Compounds > 11-o-galloylbergenin

Page last updated: 2024-11-12

11-o-galloylbergenin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

11-O-galloylbergenin: analgesic and anti-inflammatory; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	56680102
CHEMBL ID	1808739
MeSH ID	M0555377

Synonyms (8)

Synonym
11-o-galloylbergenin
CHEMBL1808739 ,
bdbm50349520
FS-8773
HY-N1023
DTXSID101315277
CS-0016259
AKOS040756354

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Albumin	Bos taurus (cattle)	IC50 (µMol)	183.7100	3.0000	3.0000	3.0000	AID609798
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (3)

Process	via Protein(s)	Taxonomy
cellular response to starvation	Albumin	Bos taurus (cattle)
negative regulation of mitochondrial depolarization	Albumin	Bos taurus (cattle)
cellular response to calcium ion starvation	Albumin	Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (8)

Process	via Protein(s)	Taxonomy
oxygen binding	Albumin	Bos taurus (cattle)
DNA binding	Albumin	Bos taurus (cattle)
fatty acid binding	Albumin	Bos taurus (cattle)
protein binding	Albumin	Bos taurus (cattle)
toxic substance binding	Albumin	Bos taurus (cattle)
pyridoxal phosphate binding	Albumin	Bos taurus (cattle)
metal ion binding	Albumin	Bos taurus (cattle)
enterobactin binding	Albumin	Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Process	via Protein(s)	Taxonomy
extracellular region	Albumin	Bos taurus (cattle)
extracellular space	Albumin	Bos taurus (cattle)
protein-containing complex	Albumin	Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (16)

Assay ID	Title	Year	Journal	Article
AID1311759	Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in cell viability at 50 umol/L after 24 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID609797	Antiglycation activity in bovine serum albumin assessed as inhibition of fructosamines formation at 200 uM in presence of glucose	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16	Synthesis and antiglycation potentials of bergenin derivatives.
AID609794	Antioxidant activity assessed as ABTS free radical scavenging activity at 200 uM	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16	Synthesis and antiglycation potentials of bergenin derivatives.
AID609800	Antiglycation activity assessed as inhibition of dicarbonyl compounds formation	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16	Synthesis and antiglycation potentials of bergenin derivatives.
AID1311784	Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as downregulation of NO levels by ELISA	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID609795	Antiglycation activity assessed as inhibition of Schiff-base formation at 200 uM	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16	Synthesis and antiglycation potentials of bergenin derivatives.
AID609799	Antiglycation activity assessed as inhibition of dicarbonyl compounds formation at 200 uM	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16	Synthesis and antiglycation potentials of bergenin derivatives.
AID1311783	Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as downregulation of COX2 levels by ELISA	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID1311782	Inhibition of NFkappaB signaling pathway in LPS-stimulated mouse RAW264.7 cells by ELISA	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID1311758	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 50 umol/L after 24 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID609798	Antiglycation activity in bovine serum albumin assessed as inhibition of fructosamines formation in presence of glucose	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16	Synthesis and antiglycation potentials of bergenin derivatives.
AID609796	Antiglycation activity assessed as inhibition of Schiff-base formation	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16	Synthesis and antiglycation potentials of bergenin derivatives.
AID1311785	Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as downregulation of PGE2 levels by ELISA	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID1311778	Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as downregulation of iNOS levels by ELISA	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID609802	Antiglycation activity assessed as inhibition of advanced glycation end product formation	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16	Synthesis and antiglycation potentials of bergenin derivatives.
AID609801	Antiglycation activity assessed as inhibition of advanced glycation end product formation at 200 uM	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16	Synthesis and antiglycation potentials of bergenin derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	8 (100.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
gallic acid gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.	3.48	7	0	trihydroxybenzoic acid	antineoplastic agent; antioxidant; apoptosis inducer; astringent; cyclooxygenase 2 inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; geroprotector; human xenobiotic metabolite; plant metabolite
pimagedine pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure. aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.	2.06	1	0	guanidines; one-carbon compound	EC 1.14.13.39 (nitric oxide synthase) inhibitor; EC 1.4.3.4 (monoamine oxidase) inhibitor
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	2.13	1	0	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
methyl gallate methyl gallate: has both immunosuppressive and phytogenic antineoplastic activities; isolated from Acer saccharinum. methyl 3,4,5-trihydroxybenzoate : A gallate ester obtained by the formal condensation of gallic acid with methanol. It exhibits anti-oxidant, anti-tumor, anti-microbial and anti-inflammatory properties.	2.11	1	0	gallate ester	anti-inflammatory agent; antioxidant; plant metabolite
catechin Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.	2.17	1	0	catechin	antioxidant; plant metabolite
bergenin bergenin: RN refers to (2R-(2alpha,3beta,4alpha,4aalpha,10bbeta))-isomer; structure	3.49	7	0	trihydroxybenzoic acid	metabolite
afzelechin afzelechin: from Hovenia dulcis; structure in first source. afzelechin : A tetrahydroxyflavan that is (2S)-flavan substituted by hydroxy groups at positions 3, 5, 7 and 4' respectively.	2.17	1	0	catechin; tetrahydroxyflavan	EC 3.2.1.20 (alpha-glucosidase) inhibitor; plant metabolite
epiafzelechin epiafzelechin: antioxidant; 3'-deoxy form of epicatechin; structure in first source. (-)-epiafzelechin : A catechin derivative having (2R,3R)-configuration.	2.17	1	0	catechin	plant metabolite
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	2.13	1	0	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
gamma-sitosterol clionasterol : A member of the class of phytosterols that is poriferast-5-ene carrying a beta-hydroxy substituent at position 3.	2.05	1	0	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; phytosterols	marine metabolite; plant metabolite
1,1-diphenyl-2-picrylhydrazyl 1,1-diphenyl-2-picrylhydrazyl: A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)	2.17	1	0
cytellin cytellin: a phytosterol preparation of mainly B-sitosterol, that was marketed by Eli Lilly to lower cholesterol 1957 to 1982	2.05	1	0
myricetin [no description available]	2.13	1	0	7-hydroxyflavonol; hexahydroxyflavone	antineoplastic agent; antioxidant; cyclooxygenase 1 inhibitor; food component; geroprotector; hypoglycemic agent; plant metabolite
lyoniside lyoniside: see also eleutherosides & syringin for eleutheroside B: 118-34-3; RN given refers to (3beta)-isomer	2.05	1	0
norbergenin norbergenin: bergenin derivative isolated from the root of Ardisia crenata	2.13	1	0

Condition	Indicated	Relationship Strength	Studies	Trials
Anasarca [description not available]	0	2.05	1	0
Innate Inflammatory Response [description not available]	0	2.05	1	0
Ache [description not available]	0	2.05	1	0
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	0	2.05	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	0	2.05	1	0
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	0	2.05	1	0