| Assay ID | Title | Year | Journal | Article |
|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6
| A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | | | |
| AID363685 | Tmax in rat brain at 20 mg/kg, ip | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363682 | Cmax in rat plasma at 20 mg/kg, ip | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID430491 | Inhibition of FAAH | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas. |
| AID363688 | Increase in anandamide levels in rat brain at 20 mg/kg, ip | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363687 | Ex vivo inhibition of FAAH in rat brain at 20 mg/kg, ip | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363659 | Inhibition of human FAAH preincubated for 10 mins | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363667 | Clearance in rat at 10 mg/kg, po | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID612783 | Inhibition of FAAH | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16
| The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH). |
| AID363678 | Half life in rat plasma at 1 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363668 | Volume of distribution in rat at 10 mg/kg, po | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363679 | Mean retention time in rat at 1 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363675 | Volume of distribution in rat at 10 mg/kg, ip | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363660 | Inhibition of human FAAH after 60 mins | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363662 | Inhibition of rat liver esterase assessed as ester (4-nitrophenyl-acetate) hydrolysis at 10 uM after 30 mins | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID590552 | Inhibition of rat FAAH assessed as hydrolysis of anandamido-amino-methyl-cumarin | 2011 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 21, Issue:8
| Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors. |
| AID363672 | Half life in rat plasma at 10 mg/kg, ip | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363674 | Clearance in rat at 10 mg/kg, ip | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363669 | Oral bioavailability in rat at 10 mg/kg | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363690 | Inhibition of rat FAAH assessed as recovery of enzyme activity at IC80 concentration after 18 hrs at 22 degC by dialysis | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363689 | Inhibition of rat FAAH assessed as recovery of enzyme activity at IC80 concentration after 18 hrs at 4 degC by dialysis | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363656 | Inhibition of rat FAAH preincubated for 20 mins | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363657 | Inhibition of human FAAH preincubated for 20 mins | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363663 | Cmax in rat at 10 mg/kg, po | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363684 | Cmax in rat brain at 20 mg/kg, ip | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363664 | Tmax in rat at 10 mg/kg, po | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363671 | Tmax in rat at 10 mg/kg, ip | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363665 | Half life in rat plasma at 10 mg/kg, po | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363692 | Increase in anandamide levels in rat brain at 20 mg/kg, ip after 4 hrs relative to control | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363666 | Mean retention time in rat at 10 mg/kg, po | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363661 | Inhibition of human FAAH preincubated for 40 mins | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363676 | Bioavailability in rat at 10 mg/kg, ip | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363670 | Cmax in rat at 10 mg/kg, ip | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363683 | Tmax in rat plasma at 20 mg/kg, ip | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363681 | Volume of distribution in rat at 1 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363680 | Clearance in rat at 1 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363691 | Ex vivo inhibition of FAAH in rat brain assessed as recovered enzyme activity at 20 mg/kg, ip after 24 hrs relative to control | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363673 | Mean retention time in rat at 10 mg/kg, ip | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID363677 | Cmax in rat at 1 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID726794 | Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting | 2013 | Bioorganic & medicinal chemistry, Jan-01, Volume: 21, Issue:1
| Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors. |
| AID612777 | Inhibition of rat FAAH | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16
| The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH). |
| AID1298618 | Reversible inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 assessed as enzyme activity recovery rate using D-AMC substrate measured 24 to 144 hrs after exhaustive dialysis by f | 2016 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 26, Issue:12
| Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties. |
| AID363686 | Blood-brain barrier coefficient in rat assessed as log of ratio of brain AUC to plasma AUC at 20 mg/kg, ip | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID1345299 | Human Fatty acid amide hydrolase (Hydrolases) | 2008 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 18, Issue:17
| Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. |
| AID1345254 | Human Fatty acid amide hydrolase-2 (N-Acylethanolamine turnover) | 2009 | Anesthesia and analgesia, Jan, Volume: 108, Issue:1
| Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3
| High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |