p-chloroamphetamine has been researched along with Pain in 14 studies
p-Chloroamphetamine: Chlorinated analog of AMPHETAMINE. Potent neurotoxin that causes release and eventually depletion of serotonin in the CNS. It is used as a research tool.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of the specific 5-HT uptake inhibitors alaproclate and zimelidine, the 5-HT releasing compound p-chloroamphetamine (PCA) and the specific NA uptake inhibitor desipramine on pain sensitivity were examined in male rats using the hot-plate and tail-flick methods." | 7.66 | Test-specific effects of the 5-HT reuptake inhibitors alaproclate and zimelidine on pain sensitivity and morphine analgesia. ( Holm, AC; Ogren, SO, 1980) |
| "In a series of experiments the effects of p-chloroamphetamine (PCA) on shock-elicited aggression in rats were investigated." | 7.65 | p-Chloroamphetamine: short and long term effects upon shock-elicited aggression. ( Davis, M; Sheard, MH, 1976) |
| "The effects of the specific 5-HT uptake inhibitors alaproclate and zimelidine, the 5-HT releasing compound p-chloroamphetamine (PCA) and the specific NA uptake inhibitor desipramine on pain sensitivity were examined in male rats using the hot-plate and tail-flick methods." | 3.66 | Test-specific effects of the 5-HT reuptake inhibitors alaproclate and zimelidine on pain sensitivity and morphine analgesia. ( Holm, AC; Ogren, SO, 1980) |
| "In a series of experiments the effects of p-chloroamphetamine (PCA) on shock-elicited aggression in rats were investigated." | 3.65 | p-Chloroamphetamine: short and long term effects upon shock-elicited aggression. ( Davis, M; Sheard, MH, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (85.71) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maneepak, M | 1 |
| le Grand, S | 1 |
| Srikiatkhachorn, A | 1 |
| Iyengar, S | 1 |
| Webster, AA | 1 |
| Hemrick-Luecke, SK | 1 |
| Xu, JY | 1 |
| Simmons, RM | 1 |
| Berge, OG | 5 |
| Hole, K | 3 |
| Ogren, SO | 5 |
| Holm, AC | 1 |
| Lorens, SA | 1 |
| Brick, J | 1 |
| Sun, JY | 1 |
| Davis, L | 1 |
| Pohorecky, LA | 1 |
| Sheard, MH | 1 |
| Davis, M | 1 |
| Bogdanov, EG | 1 |
| Eide, PK | 1 |
| Broch, OJ | 1 |
| Johansson, C | 2 |
| Fasmer, OB | 1 |
| Jørgensen, HA | 1 |
| Post, C | 1 |
| Minor, BG | 1 |
| Davies, M | 1 |
| Archer, T | 1 |
1 review available for p-chloroamphetamine and Pain
| Article | Year |
|---|---|
Some behavioral effects of serotonin depletion depend on method: a comparison of 5,7-dihydroxytryptamine, p-chlorophenylalanine, p-choloroamphetamine, and electrolytic raphe lesions.
Topics: 5,7-Dihydroxytryptamine; Animals; Avoidance Learning; Behavior, Animal; Brain Stem; Electrolysis; Fe | 1978 |
13 other studies available for p-chloroamphetamine and Pain
| Article | Year |
|---|---|
Serotonin depletion increases nociception-evoked trigeminal NMDA receptor phosphorylation.
Topics: Animals; Disease Models, Animal; Male; Oncogene Proteins v-fos; p-Chloroamphetamine; Pain; Phosphory | 2009 |
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.
Topics: Acute Disease; Amines; Amitriptyline; Animals; Conscious Sedation; Cyclohexanecarboxylic Acids; Cycl | 2004 |
Attenuation of morphine-induced analgesia by p-chlorophenylalanine and p-chloroamphetamine: test-dependent effects and evidence for brainstem 5-hydroxytryptamine involvement.
Topics: Amphetamines; Analgesia; Animals; Brain Stem; Dose-Response Relationship, Drug; Drug Antagonism; Fen | 1983 |
Test-specific effects of the 5-HT reuptake inhibitors alaproclate and zimelidine on pain sensitivity and morphine analgesia.
Topics: Alanine; Analgesia; Animals; Behavior, Animal; Brompheniramine; Desipramine; Dose-Response Relations | 1980 |
Selective lesions of the bulbospinal serotonergic pathways reduce the analgesia induced by p-chloroamphetamine in the hot-plate test.
Topics: 5,6-Dihydroxytryptamine; Amphetamines; Animals; Male; p-Chloroamphetamine; Pain; Rats; Serotonin; Sp | 1984 |
Ethanol and the response to electric shock in rats.
Topics: Animals; Dopamine; Drug Interactions; Electroshock; Escape Reaction; Ethanol; Male; Methyltyrosines; | 1976 |
p-Chloroamphetamine: short and long term effects upon shock-elicited aggression.
Topics: Aggression; Amphetamines; Animals; Catecholamines; Electroshock; Humans; Male; Methyltyrosines; p-Ch | 1976 |
[The effect of morphine and opiate receptor agonists on arterial pressure and the bioelectrical activity of the renal nerve during stimulation of the midbrain central gray substance].
Topics: Animals; Blood Pressure; Cats; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin | 1989 |
5-HT depletion with 5,7-DHT, PCA and PCPA in mice: differential effects on the sensitivity to 5-MeODMT, 8-OH-DPAT and 5-HTP as measured by two nociceptive tests.
Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; | 1988 |
Involvement of spinal serotonergic pathways in nociception but not in avoidance learning.
Topics: 5,6-Dihydroxytryptamine; Animals; Avoidance Learning; Male; Norepinephrine; p-Chloroamphetamine; Pai | 1985 |
Test-dependent antinociceptive effect of spinal serotonin release induced by intrathecal p-chloroamphetamine in mice.
Topics: Amphetamines; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Mice, Inbre | 1985 |
Analgesia induced by 5-hydroxytryptamine receptor agonists is blocked or reversed by noradrenaline-depletion in rats.
Topics: 5-Hydroxytryptophan; Analgesics; Animals; Central Nervous System; Male; Methoxydimethyltryptamines; | 1986 |
Separation of the associative and non-associative effects of brain serotonin released by p-chloroamphetamine: dissociable serotoninergic involvement in avoidance learning, pain and motor function.
Topics: Amphetamines; Animals; Avoidance Learning; Brain; Male; Motor Activity; p-Chloroamphetamine; Pain; R | 1985 |