-like activity of 20S proteasome in human DLD1 cells transfected with 4Ub-Luc gene using Succinyl-Leu-Leu-Val-Tyr-AMC as substrate at 20 uM after 6 hrs by spectrofluorometric analysis2012Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2
Semisynthetic neoboutomellerone derivatives as ubiquitin-proteasome pathway inhibitors.
AID399454Cytotoxicity against mouse 9PS cells
AID760302Inhibition of NF-kappaB (unknown origin) expressed in human HeLa cells assessed as inhibition of TNFalpha-induced RelA nuclear translocation pretreated 15 mins before TNFalpha addition measured after 30 mins by Western blot analysis2013ACS medicinal chemistry letters, Aug-08, Volume: 4, Issue:8
Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Activation.
AID380126Induction of apoptosis in human Jurkat T cells assessed as sub-G0/G1 fraction at 20 uM after 24 hrs by flow cytometry2006Journal of natural products, Mar, Volume: 69, Issue:3
Physalins from Witheringia solanacea as modulators of the NF-kappaB cascade.
AID1171129CNS toxicity in Swiss Webster mouse assessed as effect on motor performance at 100 mg/kg, ip after 40 mins by rotarod test2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Antinociceptive properties of physalins from Physalis angulata.
AID1171118Antinociceptive activity in Swiss Webster mouse assessed as inhibition of acetic acid-induced abdominal constrictions at 25 to 100 mg/kg, ip dosed 40 mins before acetic acid injection2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Antinociceptive properties of physalins from Physalis angulata.
AID1869149Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
AID1171130CNS toxicity in Swiss Webster mouse assessed as effect on motor performance at 100 mg/kg, ip after 40 mins by open field test2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Antinociceptive properties of physalins from Physalis angulata.
AID1756817Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 24 to 72 hrs by MTT assay2021Journal of natural products, 02-26, Volume: 84, Issue:2
Cytotoxic Physalins from Aeroponically Grown
AID1869147Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
AID380121Induction of apoptosis in human Jurkat T cells assessed as sub-G0/G1 fraction at 1 uM after 6 hrs by flow cytometry2006Journal of natural products, Mar, Volume: 69, Issue:3
Physalins from Witheringia solanacea as modulators of the NF-kappaB cascade.
AID1756819Cytotoxicity against human SF-268 cells assessed as cell growth inhibition measured after 24 to 72 hrs by MTT assay2021Journal of natural products, 02-26, Volume: 84, Issue:2
Cytotoxic Physalins from Aeroponically Grown
AID1756820Cytotoxicity against human WI-38 cells assessed as cell growth inhibition measured after 24 to 72 hrs by MTT assay2021Journal of natural products, 02-26, Volume: 84, Issue:2
Cytotoxic Physalins from Aeroponically Grown
AID1709397Binding affinity to C-terminal His6-tagged IDH1 R132H mutant (unknown origin) expressed in Escherichia coli BL21 (DE) measured after 20 mins by Red-NHS fluorescence dye-based microscale thermophoresis analysis2021Bioorganic & medicinal chemistry, 04-15, Volume: 36Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1.
AID351770Inhibition of Gli1-mediated transcription expressed in human PANC1 cells2009Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (36.36)29.6817
2010's4 (36.36)24.3611
2020's3 (27.27)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (8.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.0610aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
diazepam
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.. diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.		2.1101,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		2.110aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
staurosporine aglycone
staurosporine aglycone: metabolite from culture broth of Nocardiopsis sp.; a neurotrophin antag; inhibits BDNF TrkB receptor		3.1410
mefloquine hydrochloride
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol : An organofluorine compound that consists of quinoline bearing trifluoromethyl substituents at positions 2 and 8 as well as a (2-piperidinyl)hydroxymethyl substituent at position 4.		2.0610organofluorine compound;
piperidines;
quinolines;
secondary alcohol
jervine
jervine: teratogen from Veratrum grandiflorum; RN given refers to parent cpd(3beta,23beta)-isomer; structure		3.1410piperidines
betulinic acid
[no description available]		3.1410hydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
gant58
GANT58: inhibits hedgehog signalling; structure in first source		3.1410pyridines
bortezomib
[no description available]		2.0710amino acid amide;
L-phenylalanine derivative;
pyrazines		antineoplastic agent;
antiprotozoal drug;
protease inhibitor;
proteasome inhibitor
gant 61
GANT 61: a sonic hedgehog pathway inhibitor and Gli inhibitor; structure in first source. GANT61 : An aminal that is hexahydropyrimidine which is substituted on each nitrogen by a 2-(dimethylamino)benzyl group, and at the aminal carbon by a pyridin-4-yl group. A Hedgehog signaling pathway and Gli protein inhibitor.		3.1410aminal;
dialkylarylamine;
pyridines;
substituted aniline;
tertiary amino compound		antineoplastic agent;
apoptosis inducer;
glioma-associated oncogene inhibitor;
Hedgehog signaling pathway inhibitor
cyclopamine
[no description available]		3.1410piperidinesglioma-associated oncogene inhibitor
jk184
JK184: structure in first source		3.1410
luteolin
[no description available]		2.04103'-hydroxyflavonoid;
tetrahydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
morphine
Meconium: The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.		2.110morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
ombuine
ombuine: from rhizome of Alpinia tonkinensis. ombuin : A dimethoxyflavone that is quercetin in which the hydroxy groups at positions 7 and 4' are replaced by methoxy groups. Isolated from Cyperus teneriffae, it exhibits anti-inflammatory activity.		2.0410dimethoxyflavone;
flavonols;
trihydroxyflavone		anti-inflammatory agent;
plant metabolite
zerumbone
zerumbone: RN given for (E,E,E)-isomer; structure in first source. zerumbone : A sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillation from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia.		3.1410cyclic ketone;
sesquiterpenoid		anti-inflammatory agent;
glioma-associated oncogene inhibitor;
plant metabolite
lactacystin
[no description available]		2.0710lactam;
S-substituted L-cysteine
cur 61414
CUR 61414: inhibits the hedehog signaling pathway; structure in first source		3.1410
epoxomicin
[no description available]		2.0710morpholines;
tripeptide		proteasome inhibitor
2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid
alphitolic acid: from the aerial parts of Gouania longipetala; structure in first source. 2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid : A pentacyclic triterpenoid that is betulinic acid carrying an additional alpha-hydroxy group at position 2. It has been isolated from Breynia fruticosa.		3.1410dihydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
gdc 0449
HhAntag691: inhibits the hedgehog pathway and ABC transporters; has antineoplastic activity		3.1410benzamides;
monochlorobenzenes;
pyridines;
sulfone		antineoplastic agent;
Hedgehog signaling pathway inhibitor;
SMO receptor antagonist;
teratogenic agent
robotnikinin
robotnikinin: binds sonic hedgehog protein to block its signaling pathway; structure in first source		3.1410
physalin a
physalin A: an anti-inflammatory agent isolated from Physalis alkekengi var; structure in first source		2.4620physalin
physalin f
physalin F: has immunosuppressive activity; from Physalis angulata L; structure given in first source. physalin F : A physalin with antimalarial and antitumour activities isolated from Physalis angulata.		4.5470enone;
epoxy steroid;
lactone;
physalin		antileishmanial agent;
antimalarial;
antineoplastic agent;
apoptosis inducer;
immunosuppressive agent
physalin g
physalin G: has immunosuppressive activity; from Physalis angulata; structure in first source. physalin G : A physalin with antimalarial activity isolated from Physalis angulata.		2.48206alpha-hydroxy steroid;
enone;
lactone;
organic heteroheptacyclic compound;
physalin		antimalarial
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.9610
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.9610
Parasitemia
The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)		02.0610
Infections, Plasmodium
[description not available]		02.0610
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		02.0610
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.110
Anasarca
[description not available]		02.110
Allodynia
[description not available]		02.110
Ache
[description not available]		02.110
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.110
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.		02.110