caryophyllene-oxide has been researched along with Pain* in 2 studies
2 other study(ies) available for caryophyllene-oxide and Pain
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[GC-MS analysis and analgesic activity of essential oil from fresh rhizoma of Cyperus rotundus].
To observe the analgesic effect and analysis the chemical components of essential oil (EOC) from fresh rhizome of Cyperus rotundus.. Hydrodistillation method was used to extract EOC; Acetic acid induced mice stretching model was applied to evaluate the analgesic effect of EOC. Gas chromatography coupled with mass spectrometry (GC-MS) were applied for the analysis of EOC.. The yield of EOC was 0.4%. The stretching times of mice induced by acetic acid were significantly reduced by EOC at dosage of 0.1 g/kg. 54 ingredients, 85.1% of which were EOC were identified by GC-MS analysis; The major compounds were cyperene (41.03%), beta-caryophyllene oxide (5.32%), alpha-selinene (4.37%), alpha-copaene (4.36%), naphthalene, 6-isoproenyl-4,8a-dimethyl-1, 2, 3, 5, 6, 7, 8, 8a-octahydro-(3.80%) and alpha-cyperone (3.11%).. The essential oil from fresh rhizome of Cyperus rotundus shows structure diversity and good analgesic effect. Topics: Acetic Acid; Analgesics; Animals; Cyperus; Disease Models, Animal; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Mice; Oils, Volatile; Pain; Pain Threshold; Plants, Medicinal; Polycyclic Sesquiterpenes; Rhizome; Sesquiterpenes; Solvents | 2011 |
Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark.
Caryophyllene oxide was isolated from an unsaponified petroleum ether extract of the bark of Annona squamosa and studied for its analgesic and anti-inflammatory activity. Caryophyllene oxide at the doses of 12.5 and 25mg/kg body wt. and unsaponified petroleum ether extract at a dose of 50mg/kg body wt. showed significant central as well as peripheral analgesic, along with anti-inflammatory, activity. These activities of caryophyllene oxide were comparable with the standard drug used in the respective experiments. Topics: Acetic Acid; Analgesics; Animals; Annona; Anti-Inflammatory Agents; Carrageenan; Edema; Female; Hot Temperature; Male; Mice; Pain; Phytotherapy; Plant Bark; Plant Extracts; Polycyclic Sesquiterpenes; Rats; Rats, Wistar; Sesquiterpenes | 2010 |