Glucose-dependent insulinotropic receptor

A glucose-dependent insulinotropic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV5]

G-protein coupled receptor 119

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
n-oleoylethanolamine	Homo sapiens (human)	EC50	2.3043	7	7
psn 632408	Homo sapiens (human)	EC50	212.3433	3	3
ar 231453	Homo sapiens (human)	EC50	0.6217	7	7
gsk1292263	Homo sapiens (human)	EC50	0.0034	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
psn 632408	Homo sapiens (human)	Activity	0.6300	1	1

This protein enables 3 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
G protein-coupled receptor activity	molecular function	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
phosphatidylcholine binding	molecular function	Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline. [GOC:mah, ISBN:0198506732]

This protein is active in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is part of 1 target(s):

Target	Category	Definition
receptor complex	cellular component	Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]

This protein is involved in 3 target(s):

Target	Category	Definition
insulin secretion	biological process	The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. [GOC:mah, ISBN:0198506732]
adenylate cyclase-activating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
regulation of metabolic process	biological process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. [GOC:go_curators]