methylphenidate has been researched along with Pain in 28 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Although cumulative evidence suggests that dopamine is involved in pain processing, pain perception in ADHD subjects and the effect of dopamine agonists such as methylphenidate (MP, Ritalin) on it have rarely been studied." | 9.20 | Alterations in pain response are partially reversed by methylphenidate (Ritalin) in adults with attention deficit hyperactivity disorder (ADHD). ( Demeter, N; Eisenberg, E; Pud, D; Treister, R, 2015) |
| "Twenty consecutive patients with cancer pain receiving a continuous subcutaneous infusion of narcotics were admitted to a double-blind, crossover trial designed to assess the effects of methylphenidate on neuropsychological functions." | 9.07 | Neuropsychological effects of methylphenidate in patients receiving a continuous infusion of narcotics for cancer pain. ( Bruera, E; Kuehn, N; Macmillan, K; Miller, MJ, 1992) |
| "Thirty-two patients with chronic pain due to advanced cancer were treated with methylphenidate (10 mg with breakfast and 5 mg with lunch) for 3 days, versus placebo, in a randomized, double-blind, cross-over study designed to evaluate the capacity of methylphenidate to potentiate the analgesic effect of narcotics and/or to decrease sedation induced by narcotics." | 9.06 | Methylphenidate associated with narcotics for the treatment of cancer pain. ( Brenneis, C; Bruera, E; Chadwick, S; Hanson, J; MacDonald, RN, 1987) |
| "Methylphenidate hydrochloride (MPH/Ritalin) is a stimulant used for off-label management of cancer-related fatigue and sedation; however, its use in pain treatment is still relatively rare." | 7.83 | The effect of combined treatment of opioids with methylphenidate on nociception in rats and pain in human. ( Fricová, J; Rokyta, R; Šlamberová, R; Yamamotová, A, 2016) |
| "Methylphenidate was tested in each patient using three treatment strategies: no medication, low dose (5 mg × 3) and normal dose (20 mg × 3) for 4 weeks using a randomized cross-over design." | 6.79 | Evaluation of dosage, safety and effects of methylphenidate on post-traumatic brain injury symptoms with a focus on mental fatigue and pain. ( Andréll, P; Johansson, B; Mannheimer, C; Odenstedt, J; Rönnbäck, L; Wentzel, AP, 2014) |
| "Methylphenidate is a central nervous system simulant that is used for management of opioid-induced sedation." | 5.40 | Evaluation of concomitant methylphenidate and opioid use in patients with pain. ( Atayee, RS; Best, BM; Jiang, JY; Ma, JD; Morello, CM, 2014) |
| " Although cumulative evidence suggests that dopamine is involved in pain processing, pain perception in ADHD subjects and the effect of dopamine agonists such as methylphenidate (MP, Ritalin) on it have rarely been studied." | 5.20 | Alterations in pain response are partially reversed by methylphenidate (Ritalin) in adults with attention deficit hyperactivity disorder (ADHD). ( Demeter, N; Eisenberg, E; Pud, D; Treister, R, 2015) |
| " In the present study the effects of methylphenidate in two different dosages were assessed with regard to mental fatigue, pain and cognitive functions in persons who had suffered a traumatic brain injury." | 5.20 | Methylphenidate reduces mental fatigue and improves processing speed in persons suffered a traumatic brain injury. ( Andréll, P; Johansson, B; Mannheimer, C; Rönnbäck, L; Wentzel, AP, 2015) |
| "Twenty consecutive patients with cancer pain receiving a continuous subcutaneous infusion of narcotics were admitted to a double-blind, crossover trial designed to assess the effects of methylphenidate on neuropsychological functions." | 5.07 | Neuropsychological effects of methylphenidate in patients receiving a continuous infusion of narcotics for cancer pain. ( Bruera, E; Kuehn, N; Macmillan, K; Miller, MJ, 1992) |
| "Thirty-two patients with chronic pain due to advanced cancer were treated with methylphenidate (10 mg with breakfast and 5 mg with lunch) for 3 days, versus placebo, in a randomized, double-blind, cross-over study designed to evaluate the capacity of methylphenidate to potentiate the analgesic effect of narcotics and/or to decrease sedation induced by narcotics." | 5.06 | Methylphenidate associated with narcotics for the treatment of cancer pain. ( Brenneis, C; Bruera, E; Chadwick, S; Hanson, J; MacDonald, RN, 1987) |
| "Methylphenidate hydrochloride (MPH/Ritalin) is a stimulant used for off-label management of cancer-related fatigue and sedation; however, its use in pain treatment is still relatively rare." | 3.83 | The effect of combined treatment of opioids with methylphenidate on nociception in rats and pain in human. ( Fricová, J; Rokyta, R; Šlamberová, R; Yamamotová, A, 2016) |
| "Response to methylphenidate is associated with higher baseline fatigue but not with higher baseline depression or sedation." | 3.77 | Factors associated with response to methylphenidate in advanced cancer patients. ( Bruera, E; Chacko, R; Palmer, JL; Yennurajalingam, S, 2011) |
| "Methylphenidate was tested in each patient using three treatment strategies: no medication, low dose (5 mg × 3) and normal dose (20 mg × 3) for 4 weeks using a randomized cross-over design." | 2.79 | Evaluation of dosage, safety and effects of methylphenidate on post-traumatic brain injury symptoms with a focus on mental fatigue and pain. ( Andréll, P; Johansson, B; Mannheimer, C; Odenstedt, J; Rönnbäck, L; Wentzel, AP, 2014) |
| "Treatment with methylphenidate has been advocated in patients with traumatic brain injury and stroke, cancer patients, and those with human immunodeficiency virus infection." | 2.41 | Methylphenidate: its pharmacology and uses. ( Challman, TD; Lipsky, JJ, 2000) |
| "Methylphenidate is a central nervous system simulant that is used for management of opioid-induced sedation." | 1.40 | Evaluation of concomitant methylphenidate and opioid use in patients with pain. ( Atayee, RS; Best, BM; Jiang, JY; Ma, JD; Morello, CM, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (39.29) | 18.7374 |
| 1990's | 2 (7.14) | 18.2507 |
| 2000's | 3 (10.71) | 29.6817 |
| 2010's | 10 (35.71) | 24.3611 |
| 2020's | 2 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Sifeddine, W | 1 |
| Ba-M'hamed, S | 1 |
| Landry, M | 1 |
| Bennis, M | 1 |
| Bruschettini, M | 1 |
| Axelsson, I | 1 |
| Karsten Juhl Jørgensen, K | 1 |
| Lazenka, MF | 1 |
| Freitas, KC | 1 |
| Henck, S | 1 |
| Negus, SS | 1 |
| Pannett, M | 1 |
| Goodall, K | 1 |
| Bhutia, S | 1 |
| Stray, LL | 1 |
| Kristensen, Ø | 1 |
| Lomeland, M | 1 |
| Skorstad, M | 1 |
| Stray, T | 1 |
| Tønnessen, FE | 1 |
| Treister, R | 1 |
| Eisenberg, E | 1 |
| Demeter, N | 1 |
| Pud, D | 1 |
| Johansson, B | 2 |
| Wentzel, AP | 2 |
| Andréll, P | 2 |
| Odenstedt, J | 1 |
| Mannheimer, C | 2 |
| Rönnbäck, L | 2 |
| Jiang, JY | 1 |
| Best, BM | 1 |
| Morello, CM | 1 |
| Atayee, RS | 1 |
| Ma, JD | 1 |
| Yamamotová, A | 1 |
| Fricová, J | 1 |
| Rokyta, R | 1 |
| Šlamberová, R | 1 |
| Cyr, MC | 2 |
| Morgan, MM | 2 |
| Yennurajalingam, S | 1 |
| Palmer, JL | 1 |
| Chacko, R | 1 |
| Bruera, E | 5 |
| Ingram, SL | 1 |
| Aicher, SA | 1 |
| Westberg, J | 1 |
| Gobel, BH | 1 |
| Rosse, RB | 1 |
| Licamele, WL | 1 |
| Golinko, BE | 2 |
| Tennant, FS | 1 |
| O'Neill, WM | 1 |
| Challman, TD | 1 |
| Lipsky, JJ | 1 |
| Miller, MJ | 1 |
| Macmillan, K | 1 |
| Kuehn, N | 1 |
| Brenneis, C | 3 |
| Paterson, AH | 2 |
| MacDonald, RN | 3 |
| Portenoy, RK | 1 |
| Chadwick, S | 1 |
| Hanson, J | 1 |
| Korein, J | 1 |
| Maccario, M | 1 |
| Moggian, G | 2 |
| Cervellati, I | 2 |
| Tamburini, E | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methylphenidate Effect on Performing Humphrey Visual Fields[NCT02162381] | 32 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| A Parallel-group, Double-blind, Placebo-controlled Study of Methylphenidate as an Add on Therapy for Mirtazapine in the Treatment of Major Depressive Disorder in Cancer Patients Under Palliative Care[NCT01497548] | Phase 3 | 120 participants (Anticipated) | Interventional | 2011-03-31 | Recruiting | ||
| Randomized Study Evaluating the Antiasthenic Effect of Methylphenidate (Ritalin) in Palliative Care in Cancer Patients[NCT00273741] | Phase 3 | 39 participants (Actual) | Interventional | 2007-01-31 | Terminated (stopped due to difficulty of recrutement) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for methylphenidate and Pain
| Article | Year |
|---|---|
[Many sources of bias in medical research: experience from systematic reviews].
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Biomedical Research; Humans; Infant, Newborn; | 2023 |
Accidental intra-arterial injection of methylphenidate into the radial artery.
Topics: Adult; Amputation, Surgical; Compartment Syndromes; Female; Fingers; Follow-Up Studies; Humans; Infa | 2019 |
Methylphenidate: its pharmacology and uses.
Topics: Attention Deficit Disorder with Hyperactivity; Brain Injuries; Central Nervous System Stimulants; De | 2000 |
Methylphenidate: its pharmacology and uses.
Topics: Attention Deficit Disorder with Hyperactivity; Brain Injuries; Central Nervous System Stimulants; De | 2000 |
Methylphenidate: its pharmacology and uses.
Topics: Attention Deficit Disorder with Hyperactivity; Brain Injuries; Central Nervous System Stimulants; De | 2000 |
Methylphenidate: its pharmacology and uses.
Topics: Attention Deficit Disorder with Hyperactivity; Brain Injuries; Central Nervous System Stimulants; De | 2000 |
9 trials available for methylphenidate and Pain
| Article | Year |
|---|---|
Alterations in pain response are partially reversed by methylphenidate (Ritalin) in adults with attention deficit hyperactivity disorder (ADHD).
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Case-Control Studies; Central Nervous System S | 2015 |
Evaluation of dosage, safety and effects of methylphenidate on post-traumatic brain injury symptoms with a focus on mental fatigue and pain.
Topics: Adolescent; Adult; Central Nervous System Stimulants; Cross-Over Studies; Dose-Response Relationship | 2014 |
Methylphenidate reduces mental fatigue and improves processing speed in persons suffered a traumatic brain injury.
Topics: Adult; Brain Injuries; Cognition; Dose-Response Relationship, Drug; Female; Humans; Male; Mental Fat | 2015 |
Side effects of dexedrine in hyperactive children: operationalization and quantification in a short-term trial.
Topics: Anorexia; Attention Deficit Disorder with Hyperactivity; Body Weight; Child; Dextroamphetamine; Dose | 1982 |
The cognitive and psychomotor effects of opioid drugs in cancer pain management.
Topics: Adult; Amphetamines; Analgesics, Opioid; Buprenorphine; Central Nervous System Stimulants; Chronic D | 1994 |
Neuropsychological effects of methylphenidate in patients receiving a continuous infusion of narcotics for cancer pain.
Topics: Adult; Chi-Square Distribution; Cognition; Double-Blind Method; Female; Humans; Infusions, Intraveno | 1992 |
Methylphenidate associated with narcotics for the treatment of cancer pain.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Double-Blind Method; Drug Evaluation; D | 1987 |
[Critical study of the post-partum pain by means of a clinical pharmacology experiment].
Topics: Adult; Aspirin; Clinical Trials as Topic; Female; Humans; Methylphenidate; Pain; Phenobarbital; Plac | 1972 |
[Comparative study of a psychostimulating drug in the treatment of post-partum pain].
Topics: Adult; Analgesics; Aspirin; Clinical Trials as Topic; Female; Humans; Methylphenidate; Pain; Phenoba | 1973 |
16 other studies available for methylphenidate and Pain
| Article | Year |
|---|---|
Effect of atomoxetine on ADHD-pain hypersensitization comorbidity in 6-OHDA lesioned mice.
Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hy | 2023 |
Relief of Pain-Depressed Behavior in Rats by Activation of D1-Like Dopamine Receptors.
Topics: Analgesics; Animals; Behavior, Animal; Benzazepines; Conditioning, Operant; Depression; Dopamine Ago | 2017 |
Motor regulation problems and pain in adults diagnosed with ADHD.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Data Interp | 2013 |
Evaluation of concomitant methylphenidate and opioid use in patients with pain.
Topics: Analgesics, Opioid; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Drug Ut | 2014 |
The effect of combined treatment of opioids with methylphenidate on nociception in rats and pain in human.
Topics: Activities of Daily Living; Aged; Analgesics, Opioid; Animals; Central Nervous System Stimulants; Dr | 2016 |
Early methylphenidate exposure enhances morphine antinociception and tolerance in adult rats.
Topics: Age Factors; Animals; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Tole | 2009 |
Factors associated with response to methylphenidate in advanced cancer patients.
Topics: Anorexia; Anxiety; Central Nervous System Stimulants; Depression; Drug Monitoring; Dyspnea; Fatigue; | 2011 |
Chronic psychostimulant exposure to adult, but not periadolescent rats reduces subsequent morphine antinociception.
Topics: Age Factors; Analgesics; Analgesics, Opioid; Animals; Central Nervous System Stimulants; Dose-Respon | 2012 |
Methylphenidate use for the management of opioid-induced sedation.
Topics: Analgesics, Opioid; Central Nervous System Stimulants; Disorders of Excessive Somnolence; Drug Thera | 2004 |
Slow-release methylphenidate: problems when children chew tablets.
Topics: Abdomen; Anorexia; Attention Deficit Disorder with Hyperactivity; Child; Delayed-Action Preparations | 1984 |
Side effects of dextroamphetamine and methylphenidate in hyperactive children--a brief review.
Topics: Anorexia; Attention Deficit Disorder with Hyperactivity; Body Weight; Child; Dextroamphetamine; Grow | 1984 |
The California registration system for habitues to schedule II drugs.
Topics: Barbiturates; California; Chronic Disease; Humans; Methylphenidate; Pain; Registries; Substance-Rela | 1981 |
Use of methylphenidate as an adjuvant to narcotic analgesics in patients with advanced cancer.
Topics: Drug Therapy, Combination; Female; Humans; Male; Methylphenidate; Middle Aged; Morphine; Neoplasms; | 1989 |
Use of methylphenidate as an adjuvant to narcotic analgesics in patients with advanced cancer.
Topics: Adjuvants, Pharmaceutic; Humans; Methylphenidate; Neoplasms; Pain | 1989 |
Narcotics plus methylphenidate (Ritalin) for advanced cancer pain.
Topics: Drug Therapy, Combination; Humans; Mental Disorders; Methylphenidate; Narcotics; Neoplasms; Pain | 1988 |
On the diagnosis of cerebral death--a prospective study.
Topics: Brain; Coma; Death; Electroencephalography; Electrophysiology; Heating; Humans; Light; Methylphenida | 1969 |